JPH0124136B2 - - Google Patents

Description

[Detailed description of the invention]

``Technical Field'' The present invention relates to skin tumor diseases, tonsillosis, alveolar pyorrhea, hair diseases, gangrene diseases, and pyorrhea caused by infection of human skin or external mucosa with pathogens such as bacteria. Concerning therapeutic waters for pathogenic skin and mucosal diseases such as. ``Prior art and its problems'' In recent years, the development of antibiotics, antibacterial agents, chemotherapeutic agents, etc. has made great progress, which has led to advanced treatments for diseases caused by infections caused by bacteria and other pathogens, regardless of whether it is medical or surgical. It is a fact that medical treatment has started to take place. In addition, treatment that used to be surgical can now be treated by internal medicine, and many cases can be cured satisfactorily by this method. However, on the other hand, there have been cases where large doses of broad-spectrum antibiotics lead to colonization of organs by resistant bacteria, which progresses to intractable infections. In other words, the number of special and exotic infections such as opportunistic infections, bacterial replacement, and nosocomial infections is gradually increasing. In addition, patients who visit an internal medicine department with skin diseases such as wheals, blisters, pustules, cysts, and ulcers may be diagnosed with internal organs, such as liver damage, kidney damage, diabetes, or gastrointestinal or pancreatic problems. Digestive related diseases, vitamin deficiencies, endocrine hormone abnormalities,
Alternatively, if it is determined that the cause is due to an allergic disease, etc., only medical treatment is required, which may unnecessarily prolong the symptoms. When it comes to abnormalities on the skin surface caused by various internal diseases, this is because the external organs such as the patient's skin, oral cavity, digestive system, vulva, etc., have weakened resistance to infection, at least from the perspective of healthy humans. A part that comes into direct or indirect contact with
In order to ignore the possibility that infections may be caused simultaneously by various resident bacteria or transient bacteria living in the area, people may unknowingly develop intractable infections. It is something that is driven away. In other words, in such skin, there are resident bacteria and transient bacteria, and no infection of healthy skin tissue is observed, but once the balance is disrupted, the skin becomes infected. Even if the cause of the abnormality is something other than pathogenic bacteria, it is important that the condition worsens locally due to exposure to single or combined infections from the resident flora, and in the case of an endogenous disease. It is an extremely important issue to eliminate the cause and take countermeasures against bacteria on the skin or mucous membranes in parallel. By the way, the currently used chemotherapeutic agents are
They are classified into the following four types depending on their mechanism of action against microorganisms. In other words, unlike animal cells, bacterial cells have a cell wall, and this cell wall consists of two or three layers, including a peptidoglycan layer. Inhibit and lyse. For example, drugs that inhibit cell wall synthesis such as β-glycan antibiotics (penicillin, cefem drugs) and fosfomycin, damage the cell membrane of pathogenic bacteria, and various ions in the cytoplasm.
Drugs that inhibit cell (plasma) membranes, such as polypeptide antibiotics, polyene antibiotics (does not act on bacteria), and imidazole antifungal agents, which leak and kill amino acids, nucleic acids, etc. Because the cell membrane is shared with animal cells, drugs with this effect have low selective toxicity and are more likely to cause side effects), and act on the ribosomes of pathogenic bacteria cells.
Protein synthesis inhibitors that inhibit protein synthesis, such as chloramphenicol, macrolide antibiotics and similar agents, tetracycline antibiotics, aminoglycosides, tetracycline antibiotics, aminoglycoside antibiotics, etc. Drugs (which have a weak effect on ribosomes in animal cells, so they have relatively good selective toxicity), and nucleic acids such as sulfur drugs, nalidixic acid and similar drugs, flucytosine, rifapicin, etc.
DNA synthesis inhibitors (many include antitumor agents,
Drugs that act only on cells have high selective toxicity) (4)
It is one. In this way, today's chemotherapeutic agents are developed based on the above-mentioned mechanisms of action for different purposes.
