JPH0117702B2 - - Google Patents

Description

A pre-packaged fluid circuit module, characterized in that it comprises said housing means 18, which has said housing means 18.

2. A pre-populated fluid circuit module that can be selectively moved into operative engagement and disengagement with two separate pump rotors 20, 22 by an operator for blood processing from a patient/donor. a flexible first conduit means 54 forming a fluid path for drawn whole blood; and downstream of said first conduit means 54 communicating therewith for platelet-rich plasma separated from the whole blood. flexible second conduit means 7 forming a fluid passageway;
4, housing means 18 having side walls circumferentially defining a hollow interior for supporting a portion of each of said conduit means 54, 74 within said hollow interior compartment;
and a pump rotor 20 having two modules;
said conduit means 54 when not in operative engagement with 22;
74 in a predetermined arcuate configuration arched outwardly from one of said side walls and resiliently biased toward an upright, freestanding position generally perpendicular to said one side wall. and the first and second conduits are arranged in such a way that the outwardly bowed portions of each of the first and second conduit means 54, 74 can be separately spaced apart from the respective pump rotors 20, 22. Means 54, 74
A pre-packaged fluid circuit module characterized in that said housing means 18 includes said one side wall supporting said housing means 18.

3. A blood processing device 10 including at least two pump rotors 20, 22 and a centrifuge 14, and a pre-installed fluid circuit module 11.
a blood processing assembly comprising: the fluid circuit module 11 having an inlet end suitable for communication with the circulatory system of the patient/donor and an outlet end remote therefrom; a first flexible conduit means 54 forming a fluid passageway for the centrifuge 14; The centrifuge 14
a first fluid-receiving container 66 including a zone for collecting platelet-rich plasma and red blood cells in response to actuation of said first fluid-receiving container 66 for collecting platelet-rich plasma; a flexible second conduit means 74 having an inlet end connected to and in communication with said zone and an outlet end remote therefrom, forming a fluid passageway for platelet-rich plasma; a second fluid-receiving container 80 connected to said outlet end of conduit means 74 of said centrifuge 14 and suitable for mounting within said centrifuge 14;
a second fluid-receiving container 80 including a zone for collecting plasma in response to actuation of the housing means 18 having side walls circumferentially defining a hollow interior; supporting intermediate portions of said inlet and outlet ends of each of said conduit means 54, 74;
74 in a predetermined arcuate configuration arched outwardly from one of said side walls and resiliently biased toward an upright position generally perpendicular to said one side wall; 1st and 2nd
said one side wall supporting said first and second conduit means 54, 74 such that said outwardly bowed portions of said conduit means 54, 74 of said conduit means 54, 74 can be separately spaced apart from said respective pump rotors 20, 22; a housing means 18 including a housing means 18; the outwardly bowed portion of the first conduit means 54 is connected to one of the pump rotors 20; and the outwardly bowed portion of the second conduit means 74 is connected to one of the pump rotors 20; removably mounting the fluid circuit module 11 onto the apparatus 10 with the one side wall adjacent the pump rotors 20, 22 such that the fluid circuit module 11 is in operative contact with the other pump rotor 22; A blood processing assembly characterized in that it comprises means 19 for.

4 said fluid circuit module 11 further comprises a flexible first auxiliary conduit means 102 having an inlet end suitable for communication with a source of anticoagulant and an outlet end in communication with said first conduit means 54; and one side wall of said housing means 18 supports a portion of said first auxiliary conduit means 102 within said hollow interior compartment and supports another portion of said first auxiliary conduit means 102 within said one. arching outwardly from a side wall and resiliently biased toward an upright position generally perpendicular to said one side wall and concentrically proximate with said first conduit means 54 to said one pump rotor 20; 4. The blood processing assembly of claim 3 operative to support a predetermined arcuate configuration disposed in the blood processing assembly.

5 said first auxiliary conduit means 102 and said first conduit means 54 merge into flow communication with each other, the merging being upstream of said outwardly arching portion of said first conduit means 54; 5. A blood processing assembly according to claim 4, and located downstream of said outwardly arcuate portion of said first auxiliary conduit means 102.

6 further comprising a first sealed fluid container 100 for containing an anticoagulant, the inlet end of the first auxiliary conduit means 102 being outside the hollow interior of the first sealed fluid container 100; 6. The blood processing assembly of claim 5, wherein the first sealed container 100 forms an integral part of the module 11.

