JPS6340766B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a method for producing a patch, and more particularly to a method for producing a patch having an adhesive strength between that of a patch and a poultice. Conventional patch medicines can be roughly divided into raw rubber, softeners,
a mixture containing a tackifying resin and a filler;
A so-called balm paste is produced by applying and spreading this composition on a support, and a water-soluble polymer compound such as gelatin is blended with a humectant, kaolin, water, and a paste base. It is classified as a so-called poultice, which is produced by coating and spreading a kneaded product on a support. Among these, the former type, Hatsuka rubber plaster, uses raw rubber as the base material, so if it is applied to a person with an idiosyncratic constitution, it may cause allergic symptoms due to impurities (proteins, etc.) in the raw rubber. Even if you have a normal constitution, the adhesive is relatively strong, so if you apply it to an area with thick hair, it will be painful to remove it, and even if it is not such an area, you may be able to repeatedly apply it to the same area. If it is pasted, there is a risk that the epidermis of the area will be damaged when it is removed. In addition to these drawbacks in use, Hatsuka rubber plaster is also disadvantageous in that the series of steps for preparing the base material, starting from mastication of raw rubber, are complex and varied, and the costs associated with this process account for a major portion of the production cost. . On the other hand, poultices generally have weak adhesive strength, so when peeled off, the pain experienced with adhesive plasters is hardly felt. However, as the moisture content evaporates during use, the adhesive strength of this poultice rapidly decreases, causing it to easily peel off, and depending on the area where it is used, the four corners of the poultice may need to be fixed with adhesive tape, which is a fatal problem. There were flaws. The present invention proposes a new method for producing a patch that uses a special synthetic polymer compound as a plaster base material. Because it is used, there is no need to worry about developing allergic symptoms even if it is applied to people with idiosyncratic constitutions, and the adhesive strength is moderate, so when using it, there is no need to worry about the problems that occur with adhesive plasters and poultices. There is no. The method for producing the patch according to the present invention is to prepare a styrene/isoprene/styrene block copolymer (A) or a styrene/butadiene/styrene block copolymer (B) from a modified copolymer obtained by graft polymerization of methyl methacrylate. A paste base material is mixed with a mixture containing a paste base material, liquid paraffin, a tackifying resin, and a filler, and the paste base agent is mixed and kneaded, and the kneaded product is coated and spread on a support. The modified block copolymer used as the plaster base material in the present invention contains a segment consisting of a crystalline phase (styrene) and a segment consisting of an amorphous phase (isoprene or butadiene), and it flows when heated. It is a thermoplastic synthetic rubber that exhibits viscoelasticity and hardens into a semi-solid upon cooling. By the way,
The elastic modulus of the synthetic rubber is at 200% elongation.
Indicates a value of 0.08-0.8Kg/ ^cm2 . The styrene/isoprene/styrene block copolymer (A), hereinafter abbreviated as SIS, has a trade name of Califrex TR1107 (manufactured by Siel Chemical Co., Ltd.), while the styrene/butadiene/styrene block copolymer (A), abbreviated as SBS, (B) is Califlex TR1101 or
Both are available on the market under the trade name TR1102 (same as above). And SIS-MMA to SBS-
The modified copolymer of the present invention, abbreviated as MMA, is obtained by graft-polymerizing methyl methacrylate (MMA) onto the above-mentioned SIS or SBS using a radiation polymerization method, and generally contains 90 to 95 parts by weight of SIS or SBS.
A material obtained by graft polymerization of MMA in a proportion of 10 to 5 parts by weight is acceptable. SIS- as a plaster base material
One or more types of MMA and SBS-MMA can be used, but the amount of the plaster base material is 20 to 45% by weight of the mixture containing liquid paraffin, tackifier resin, filler, etc. It is preferable that there be. In addition to the polybutene and process oil used in conventional adhesive plasters, liquid paraffin is used as a softening agent in the present invention, but the amount used is the same as before. Tackifiers, fillers and base ingredients include:
There are some that have been conventionally used in this industry, and they are used in conventional amounts. For example, tackifying resins include polyterpene resins (e.g. YS-resin), linear hydrocarbon resins (e.g. Escorets), hydrogenated rosin esters (e.g. ester gum), and fillers include zinc white or dioxide. White pigments such as titanium are used as base ingredients for the paste, such as methyl salicylate, glycol salicylate, camphor, l-menthol, capsicum (extract), capsaicin, nonylic acid vanillylamide, adrenocortical hormones, and skin protection agents in the same amount as before. used in Since the adhesive patch of the present invention uses a special synthetic polymer compound as a base material, 3 to 20% by weight of water can be blended in the presence of a surfactant. By adding water, the skin irritation of the patch is enhanced, so it exhibits the effect of promoting skin blood flow. In this case, the surfactant may be sorbitan monooleate, sorbitan monostearate, polyoxyethylene allyl alcohol ester, etc., and the amount used is 1.5 to 15.0% by weight.
It is preferable to set it as the range of. It is also recommended to use humectants such as propylene glycol and glycerin. It should be noted that there are no examples of conventional adhesive patches that use raw rubber as a base material to include water. Table 1 shows a comparison between the adhesive patch of the present invention and conventional adhesive plasters and poultices.

[Table] Examples of the present invention will now be shown. Example 1 Plaster base material (SIS-
MMA, SBS-MMA), a softener (liquid paraffin), and a filler (titanium dioxide) are homogeneously mixed in a heating and pressure kneading machine, and a tackifier resin (ester gum) is added to this, followed by the base agent for the paste. A kneaded product having a temperature of around 100°C was obtained by blending. After coating and spreading this kneaded material on a support made of sfumos, nonwoven fabric, etc.
The adhesive patch of the present invention was manufactured by cutting it into an arbitrary size. Note that the above-mentioned Califrex TR1107 and TR1101 were used for the SIS and SBS, respectively, and cellophane, polyethylene or polypropylene film, release paper, etc. were pasted on the surface of the patch.

[Table] Example 2 This example shows an example of manufacturing a water-containing patch, in which plaster base materials (SIS-MMA, SIS-MMA,
SBS-MMA), liquid paraffin equivalent to 25% by weight, and titanium dioxide were placed in a pressurized and heated kneader and mixed together, and to this was added liquid paraffin equivalent to 70% by weight and kneaded. On the other hand, an emulsion was prepared by mixing the remaining liquid paraffin (equivalent to 5% by weight), water, propylene glycol, glycerin, and a surfactant in the proportions shown in Table 3, and this emulsion was mixed with the above-mentioned kneaded material. Mixed. Next, a paste base material was added to this mixture to obtain a kneaded product, and thereafter a water-containing patch was obtained in the same manner as in Example 1.

【table】

Claims (1)

[Claims] 1. A plaster made of a modified copolymer obtained by graft polymerizing methyl methacrylate to a styrene/isoprene/styrene block copolymer (A) or a styrene/butadiene/styrene block copolymer (B). A patch drug consisting of a mixture containing a base material, liquid paraffin, a tackifying resin, and a filler, mixed with a paste base agent and kneaded homogeneously, and the kneaded product is spread on a support. manufacturing method. 2 The amount of plaster base material in the above mixture is 20 to 45% by weight.
A method for manufacturing a patch medicine according to claim 1. 3 In the above kneaded material, 1.5 to 15.0% by weight of a surfactant selected from sorbitan monooleate, sorbitan monostearate, and polyoxyethylene stearyl alcohol ether, and 3 to 3% of water.
Claim 1 or 2 containing 20% by weight
Method for manufacturing patch medicines described in Section 1. 4. The method for producing a patch according to claim 3, wherein a humectant is further added to the kneaded product.