JPS6338001B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a water-soluble insecticidal/sterilizing gel composition that utilizes the properties of carrageenan, particularly lambda-type carrageenan, and that dissolves into water after gel solidification to exhibit insecticidal/sterilizing effects. Traditionally, carrageenan has been used as a gelling agent and thickening agent in all fields. For example, JP-A No. 49-12046 discloses a volatile solid deodorant fragrance using carrageenan as a gelling agent, and JP-A No. 53-50346 discloses insecticidal, It has been disclosed that carrageenan is used in combination with locust bean gum and xanthan gum as a gelling agent for a bactericidal and antifungal gel. However, in all of these active ingredients (insecticides,
It is a composition for volatilizing germicidal agents, antifungal agents, fragrances, etc., and contains carrageenan as a gelling agent. No such gel compositions are found, nor are any such gel compositions known. On the other hand, some commercially available water-soluble compositions include formulations in which insecticides or fungicides are adsorbed to water-soluble substances such as D-sorbitol, but these water-soluble substances do not adsorb active ingredients. The amount is around 10% of the weight of the substance, and the cost is high,
Furthermore, the rate of dissolution in water is extremely high, and the rate of dissolution of the active ingredient is determined only by the water-soluble substance to be adsorbed, so there is a drawback that the rate of dissolution of the active ingredient cannot be freely adjusted. In view of the above circumstances, the present inventors have conducted intensive research on gel compositions in the form of dosage forms that are used by dissolving them in water after gel solidification.
60 lambda type carrageenan from 7 types of theta
It has been found that when carrageenan containing % or more is used as a gelling agent, the active ingredient can be blended at a high concentration and a gel composition that is water-soluble after gel solidification can be obtained. They have discovered that by incorporating a fast-dissolving substance and/or a slow-dissolving substance, it is possible to freely adjust the dissolution rate of a water-soluble gel and, ultimately, the active ingredient contained in the gel composition, and have completed the present invention. It is ivy. That is, the present invention provides a water-soluble insecticidal/sterilizing agent which has an insecticide and/or bactericidal agent and carrageenan containing 60% or more of lambda type carrageenan as its main components, and which exhibits an insecticidal/sterilizing effect by being dissolved in water after gel solidification. A gel composition is provided. Furthermore, the present invention provides, by incorporating a fast-dissolving substance and/or a slow-dissolving substance into the gel composition,
The present invention provides a water-soluble insecticidal/sterilizing gel composition in which the dissolution rate of the insecticidal/sterilizing agent is controlled. The essential feature of the present invention is to use carrageenan containing 60% or more of lambda type carrageenan as a gelling agent. If the lambda type in carrageenan is less than 60%, the solubility in water is poor, and it is difficult to obtain a gel composition with good water solubility after gel solidification. The amount of carrageenan containing 60% or more of lambda type carrageenan is preferably 1 to 5% by weight of the gel composition. Since 10 times the amount of insecticides and fungicides can be blended with the above carrageenan, there is no point in blending more than 5% by weight of the above carrageenan. It may be selected within the above range depending on the amount. Insecticides and fungicides used in the present invention include pyrethroid-based, organophosphorus-based, carbamate-based insecticides, organophosphorus-based, phenol-based, etc.
These include organic sulfur-based fungicides, etc., and at least one of these insecticides and fungicides is blended.
The blending amount is preferably 1 to 25% by weight, and may be selected within this range depending on the application. A gel-like material can be obtained by dissolving the carrageenan, insecticide, and/or bactericide described above in water, and then heating the solution together with a detergent or the like depending on the application. In other embodiments of the invention, fast-dissolving substances or slow-dissolving substances, or both, are included in order to control the dissolution rate of active ingredients (primarily insecticides and fungicides). The amount of each is 1
It is preferably 15% by weight, and is appropriately selected within this range depending on the desired dissolution rate. Fast-soluble substances include sodium nitrate, ammonium sulfate, sodium sulfate, sodium chloride, boric acid, and sodium organic acids; slow-soluble substances include aluminum sulfate, calcium sulfate, potassium sulfate, ferrous sulfate, magnesium sulfate, calcium chloride, Potassium chloride, magnesium chloride, zinc chloride, potassium ferricyanide and potassium organic acids. The effects and effective concentrations of these additives on the dissolution rate are shown in Tables 1 and 2. In addition,
The dissolution rate was determined by the following test. [Dissolution rate test] Tap water is poured from the bottom into a cylinder with a diameter of 10 cm and a height of 50 cm. When a certain volume is reached, the tap water flows down in a siphon style. Gel is poured into the cylinder at intervals of 6 cm from the bottom. Secure 5 pieces with wire mesh. When using a fast-dissolving gel, the reference gel is placed on the bottom row, while when using a slow-soluble gel, the reference gel is placed on the top row and the sample gels are placed on each other row. The decrease is measured gravimetrically over time. The dissolution rate is expressed as the logarithm of the weight of the sample gel and the reference gel when the weight of the reference gel is reduced by half. That is, dissolution rate = log Msampl/M _STD , where M _STD is the half weight (g) of the reference gel after a certain period of time, and Ms ampl is the weight (g) of the sample gel after the same period of time. . Note that Msampl is placed at the top of the cylinder when it is a fast-dissolving gel, and at the bottom when it is a slow-dissolving gel.

