JPH0230256B2 - - Google Patents
Info
- Publication number
- JPH0230256B2 JPH0230256B2 JP57152337A JP15233782A JPH0230256B2 JP H0230256 B2 JPH0230256 B2 JP H0230256B2 JP 57152337 A JP57152337 A JP 57152337A JP 15233782 A JP15233782 A JP 15233782A JP H0230256 B2 JPH0230256 B2 JP H0230256B2
- Authority
- JP
- Japan
- Prior art keywords
- electrode
- gas
- sensor
- carbon dioxide
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 34
- 239000007789 gas Substances 0.000 claims description 23
- 238000005259 measurement Methods 0.000 claims description 21
- 239000001569 carbon dioxide Substances 0.000 claims description 17
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 17
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 14
- 229910001882 dioxygen Inorganic materials 0.000 claims description 14
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 8
- 239000004332 silver Substances 0.000 claims description 8
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 7
- 229910052709 silver Inorganic materials 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 6
- 229920005597 polymer membrane Polymers 0.000 claims description 6
- 239000004593 Epoxy Substances 0.000 claims description 4
- 239000011810 insulating material Substances 0.000 claims description 4
- 229910000510 noble metal Inorganic materials 0.000 claims description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052737 gold Inorganic materials 0.000 claims description 2
- 239000010931 gold Substances 0.000 claims description 2
- 238000001139 pH measurement Methods 0.000 claims description 2
- 229910052697 platinum Inorganic materials 0.000 claims description 2
- 239000003792 electrolyte Substances 0.000 description 5
- 239000012212 insulator Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 206010033675 panniculitis Diseases 0.000 description 3
- 210000004304 subcutaneous tissue Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229910000881 Cu alloy Inorganic materials 0.000 description 1
- 206010029113 Neovascularisation Diseases 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Description
【発明の詳細な説明】
本発明は組織内又は血液中の酸素ガス及び炭酸
ガスの濃度（又は分圧）を同時に経皮的に測定す
るセンサーに関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a sensor that simultaneously measures the concentration (or partial pressure) of oxygen gas and carbon dioxide gas in tissue or blood transcutaneously.
血液中の酸素ガス濃度及び炭酸ガス濃度を知る
ことは、生体の呼吸及び代謝機能の良否を知る上
で重要である。 Knowing the oxygen gas concentration and carbon dioxide gas concentration in the blood is important in knowing the quality of the respiratory and metabolic functions of a living body.
従来、血液中の酸素濃度及び炭酸ガス濃度を同
時に経皮的に測定する方法として、第１図に示す
如く、水素イオン透過性のガラス薄膜を使用した
ガラス電極１と、金、白金等の貴金属線をガラ
ス、エポキシ等の絶縁材２の中に封入した酸素電
極の陰極部３とを互いに隣接配置せしめこの外周
にガラス電極１の対極及び酸素電極の陽極とを兼
用する銀／塩化銀電極４を設けた電極本体部５を
有し、該電極本体部の端面に電解液６の薄層を保
持せしめるように酸素ガス及び炭酸ガス透過性の
高分子膜７を被覆せしめ、該高分子膜近傍の皮膚
を動脈化するための加熱機構８を有するセンサー
は公知である。該センサーは加熱機構８によりセ
ンサーの皮膚加熱部９を43〜44℃になるごとく設
定し、該センサーを両面粘着テープで皮膚面に取
付ける。これによりセンサーと接した皮膚部分及
びその周辺部が加熱されて皮下組織が動脈化され
る。このため組織内の酸素ガス濃度（分圧）及び
炭酸ガス濃度は動脈血に含まれるものと実質的に
等しいものとなり、この酸素ガス及び炭酸ガスが
皮膚組織を拡散して電極膜７に到達してこれを透
過し、電解液６を経て陰極３に達する。陰極に到
達した酸素ガスは陰極で還元されて陽極４との間
に電流が流れ、該電流を測定することにより皮下
組織、従つて動脈血内の酸素濃度を近似的に測定
することができる。また電解液６に到達した炭酸
ガスは電解液中のPHを変化させ、これによりガラ
ス電極１と参照電極４との間に生ずる電位差の変
化よりPHを測定することによつて皮下組織内の炭
酸濃度をも同時に測定することができるようにな
