JPS6352606B2 - - Google Patents

Description

[Detailed description of the invention]

SUMMARY OF THE INVENTION The present invention relates to a retention composition for a fixed denture which, in addition to the essential retention agent, also contains sodium bicarbonate to inhibit the growth of bacteria and fungi. The main objective of the present invention is to obviate the problems of conventional inhibitors, which have been found to cause toxicity and allergic reactions in mucosal tissues in compositions of this type. The present invention relates to a retention composition for a denture that is applied to the surface of the denture facing the oral mucosa to hold the denture in a predetermined position when installed in the mouth. It contains at least one orally acceptable retention agent that provides the composition with the properties necessary for retaining the denture, and a compound that inhibits the growth of bacteria and fungi. Many people (approximately 50
~65%) are more or less worried about their dentures (Miller, E.L., Journal of Dental Association South Africa, 30(1), pp. 89-93 (1975) and Jorgensen, E., JADA, 96, 96, pp. 474-479 (1978)). This problem manifests itself in different ways and for different reasons. For many people, keeping the denture fixed in the desired position during donning and doffing and speaking, especially during movements associated with obstruction, may be a problem for many people. These inconveniences arise even if the dentures are manufactured in accordance with all regulations regarding dental technology. The reason for this is the irreversible anatomical oral conditions, which arise from unfavorable or personal causes, such as, for example, dyskinesia in the oral cavity and jaw area. This often occurs in the case of certain human beings, for example the elderly and the physically or mentally disabled (Nordenram E., Tandrekaltideningen Vol. 69, No. 7 (1977)). The inability to secure dentures causes a sense of anxiety in the individual and is often a psychological barrier to social contact with others. Some denture users often develop inflammatory changes in the oral mucosa that the bottom of the denture contacts. Intensive research in this field has now shown that the main cause of this type of pathological condition is of a microbial nature.
It was confirmed that the occurrence of fungi was emphasized. That is, inflammatory conditions in the mucous membranes are often associated with the development of fungi on the base of the denture itself, which is extremely difficult to overcome.
of Dental Research, 82:151 (1974)). Therefore, various practical solutions have been attempted in the past to solve the above-mentioned problems. The surface of the denture that faces the oral mucosa (usually referred to as the mucosal surface of the denture) to improve denture retention.
It has become very common to apply fixative preparations containing adhesives or glue-like substances, preferably sodium carboxymethyl cellulose. These fixative formulations usually consist of a powder that is applied onto the mucosal surface of the denture, which forms a gel with adhesive properties on contact with the saliva-coated or saliva-secreting mucosa. Dentures are often moistened with some water before being inserted into the mouth to encourage gel formation. Fixative preparations are also available in the form of pastes, which are prepared ready-to-use at the time of manufacture. The gelling agent or adhesive in fixative formulations is usually sodium carboxymethylcellulose. The method described above allows the user to secure the denture in a simple manner and is often used for this reason. However, there are certain drawbacks, especially when using this composition for a long period of time. This fixative formulation does not inhibit bacterial and fungus colonies normally present in the oral cavity. On the contrary, experience has shown that these compositions may promote opportunities for microbial colonization. Chemical inhibitors have been added to some fixatives to prevent proliferation, but this has introduced new problems. Continuous use of chemical inhibitors of this type can easily lead to toxic and allergic reactions in mucosal tissues as a result of exposure of the inhibitor, especially if this use is carried out by intermittent application over many years. Denture users, with or without the use of retention compositions, must always maintain a careful oral hygiene program, cleaning their dentures, oral cavity, and remaining teeth daily to prevent bacterial plaque that is constantly produced and difficult to prevent. The accumulation of food particles must be removed (Hedegrad E., Tandrekartidoningen Vol. 69, No. 7 (1977)). In addition to the discomfort of bad odor and taste, incomplete dentures or lack of oral hygiene can lead to an inflammatory condition or more serious changes in the mucous membranes known as denture stomatitis, and caries can invade remaining teeth. In order to clean dentures as effectively and gently as possible, dentists recommend brushing them with a soft toothbrush and a suitable chemical wetting agent, preferably with microbicidal properties (Andrup Bee, Tandre Caltidoningen, Vol. Volume 69, No. 7 (1977), Hetsselgren S.G., Swedish Dental Journal, Vol. 66
181 pages). Regarding chemical cleaning, there are many compositions available specifically for denture purposes. Basically, cleaning compositions consist of a combination of two or more chemicals in powdered or tablet form that, when dissolved in ordinary water, react violently with each other, producing gas or bubbles (CO ₂ ). Occur. This is an effervescent solution intended to automatically remove bacterial plaque coatings and fixative residues from dentures without further mechanical cleaning when the dentures are immersed in the solution. According to the present invention, there is provided a retention composition for a denture that is applied to the surface of the denture facing the oral mucosa when installed in the mouth to hold the denture in a predetermined position, and this composition It contains at least one orally acceptable retention agent to provide the composition with the properties necessary for retaining the denture, and also contains sodium bicarbonate to inhibit the growth of bacteria and fungi. Preferably, sodium bicarbonate is added to the composition.
Present in an amount of 10-90% by weight. The retention agent can be an alkali metal salt, preferably a sodium salt, or an alginate of carboxymethylcellulose. Preferably, the alginate is initially water-soluble and converts to a water-insoluble alginate upon contacting the composition with an aqueous medium. Advantageously, the water-soluble alginate is contained in dental impression materials known per se, which solidify to form a water-insoluble alginate on addition of the aqueous medium;
Preferably it also contains another retention agent in the form of sodium carboxymethylcellulose. Preferably, the retention composition contains 10-50% by weight sodium bicarbonate, 20-60% by weight sodium carboxymethyl cellulose, and 20-60% by weight alginate-based dental impression material. The present invention eliminates the risk of toxic or allergic effects on mucous membranes caused by previously used chemical fungal and bacterial inhibitors. Microbiological experiments have now shown that sodium bicarbonate, in its aqueous state, is an effective inhibitor against the growth of bacteria and, in particular, the difficult to overcome fungal growth. It is believed that this inhibition of reproduction is probably primarily due to high pH levels, but there is no conclusive evidence to support this. Mold growth is mainly active in acidic environments. Therefore, sodium bicarbonate,