7. a flexible second auxiliary conduit means 110 forming a fluid passageway suitable for communication with a saline source and communicating with said first conduit means 54 upstream of said outwardly bowed portion thereof; 5. The blood processing assembly of claim 4, further comprising:

8 further comprising a second sealed fluid container 108 for containing a saline solution, said second auxiliary conduit means 110 extending outwardly of said hollow interior and in flow communication with said second sealed fluid container 108; 8. A blood processing assembly according to claim 7, including an inlet end integrally integrated with said second sealed container 108 forming an integral part of said module 11.

9 The fluid circuit module 11 is connected adjacently to and in communication with the red blood cell collection zone of the first fluid receiving container 66 and an inlet end suitable for communication with the patient/donor's circulatory system. further comprising a flexible third conduit means 82 having an exit end for returning the
Said housing means 18 is connected to said third conduit means 8
4. A blood processing assembly according to claim 3 operative to support a portion intermediate said inlet and outlet ends of said housing means 18 within said hollow interior compartment of said housing means 18.

10 The fluid circuit module 11 has an inlet end in communication with a third fluid receiving container 124 for collecting plasma, and with the second fluid receiving container 80 in the plasma collection zone;
10. The blood processing assembly of claim 9 further comprising a flexible fourth conduit means 94 having an outlet end in communication with the fluid receiving container 124 of the blood treatment assembly.

11 The fluid circuit module 11 includes the first, second, third and fourth conduit means 54, 7.
4, 82, 94 adjacent to their associated fluid receiving vessels 66, 80, thereby forming an umbilical cord 139 supported on the outside of said housing means 18. 11. The blood processing assembly of claim 10, comprising:

12. The blood processing assembly of claim 11, wherein said umbilical cord 139 extends outwardly from a side wall of said housing means 18 oppositely spaced from said one side wall.

13 said blood processing device 10 further comprises at least one sensing means 63, 65, 85 located adjacent said pump rotors 20, 22, said fluid circuit module 11 said first and third conduit means 54, at least one monitoring device 62, 64, supported by said housing means 18 in flow communication with at least one of 82;
10. The blood processing assembly of claim 9, further comprising: 84, wherein said housing mounting means 19 is operative to place said housing means 18 on said device 10 to maintain said monitoring device in operative contact with said sensing means.

14 The blood processing device 10 includes optical sensing means 8 located adjacent to the pump rotors 20, 22.
7, said fluid circuit module 11 further comprising a bubble trap 8 carried by said hashing means 18 and joined in flow communication with said third conduit means 82.
6, wherein said housing mounting means 19 maintains said optical sensing means 87 in operative contact with said bubble trap 86 to attach said housing means 18 to said device 10.
10. The blood processing assembly of claim 9, wherein the blood processing assembly is operative to be disposed over the blood treatment assembly.

15 The fluid circuit module 11 further includes a third auxiliary conduit means 118 forming a fluid passageway having an inlet end suitable for flow communication with a saline source and an outlet end joining in flow communication with the bubble trap 86. 15. The blood processing assembly of claim 14, wherein said conduit support means is operative to support said outlet end of said third auxiliary conduit means 118 within a compartment within said housing.

16 said fluid circuit module 11 further includes a sealed container 108 for saline solution, said inlet end of said third auxiliary conduit means 118 being integrated into flow communication with said container 108, said container 108 said 15. A blood processing assembly according to claim 14 forming an integral part of module 11.

17 The blood processing device 10 includes a light sensor 76 located adjacent to the pump rotors 20, 22, the second conduit means 74 includes a transparent portion, and the housing mounting means 19 includes a light sensor 76 located adjacent to the pump rotor 20, 22; 4. A blood processing assembly as claimed in claim 3 operative to place said housing means 18 on said device 10 in operative contact with a transparent portion of second conduit means 74.

18 The blood processing apparatus 10 includes at least one valve means 60, 88 located adjacent the pump rotors 20, 22, and the housing mounting means connects the valve means 60, 88 to the first and third conduits. operative to place said housing means 18 onto said apparatus 10 in operative contact with said conduit means 54, 82 for selectively controlling fluid flow through at least one of said means 54, 82; Blood processing assembly according to clause 9.