つている。 Conventionally, as a method for transcutaneously measuring the oxygen concentration and carbon dioxide concentration in blood at the same time, as shown in FIG. A cathode part 3 of an oxygen electrode, in which a wire is enclosed in an insulating material 2 such as glass or epoxy, is placed adjacent to the cathode part 3 of the oxygen electrode, and a silver/silver chloride electrode 4 is formed on the outer periphery of the electrode part 4, which serves both as a counter electrode of the glass electrode 1 and as an anode of the oxygen electrode. The end face of the electrode body is coated with a polymer membrane 7 that is permeable to oxygen gas and carbon dioxide so as to retain a thin layer of electrolyte 6, and the vicinity of the polymer membrane is coated with a polymer membrane 7 that is permeable to oxygen gas and carbon dioxide. Sensors with a heating mechanism 8 for arterializing the skin of the skin are known. The temperature of the skin heating part 9 of the sensor is set to 43 to 44° C. using the heating mechanism 8, and the sensor is attached to the skin surface using double-sided adhesive tape. This heats the skin area in contact with the sensor and its surrounding area, causing arterialization of the subcutaneous tissue. Therefore, the oxygen gas concentration (partial pressure) and carbon dioxide concentration in the tissue are substantially equal to those contained in arterial blood, and this oxygen gas and carbon dioxide gas diffuse through the skin tissue and reach the electrode membrane 7. It passes through this and reaches the cathode 3 via the electrolyte 6. The oxygen gas that has reached the cathode is reduced at the cathode, and a current flows between the cathode and the anode 4. By measuring this current, the oxygen concentration in the subcutaneous tissue and therefore in the arterial blood can be approximately measured. In addition, the carbon dioxide that has reached the electrolyte 6 changes the pH in the electrolyte, and by measuring the PH from the change in potential difference generated between the glass electrode 1 and the reference electrode 4, carbon dioxide in the subcutaneous tissue can be detected. It is now possible to measure concentration at the same time.
しかしながら、上記従来のセンサーにあつて
は、PH測定用電極としてアンプを内蔵せる大寸法
のガラス電極を使用しているためにセンサー全体
が大型にならざるを得ず、また、参照電極４が酸
素ガス測定と炭酸ガス測定に共用されているため
に酸素ガス測定の電流により分極を生じ参照電極
の電位が該酸素ガス測定の電流変化によつて変動
する結果炭酸ガス測定値に影響を与えるという欠
点がある。 However, in the case of the above-mentioned conventional sensor, since a large-sized glass electrode with a built-in amplifier is used as the electrode for measuring pH, the entire sensor has to be large, and the reference electrode 4 is Since it is used for gas measurement and carbon dioxide gas measurement, the current for oxygen gas measurement causes polarization, and the potential of the reference electrode fluctuates due to changes in the current for oxygen gas measurement, which affects the carbon dioxide measurement value. There is.
本発明は上記従来の欠点を除去すべくなされた
ものであつて、このため本発明はPH測定用のセン
サーとして小型軽量のISFET（イオンセンシテイ
ブFETセンサー）を使用し、かつ参照電極を酸
素ガス測定用と炭酸ガス測定用とに分割形成し、
似てセンサー全体を小型軽量化するとともに酸素
ガス測定の電流変化が炭酸ガス測定に影響を与え
ないようにしたことを特徴とする。 The present invention has been made to eliminate the above-mentioned conventional drawbacks, and for this reason, the present invention uses a small and lightweight ISFET (ion sensitive FET sensor) as a sensor for PH measurement, and uses oxygen as a reference electrode. Divided into one for gas measurement and one for carbon dioxide measurement,
Similarly, the sensor as a whole is made smaller and lighter, and changes in the current used to measure oxygen gas do not affect carbon dioxide measurement.
以下、添付図に沿つて本発明の好適な実施例に
つき説明する。 Preferred embodiments of the present invention will be described below with reference to the accompanying drawings.