【table】

【table】

[Table] In Tables 1 and 2 above, additive-free means carrageenan containing 65% lambda-type carrageenan.
3.2% by weight of potassium chloride, 0.3% by weight of potassium chloride, and other water gels, and the dissolution rate values of the gels containing additives are the values when 2% by weight of the additives are added. As described above, according to the present invention, by using carrageenan containing 60% or more of lambda type carrageenan as a gelling agent, it is possible to make an insecticidal/sterilizing gel that dissolves in water. As is clear from the above, in addition to being able to obtain a water-soluble insecticidal/sterilizing gel composition in which the active ingredient is eluted in water at a constant concentration, it is also possible to incorporate the active ingredient at an extremely high concentration for a water-soluble composition. There is an advantage. For example, 10 times or more of the insecticide or fungicide can be contained in 1.5 g of carrageenan containing 60% or more of lambda-type carrageenan. Furthermore, by incorporating a fast-dissolving substance and/or a slow-dissolving substance, the dissolution rate of the gel, that is, the dissolution rate of the active ingredient, can be adjusted as desired. Furthermore, the most characteristic feature of the water-soluble insecticidal/sterilizing gel composition of the present invention is that it always provides a fresh surface when releasing active ingredients (mainly insecticides and fungicides) into water. This means that when conventional volatile solid fragrances evaporate their active ingredients (mainly fragrances) into the air, as water evaporates,
This is in contrast to the case where a carrageenan film is formed on the surface, which has a negative effect on the volatilization of the active ingredient. It clearly shows. In addition, carrageenan is safe enough to be eaten, is non-polluting, does not pollute the environment, and does not affect activated sludge. Moreover,
It is extremely easy to transport and store, has excellent resilience even if a small amount of moisture evaporates into the air, and there is no risk of fire. Therefore, the water-soluble insecticidal/sterilizing gel composition according to the present invention also has the above effects. By having the above-mentioned advantages or effects, the water-soluble insecticidal/sterilizing gel composition according to the present invention can be used for various purposes. For example, it is suitable for formulations that are immersed in running water such as in ditches or gutters, and the insecticide is gradually eluted into the running water, thereby suppressing the occurrence of flycatchers, etc. for a long period of time (30 days or more). Also,
It can also be applied to insecticides and fungicides for gardening, where it is connected directly to a tap water faucet and a certain amount of insecticide or fungicide is eluted into the tap water. Furthermore, it can be used in various preparations, such as toilet bowls used in men's toilet bowls, which have an insecticidal and sterilizing effect when dissolved in water, and at the same time have other effects such as a cleaning effect (containing a detergent). In addition, certain compositions of the present invention can be used by dissolving the gel composition in water by stirring it in a bucket and spraying it as an emulsion. EXAMPLES The present invention will be explained in more detail with reference to Examples below. Example 1 Table 3 shows a formulation example of a water-soluble gel composition for epidemic prevention that exhibits long-term insecticidal efficacy when soaked in running water such as a ditch or gutter.

[Fast dissolution test]

Add gelling agent, insecticide, etc. to a total of 50g in a 100ml beaker, and heat to gel. Pour 150 ml of tap water into a 300 ml beaker so that the entire gel is immersed, measure the weight every day, and calculate the number of days required for the weight of the gel to become 0 from a graph. This is defined as rapid dissolution (unit: days). The tap water was replaced once a day.