[Detailed description of the invention]

The present invention relates to a fluid circuit module for use in a device for processing whole blood, and more particularly to a compact, disposable fluid circuit module for collecting desired blood components, such as platelets.

Various devices have been proposed for processing whole blood and separating it into various components. These prior art devices remove whole blood from a donor, separate it into its constituent components in a processing system, separate them to collect the desired components from the donor, and return the remaining blood fluid to the donor. Includes blood processing. Typically, the blood components separated are plasma, red blood cells, white blood cells and platelets.
Devices and methods particularly suitable for separating platelets from whole blood are commonly referred to as platelet separation methods.

Apparatus for performing biological blood processing used in the past typically included a separation chamber in which whole blood from a donor was subjected to centrifugal force. This is typically accomplished with a centrifuge. Due to the difference in density,
The various blood components collect in different zones at different radial distances from the center of rotation of the separation chamber. Collection ports in the chamber are then utilized to remove blood components from various areas within the separation chamber for storage or recirculation.

Heretofore, such devices have required various fluid couplings and pressure monitoring devices that must be thoroughly cleaned after each use and/or that portions of the fluid system or circuitry must be replaced.

As will be described in detail later, the first and second inventions of the present application can be easily attached to a blood processing device,
A fluid circuit module is provided that can be connected and easily removed from the device for separation of blood component collection bags, such as platelet bags. Also, the module is made of inexpensive plastic material, so that the module can be disposable, except for the collection bag.

The first invention of the present application is defined in claim 1.

The advantage of the invention is that the first conduit means for whole blood and the first auxiliary conduit for anticoagulant are presupported in a common single housing in such a position that they can be arranged concentrically to the same pump rotor. The provision of a pre-packaged disposable module containing the conduit means and the housing, which is adapted for attachment to a blood processing device with a pump rotor, prevents misplacement of the blood circuit. , and the preparation work for blood processing is significantly simplified.

The second invention of the present application is defined in claim 2.

The advantage of the invention is that the first conduit means for whole blood and the second conduit means for plasma are pre-supported in a common single housing in such a position that they can be placed as they are separately on separate pump rotors; and a pre-populated disposable module containing the conduit means and the housing, configured for attachment to a blood processing device with a pump rotor, thereby preventing misalignment of the first and second conduits with respect to the pump rotor. It is safe and the preparation work for blood treatment is significantly simplified.

The third invention is defined in claim 3.

The object of the invention is to provide a blood processing device comprising a pump and a centrifuge, and a fluid circuit module comprising a container and conduits for separating blood into its components suitable for installation into the centrifuge. An object of the present invention is to provide a blood processing assembly.

The effect of this invention, as well as other inventions, is that the preparatory work for blood treatment is significantly simplified.

FIG. 1 is a perspective view of an apparatus in which the fluid circuit module of the present invention is used.

FIG. 2 is an enlarged perspective view of the top of the device of FIG. 1 with the fluid circuit module removed.

FIG. 3 is a schematic block flow diagram of the fluid circuit of the module.

FIG. 4 is a perspective view of the fluid circuit module of the present invention.

FIG. 5 is a perspective view of the monitoring device of the module.

With detailed reference to the drawings, reference numeral 10 is shown in FIG.
A blood processing device, generally designated as , is shown.

The apparatus 10 includes a fluid circuit module of the present invention, shown in detail at 11 in FIG.

The apparatus 10 further includes a centrifuge hidden within the cabinet 12. This centrifuge is schematically illustrated in FIG. 3 and designated by the reference numeral 14. Further details of the structure and operation of the centrifuge 14 are described in Japanese Patent Application Laid-Open No. 54-64893.

The fluid circuit module 11 is shown in FIG.
16 and best illustrated in FIG. As described in connection with FIGS. 3 and 4, fluid circuit 16 includes a plurality of flexible plastic tubes that form fluid couplings between various portions of fluid circuit 16. These tubes are received through a holder 18 which is a housing means forming part of the assembly and into which the monitoring device is mounted.

As shown in FIGS. 1 and 2, several loops of tubes (54, 74 and 102 in FIGS. 3 and 4) are housed around the two peristaltic pumps 20 and 22, and some of them It consists of Pump 20 is referred to as the first or whole blood pump and pump 22 is referred to as the second or plasma pump, as will be discussed in more detail below. Whole blood pump 20 is used to withdraw whole blood from a donor, while plasma pump 22 is used to transfer plasma from one chamber to another (FIG. 3) within centrifuge 14.