第２図は本発明の一好適例を示し、図において
３は金、白金等の貴金属からなる酸素ガス測定用
の陰極でガラス、エポキシ等の絶縁体の中に封入
されている。１０は炭酸ガス測定用のISFETで
PH感応面を下側にし、上記陰極３とともに絶縁材
２の中にて互いに隣接配置されている。４ａは
O2測定電極の陽極を構成する銀／塩化銀電極、
４ｂはCO2測定の参照電極を構成する銀／塩化銀
電極で、これら両電極４ａ，４ｂは陰極３および
ISFET１０を取囲んで絶縁体２の外周部にリン
グ状に形成されるが、図示のように互いに分離さ
れている。これら貴金属電極３、ISFET１０、
絶縁体２および銀／塩化銀電極４ａ，４ｂよりな
る電極本体部５はエポキシ、ポリエチレン等の絶
縁材料からなる電極ホルダー１１に固着支持され
ている。該電極本体部５の下端部にはKclを主体
としNaHCO3等を緩衝液として加えた電解液６
が電極膜７により薄層状に保持されている。該電
極膜７は疎水性でかつ酸素ガス及び炭酸ガス透過
性の例えばテフロン、ポリエチレン等の高分子膜
からなり、外周部をリング状の膜ホルダー１２に
より固着支持されている。８は銅、銅合金、Al
合金等熱伝導性の良好な材料よりなる加熱機構
で、底面中央に膜露出穴１３を有し、周辺部にヒ
ーター線１４および感熱素子１５を備えている。
該加熱機構８はねじ１６により電極ホルダー１１
に着脱自在に取付けられている。 FIG. 2 shows a preferred embodiment of the present invention, in which reference numeral 3 denotes a cathode for measuring oxygen gas made of a noble metal such as gold or platinum, which is sealed in an insulator such as glass or epoxy. 10 is an ISFET for measuring carbon dioxide gas.
They are placed adjacent to each other in the insulating material 2 together with the cathode 3, with the PH sensitive surface facing downward. 4a is
silver/silver chloride electrode, which constitutes the anode of the O 2 measurement electrode;
4b is a silver/silver chloride electrode that constitutes a reference electrode for CO 2 measurement, and both electrodes 4a and 4b are connected to the cathode 3 and
They are formed in a ring shape on the outer periphery of the insulator 2 surrounding the ISFET 10, but are separated from each other as shown. These noble metal electrodes 3, ISFET 10,
An electrode main body 5 consisting of an insulator 2 and silver/silver chloride electrodes 4a and 4b is fixedly supported by an electrode holder 11 made of an insulating material such as epoxy or polyethylene. At the lower end of the electrode body 5 is an electrolytic solution 6 containing Kcl as a main component and NaHCO 3 etc. as a buffer solution.
is held in a thin layer by the electrode film 7. The electrode membrane 7 is made of a polymer membrane, such as Teflon or polyethylene, which is hydrophobic and permeable to oxygen gas and carbon dioxide gas, and its outer periphery is fixedly supported by a ring-shaped membrane holder 12. 8 is copper, copper alloy, Al
The heating mechanism is made of a material with good thermal conductivity, such as an alloy, and has a membrane exposure hole 13 at the center of the bottom surface, and a heater wire 14 and a heat-sensitive element 15 around the periphery.
The heating mechanism 8 is connected to the electrode holder 11 by screws 16.
It is removably attached to the
上記貴金属電極３と銀／塩化銀電極４ａは、第
３図ａに示すごときO2ガス測定系を構成し、ま
たISFET１０と銀／塩化銀電極４ｂは同図ｂに
示すごときCO2ガス測定系を構成する。 The noble metal electrode 3 and the silver/silver chloride electrode 4a constitute an O 2 gas measurement system as shown in Figure 3a, and the ISFET 10 and the silver/silver chloride electrode 4b constitute a CO 2 gas measurement system as shown in Figure 3b. Configure.
かかる構成よりなるセンサーを用いて経皮的に
動脈血中のO2ガス及びCO2ガスを測定する方法は
従来センサーと本質的に同様であるが、本発明に
おいてはPH測定用センサーとして小型軽量の
ISFETを用いているのでセンサ全体を小型軽量
化させることができ、またO2ガス測定系とCO2ガ
ス測定系に対し分離された参照電極４ａ，４ｂを
使用しているのでO2ガス測定による電流変化が
CO2ガス測定に影響を与えずO2ガスとCO2ガスの
正確な測定が可能である。 The method of percutaneously measuring O 2 gas and CO 2 gas in arterial blood using a sensor with such a configuration is essentially the same as that of conventional sensors, but in the present invention, a small and lightweight sensor for measuring PH is used.