[Table] In Table 4, the dissolution rate is formulation number 1 (control).
The higher the value compared to -1.2, the slower the solubility in water due to repeated water-air contact. In addition, regarding fast dissolution, the larger the value compared to 10.0 days for formulation number 1 (control), the slower the dissolution when immersed in water. Next, Table 5 shows the results of measuring the elution of insecticides using the formulations shown in Table 3.

[Table] Shows the amount eluted. Sumithion's analysis method is spectrophotometry, and Smithlin's analysis method is gas chromatography.
I used the graph method.
In addition, fast-dissolving test liquid (liquid dissolved on each elapsed day)
Table 6 shows the results of an insecticidal efficacy test on the final instar larvae of the Culex mosquito by diluting it 1000 times.

[Table] Example 2 Table 7 shows formulation examples of ready-to-dissolve insecticidal gel compositions for epidemic prevention, selected at random from a large number of experiments conducted with organophosphorus-based, pyrethroid-based, and other insecticides. These are suitable for use by stirring the gel in a bucket or the like, dissolving the gel in water to form an emulsion, and then spraying it.

[Table] Table 8 shows the results of measuring the dissolution rate and quick solubility of the immediately soluble insecticide compositions shown in Table 7.

[Table] Amount % and other water prescriptions.
In Table 8, the dissolution rates of the fast-dissolving insecticide compositions are all on the same side, compared to +1.2 for the control, indicating that the dissolution is extremely fast. This is extremely fast compared to the control. Next, Table 9 shows the results of an insecticidal efficacy test conducted on the immediately soluble insecticide compositions shown in Table 7. For the insecticidal efficacy test, take 1 g of each prescription gel,
The solution was dissolved in tap water and tested on the last instar larvae of the Culex mosquito, and the mortality rate was observed after 1 day.

[Table] Table 10 shows the results of testing the insecticidal efficacy of the immediately soluble insecticide composition of Formulation No. 9 on the final instar larvae of the Culex mosquito per gel reduction.

【table】
1 1 1 1
Note) The gel weight loss rate is the gel weight loss rate at the time of departure (50
g) of

Claims (1)

[Scope of Claims] 1. A water-soluble insecticidal/sterilizing gel composition comprising an insecticide and/or bactericide and carrageenan containing 60% or more of lambda-type carrageenan. 2. The water-soluble insecticidal/sterilizing gel composition according to claim 1, wherein the amount of carrageenan containing 60% or more of lambda type carrageenan is 1 to 5% by weight. 3. The insecticide and/or fungicide is at least one selected from pyrethroid, organophosphorus, and carbamate insecticides, and organophosphorus, phenol, and organic sulfur fungicides;
Claim 1 containing 1 to 25% by weight
The water-soluble insecticidal/sterilizing gel composition according to item 1 or 2. 4. A water-soluble insecticidal/sterilizing gel composition comprising an insecticide and/or bactericide, carrageenan containing 60% or more of lambda-type carrageenan, and a rapidly soluble substance and/or a slowly soluble substance. 5. The water-soluble insecticidal/sterilizing gel composition according to claim 4, wherein the amount of carrageenan containing 60% or more of lambda type carrageenan is 1.0 to 5.0% by weight. 6. The insecticide and/or fungicide is at least one selected from pyrethroid, organophosphorus, and carbamate insecticides, and organophosphorus, phenol, and organic sulfur fungicides;
Claim 4 containing 1 to 25% by weight
The water-soluble insecticidal/sterilizing gel composition according to item 1 or 5. 7. According to any one of claims 4 to 6, the rapidly soluble substance is sodium nitrate, ammonium sulfate, sodium sulfate, sodium chloride, boric acid, and sodium organic acid, and is blended in an amount of 1 to 15% by weight. A water-soluble insecticidal/sterilizing gel composition. 8 Slowly soluble substances are aluminum sulfate, calcium sulfate, potassium sulfate, ferrous sulfate, magnesium sulfate, calcium chloride, potassium chloride, magnesium chloride, zinc chloride, potassium ferricyanide, and potassium organic acid, and are blended in an amount of 1 to 15% by weight. A water-soluble insecticidal/sterilizing gel composition according to any one of claims 4 to 6.