【発明の詳細な説明】[Detailed description of the invention]
本発明は養毛・育毛料に関し、更に詳しくは血
行促進剤及び炭酸ガスを配合した養毛・育毛料に
関する。
従来より養毛・育毛料には血行促進作用を有す
る合成又は天然物抽出エキス等が適用されてる
が、少量の添加では充分な効果が得られず、また
多量に配合するとある程度効果が得られるものの
適用部位に不快な刺激感を与え、さらに連続使用
すると皮膚炎を起こす等の欠点があつた。
一方炭酸ガスは血管拡張作用を有することが知
られており、臨床的にも炭酸ガス浴としてリハビ
リテーシヨンなどに使用されている。
そこで、本発明者は、炭酸ガスを養毛・育毛料
に配合することに着目し種々研究を行なつた結
果、養毛・育毛料に血行促進剤と炭酸ガスを併用
すれば頭皮における血流の増加及び血流増加の持
続をはかることができ、頭髪の脱毛の減少及び頭
髪の成長を促進できることを見出し、本発明を完
成した。
すなわち、本発明は血行促進剤を含有する養
毛・育毛料に炭酸ガスを配合して耐圧容器に密封
した養毛・育毛料を提供するものである。
本発明に使用される血行促進剤としては、合成
又は天然成分である。酢酸dl―α―トコフエロー
ル、ジカプリル酸ピリドキシン、ビオチン、ニコ
チン酸及びその誘導体、塩酸トラゾリン、グリチ
ルレチン酸グリセリル、ヒノキチオール、センブ
リ抽出物、ニンニク抽出物、当帰抽出物、川〓抽
出物、陳皮抽出物、カミツン抽出物及び薄荷葉抽
出物などが挙げられるが、これらのうち酢酸dl―
α―トコフエロール、センブリ抽出物、当帰抽出
物及び川〓抽出物が特に好ましい。この血行促進
剤は水又は水―低級アルコール等の溶媒に配合し
て使用される。血行促進剤は本発明の養毛・育毛
剤中に0.001〜５重量％（以下単に％で示す）配
合するのが好ましい。0.001％以下では充分な効
果が得られず、また５％以上配合すると頭皮に不
快な刺激感を与え好ましくない。
ところで、炭酸ガスは、これが溶解している溶
液のPHが酸性の場合にはCO2分子として存在し、
血管拡張作用を示すことが知られている。従つ
て、本発明の養毛・育毛料の液性はPH７以下、特
にPH4.5〜6.5に調整するのが好ましい。なお、養
毛・育毛料のPHは炭酸ガスが圧入され、これが養
毛・育毛料中に溶け込むと更に酸性度が強くなる
が、最終PHが上記範囲になるように調節すればよ
い。このPH調節剤としては、例えばクエン酸、酒
石酸、乳酸等の有機酸又はこれらの塩、あるいは
リン酸又はその塩が好適に使用される。
炭酸ガスを養毛・育毛料に配合するには、養
毛・育毛料を耐圧容器に入れ、これに高圧ガスを
封入する方法、耐圧容器に炭酸水素ナトリウム等
の炭酸塩を含ませた養毛・育毛料を入れ、これに
PH調節剤を加えて炭酸ガスを発生させ、直ちに密
封する方法、あるいはドライアイスペレツトを容
器内に入れて密封する方法等が採用されるが、就
中特に高圧ガスを封入する方法が好ましい。
このようにするとき、炭酸ガスの一部は養毛・
育毛料中に溶解して配合され、また一部は容器中
に気体として存在する。本発明においては炭酸ガ
スが養毛・育毛料中に溶けて配合されていること
が重要であり、この配合量は炭酸ガス濃度が
60ppm以上であることが好ましく、これより少な
いと充分な血管拡張作用を期待できず、本発明の
効果は得られない。炭酸ガスの配合量の調節は、
炭酸ガスの注入（圧入）量によつて行うことがで
き、一般には容器中の圧力が35℃の温度で1.2〜
８Kg／cm2（ゲージ圧）になるようにするのが好ま
しい。
また、本発明で使用される耐圧容器は、調製後
使用されるまで上記圧力に耐えて養毛・育毛料を
密封状態で保持できるものであることが必要であ
り、例えばアルミ、ブリキ等の金属容器、アセタ
ール系樹脂、ポリカーボネート系樹脂等の合成樹
脂容器及びガラス容器が用いられる。
一方吐出ノズルはその径が小さいと充填液は霧
状に、大きいと泡状又は液状に噴射される。噴射
形態は、また缶内圧によつても異なるが、一般に
エアゾール噴霧容器の吐出ノズルの径は0.3mm以
下であり、これを本発明の養毛・育毛料に適用し
た場合、霧状に噴霧されて炭酸ガスがすぐ飛散し
てしまうので充分な効果が得られない。本発明の
効果をより高めるためには、養毛・育毛料中の炭
酸ガスの滞留時間を長くする必要があり、本発明
養毛・育毛料を頭髪に付着することなく、頭皮に
直接泡状又は液状で塗布し、頭皮上で発泡させる
のが好ましい。このため、吐出ノズルの径を0.3
〜1.5mm、長さを１〜15cmにすることが好ましい。
更に使用に伴なう缶内圧の減少による炭酸ガスの
溶解量の減少を防ぎ、又噴射状態を一定に保つた
めに、容器中に炭酸ガスのミニボンベを内蔵し、
使用量圧力が低下した場合に、新たに炭酸ガスを
供給する特開昭57−153752号のようなエアゾール
噴射装置と組み合わせることが好ましい。斯くす
れば、使用当初から使用終了まで炭酸ガス濃度を
一定に維持することができる。
本発明の養毛・育毛料には上記必須成分のほか
に、通常の化粧料に使用される油性基剤、エモリ
エント剤、ゲル化剤、各種乳化剤、香料、パラヒ
ドロキシ安息香酸エステル等の防腐剤、ブチルヒ
ドロキシアニソール等の酸化防止剤、染料等の着
色剤、メントール等の清涼剤、ヒノキチオール等
の殺菌剤、プロピレングリコール等の湿潤剤を添
加配合することができる。
叙上の如く、本発明の養毛・育毛料は、血行促
進剤と炭酸ガスを含有しているため、短時間で血
流を増加させ、かつ、ある程度まで血流増加を持
続することができ、優れた養毛・育毛効果及び脱
毛抑止効果を示す。また、炭酸ガスを併用するこ
とにより刺激性の強い血行促進剤の配合量を少な
くできるので、連続使用が可能となり、上記効果
をより高めることができる。更に、炭酸ガスの発
泡効果により頭皮に快適な刺激感及びマツサージ
効果を与えることができ、また養毛・育毛料自体
のPHが弱酸性であるので皮膚のPHに近くなり、皮
膚に好ましい影響を与えることができる。
次に実施例を挙げ本発明を説明する。
参考例 １