Since ISFET is used, the entire sensor can be made smaller and lighter. Also, separate reference electrodes 4a and 4b are used for the O 2 gas measurement system and the CO 2 gas measurement system, so the O 2 gas measurement The current change
Accurate measurement of O 2 gas and CO 2 gas is possible without affecting CO 2 gas measurement.
以上のように、本発明によれば小型軽量でかつ
正確な測定をなし得る血中O2ガス及びCO2ガスの
経皮的同時測定センサーが得られる。 As described above, according to the present invention, a sensor for simultaneous transcutaneous measurement of blood O 2 gas and CO 2 gas can be obtained which is small and lightweight and capable of accurate measurement.
第１図は従来センサーの構造を示すもので同図
ａは中央断面図、同図ｂは部分的平面図、第２図
は本発明センサーの一例を示す図で、同図ａは中
央断面図、同図ｂは部分的平面図、第３図ａ，ｂ
はそれぞれ第２図のセンサーのO2ガスおよびCO2
ガスの測定系を示す図である。
２……絶縁体、３……陰極、４ａ，４ｂ……
銀／塩化銀電極、５……電極本体部、６……電解
液、７……電極膜、８……加熱機構、１０……
ISFET。
Figure 1 shows the structure of a conventional sensor; Figure a is a central sectional view, Figure b is a partial plan view, and Figure 2 is a diagram showing an example of the sensor of the present invention; Figure A is a central sectional view. , Figure b is a partial plan view, Figure 3 a, b
are the O 2 gas and CO 2 of the sensor in Figure 2, respectively.
FIG. 3 is a diagram showing a gas measurement system. 2... Insulator, 3... Cathode, 4a, 4b...
Silver/silver chloride electrode, 5... Electrode body, 6... Electrolyte, 7... Electrode film, 8... Heating mechanism, 10...
ISFET.
Claims (1)
センサー）と金、白金等の貴金属よりなる酸素電
極の陰極とをガラス、エポキシ等の絶縁材中にて
互いに隣接配置せしめ、この外周にそれぞれ
ISFETの対極及び酸素電極の陽極を形成する分
離された銀／塩化銀電極を設けた電極本体部を有
し、該電極本体部の端面に電解液の薄層を保持せ
しめるように酸素ガス及び炭酸ガス透過性の高分
子膜を被覆せしめ、該高分子膜近傍の皮膚を動脈
化するための加熱機構を設けた経皮血中酸素ガス
及び炭酸ガス同時測定用センサー。1 ISFET (ion sensitive FET) for PH measurement
A sensor) and a cathode of an oxygen electrode made of a noble metal such as gold or platinum are placed adjacent to each other in an insulating material such as glass or epoxy, and each
It has an electrode body with a separate silver/silver chloride electrode that forms the counter electrode of the ISFET and the anode of the oxygen electrode, and the oxygen gas and carbon dioxide A sensor for simultaneous measurement of percutaneous blood oxygen gas and carbon dioxide gas, which is coated with a gas-permeable polymer membrane and equipped with a heating mechanism to arterify the skin near the polymer membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57152337A JPS5940844A (en) | 1982-09-01 | 1982-09-01 | Sensor for simultaneously measuring oxygen and carbon dioxide in blood subcataneously |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57152337A JPS5940844A (en) | 1982-09-01 | 1982-09-01 | Sensor for simultaneously measuring oxygen and carbon dioxide in blood subcataneously |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5940844A JPS5940844A (en) | 1984-03-06 |
| JPH0230256B2 true JPH0230256B2 (en) | 1990-07-05 |
Family
ID=15538326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57152337A Granted JPS5940844A (en) | 1982-09-01 | 1982-09-01 | Sensor for simultaneously measuring oxygen and carbon dioxide in blood subcataneously |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5940844A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2773266B1 (en) | 2011-10-31 | 2022-11-30 | Sentec Ag | A device for application of a sensor to a measurement site, a kit of an application device and sensor and use of an application device for optical measurements of physiological parameters |
| US10136969B2 (en) | 2014-02-20 | 2018-11-27 | Alireza Tavassoli | Method and system for tooth restoration |
-
1982
- 1982-09-01 JP JP57152337A patent/JPS5940844A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5940844A (en) | 1984-03-06 |
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