JPS6341883B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention generally relates to pellets suitable for oral administration to ruminants;
It passes through the rumen and becomes beneficial to the ruminant after reaching the stomach and/or intestines. In particular, the present invention structurally protects nuclear substances such as nutrients and drugs, and in the environment of the rumen, but loses binding properties under the more acidic conditions of the rumen, making it difficult for animals to use. The present invention relates to pellets having a non-porous coating on the nuclear material which allows the nuclear material to be eluted for utilization. In ruminants, ingested food first enters the rumen, where it is predigested or broken down by fermentation. During this fermentation period, the ingested food can be passed through the stomach where it is ruminated and then regurgitated back into the mouth. controlled by natural processes,
After a period of fermentation, which also varies depending on the animal and diet,
Absorption of digested nutrients begins and is passed on to the next part of the ruminant's digestive tract. This process is described by DCChuxh, “Digestive Physics and Nutrition of Luminants”.
Physiology and Nutrition & Ruminants, Volume 1, OSU Book Stores, Inc., Corvallis, Oregon. The largest of the compartments (the rumen) serves as an important site for the metabolic breakdown of ingested food by the action of the microorganisms that live there. It remains in the rumen for a long time, during which time it is subjected to metabolic decomposition by the rumen's microorganisms.Many ingested protein substances are broken down into soluble peptides and amino acids in the rumen, and then processed by the rumen's microorganisms. When the contents of the rumen pass through the rumen and intestines, the microbial population is digested, thereby providing the ruminant with protein; i.e., the ruminant's natural nutritional balance is Basically, it is related to the composition and population of the microorganisms.When preparing nutrients and drugs for administration to ruminants, it is important to consider the environmental conditions of the rumen, i.e., microbial decomposition and pH of approximately 5.5. It is important to protect the active ingredient against the effects of, thereby retaining the active substance until it reaches a certain site where inhalation occurs.Essential amino acids and/or drugs that live in the rumen. It is well known that the production rate of meat, wool and/or milk can be improved if it can be protected from microbial deterioration and absorbed directly into the animal later in the gastrointestinal tract. The substance that protects the active ingredients in the nuclear material against degradation by the enzymes and microorganisms should be resistant to attack by ruminal juices containing enzymes and microorganisms, but at a pH within the normal physiological range of about 2 to about 3.5. It must provide the active ingredient rapidly in the more acidic fluids of the stomach.In order to more easily coat or encapsulate the active ingredient in the protective substance, the protective substance must be Since proteins are subject to degradation in the rumen, protein-containing nutrients given to ruminants should pass through the rumen and into the rumen without undergoing microbial degradation. It has been previously suggested that this should be done.
Suggested methods include coating the protein material with, for example, fats or vegetable oils, heat treating the protein material, coating the protein material with formaldehyde, acetylenic esters, polymerized unsaturated carboxylic acids or acid anhydrides, and phosphonitrilic halides ( reactions with various compounds such as phosphonitrilic halides), and so on. All proteins found in animals and animal life forms are chemical substances consisting of more than 20 amino acids with different compositions, and the number and sequence of acids are fixed in each individual protein. Twelve of these amino acids are normally synthesized in nutritionally sufficient quantities from other substances by biochemical processes that occur in many animals, but the remaining ten essential amino acids are synthesized in sufficient quantities. Therefore, it must be ingested by animals. Since the proportion of constituent amino acids in individual proteins cannot be varied, the minimum essential amino acids in supply will limit the amount of protein that can be made by an animal. Therefore, for any given diet, one particular essential amino acid limits the production of proteins containing essential amino acids, unless two or more such amino acids equally limit the amount of protein, of course. There will be. Recognition of the above-mentioned principles has led to the formulation of non-ruminant feeds, which provides the best proportion of amino acids and also allows for a considerable increase in targeted protein production. In ruminants, dietary proteins and amino acids are broken down in varying proportions into ammonia and various organic compounds by microbial fermentation in the first two compartments of the stomach (the rumen and the humus). Bacteria and protozoa in these organs use these metabolites for their own growth and multiplication, and the resulting microbial proteins are deposited in the gastric septum, which corresponds to the stomach of non-ruminants. chamber, where it is partially digested. This process is completed in the small intestine, where the amino acids are absorbed. Similarly, it is well known that drugs are more effective when they are protected from the ruminal environment. For example, US Patent No. 3041243 and
