JPS6336780B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for manufacturing a bag with a communicable cylinder, which is used, for example, as a blood bag.

Gone are the days when blood transfusions were whole blood transfusions, and in order to use blood more effectively, blood is now fractionated into each component and transfused with appropriate components for each patient. Against this background, so-called multiple bags, in which a plurality of soft plastic blood bags are connected by connecting tubes, have been provided. This multiple bag collects blood into a blood collection bag, centrifuges the blood to separate it into plasma and blood cells, and transfers the upper layer of plasma to a secondary bag via a connecting tube to divide the blood into two parts. Furthermore, the plasma is centrifuged to separate it into blood cell components such as platelets and white blood cells and plasma components, and the upper layer of blood cell components is transferred to another subbag via a connecting tube to divide the blood into three fractions. It is used when doing something.

Now, during blood centrifugation, it is necessary to prevent some blood from remaining in the connecting tube.

This is because when the separated plasma is transferred to the child bag, the blood remaining in the connecting tube mixes with the plasma, making the plasma impure.

To do this, conventionally, a thin film was installed in the connecting tube near the blood collection bag to isolate the blood collection bag from the child bag, and after the blood was centrifuged, the thin film was pierced through and the blood collection bag and child bag were communicated, allowing the separated plasma to be transferred to the child bag. It was being transferred to.
An example is shown in FIG.

In the figure, reference numeral 1 denotes a connecting tube that connects the blood collection bag and the child bag, and is blocked by a thin film 2. A breaking needle 3 for breaking through the thin film is installed inside the connecting pipe (see Figure A). During blood transfer, a breaking needle 3 is moved from the outside of the connecting tube 1 to pierce the thin film 2 and communicate the blood bags with each other (see Figure B).

The blood bag communication mechanism using a thin film as described above is difficult to operate for a beginner, and its manufacture is also troublesome.

SUMMARY OF THE INVENTION An object of the present invention is to provide a method for manufacturing a bag with a communicating cylinder that is easy to manufacture and handle.

That is, in the present invention, a soft synthetic resin cylindrical body having both open ends is formed of a small diameter portion that terminates in a sealed end with a small cross-section and a large diameter portion that terminates in an open end, and that the outer diameter of the small diameter portion is is smaller than the inner diameter of the cylinder,
The outer diameter of the large diameter portion is slightly larger than the inner diameter of the cylindrical body, and a thin wall portion is provided at one location of the small diameter portion to allow the opening of the small diameter portion to allow communication between the cylindrical bodies. A hollow hard synthetic resin communicating cylinder is inserted from the open end of the large diameter part beyond the thin wall part, and a certain distance is reached from the open end of the communicating cylinder to one open end of the cylinder. The outer wall of the large diameter portion of the communicating cylinder and the inner wall of the cylinder body are closely fixed by providing a gap, and a high-frequency sealing jig is inserted into the gap, and at least two sheets of soft synthetic resin for forming a bag are attached. It is characterized by stacking the sheets so as to sandwich the gap portion of the cylindrical body over one circumferential edge of the sheet, applying high frequency sealing to the circumferential edge, and further applying high frequency sealing to the remaining circumferential edge of the sheet to form a bag shape. This is a method of manufacturing a bag equipped with a cylindrical body that can communicate with each other.

An embodiment in which the present invention is applied to a blood bag will be described with reference to the drawings.

The one shown in FIG. 2 is a double blood bag made of soft plastic, which is used to divide blood into two fractions. The blood collection bag 11 and the child bag 14 are connected by a connecting tube 13 made of soft plastic such as soft polyvinyl chloride, and both bags 11 and 14 are manufactured by the manufacturing method of the present invention. It is interrupted at part A by a communication mechanism which is a cylindrical body that can communicate. Connecting tube 13 is blood collection bag 1
It is fitted and bonded into a connecting tube 12 which is a cylindrical body provided in 1.