A broad antibacterial spectrum cannot be obtained when used alone, so they are often used in combination to expand the antibacterial spectrum, but this creates resistant bacteria and leads to opportunistic infections and other difficult-to-treat infections. Furthermore, as mentioned above, many of today's chemotherapeutic agents produce pharmacological effects by striking and damaging the living body according to their respective genres, but even when considering the safety factor of LD ₅₀ / ED ₅₀ , Even if it is safe for the current generation of living humans, it is not guaranteed for future generations or heritability. In view of the above, as a treatment for pathogenic skin and outer mucosal diseases caused by infection of the human skin or outer mucosa with pathogens such as bacteria, in place of current chemotherapeutic agents, It is hoped that a treatment method based on a new mechanism of action will emerge. ``Object of the Invention'' Therefore, the object of the present invention is to provide a novel therapeutic water for pathogenic skin and outer mucosal diseases. The present invention also aims to provide a therapeutic water for pathogenic skin and extraluminal mucosal diseases that can bacteriostatically kill pathogenic bacteria and further promote the recovery mechanism of living cells based on the mechanisms of natural biological systems. purpose. The present invention is capable of simultaneously performing three mechanisms: bacteriostatic or sterilizing bacteria that may be involved, disintegrating and absorbing destroyed tissue, and rapidly regenerating new tissue, and is odorless and colorless. ,
The purpose of the present invention is to provide a fast-acting, simple treatment water for pathogenic skin and extraluminal mucosal diseases. "Structure of the Invention" The above objectives are to have a pH of 5 or less, and an Ag ⁺ ion concentration of 0.5.
This is achieved by a therapeutic water for pathogenic skin and mucosal mucosal diseases consisting of ~10 ppm Ag ⁺ ionized water. Furthermore, in a preferred embodiment of the present invention,
The therapeutic water has an electrical conductivity of 350 to 2000 μ/cm ³ and a dissolved oxygen amount of 12 to 30 ppm. The therapeutic water for pathogenic skin and external mucosal diseases of the present invention (hereinafter simply referred to as therapeutic water) is based on a completely different mechanism from that of conventional therapeutic agents. In other words, as mentioned above, conventional therapeutic agents exhibit medicinal efficacy through inhibitory effects on living organisms such as inhibition of cell wall synthesis, inhibition of cytoplasmic membranes, inhibition of protein synthesis, or inhibition of nucleic acid and DNA synthesis. None of the mechanisms in the system were expected to have that effect. In particular, since they have many things in common with animal cells when it comes to inhibiting the cytoplasmic membrane, side effects are likely to occur, and their use is extremely limited. Therefore, the present inventors discovered for the first time the mechanism of artificial bacteriostatic bacteria in a natural biological system by analyzing the growth and development of cells in living organisms. In other words, among the cells that make up the body, there are a variety of cells, including those that continue to live for the duration of their lifespans once they are completed, and those that repeatedly regenerate and disintegrate. often appear. The change that appears in the nucleus is the condensation of chromosomes, in contrast to which diffusion occurs due to the influx of external water into the cytoplasm. A cell can be said to be alive when the cell membrane controls the entry and exit of substances and is actively functioning, and dead when that function is lost. As a result of the influx of water into the cytoplasm, membrane structures become vacuolated and eventually break down, losing their shape, and organelles are thrown out, leading to death. However, even if there is some damage to the cytoplasm, it can be repaired if the nucleus functions sufficiently. Analysis of these mechanisms shows that the goal can be achieved by artificially deactivating the cell membrane function for a period of time, that is, by deactivating the composition that forms the cell plasma membrane with a special catalytic function. However, the premise is that there is no impact on animals. As a result of many experiments and demonstrations, we have discovered that Ag ions have

Utilizing a mechanism that only works on [Formula], we succeeded in inactivating the target bacteria by catalyzing and ethyleneizing the unsaturated fatty acids in the phospholipids that make up the plasma membrane. What's more, even if the target bacteria were made bacteriostatic by adjusting the Ag ion concentration, they were able to revive them freely. Naturally, in the mixture of proteins, Ag ⁺
In order to send ions, it is necessary to prevent the Ag ⁺ ion effect from decreasing due to complex binding of proteins during the process. To this end, we created conditions at a pH of 5 or below, where no complex binding occurs, and electrochemically provided a potential so that even if the bacterial cells take the form of spores, they can invade by utilizing the difference in potential gradient. On the other hand, regarding the safety of Ag ⁺ ionized water to humans, for example, in the case of silver nitrate, the LD ₅₀ for oral administration to mice is 50.