The device 10 also includes a display panel 24 that includes a number of windows that display information useful to the operator.

In this regard, the alarm window 26 indicates a malfunction of the device 10 or some condition occurring within the fluid circuit 16 within the device. There is also a window 28 that displays the blood component being collected, a window 32 that displays the elapsed time the device has been in operation, the flow rate of whole blood, and the flow rate of platelet-rich plasma.

A number of push buttons 41-47 for controlling various stages of operation of the device 10 and a window 48 on the panel 24 for displaying the donor's hematocrit.
and 49 are also provided.

Additionally, the device 10 includes a manual control panel 50;
It includes a plurality of knobs and switches for manual operation of the device 10, as best shown in FIG. Nameplates on manual panel 50 represent various toggle switches and pushbutton switches whose purposes will become apparent from the detailed description of the operation of apparatus 10 below.

Referring now to FIG. 3, a block flow diagram of fluid circuit 16 is illustrated. As shown, the circuit 16 includes a hypodermic needle 5 that is injected into the arm.
a first tube 5 which is a first conduit means suitable for connection to a vein in one of the donor's arms by means of a first tube 5;
Contains 4. A fluid clamp 58 (shown schematically) can be provided to tube 54 if desired. First tube 54 has valve #1 attached thereto.
It includes a solenoid actuated clamp 60 that constitutes a. The first tube 54 has a venous occlusion monitoring device 62 with an attached sensor 63 connected in series thereto. The first tube 54 then extends around and becomes part of the peristaltic pump 20 and is connected in series to a high pressure monitoring device 64 with an attached sensor 65. From the monitoring device 64, a first tube 54 extends into the centrifuge 14 and to an inlet at the bottom of a first fluid receiving container 66 which constitutes a whole blood separation chamber, designated as a whole blood bag.

Container 66 has a first outlet 68 in its center adjacent to the area of container 66 where platelet-rich plasma collects. Container 66 also has two outlets 70 and 72 in its upper corners where red blood cells collect. The outlet 68 serves not only as an outlet for platelet-rich plasma but also as a return inlet for platelet-rich plasma mixed with red blood cells when red blood cells spill from the outlet 68.

The outlet 68 of the first container is connected to a second tube 74 , a second conduit means, which extends to a loop 75 located outside the centrifuge 14 . The loop 75 extends around and forms part of the peristaltic pump 22. Located adjacent to the transparent or translucent section of loop 75 extending outside of centrifuge 14 is a spill detector 76, which is an optical sensor for detecting spillage of red blood cells mixed with platelet-rich plasma. Detector 76 is manufactured by Instrument Company, Texas with model number
These include light emitting diodes (LEDs), such as the infrared light emitting diode sold as TIL32, and phototransistors, such as the phototransistor sold by the company as model number TIL81. Next, the second tube 74 is connected to the centrifuge 1
4 and is connected to the inlet 78 of a second fluid-receiving container 80, called the platelet bag, which forms the chamber in which the platelets are separated from the plasma.

The third tube 82, which is the third conduit means,
High/low pressure monitoring device 8 with attached sensor 85 to outlets 70 and 72 of first vessel 66
4 and an air bubble trap/filter 86 having an attached air bubble sensor 87;
The monitor device 84 and filter 86
It is connected in series to the tube 82 of. Also, the portion 8 of the tube 82 where another solenoid actuated clamp 88 exits the air bubble trap/filter 86.
9 and constitutes valve #3. Sensor 87 can be an optical or ultrasonic sensor.

The end of the third tube is connected to a hypodermic needle 90 that is injected into the donor's other arm, and if desired a fluid clamp (shown schematically) can be attached to the tube 82 in front of the needle 90. .

The fluid circuit 16 further includes a fourth tube 94, which is a fourth conduit means.
It is connected between the outlet 96 of the second container 80 and the confluence 99 with the third tube 82 via a solenoid actuated clamp 98 that constitutes valve #6.