See 3697640. According to the invention, the coating or film-forming material is responsible for the protection and release of the properties of the core material, and also comprises a mixture of at least one hydrophobic polymeric material, which is insoluble in the aqueous acidic liquid, and is dispersed therein. Contains materials that are exposed to attack by aqueous acidic liquids. The polymeric material is usually a continuous matrix. The dispersed substance may be organic or inorganic, and in an aqueous environment below a pH of about 4, it may leach out of or be integrated with the continuous phase polymer (matrix) constituting the polymer matrix (coating). The coating material is capable of resisting the environmental conditions of the rumen and the ability to expose pellet nuclear material in the ruminal environment; i.e., the coating material has a It is resistant to PH conditions for at least approximately 24 hours.The coating material also has a
When exposed to the environmental conditions of the stomach with a pH of approximately 10
The nuclear material is released after a minute to about six hours. Exposure of the nuclear material can occur by the coating becoming permeable to the liquid, or by dissolution or decomposition. Another requirement for the coating material is that it should have the ability to resist relatively high heat and/or humidity storage conditions without a significant degree of damage. Pellets The pellets according to the invention are adapted for oral administration to ruminants. The pellet has a diameter of approx.
It has a suitable size, such as between 0.05in and 0.75in (0.127-1.91cm). The pellets also have a suitable density, i.e., a specific gravity of between about 1 and 1.4;
It must have an acceptable odor, taste, feel, etc. The pellet contains the core material and a continuous thin film or coating that completely encloses the material. Although the shape is usually not critical, the pellets are usually spherical for ease of coating. Nuclear material is material that becomes beneficial to the ruminant when it passes through the rumen and reaches the rumen and/or intestine. Normally, the nuclear material is a solid substance formed into granules, such as by spheroidization. The nuclear material is then rotated (tumbling) if necessary.
It can be made into a spheroid by a conventional method such as by. The core material should have sufficient viscosity or consistency to remain intact during handling, especially during coating operations. Suitable nuclear materials include, for example:
Contains various drugs and nutrients such as antibiotics, laxatives, drugs, anti-parasitic agents, amino acids, proteins, carbohydrates, carbohydrates, etc. The core material may also contain inert fillers such as clays. Amino acids suitable for use as nuclear materials, their PH
and solubility are as follows:

Table: Proteins from a variety of sources are useful in the practice of this invention. Proteins are generally polymers derived from various combinations of amino acids. Proteins are amphoteric substances, meaning they can be soluble or suspended in aqueous fluids that are more acidic or more basic than the particular protein under consideration. Nuclear material can be made ready for coating by the following method. Nutrients, drugs, etc. are mixed with water, binders, and sometimes inert inorganic substances added to adjust the specific gravity of the pellet, and the resulting plastic dough is extruded or rolled to obtain particles of the appropriate size. . Adhesive binders are added to strengthen the pellets, as well as non-toxic vegetable gums, starches, cellulose derivatives, animal gums and other similar substances well known in the food fortification and tablet manufacturing fields. May be added. Inorganic additives used to adjust the pH or specific gravity of the pellets include insoluble, non-toxic pigment-like substances such as relatively high density metal sulfates, oxides and carbonates. The final range of desired density of pellets, which are protected in the rumen, is from 1.0 to
It is 1.4. After forming pellets of appropriate size by extrusion, rolling or other suitable means, the pellets are dried to remove water. The pellets are then coated by contacting them with a solution of the protective coating material in a suitable solvent or mixture of solvents as described below. Solvents of typical utility include lower alcohols, ketones, esters, hydrocarbons, and hydrogen chlorides. Coating A coating material is one that can form a continuous thin film around the nuclear material by distilling off the solvent from the coating material. It has the ability to resist the environmental conditions of the rumen and to expose the core material of the pellet in the ruminal environment. That is, the coating material has a pH greater than 5.