It has been confirmed that mg/Kg. In addition, although the pH and concentration are different compared to the Ag ⁺ ion water of the present invention, silver ion water produced by a method called the Katadain method was found to be harmless to the human body in tests conducted by the American Institute of Health. death,
Certain cantons supply their citizens with water containing 0.2 to 0.3 mg/litre of silver, which has been used in the soft drink industry in Switzerland since around 1930, and when introduced to Germany. Tests have been carried out in many laboratories and universities for about five years, and the production equipment has been approved by health authorities. Silver ions are found to be 500 to 1000 γ/litre in concentrated fruit juice and 300 to 500 γ/litre in soft drinks. It is already known that food is added ("Food Industry", 1965
(See "On Sterilization by Silver," Dr. F. Zobrist, 2006, 11 vol., pp. 84-86). In the present invention
The concentration of Ag ⁺ ions is about 10 times higher than the concentration used in the above drinks, but since the therapeutic water of the present invention is not meant to be ingested in large quantities like a drink, it can be used properly to protect the human body. Safety is fully ensured. The therapeutic water of the present invention will be explained in detail based on more specific effects. All cells, from animal cells to pathogens such as bacteria, fungi, viruses, and protozoa, are surrounded by cell membranes, and the relationship between these membranes and living organisms is insufficient, and life cannot exist without membranes. not exist. These biological membranes are the source of the basic activities of various life phenomena, and the natural order is reflected in the complexity, such as the concentration or potential difference of substances inside and outside the membrane, differences in the mode of existence, and counterattacks in other cells. It is constructed with a rational mechanism. The structure of the biological membrane is a double membrane composed of phospholipids, and among these phospholipids, phosphadylserine, phosphatidylethanolamine, and phosphatidylinositol exist mainly on the inside of the membrane; Phosphatidylcholine is abundant on the outside of the membrane. In addition, many of these membrane-bound proteins that bind to biological membranes exhibit various physiological activities, including enzymatic activity, and include their receptors, ion channels, and carrier proteins involved in the transport of substances. It is well known that Now, when we analyze the material composition of cells, we find that they contain about 25 to 60% polar lipids, and the basic structure of the membrane is made up of a lipid bilayer and membrane proteins. Among these, phospholipids are rich in polyunsaturated fatty acids that are easily oxidized. Among polar lipid molecules,
The hydrophilic part is in direct contact with the water phase, and the electrical resistance value is 10 ²
As low as ~10 ⁵ Ω/cm ² . On the other hand, the hydrophobic part has a double structure in which -CH ₂ -, such as fatty acids, are arranged parallel to each other by hydrophobic bonds. Note that, compared to eukaryotic cells such as animal cells, in prokaryotic cells such as bacteria, many of the functions of biological membranes are concentrated in the plasma membrane, but its composition remains unchanged. Furthermore, on the cytoplasmic side of the cell membrane of eukaryotic cells, there is a fibrous protein complex called the cytoskeleton that lines the cytoplasmic membrane, while prokaryotic cells and microorganisms such as fungi have a cell wall on the outside of the cell membrane. There is, and it maintains its shape. Furthermore, in subgroups such as viruses, cells (plasma)
Some of them have spike-like envelopes made of glycoproteins or phospholipids on the outer surface of their membranes, and these have great significance in disease bed expression. Here, cell inactivation is an entity that involves the cell membrane, and if we look at how the cell membrane itself is inactivated even in the natural environment, it can be seen that when peripheryel ion type substances or OH are formed near the membrane. Radicals of polyunsaturated fatty acids are generated, which combine with the oxygen of biradicals to produce fatty acid peroxyl radicals, which undergo hydrolysis one after another and rupture the membrane. In order to artificially create this mechanism and deactivate the target bacteria, a catalyst is required to cause these chemical reactions, and there is no substance other than silver that has this function, and ethylene oxidation The catalytic action of silver to form C ₂ H ₄ O as a partial oxidation product in the reaction is a selective action that cannot be replaced by other metals. Therefore, the therapeutic water of the present invention contains silver that has such an effect.
It contains 0.5 to 10 ppm, more preferably 1 to 7 ppm, and most preferably 3 to 6 ppm of Ag ⁺ ions. The Ag ⁺ ions in the treatment water of the present invention pass through the cell plasma membrane (as well as the cell wall) by electrochemical potential, which has the function of separating proteins and other macromolecular colloidal particles of 50 Å to 1000 Å from the liquid. Enters the bacterial body and has the selective function of Ag ⁺

The catalytic function of [Formula] deactivates the function of cell membranes. According to our experiments, when the Ag ⁺ ion concentration is around 100 to 500 ppb, temporarily bacteriostatic bacterial cells begin to reproduce and proliferate again, and as the concentration increases, the regeneration rate decreases and the concentration decreases.