The fluid circuit 16 also includes a first sealed liquid container, a container 100 of an anticoagulant, such as citrate dextrose (ACD);
0 extends around (becomes part of) the peristaltic pump 20 and connects needle 56 and valve #1 via a solenoid actuated clamp 104 that constitutes valve #2.
The first auxiliary conduit means, the fifth tube 102, extends to a junction 105 with the first tube 54 between the first and second tubes 54 and 54.

First tube 54 and fifth tube 10
2 pass over the same peristaltic pump 20, mixing of the anticoagulant with whole blood and withdrawal of whole blood from the donor are accomplished substantially simultaneously. Also, the cross-sectional area of the tube 102 inside the tube 54 is
The ratio of the anticoagulant to the internal cross-sectional area is selected to obtain the desired mixing ratio of anticoagulant to whole blood. This ratio is preferably 8 to 1, resulting in a ratio of 8 parts whole blood to 1 part coagulant.

The apparatus 10 and fluid circuit 16 further contain a second sealed liquid container, a saline container 108, which is connected to a drip chamber 112 and a saline container 108 by a second auxiliary conduit means, a sixth tube 110. It is connected to the first tube 54 at a junction 115 between the solenoid operated clamp 60 and the venous occlusion monitoring device 62 via a solenoid operated clamp 114 that constitutes valve #4. Salt water container 1
08 is also the third auxiliary conduit means tube 1
18 also connects to the top of the air bubble trap/filter 86 via a solenoid actuated clamp 120 that constitutes valve #5.

Device 10 and fluid circuit 16 include a third fluid receiving container 124 located external to centrifuge 14 for collecting plasma. This container 124 is connected to solenoid valve #7 by an eighth tube 126.
It is connected to the fourth tube 94 at a confluence point 129 through a solenoid actuated clamp 128 constituting the tube.

The operation of apparatus 10 for processing whole blood through fluid circuit 16 will now be described with reference to FIG.

First, a healthy donor is selected who will donate platelets and will be treated like a regular blood donor. Once the device is ready, a venipuncture is made in each arm with needles 56 and 90.

Valve #1 is opened first to allow saline to force air out of needle 56 and into the donor prior to puncturing. Next, close valves #1, #2, #5, and #7. Valve #3,
#4 and #5 are opened.

Saline is then pumped by the first pump 20 through the liquid circuit 16 until no more air bubbles are detected by the air bubble sensor 87, ie, until saline is detected. The second pump 22 is then started and saline is pumped through the platelet container 80. Since centrifuge 14 is not rotating at this time, containers 66 and 80 are not filled to capacity. Air is forced out of needle 90.

After a short period of time, for example 1 to 5 minutes, the platelet bag 80 is filled, all air is expelled, and the saline solution fills the entire system, circuit 16 up to valve #3. When saline is detected by detector 87, valve #3 is closed and valve #5 is closed.
will be held. After the saline circulation period, pump 20
and 22 are stopped and valve #8 is opened.

During this priming operation, the air bubble sensor 87 is connected to the air bubble trap/filter 86 to ensure that the sensor is operating properly.
The sensor 87 is checked to ensure that there are no more air bubbles present after the system is filled with saline.

Needles 56 and 90 are now injected into the arm of donor 52, valves #1, #2, #5 and #6 are opened and valves #3 and #7 are closed.

With needles 56 and 90 connected to the patient's veins and the system filled with saline, pumps 20 and 22 are started to pump whole blood into the system and centrifuge 14.

Tubes 54, 7 extending into the centrifuge 14
4, 82 and 94 are umbilical cables (1 in Figure 4).
39) and the cables are rotated at 1/2 the speed of the centrifuge 14 so that kinking is prevented and no fluid seals are required. This centrifuge 14
The structure and operation of this device are described in detail in the aforementioned Japanese Patent Application Laid-open No. 54-64893.

When approximately 120 ml of whole blood has been pumped into fluid circuit 16, most of the saline is pumped back into container 108. Valve #3 is now opened and the treated blood fluid, which contains some saline, is returned to the donor.

Also, if the plasma collection button is pressed, valve #6 is closed, valve #7 is opened, and the desired amount of plasma is removed from the fluid circuit. 16 during processing.

After the pumps 20 and 22 are started, no operator attention is required until a single treatment operation is completed.