It should be resistant to the conditions for 6 to 30 hours. The coating material must also release heartwood after exposure to the environmental conditions of the rumen, which have a pH of 2 to 3.3. Release should occur within the residence time in the stomach or later intestinal tract, but at least within 6 hours after contact with a pH of 3.5 or below. Exposure of the core material may result from leaching of the dispersed layer material from the polymer matrix, such as by dissolution, disintegration, or significant swelling. The coating material should be physiologically acceptable and the coating material should not interfere with the healthy or normal body functions of the ruminant. Another requirement for the coating material is the ability to resist relatively high heat and/or humidity storage conditions without a significant degree of damage. It should have a Sticking temperature of 50°C or above. Sticking temperature is defined as the temperature at which, when the particles are held in contact for 24 hours at a stress of 0.25 Kg/cm ² , they become sticky enough to cause rupture of the coating resulting in forced separation between the coated particles. Ru.
It is also important that the coating material be soluble or dispersible in an organic solvent with a boiling point between 40°C and 140°C to enable conventional coating processes to be used, such as spray coating. desirable. Particularly suitable solvents include methylene chloride, chloroform, ethanol, methanol, ethyl acetate, acetone, toluene, isopropanol or mixtures thereof. Polymeric Matrices and Dispersed Materials Polymeric materials useful in the coatings of the present invention include those that are resistant to the acidic conditions of the rumen and rumen at the normal body temperature of ruminants, i.e., 37°C and its normal range of variation. , including those that are physiologically acceptable. The polymeric materials include polystyrene, poly(methyl methacrylate), poly(vinyl chloride), copolymers of vinylidene chloride, poly(dimethylsiloxane),
Cellulose esters, polyesters made from dicarboxylic acids with 8 to 22 carbon atoms and 4 to 16 glycols, condensed with amino acids with 8 to 22 carbon atoms or diamines with 4 to 16 carbon atoms Polyamides from dicarboxylic acids having 8 to 22 carbon atoms and 2
at least one polymer, copolymer or mixture of polymers selected from the group consisting of polymethacrylates having a silicon or fluorine substituted alcohol moiety of 8 carbon atoms. Polystyrene and poly(methyl methacrylate) are preferred. Acid-sensitive organic or inorganic dispersed layer materials useful in the present invention include magnesium phosphate, basic magnesium phosphate, aluminum phosphate, magnesium phosphite, ferrous phosphate, ferric phosphate, and calcium phosphate. There are non-toxic, insoluble polycationic salts of phosphoric acid and phosphorous acid, such as. Useful organic dispersion layer materials include basic amino groups ranging from 3 to
cross-linked particles of polymers containing 14% nitrogen, polymers containing basic amino groups are high molecular weight acids,
Particles of polyelectrolyte complexes in which the acidic polymer is combined with a high molecular weight amine, especially a polymer containing amino groups, in particular particles of a polyelectrolyte complex in which an acidic polymer is combined to produce an insoluble powderable composition; particles, and polycationic salts of acidic polymers. The coating may also contain plasticizers, inert fillers, and the like. In either case, the acid-sensitive dispersion layer material is present in an amount between 35 and 65%, preferably 40 to 60%, of the thin film by volume. Specific examples of useful dispersion layer materials will appear in the examples. After preparation of the acid-sensitive acid layer material, it is optionally pulverized by grinding to obtain particles in the range of 40 to 400 meshes. These particles are then mixed or blended with a suitable continuous matrix polymer, mixture of polymers, or mixture of plasticizer and polymer. The mixing operation may be by any method known in the art of mixing paints and other protective coatings, but may include kneading the polymer melt in contact with the particles and mixing the particles with a continuous matrix polymer. Mixing in solution is the preferred method. If mixing is carried out using a hot melt method, the polymer is then dissolved in a suitable solvent. Pellets of nutritional or therapeutic value may also be coated by atomization spraying of solutions of polymers containing dispersed acid-sensitive particles. The coating will normally account for 5-50% of the pellet by weight. Neutralization of Nuclear Material The pH of nuclear material can be raised to a predetermined degree if necessary by mixing with a basic neutralizing material or by coating the nuclear material with a basic neutralizing material. Acidity can be modified by adding non-toxic, insoluble basic substances such as alkaline earth oxides, hydroxides or carbonates to the nuclear material prior to the pelleting step. Various forms of hydrated alumina, basic compounds of aluminum such as aluminum hydroxide, and dibasic aluminum salts of organic acids with up to 6 carbon atoms, such as dibasic aluminum acetate, are also used. good. These basic materials are added to the pellet by combining the core material, basic material and binder as described above before adding water. The amount used depends on both the solubility and relative acidity of the proteinaceous material, the coating composition used to provide rumen protection, and the thickness of the coating applied. The pH of the nuclear material is preferably at least 5.5, particularly preferably 7. If the nuclear material is acidic, the water that permeates through the membrane is thought to ionize its acidic groups, which then react with the amino groups in the polymer, eventually destroying it from within the pellet. . If the nuclear material is soluble and acidic, both destructive forces act and the protective thin film quickly becomes ineffective as a stable coating within the rumen. At this time, as the polymer buildup actually dissolves, the hydrophobic substances in the dispersed layer are removed by the scavenging process, resulting in the destruction of the polymer thin film.