After the blood collection needle 16 is pierced into the venous blood vessel of the blood sample recipient and an appropriate amount of blood is collected into the blood collection bag 11 via the blood collection tube 15, it is centrifuged under appropriate conditions. The blood in the blood collection bag 11 is separated into plasma and concentrated red blood cells.

Next, after establishing communication between the blood collection bag 11 and the child bag 14 through the A portion, the plasma forming the upper layer is transferred to the child bag 14, thereby completing the two-parting of the blood.

That is, the present invention is a method of manufacturing a bag 11 having the above-mentioned portion A, and one embodiment thereof is shown in FIG.

First, the hard communicating tube 17 is inserted from the small diameter portion 19 side through one end opening of the connecting tube 12, which is made of soft polyvinyl chloride and has both open ends. In this case, the communication tube is shown in Figure 4 and X--X in this figure.
As shown in FIG. 5, which is a cross-sectional view, the communication tube 17 is composed of a small diameter portion 19 that terminates at a sealed end 18 and a large diameter portion 21 that terminates at an open end 20. The diameter is slightly larger than the inner diameter of the connecting cylinder 12, and the outer diameter of the small diameter portion 19 is smaller than that. Furthermore, a thin wall portion 22 is formed at one location of the small diameter portion 19 to allow the opening of the small diameter portion to allow communication between the cylinders.
By bending 7, the communicating tube 17 can be separated into two from this thin portion. By this separation, the communication cylinder portion including the large diameter portion 21 forms a complete passage, so that the inside of the communication cylinder beyond at least the thin wall portion 22 from the open end 20 is hollow. This communication tube 17 is preferably made of hard polyvinyl chloride molded by injection molding. The communicating tube 17 preferably has a tapered step between the large diameter portion 21 and the small diameter portion 19, so that the third
As shown in the figure on the left, the tip 1 of the large diameter portion 21
When fitting into the connecting cylinder at a distance of about 2 mm and then using adhesive, insert the communicating cylinder part exposed from the connecting cylinder perpendicularly from the longitudinal direction of the part to such an extent that the end of the connecting cylinder 12 is slightly immersed. completely glue 2
3. For example, immerse in tetrahydrofuran and take out. At this time, the adhesive does not enter the hollow part of the communication cylinder because the upper part is sealed and an air layer is formed.

Thereafter, the communicating tube is set using a setting pin 24 or the like so that it fits completely in the connecting tube, and the large diameter portion 21 of the communicating tube is fixed with the adhesive 23.
The outer wall of is securely fixed to the inner wall of the connecting cylinder. The setting pin 24 consists of a tip 25 having an outer diameter slightly smaller than the inner diameter of the connecting tube 12, and a base 26. Excess adhesive flows out from the gap between the tip 25 and the inner wall of the connecting tube and is bonded. Do not leave excess adhesive on the parts. At this time, the adhesive fills the gap between the outer periphery of the opening of the communicating tube and the connecting tube, so no blood remains. Further, the height h of the tip portion 25 is approximately 10 mm, and the distance corresponding to this height h is the distance from the open end of the connecting tube 12 to the open end 20 of the communicating tube, and the gap 2
7 is formed, and at the other open end of the connecting tube 12 is a connecting tube 1 having an outer diameter that is approximately the same as the inner diameter of the connecting tube 12.
One open end of No. 3 is inserted and bonded.

The other end of the connecting pipe 13 is connected to at least one child bag 14, and is connected to the child bag 1 in advance.
It is better to prepare by attaching the connecting pipe 13 to 4.
At this stage, from the sealed end 18 of the communicating tube 17 to the connecting tube 1
The distance from No. 3 to the opening end is preferably 5 mm or more. This is because the outer diameter of the small diameter portion 19 of the communicating tube 17 is slightly larger than the inner diameter of the connecting tube 13, so the spacing is such that the small diameter portion 19 including the sealed end 18 does not restrict floating within the connecting tube due to the disconnection of the communicating tube 17. It is.