C3Hマウス（〓）の休止期にある背部皮膚の
毛を皮膚を傷つけないように刈り、次期成長期毛
の成長を観察した。皮膚表面上に毛の成長を認め
た部位の面積を経日的に測定し、その刈毛部の面
積に対する割合（ｒ）を求めた。結果を第１表に
示す。
TECHNICAL FIELD The present invention relates to a hair nourishing/growth agent, and more particularly to a hair nourishing/hair growing agent containing a blood circulation promoter and carbon dioxide gas. Conventionally, synthetic or natural extracts that have a blood circulation promoting effect have been used in hair nourishing and restoring products, but adding a small amount does not provide sufficient effect, and adding a large amount does produce some effect. It has disadvantages such as giving an unpleasant irritation to the application site and causing dermatitis when used continuously. On the other hand, carbon dioxide gas is known to have a vasodilating effect, and is clinically used as a carbon dioxide gas bath for rehabilitation. Therefore, the present inventor focused on incorporating carbon dioxide gas into hair nourishing and hair growth products, and as a result of conducting various researches, we found that if a blood circulation promoter and carbon dioxide gas are used together in hair growth products, the blood flow in the scalp can be improved. The present invention has been completed based on the discovery that it is possible to increase hair flow and sustain the increase in blood flow, reduce hair loss and promote hair growth. That is, the present invention provides a hair nourishing and hair growing agent containing a blood circulation promoter, mixed with carbon dioxide gas, and sealed in a pressure-resistant container. The blood circulation promoter used in the present invention is a synthetic or natural ingredient. dl-α-tocopherol acetate, pyridoxine dicaprylate, biotin, nicotinic acid and its derivatives, tolazoline hydrochloride, glyceryl glycyrrhetinate, hinokitiol, Jasperia japonica extract, garlic extract, Toki extract, Kawata extract, Chinpi extract, Among these, acetic acid dl-
Particularly preferred are α-tocopherol, Oriental japonica extract, Oriental japonica extract, and Oriental japonica extract. This blood circulation promoter is used by blending it with a solvent such as water or water-lower alcohol. The blood circulation promoter is preferably blended in the hair nourishing and restoring agent of the present invention in an amount of 0.001 to 5% by weight (hereinafter simply expressed as %). If it is less than 0.001%, a sufficient effect cannot be obtained, and if it is more than 5%, it gives an unpleasant irritation to the scalp, which is undesirable. By the way, carbon dioxide gas exists as CO 2 molecules when the pH of the solution in which it is dissolved is acidic.