The solubility of the polymer at pH below 3.0 is not altered. The theoretical function of a basic substance added to nuclear material is that it serves to maintain basicity. That is, the water that tends to ionize the acidity of the pellet also neutralizes that acidity and prevents it from attacking the protective membrane. Nuclear material can be neutralized by the following methods: Finely divided nutrients and/or therapeutic substances and their preparation into pellets may contain non-toxic substances such as oxides, hydroxides, carbonates and basic salts of magnesium, calcium and aluminum. Insoluble basic substances are mixed. The amount of basic substance used, if necessary,
It depends on several interacting factors related to the relative acidity and/or solubility of the pellet, the time required for protection in the rumen and the time required for release in the rumen. Typically, the weight of the basic material, if used, will be in the range of 1-20% of the total weight of the nuclear material. In addition to nutritional or therapeutic substances and basic substances, the pellets may contain binders, density regulators and other minor ingredients required for specific properties, as is customary in the field of tablet manufacturing. Good too. In the practice of this invention, the various powdered ingredients are first dry mixed to obtain a generally homogeneous mixture, and then water is added to obtain a plastic dough-like material. The dough is then formed into pellets by extrusion, extrusion and rolling, or any other method known in the art of pelletizing or tabletting. Water is removed by drying in a heated oven or fluidized bed under conventional conditions. The dried pellets are then subjected to subsequent coating operations, which may be carried out by any method such as pan coating, fluidized bed coating, or spray coating or a combination thereof. Other methods of neutralizing nuclear material are based on the concept that although the coating is permeable to water carrying molecules and acidic water, it does not require that everything inside the pellet be neutralized. be. A non-toxic, inorganic basic substance may be deposited on the surface of the core material prior to application of the coating. In practice, the preformed pellets are placed in a fluidized bed or other coating equipment;
The pellets are sprayed with a dispersion of an oxide, hydroxide, carbonate or basic salt of magnesium, calcium or aluminum in water or an organic liquid. The dispersion of the basic substance desirably contains a binder, and can also contain a colloidal protective substance, with the ratio of the binder plus the colloidal protective substance to the basic substance being 1:3 or less. If used, the amount of basic material coated onto the pellets is typically 1 to 20% of the weight of the nuclear material. The binder and colloidal protective material may be the same or different materials and are preferably soluble or dispersible in the water or organic liquid used to suspend the basic material. Binder materials known in the art of tablet manufacturing, such as relatively low molecular weight cellulose derivatives, synthetic polymers, and natural rubber, are suitable for the practice of this invention. The organic liquid may be any with suitable solvent power and a boiling point in the range of 40-140°C. The following examples are presented for a better understanding of the invention. Although the Examples are based on in vitro studies, the in vitro experiments described in the Examples mimic conditions existing in ruminants, thereby making it difficult to use live animals. This makes it possible to study coated pellets without the need for a coated pellet. Testing of the pellets in the aqueous liquid used in the examples, which mimics the environmental conditions of the rumen and rumen in terms of temperature, pH, etc., demonstrates the protection afforded by the coating in the rumen and the release ability of the coating in the rumen. It has been clarified by actual in-vivo tests that it provides reliable data regarding. Nutrients such as amino acids and proteins that can be used as nuclear substances are known to be beneficial to ruminants when placed in the descending flow from the rumen to the intestinal tract. The liquid used to mimic the environmental conditions of the rumen (PH 5.5) was 11.397 grams of sodium acetate.