The sealed end 18 has a small cross-sectional shape, that is, a convex shape or a V-groove, so as not to block the opening of the connecting pipe 13.

Next, the two sheets 28, 28 made of soft polyvinyl chloride for creating the blood collection bag 11 are sandwiched between one periphery of the connecting tube 12, including the open end on the side where the communicating tube 17 is inserted. The sheets 28, 28 are overlapped in the same manner.

Furthermore, a jig 29 made of brass (not necessarily limited to this) is inserted into the connecting cylinder up to the gap 27 for high-frequency sealing, and the molds 30, 30 are fixed so as to sandwich it from above. Kake sheet 2
8, 28 and the connecting cylinder 12 with the seat 28
to seal. At this time, other tubes necessary for the blood collection bag (for example, blood discharge ports, blood collection tubes, etc.) can also be similarly inserted into the peripheral edges of the sheets 28, 28 and sealed at the same time.

Thus, the communication mechanism is completed, but the sheets 28,
28 is then sealed at the remaining three peripheries to form a blood collection bag, creating a so-called multiple bag with a communication mechanism as a whole.

In the communication mechanism produced by the manufacturing method of the present invention, when communication is desired, the connecting cylinder 12 is bent, and the internal communicating cylinder 17 is broken from its thin part 22 to separate it into two parts, thereby creating a connection between the bags. Since the communicating tube does not escape from the inside of the connecting tube even when separated, the separated communicating tube portion does not get mixed into the child bag.

In addition, the open end of the communication tube is on the blood collection bag side, and its outer periphery is filled with adhesive and smooth, so there is no residual blood during centrifugation, and the separated blood components can be transferred to the child bag. There is no residual blood contamination.

As detailed above, according to the present invention, it is possible to provide a communication mechanism with extremely good performance, and since the gap 27 is provided for insertion of a jig for high-frequency sealing, it is extremely easy to attach the communication mechanism to the blood collection bag. It has various advantages such as being able to be attached easily.

It should be noted that the present invention is not limited to the examples.

[Brief explanation of the drawing]

FIG. 1 is a sectional view showing a conventional blood bag communication mechanism, and FIG. 2 is a plan view showing a double blood bag.
Fig. 3 is a process diagram showing an embodiment of the present invention, Fig. 4 is a partially cutaway enlarged perspective view showing a communication mechanism manufactured by the present invention, and Fig. 5 is taken along the line X--X of Fig. 4. FIG. DESCRIPTION OF SYMBOLS 11...Blood collection bag, 12...Connection tube, 13...Connection tube, 14...Sub bag, 17...Communication tube, 18...Sealed end, 19...Small diameter part, 20...Open end, 21...Large diameter part, 22...Thin wall part , 29... jig.

Claims (1)

[Claims] 1 A soft synthetic resin cylindrical body having both open ends consists of a small diameter part that ends at a sealed end with a small cross-section and a large diameter part that ends at an open end, starting from one end opening of a soft synthetic resin cylinder having both open ends, and the outer diameter of the small diameter part is the same as that of the cylinder. The outer diameter of the large diameter portion is slightly larger than the inner diameter of the cylindrical body, and an opening in the small diameter portion is allowed at one location to allow communication between the cylindrical body and the cylindrical body. A hollow hard synthetic resin communicating tube is inserted beyond the thin walled portion from the open end of the large diameter portion, and the cylinder body is provided with a thin walled portion. The outer wall of the large diameter portion of the communicating cylinder and the inner wall of the cylinder are tightly fixed by providing a certain amount of air gap up to one opening end, and a high-frequency sealing jig is inserted into the air gap, and at least two sheets for forming a bag are formed. The soft synthetic resin sheet is overlapped so as to sandwich the gap between the cylinders, the peripheral edge is high-frequency sealed, and the remaining peripheral edge of the sheet is high-frequency sealed to form a bag shape. A method for manufacturing a bag having a cylindrical body that can communicate.