It is known to exhibit vasodilatory effects. Therefore, it is preferable that the liquid nature of the hair nourishing/restorer of the present invention is adjusted to pH 7 or lower, particularly pH 4.5 to 6.5. Note that the pH of the hair nourishing/hair growing agent becomes even more acidic when carbon dioxide gas is pressurized and dissolved in the hair nourishing/hair growing agent, but the final pH may be adjusted to be within the above range. As the PH regulator, organic acids such as citric acid, tartaric acid, and lactic acid or salts thereof, or phosphoric acid or salts thereof are preferably used. To incorporate carbon dioxide gas into a hair growth product, put the hair growth product into a pressure-resistant container and fill it with high-pressure gas.・Put the hair growth fee into this.
Methods such as adding a PH regulator to generate carbon dioxide gas and immediately sealing the container, or placing dry ice pellets in a container and sealing the container are employed, but a method in which high-pressure gas is sealed is particularly preferred. When doing this, some of the carbon dioxide gas is used for hair growth and
It is dissolved and blended into the hair growth agent, and a portion is present in the container as a gas. In the present invention, it is important that carbon dioxide is dissolved in the hair nourishing and hair growth agent, and the amount of carbon dioxide gas to be added is determined by adjusting the carbon dioxide concentration.
It is preferable that the amount is 60 ppm or more; if it is less than this, a sufficient vasodilatory effect cannot be expected and the effects of the present invention cannot be obtained. To adjust the amount of carbon dioxide gas,
This can be done by adjusting the amount of carbon dioxide gas injected (injected), and generally the pressure in the container is 1.2 to 1.2 at a temperature of 35℃.
It is preferable to adjust the pressure to 8 Kg/cm 2 (gauge pressure). In addition, the pressure-resistant container used in the present invention must be able to withstand the above-mentioned pressure and keep the hair growth agent in a sealed state until it is used after preparation, and for example, it must be made of metal such as aluminum or tin. Containers, synthetic resin containers such as acetal resin, polycarbonate resin, etc., and glass containers are used. On the other hand, if the diameter of the discharge nozzle is small, the filling liquid is sprayed in the form of mist, and if the diameter is large, the filling liquid is sprayed in the form of foam or liquid. The spray form also differs depending on the internal pressure of the can, but generally the diameter of the discharge nozzle of an aerosol spray container is 0.3 mm or less, and when this is applied to the hair nourishing/growth agent of the present invention, the spray is atomized in the form of a mist. Since the carbon dioxide gas immediately scatters, the sufficient effect cannot be obtained. In order to further enhance the effects of the present invention, it is necessary to lengthen the residence time of carbon dioxide gas in the hair nourishing and restoring agent. Alternatively, it is preferable to apply it in liquid form and foam it on the scalp. For this reason, the diameter of the discharge nozzle was set to 0.3
~1.5 mm, preferably with a length of 1 to 15 cm.
Furthermore, in order to prevent the amount of dissolved carbon dioxide gas from decreasing due to the decrease in the internal pressure of the can due to use, and to maintain a constant injection condition, a mini cylinder of carbon dioxide gas is built into the container.
It is preferable to combine it with an aerosol injection device such as that disclosed in Japanese Patent Application Laid-Open No. 153752/1983, which supplies new carbon dioxide gas when the usage pressure decreases. In this way, the carbon dioxide concentration can be maintained constant from the beginning of use until the end of use. In addition to the above-mentioned essential ingredients, the hair nourishing and restoring agent of the present invention contains oil bases, emollients, gelling agents, various emulsifiers, fragrances, and preservatives such as parahydroxybenzoic acid esters, which are commonly used in cosmetics. , an antioxidant such as butylhydroxyanisole, a coloring agent such as a dye, a cooling agent such as menthol, a bactericidal agent such as hinokitiol, and a wetting agent such as propylene glycol can be added and blended. As mentioned above, the hair nourishing/growth agent of the present invention contains a blood circulation promoter and carbon dioxide gas, so it can increase blood flow in a short time and maintain the increase in blood flow to a certain extent. , exhibits excellent hair growth and hair growth effects and hair loss prevention effects. Furthermore, by using carbon dioxide gas in combination, the amount of the highly irritating blood circulation promoter can be reduced, allowing continuous use and further enhancing the above-mentioned effects. Furthermore, the bubbling effect of carbon dioxide gas can provide a comfortable stimulation sensation and pine surge effect to the scalp, and the pH of the hair growth agent itself is slightly acidic, so it is close to the pH of the skin, which has a favorable effect on the skin. can give. Next, the present invention will be explained with reference to Examples. Reference Example 1 The hair on the back skin in the telogen phase of C3H mice (〓) was clipped without damaging the skin, and the growth of the next anagen hair was observed. The area of the area where hair growth was observed on the skin surface was measured over time, and the ratio (r) to the area of the shaved area was determined. The results are shown in Table 1.
【表】
成長期毛成長面積
＊ r＝[Table] Anagen hair growth area * r=