It was prepared by mixing with 1.322 grams of acetic acid and diluting the mixture to 1 liter with deionized water. The liquid used to mimic the environmental conditions of the rumen (PH 2.9) was prepared by mixing 7.505 grams of glycine with 5.85 grams of sodium chloride and diluting this mixture to 1 liter with deionized water. Eight parts of this solution were mixed with two parts of 0.1N hydrochloric acid to prepare a test solution. These fluids have been shown to give reliable results in pellet tests through similar experiments using actual rumen and ruminant fluids taken from ruminants. Example 1 Acid-sensitive dispersion layer particles were prepared by the following method. 250 grams of magnesium phosphate was placed in a ball mill. 250 grams of methyl ethyl ketone and 2.5 grams of stearic acid were also placed in the ball mill. This mixture was milled for 24 hours to obtain a suspension of magnesium phosphate having a particle size of approximately 250 mesh. Polymer particles for the coating matrix were prepared in Examples 2, 3, 4, 5 and 6. Example 2 100 grams of 2-vinylpyridine, 2 grams of soap, 2 grams of potassium persulfate and 10 grams of divinylbenzene were dissolved or mixed with 1000 grams of water. This mixture was rotated in a 50°C water bath for 24 hours to obtain a suspension of cross-linked poly(2-vinylpyridine). The particle size of this dispersed cross-linked polymer was approximately 150 mμ. The polymer was separated from the water by spray drying the dispersion in heated air and collecting the dried polymer particles. It has been found that contacting the dried polymer with a solvent such as toluene suspends the polymer and provides novel particles such as those produced by emulsion polymerization. This test confirms the suitability of this cross-linked particle for use in the practice of this invention. Example 3 100 grams of 2-methyl-5-vinylpyridine,
2g of soap, 2g of potassium persulfate were dissolved or mixed in 1000g of water. This mixture in a water bath
Rotation was performed at 50°C to obtain a dispersion of poly(2-methyl-5-vinylpyridine) having a diameter of approximately 150 mμ. This polymer dispersion was mixed with 25 g of sodium sulfate to precipitate the dispersed polymer. The polymer was filtered and separated from the liquid section. After removing the remaining salt by washing, the precipitated polymer was dried to obtain a fine powder. A solution of the new particles was prepared by contacting the powder with an organic liquid that was a solvent for poly(2-methyl-5-vinylpyridine). Example 4 80 grams of 2-methyl-5-vinylpyridine,
20g styrene, 2g soap, 2g potassium persulfate and 8g divinylbenzene were mixed with 1000g water. This mixture was rotated at 60° C. for 24 hours to obtain a dispersion of a cross-linked copolymer of 2-methyl-5-dinylpyridine and styrene. The particle size of this dispersion was approximately 150 mμ. The purified dry polymer was obtained by precipitating the polymer from the dispersion by adding 20 g of sodium sulfate. Separating the precipitated polymer,
The separate cake was washed to remove salt. The cake was then dried to obtain a fine powder of cross-linked polymer. Example 5 100 grams of diethylaminoethyl acrylate,
1 g Dupanol ME (emulsifier sold by DuPont), 1 g Emulphor ON-870 (emulsifier sold by GAF), 15 g ethylene diacrylate, 1 g potassium persulfate. and 0.5
g of sodium bisulfite was mixed with 1000 g of water. This mixture was rotated in a water bath at 60° C. for 24 hours to obtain a dispersion of cross-linked polymers. The polymer was separated from the dispersion in water as described in Example 4. Example 6 50 grams of N,N-diethylaminoethyl methacrylate, 50 grams of methyl methacrylate, 1 grams of Dupanol ME, 1 grams of Emulphor ON-870,
6 g ethylene diacrylate, 1 g potassium persulfate, and 0.5 g sodium bisulfite in 1000 g
g of water. This mixture at 60℃
The mixture was rotated in a water bath for 24 hours to obtain a cross-linked copolymer of methyl methacrylate and N,N-diethylaminoethyl acrylate. This cross-linked polymer was separated from the aqueous dispersion by the method described in Example 4. Dispersion layer particles were prepared in Examples 7 and 8. Example 7 25 grams of aluminum phosphate were mixed with 250 grams of toluene and 5 grams of poly(methyl methacrylate) having an intrinsic viscosity of 0.25. The mixture was milled in a ball mill for 24 hours to yield finely divided aluminum phosphate protected from recombination by the dissolved poly(methyl methacrylate).