It has become clear that when the concentration is 0.5 to 10 ppm, it becomes almost sterile. In addition, a remarkable phenomenon was discovered in which cells infected by pathogens follow almost the same tendency as bacterial bodies. Therefore, by treatment with the therapeutic water of the present invention, it is possible to deactivate pathogenic bacteria and at the same time dismantle tissues damaged by pathogenic bacteria, and also remove the inhibition of tissue regeneration caused by such tissues. It is possible. On the other hand, there was no adverse effect on normal tissue cells, and there were no problems even in mucous membranes, which have a weaker resistance than the skin. In addition, the therapeutic water of the present invention has a PH value of 5
The pH is below, more preferably PH4 or below, and even more preferably PH3 or below. In this way, by setting the PH value of the treatment water to 5 or less, it is possible to prevent Ag ⁺ ions from being adsorbed to proteins, and even in the coexistence of proteins, the catalytic activity of Ag ⁺ ions is prevented from ^decreasing . allows it to freely pass through the plasma membrane of the target bacterial cell. Furthermore, the therapeutic water of the present invention has an electrical conductivity of 350 to 2000 μ/cm ³ , more preferably 1000 μ/cm 3 .
/cm ³ or more, most preferably 1500 μ/cm ³ or more. By setting the electrical conductivity to 350 to 2000 μ/cm ³ in this way, the cell permeability of Ag ⁺ ions becomes better, and the action of Ag ⁺ ions can be fully expressed. In addition, in the therapeutic water of the present invention, setting the amount of dissolved oxygen to 12 to 30 ppm provides a favorable environment for repair and regeneration of affected tissues. The present inventors first determined that the pH is below 5 and the Ag ⁺ ion concentration.
Ag ⁺ ionized water with an electrical conductivity of 0.5 to 10 ppm, an electrical conductivity of 300 to 2000 μ/cm ³ , and a dissolved oxygen content of 12 to 30 ppm is produced as described below and applied to the affected area of pathogenic (Staphylococcus aureus) skin disease. When immersed in water, it produced dramatic effects not seen with conventional chemical treatments. Therefore, when applied to diseases such as acemocytosis, cephalic acidosis, gangrene, Lin's disease, alveolar pyorrhea, and athlete's foot, it was found that regardless of the type of pathogenic bacteria in the affected area, the bacteria remained for about 1 day. died in
The pain is immediately resolved after treatment, and it also has a hemostatic effect. Damaged cells are broken down and absorbed, and only healthy cells begin to regenerate. Due to the supply of active oxygen, etc., it shows amazing recovery power, and within 24 to 50 hours, The therapeutic effect has been achieved to the extent that there is no problem even when performing contact bending and stretching. In order to produce the therapeutic water of the present invention without producing silver colloid, for example, as previously discovered by the present inventors (see Patent Application No. 123133 of 1988),
The first electrode has an anode and a cathode, and the anode is provided with silver.
Silver ions are eluted through the source water while applying a voltage to the electrolytic chamber, and then a second electrolytic chamber is formed which has an anode and a cathode, a diaphragm is formed between the two electrodes, and is divided into an anode chamber and a cathode chamber. This can be suitably carried out by passing source water in which the silver ions have been eluted through the anode chamber of the chamber. "Examples of the Invention" The present invention will be described in more detail below with reference to Examples. Example 1 (Symptoms) Depressive eczema Lower limbs with varicose veins. Has strong moisturizing properties with flushing. Some cases of autologous dermatitis. (Treatment) PH3, Ag ⁺ ion concentration 3ppm, electrical conductivity 1000μ
Apply Ag ⁺ ions with a dissolved oxygen concentration of 15 ^ppm to the affected area, and then apply a compress with the same Ag ⁺ ion water for 30 minutes. (Effects) The itching sensation disappeared 5 minutes after treatment, the flushing disappeared 30 minutes later, and the skin returned to normal within 1 day. Example 2 (Symptoms) Acute prurigo strophilus in children There was erythema and wheal, and vesicles were observed on the extremities and trunk due to scratching. (Treatment) PH3, Ag ⁺ ion concentration 3ppm, electrical conductivity 1000μ
After spraying Ag ⁺ ion water with a dissolved oxygen content of ¹⁵ ppm over the whole body, a cold compress was applied with the same Ag ⁺ ion water. (Efficacy) The itching and pain disappeared within about 10 minutes after treatment, the wheal subsided after 24 hours, the scratching on the skin almost disappeared, and the patient was completely healed after 3 days. Example 3 (Symptoms) Pustular psoriasis Erythroderma, mucous membrane symptoms, stomatitis also occurred,
Desquamation is seen on the skin of the hands. (Treatment) PH4, Ag ⁺ ion concentration 4ppm, electrical conductivity 800μ
/cm ³ , and after spraying Ag ⁺ ion water with a dissolved oxygen amount of 20 ppm, apply a poultice with the same Ag ⁺ ion water. In the oral cavity, provide the same Ag ⁺ ionized water for gargling.