While the whole blood is drawn into the fluid circuit 16 and into the separation chamber in the container 66, the centrifugal force acting on the container 66 causes the separation of the whole blood into its components. In this regard, platelet-rich plasma collects in the area at the top of container 66 adjacent outlet 68 and red blood cells collect in the upper corner of container 66 adjacent outlets 70 and 72. This is achieved by the specific construction and configuration of the container 66, which is described in detail in the above-mentioned Japanese Patent Publication No. 54-64893.

In one working example of the device 10, the pump 20 delivery volume starts at an initial speed and is increased by 1 ml/min for every 120 ml of whole blood processed through the fluid circuit without spilling red blood cells. . However, when spillage of red blood cells from container 66 is detected by spill detector 76, pump 22 is stopped and then reversed to return the mixture of platelet-rich plasma and red blood cells to container 66. . The speed of the first pump 20 is then reduced by 1 ml/min and the speed of the second pump 22 is proportionally reduced. Then both pumps are in the normal direction (forward)
The next 120 ml of whole blood is rotated until it is processed without spillage. When no spill is detected by the detector 76, the speed of the second pump 22 is increased by 0.25 ml for each 120 ml of whole blood processed without a spill until a spill is detected.
The next time a spill is detected, pump 22 is again stopped and reversed to return the spilled mixture to container 66. The second pump's delivery rate is then reduced by 0.25 ml/min and the speed of pump 22 is returned to forward and this operation is repeated until the end of the single operation is reached. End point means that approximately 3 volumes of whole blood have been processed. Operating in this manner, device 10 achieves highly efficient and effective separation of platelet-rich plasma from whole blood.

The platelet-rich plasma removed from container 66 passes through platelet bag or container 80. The centrifugal force acting on the bag 80 causes platelet deposition on the sides of the bag 80 while plasma flows through the bag 80. This results in plasma flowing in the bag or container 80 in the direction of the arrow in FIG.

Plasma exiting bag 80 flows through tube 94 and recombines at confluence 99 with the red blood cell-rich blood fluid flowing through tube 82. Recombined platelet-poor blood has the next high/high platelet count.
The blood is returned to the donor 52 via a low pressure monitor 84 and an air bubble trap/filter 86 through a needle 90.

Once the desired whole blood, ie, whole blood 3, has been processed, valves #1 and #2 are closed and valve #4 is opened, allowing saline to flow into the system, ie, fluid circuit 16. Salt water is fluid circuit 1
The amount of blood remaining in 6 is expelled and pushed back to the donor. Centrifuge 14 is then stopped after a sufficient amount of saline has been pumped into the system. Approximately 3 ml of blood fluid is left in the system which can be returned to the donor by allowing a brief overrun of pump 20.
Cabinet 12 can now be opened and tubes 74 and 94 can be cut, for example using a heating element, as shown by break lines 131 and 132 in FIG. A sealed platelet container or bag 80 containing a minimal amount of plasma therein is removed from the centrifuge 14 and stored for use.

Referring to FIG. 4, there is illustrated a fluid circuit module 11 of the present invention. As shown, this module 11 is housed with all tubes passing through it except tube 110.
It includes a holder 18 which is a housing means. Tubes 54 and 102 are the first conduit means and the first auxiliary conduit means as shown.
extend to the bottom of the holder 18 and extend out of the top in such a way as to form loops parallel to each other. These loops of tubes 54 and 102 extending from the top of holder 18 are housed around and are part of peristaltic pump 20. In a similar manner, tube 74
extends to the bottom of holder 18, exits from the top of holder 18 to form loop 75, and returns to and passes through holder 18. This loop 75 is housed around and forms part of the second peristaltic pump 22. Valves #1 through #7 are illustrated as blocks. It will be appreciated that these valves #1 through #7 are actually solenoid actuated clamps as described above.