It replaces previously used bacterial inhibitors that were harmful in some respects. Sodium bicarbonate can be present in an amount of 10 to 90% by weight, calculated on the composition. It is inevitable that small amounts of the applied retention composition or one or more of its components will dissolve in the saliva in the oral cavity. However, there is no danger in swallowing the resulting amount of sodium bicarbonate. It is generally known that sodium bicarbonate is commonly used in very large doses to treat common gastrointestinal disorders and does not exhibit any harmful side effects. The appearance of inflammatory changes in the oral mucosa mainly caused by mold growth on the mucosal side of dentures.
In particular, it has been found that the growth of bacteria and fungi is surprisingly addressed by the use of the retention composition of the invention containing sodium bicarbonate which acts as an inhibitor. It has been found that the problems caused by the use of the previously known chemical inhibitors mentioned above are also eliminated at the same time, since the toxic and allergic effects on the mucous membranes are eliminated. It has been found that the retention compositions of the present invention can be used without interruption for long periods of time and do not need to be replaced in any case by ones that do not contain chemical inhibitors. Additional benefits are obtained through the use of a sodium bicarbonate component in the retention composition. for example,
It is known that remaining natural teeth are extremely susceptible to carious erosion associated with the use of partial dentures. Since caries erosion is characterized by acid erosion of the hard tissues of the tooth, sodium bicarbonate, released by saliva or where the retainer comes into direct contact with the tooth surface, acts as a buffer against the drop in pH. Therefore, it contributes to the prevention of caries. As previously mentioned, the retention composition of the present invention contains a retention agent that provides the properties necessary for the desired retention when the composition is applied. This holding agent and/or certain inert additives contained therein act as a carrier for the sodium bicarbonate;
It therefore also acts as a reservoir for sodium bicarbonate, from which a saturated solution is continuously released. Retaining agents can generally be defined as fixatives, if by fixation we mean adhesive fixation. An example of this type of retention agent is sodium carboxymethylcellulose,
When it comes in contact with aqueous fluids or saliva, it develops a tackiness with adhesive or glue-like properties. Other alkali metal salts of carboxymethyl cellulose can also be used. As mentioned above, sodium carboxymethylcellulose is a known retention agent in this type of composition. for example,
Other known retention agents such as acacia gum, dextrin and starch may also be used. Additives such as polyethers and polyacrylates may also be included in the composition to reduce the solubility of the retention agent in water and to adjust the viscosity of the composition. The present invention also encompasses a completely new class of retention agents for the applications in question. These new types of retention agents are based on salts of alginic acid, which are insoluble or sparingly soluble in water and may be included in the composition as such or formed in situ. Examples of such water-insoluble compounds are calcium alginate and lead alginate, the former being preferred. Preferably these are:
A composition comprising a water-soluble alginate, such as sodium, potassium, ammonium or magnesium alginate, preferably potassium and sodium alginate, and a compound that releases metal ions (e.g. calcium or lead salts) to form an insoluble alginate. It is generated on the spot. Calcium salts are preferred, especially calcium sulfate, which exists in different forms with varying degrees of solubility. Calcium sulfate is generally said to be poorly soluble. However, its solubility is sufficient for the purpose of the present invention to elute and react calcium ions with alginate molecules. Calcium sulfate materials include anhydrous salt CaSO ₄ and hemihydrate salt (CaSO ₄ ) ₂ .
It can be present as H ₂ O and the dihydrate salt CaSO ₄ .2H ₂ O. Of these, the hemihydrate salt is preferred as it has the highest solubility, i.e. 0.9 g/100 ml. In the presence of an aqueous medium, calcium ions will replace the sodium or potassium ions in the sodium or potassium alginate molecules by cross-linking, which is considered a type of polymerization. The composition of the present invention containing an alginic acid-based retention agent has adhesive properties unless it contains special additives to remove the adhesive properties. One type of special additive of this kind is a filling in the form of diatomaceous earth,
This gives the composition a firm, slightly elastomeric consistency, but also provides other desirable effects. In view of the foregoing, the compositions of the present invention contain, in addition to sodium bicarbonate, equivalent to or substantially equal to known alginate-based materials used for impressions of teeth and surrounding tissue and commonly referred to as "dental impression compounds." It may also contain a retention agent corresponding to . When a mixture of alginate-based impression materials of this type according to the invention and sodium bicarbonate is brought into contact with an aqueous medium, such as saliva, a slightly firm, slightly rubbery-elastic consistency is obtained. When such a retainer is applied to a denture, a membranous layer is formed between the mucosa and the denture base, which can be easily removed in large pieces and peeled as described in detail below. . Since this type of layer has a somewhat firmer consistency and is longer lasting than a layer of carboxymethylcellulose or similar material, it is also not dissolved by saliva as rapidly as a retention composition containing only carboxymethylcellulose. Thus, what is known in dentistry as a temporary denture replacement can be obtained in a simple manner. This is particularly desirable when the fit of the denture to the supporting surface changes over time and becomes unsatisfactory, but this change is not significant enough to require permanent floorboard replacement by the dentist. Therefore, the denture user can easily make this adjustment without having to visit a dentist. Although some amount of adhesive is present in compositions based on dental impression materials, at least initially, denture retention is primarily based on the improved seal;
This sealing is accomplished using a rigid baseboard replacement made of alginate material, particularly at the edges of the denture associated with the transition between the relatively firm mucosa of the gums and the relatively soft mucosa of the cheeks. The plastic consistency of alginate provides an optimal fit in this area after insertion of the denture, and this fit is transformed into an elastic, rigid consistency by the solidification process during which insoluble alginate is formed. It will last for a long time. Compared to alginate compositions, carboxymethylcellulose lacks this ability. Additional retention agents, such as sodium carboxymethyl cellulose, can be used in the alginate composition if increased adhesion is desired. In this case, the proportions of the three main components can be in the following range. i.e. 10-50% by weight of sodium bicarbonate and 20-50% by weight of sodium bicarbonate
60% by weight of sodium carboxymethylcellulose and 20-60% by weight of alginate based dental impression material. The present invention will be further explained below with reference to some examples, but the present invention is not limited thereto. Example 1