The particle size of this polymer was in the range of 250 mesh. Example 8 Ferric phosphate was milled by the same method described in Example 7. The following examples illustrate the invention. Example 9 120 grams of the magnesium phosphate dispersion described in Example 1 was mixed with 34 grams of poly(methyl methacrylate) dissolved in 500 grams of methyl ethyl ketone. Pellets consisting of 90% methionine with a diameter of 3 mm were suspended in a fluidized bed with air and sprayed with the coating mixture described above. The solvent was removed with flowing air to produce the final product, particles of methionine coated with poly(methyl methacrylate) containing dispersed magnesium phosphate. The thickness of the coating is 6 mils and the weight of the coating is in this case 20% of the weight of the coated pellets.
It was hot. The resulting pellets were resistant to rumen-mimicking conditions, but were readily permeable to ruminal-mimulating conditions. Example 10 60 grams of polystyrene having an intrinsic viscosity of 0.35 and 40 grams of the cross-linked poly(2-vinylpyridine) described in Example 2 were dissolved or suspended in 500 grams of ethylene trichloride. Pellets consisting of 75% lysine monohydrochloride, 15% magnesium carbonate and 10% binder and having a diameter of approximately 3 mm were suspended in a fluidized bed with air and the solution was sprayed while suspended. The solvent was removed with flowing air to yield a 6 mil layer of polystyrene coated particles containing dispersed cross-linked poly(2-vinylpyridine). The coated layer was resistant to conditions that mimic rumen. However, when the coated pellets were exposed to conditions simulating the stomach, the thin film became permeable to the extent that the amino groups of the dispersed layer particles could react with the acidic groups. This reaction then causes swelling of the polymer particles,
The entire coating thereby becomes permeable, or the swelling action can even destroy the continuity of the coating itself. In both cases, the lysine-containing nuclear material was released, resisted attack and penetration within the rumen, and became available to the ruminant within the rumen. Example 11 30 grams of poly(2-methyl-5-vinylpyridine) as described in Example 3 was dissolved in 200 grams of ethyl acetate. This solution has an intrinsic viscosity of 0.05
Contains 40g of dissolved poly(methacrylic acid)
Mixed with 200g of ethyl alcohol. Contact of both solutions immediately produced a precipitate consisting of a polyelectrolyte complex between acidic and basic polymers. This mixture was crushed in a ball mill for 36 hours to reduce the particle size and obtain a dispersion of a polyelectrolyte complex in which each particle had a diameter of 100 meshes. This dispersion was mixed with 100 g of ethyl acetate containing dissolved 30 g of poly(methyl methacrylate) having an intrinsic viscosity of 0.30. Pellets containing 90% threonine were made flowable as in Examples 9 and 10 and the polymer coating mixture described above was applied as in Example 10. The resulting coated pellets were tested and found to resist penetration by simulated rumen fluid;
It was also easily penetrated by simulated ruminal fluid. Example 12 125 g of 50 g of cross-linked poly(2-methyl-5-vinylpyridine) as described in Example 4
of ethanol by stirring. This ethanol solution was then mixed with 850 g of toluene and 100 g
400 g of a mixture consisting of polystyrene having an intrinsic viscosity of 0.25. This final mixture is
The fluidized bed coating method was used to coat 3 mm pellets of 90% threonine and 10% binder. The pellets coated at a coating weight of 12% resisted penetration of the simulated ruminal fluid, but water intrusion and dissolution of threonine by the simulated rumen fluid readily occurred. These coated pellets are suitable as feed additives for ruminants; absorption of threonine takes place after the rumen. The solution used to mimic the environmental conditions of the rumen (PH 5.5) contained 11.397 grams of sodium acetate.