Pressure monitoring devices 62, 64 and 84 are of the same construction, only one of which is shown in a cutaway perspective view in FIG. Devices 62, 64 as shown
and 84 are attached tubes 54 or 82
a fluid passage chamber 133 connected in series therein, a flexible diaphragm 135 forming part of one wall of the passage chamber, and an attached pressure transducer for sensing pressure changes on the outer wall 136. an air-filled sealed chamber 13 having an outer wall 136 located adjacent to the sensor 63, 65 or 85;
Contains 4. Monitoring device 63, 65 or 85 and air bubble trap/filter 86
are all mounted within holder 18 in the positions shown in FIG. Also, individual monitor devices 62,
64 and 84 are the mating solid cylindrical pressure sensors 6 shown in FIGS. 2 and 3.
It has a hollow cylindrical projection extending therefrom for fitting around the 3, 65 or 85 sides. Holder 18 has been removed in FIG. 2 and sensors 63, 65 or 85 are not shown in FIG. 4, which only shows assembly 11. A transparent section of tube 74, designated generally as 137 in FIG. 4, is located adjacent sensor 76 and also includes an air bubble trap/
The transparent section of filter 86 is also attached to holder 1.
8 is located at the top on the device 10 shown in FIG. 2 and will be located adjacent to the sensor 87 when the clamp 19 is moved to secure the holder 18 in place. Sensor 1 of device 10
It should be noted that 38 (FIG. 2) senses when the holder 18 is in place.

Tubes 64, 74, 8 coming out of holder 18
2 and 94 are the umbilical cables 139 housed in the rotating holder of the centrifuge 14 as described above.
pass through.

Containers 100 and 108 may form part of assembly 11 and tube 10
2, 110 and 118 as shown, or the assembly 11 may simply include a syringe-shaped connector suitable for connection to one of the containers 100 and 108 at the outer ends of the tubes 102, 110 and 118, respectively. It may just include the connectors. Such a fitting is injected into the membrane at the mouth of container 108 and is generally designated by reference numeral 14.
It is shown represented as 0. Additionally, these containers can typically be constructed from flexible, disposable plastic materials.

It will be appreciated that holder 18 can be made of inexpensive, disposable materials, such as the same plastic as tubes and containers 66, 80 and 124. Similarly monitor devices 62, 64 and 8
4 can also be made of inexpensive plastic material so that once the assembly 11 is used to collect platelets and the platelet container or bag 80 is removed, they can be easily disposed of.

It will be appreciated that, with the exception of holder 18, assembly 11 constitutes the entire fluid circuit 16 of device 10. Also, the placement of the monitoring devices 62, 64 and 84 within the holder 18 and the position of the optically transparent walls within the holder 18 of the optically transparent tube section 137 and air bubble trap/filter 86 as shown. The loops of tubes 54, 74 and 102 are then housed on and form part of the peristaltic pumps 20 and 22, and the vessels 66 and 80 are inserted into the rotor of the centrifuge 14 of the device 10 and rotated. A simple and compact fluid circuit module is provided that can be easily installed in position by manipulating the flexible clamp 19. Then, when the processing of a predetermined amount of whole blood, e.g. Once cut and sealed at 132, platelet container 80 can be removed from module 11 and stored for future use.

[Brief explanation of drawings]

FIG. 1 is a perspective view of a blood processing device using the fluid circuit module of the present invention, FIG. 2 is an enlarged perspective view of the upper part of the device in FIG. 1, FIG. 3 is a flow diagram of the fluid circuit, and FIG. A perspective view of the fluid circuit module of the present invention, and FIG. 5 is a partially cutaway perspective view of the monitor device. 18 is a holder, 54, 74, 102 are tubes, 20, 22 are pump rotors, 62, 64, 8
4 is a monitor device, 14 is a centrifuge, 66 is a whole blood bag, and 80 is a platelet bag.

Claims (1)

Claims: 1. A pre-loaded fluid circuit module that can be selectively moved into and out of operative engagement with a pump rotor 20 by an operator for blood processing and withdrawn from a patient/donor. a first flexible conduit means 54 forming a fluid path for whole blood; and a first flexible conduit means 54 forming a fluid path for an anticoagulant that merges with said first conduit means 54. auxiliary conduit means 102; housing means 18 having side walls circumferentially defining a hollow interior for supporting a portion of each of said conduit means 54, 102 within said hollow interior compartment; When not in operative engagement with the rotor 20, the other portion of each of said conduit means 54, 102 is arched outwardly from one of said side walls and is free standing upright and generally perpendicular to said one side wall. The conduit means 54, 102 are supported in a predetermined arcuate shape that is elastically biased towards the position, and furthermore, the outwardly arched portions of each of the conduit means 54, 102 are arranged side by side in concentric positions close to each other to the same pump rotor 20. said one side wall supporting said conduit means 54, 102 so as to