[Table] Cellulose sodium bicarbonate 50 75 25

Claims (1)

[Scope of Claims] 1. A retention composition for a denture that is applied to the surface of a denture facing the oral mucosa to hold the denture in a predetermined position when installed in the mouth, the composition comprising: is characterized in that it contains at least one intraorally usable retention agent which imparts to the composition the properties necessary for the retention of dentures, and contains sodium bicarbonate which inhibits the growth of bacteria and fungi. A retaining composition for dentures. 2. A denture retention composition according to claim 1, wherein the sodium bicarbonate is present in an amount of 10 to 90% by weight of the composition. 3. The retention composition for a denture with a backing according to claim 1 or 2, wherein the retention agent is an alkali metal salt of carboxymethyl cellulose. 4. The retention composition for a denture with a denture according to claim 1 or 2, wherein the retention agent is an alginate. 5. The retention composition for a denture with a denture according to claim 4, wherein the alginate is initially water-soluble and changes to a water-insoluble alginate when the composition is brought into contact with an aqueous medium. 6. The denture retainer according to claim 5, wherein the water-soluble alginate is contained in a dental impression material known per se that forms and solidifies water-insoluble alginate upon addition of an aqueous medium. Composition. 7 Claim 4 further comprising a retention agent in the form of sodium carboxymethyl cellulose
6. The retention composition for dentures according to item 5 or 6. 8 10-50% by weight of sodium bicarbonate and 20-60% by weight of sodium carboxymethyl cellulose.
8. The denture retention composition according to claim 7, which contains 20 to 60% by weight of an alginate-based dental impression material.