It was prepared by mixing with 1.322 grams of acetic acid and diluting the mixture to 1 liter with deionized water. The solution used to mimic the environmental conditions of the rumen (PH 2.9) was prepared by mixing 7.505 grams of glycine with 5.85 grams of sodium chloride and diluting this mixture to 1 liter with deionized water. . Eight parts of this solution was mixed with two parts of 0.1N hydrochloric acid to prepare a test solution. These fluids have been shown to give reliable results in pellet tests by similar experiments using actual rumen and ruminal fluids obtained from ruminants. In order to be useful and practical as a diet for ruminants, at least 60%, preferably at least 75%, of the nuclear active components of the pellets according to the invention must be stable in the rumen and released in the ruminant. it is conceivable that. All parts, proportions, percentages, etc. are by weight unless otherwise specified.

Claims (1)

[Claims] 1. Nuclear substances that are beneficial after passing through the rumen of ruminants and organic or inorganic substances that are insoluble in acidic aqueous solutions and that can be leached from the matrix at a pH of 4 or less are dispersed therein. a coating covering said core material which is a continuous matrix of hydrophobic polymers comprising: (a) a copolymer of cellulose ester, polyvinyl chloride, vinylidene chloride; Polyesters prepared from polystyrene, poly(methyl methacrylate), poly(dimethylsiloxane), dicarboxylic acids with 8 to 22 carbon atoms and glycols with 4 to 16 carbon atoms,
from amino acids having 22 carbon atoms or 4
polyamides from dicarboxylic acids having from 8 to 22 carbon atoms condensed with diamines having 16 carbon atoms from methacrylates, essentially comprising at least one polymer, copolymer or mixture of polymers and copolymers, which is insoluble in the ruminal and ruminal environment and is physiologically acceptable. (b) a polycationic salt of phosphoric acid and phosphorous acid and a polymer or copolymer containing from 3 to 14% nitrogen as basic amino groups; A pellet as described above, which is a material dispersed in a polymer matrix. 2. A pellet according to claim 1, wherein the coating comprises from 35% to 65% by volume of the dispersed material and has a sticking temperature of at least 40°C. 3. Claim 2, wherein the dispersed substance is selected from the group consisting of magnesium phosphate, basic magnesium phosphate, aluminum phosphate, magnesium phosphite, ferrous phosphate, and calcium phosphate. pellets. 4. The pellet according to claim 2, wherein the nuclear material is a nutrient for ruminants. 5 Claim 4 in which the nuclear substance is an amino acid
Pellet as described in section. 6. The pellet according to claim 2, wherein the nuclear material is a drug for ruminants. 7 (a) 35 to 65 percent by volume of a hydrophobic polymer that is insoluble in the ruminal and ruminal environments, and (b) 65 to 35 percent by volume of a hydrophobic polymer that is stable in the ruminal environment. However, in the environment of the stomach, substances that can be leached from the hydrophobic polymer are mixed,
Oral administration to ruminants, characterized in that the pellets are coated to form a thin film on the pellets, comprising a nuclear material that is post-ruminantly beneficial to the ruminant, and a coating covering the nuclear material. Method of manufacturing pellets suitable for administration. 8 (a) Polyvinyl chloride, vinylidene chloride, polystyrene, poly(methyl methacrylate), poly(dimethylsiloxane), dicarboxylic acids having 8 to 22 carbon atoms and 4 to 65% by weight Polyesters prepared from glycols with 16 carbon atoms, from amino acids with 8 to 22 carbon atoms or from 4
8 fused with a diamine having 16 carbon atoms
and polymethacrylates having an alcohol moiety of 2 to 8 carbon atoms substituted with silicon or fluorine. (b) a physiologically acceptable polymer matrix insoluble in the rumen and ruminal environment, comprising a polymer, copolymer or mixture of polymers and copolymers; and (b) a 65 to 35 by volume ratio. % of a substance that is stable in the ruminal environment but can be leached from the matrix in the rumen environment, and a coating composition with a weight ranging from 5 to 50% of the total weight of the pellets is applied to the pellet. A method for producing pellets according to claim 7, characterized in that the pellets are coated to form a thin film.