The patient was instructed to gargle three times a day. (Effects) The mucous membrane symptoms were cured within one day, and the erythematous skin condition faded and returned to normal skin after three days. The oral inflammation completely resolved within 12 hours. Example 4 (Symptoms) Folliculitis baldness A purulent eruption occurs in the hair follicle, which gradually spreads to adjacent hair follicles. Mycobacterium Spotolicones. (Treatment) PH4, Ag ⁺ ion concentration 4ppm, electrical conductivity 800μ
/cm ³ and 20 ppm of dissolved oxygen in the form of a mist of Ag ⁺ ion water using a spray gun to perform pine surge. (Efficacy) The dandruff-like skin disappears within 1 day after treatment, and after 3 days,
After just one spray, I was almost completely cured. Example 5 (Symptoms) Herpes simplex A rash of small blisters accompanied by red halos, with some erosions. Viral disease. (Processing) PH4, Ag ⁺ ion concentration 4ppm, electrical conductivity 800μ
m/cm ³ , and a poultice impregnated with Ag ⁺ ionized water with a dissolved oxygen content of 20 ppm, and replaced several times every hour or so. (Effects) The tingling sensation disappeared within about 5 minutes after the treatment, and 24 hours later, most of the blisters had subsided and the skin's surface tension had returned. No recurrence was observed thereafter. Example 6 (Symptoms) Condyloma acuminata Symptoms: Papules around the labia and anus, the surface is macerated, and there is a strong odor.
Chancroid complications, viral diseases. (Treatment) PH4, Ag ⁺ ion concentration 4ppm, electrical conductivity 800μ
^A water basin was filled with Ag ⁺ ion water with a concentration of 20 ppm and a dissolved oxygen content of 20 ppm, and the water was immersed for about 2 hours. (Effect) After 2 hours, the bad odor disappears and the pain caused by friction due to maceration disappears. After visiting the hospital for 3 days, the superficial symptoms disappeared, the scars fell off, and the chancre symptoms were completely cured in 5 days. Example 7 (Symptoms) Tinea pedis (athlete's foot) The skin between the toes, especially the fourth toe, was macerated, with red erosion and cracks. Trichophyton. (Treatment) PH2.5, Ag ⁺ ion concentration 5ppm, electrical conductivity
Put Ag ⁺ ion water with 1500μ/cm ³ and dissolved oxygen content of 15 ppm into a bucket, soak the feet for 30 minutes for 1 hour, apply a compress with the same Ag ⁺ ion water, and stop after 24 hours. (Effect) After 1 hour of soaking, the pain in the soles of my feet completely disappeared, and after 24 hours
After some time, the fissure had closed, and white collagen-like granulation and epidermis had formed, and no recurrence was observed after 3 days of continued use of the compress. Example 8 (Symptoms) Alveolar pyorrhea (proximal periodontitis) A mixed bacterial infection of the periodontal pockets resulted in congestion and gingivitis, with bleeding seen in some areas and strong bad breath. (Treatment) PH3, Ag ⁺ ion concentration 4ppm, electrical conductivity 1100μ
After gargling with Ag ⁺ ionized water containing 12 ppm of dissolved oxygen per cm ³ , soak cotton in the same Ag ⁺ ionized water and thoroughly apply the bacteria around the meat and gargle again.
Give one day's supply of the same Ag ⁺ ionized water as gargling water. "Effects of the Invention" As described above, the water for treating pathogenic skin and external mucosal diseases of the present invention is composed of Ag ⁺ ion water with a pH of 5 or less and an Ag ⁺ ion concentration of 0.5 to 10 ppm, so it has a good antibacterial spectrum. Conventional chemotherapeutic agents that simultaneously perform three mechanisms: bacteriostasis or sterilization of all bacteria that are likely to be widely involved, disintegration and absorption of destroyed tissues, and prompt regeneration of new tissues. It is an excellent therapeutic water that provides treatment through a completely different mechanism of action and has the following requirements: odorless, colorless, fast-acting, and simple. Skin tumor diseases caused by infection with pathogenic bacteria, tonsillosis, alveolar pyorrhea, hair diseases,
It can be preferably used for the treatment of all pathogenic bacterial skin and extraluminal mucosal diseases such as gangrene and sclerosis.

Claims (1)

[Scope of Claims] 1. Treatment water for pathogenic skin and external mucosal diseases caused by infection with pathogenic bacteria,
Treatment water for pathogenic skin and external mucosal diseases consisting of Ag ⁺ ion water with a pH of 5 or less and an Ag ion concentration of 0.5 to 10 ppm. 2. The therapeutic water for pathogenic skin and extraluminal mucosal diseases according to claim 1, which has an electrical conductivity of 350 to 2000 μ/cm ³ and a dissolved oxygen content of 12 to 30 ppm.