JPH023425B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION This invention relates to relatively high molecular weight polyisobutylene emulsions.

Polyisobutylene is considered a hygienically safe compound and is used in medical applications, such as adhesive base polymers for poultices.

Furthermore, when used in these applications, for example when applying polyisobutylene to a substrate, the emulsion type is easier to operate. It is preferable that the higher the molecular weight of polyisobutylene, the emulsion type is easier to handle.

Naturally, an emulsifier is required to produce this polyisobutylene emulsion, but there are many problems with this emulsifier in terms of food hygiene. Polyisobutylene emulsions were also not safe from a food hygiene perspective, and could not be used for medical purposes. This situation was also the same for emulsions produced by emulsion polymerization. Furthermore, as the molecular weight of polyisobutylene increases, it becomes extremely difficult to form it into an emulsion, and emulsifiers used in emulsions of so-called polybutene, which has a relatively low molecular weight, are ineffective in emulsifying high molecular weight polyisobutylene.

In view of the above circumstances, the present inventors have searched for a relatively high molecular weight polyisobutylene emulsion that is food hygienically safe and suitable for medical use. The present invention was completed by discovering a good thing.

That is, the present invention provides solid content of (a) per 100 parts by weight of polyisobutylene having a viscosity average molecular weight of 10,000 to 70,000, (b) 7.5 to 20 parts by weight of sucrose fatty acid ester, and (c) polyalkylene glycol monoalkyl. (or alkenyl) ether 2 parts by weight or more
10 parts by weight of an extremely stable O/W type polyisobutylene emulsion.

The polyisobutylene of the present invention is produced by converting isobutylene in a solvent such as hexane, a _C4 fraction from FCC in petroleum refining, a _C4 fraction from a naphtha cracker, etc. to aluminum chloride, etc.
It is obtained by polymerizing with a Friedel-Crafts catalyst such as boron fluoride, and its viscosity average molecular weight (Flory method) is 10,000 to 70,000.

Per 100 parts by weight of the polyisobutylene, the amount of sucrose fatty acid ester blended as an emulsifier is 7.5 parts to 20 parts by weight, more preferably 10 parts to 15 parts by weight, and polyalkylene glycol alkyl ether as an emulsifier used in combination. The blending amount is from 2 parts by weight to 10 parts by weight, more preferably from 3 parts by weight to 6 parts by weight. The above two types of emulsifiers have poor stability when used alone, so they must be used together, but even if they are used together, if they are outside the above blending range, they will become unstable and produce fine and uniform particles of 1 micron or less. This is not preferable because it does not form an emulsion with a diameter.

The sucrose fatty acid ester in the present invention refers to higher fatty acids obtained from hardened beef tallow, such as stearic acid, palmitic acid, and oleic acid;
Alternatively, it is an ester of lower fatty acids such as acetic acid or isobutyric acid and sucrose, and is a nonionic surfactant. Among these sucrose fatty acid esters, HLB
is preferably 15 or more.

In addition, polyalkylene glycol alkyl ether is a higher alcohol such as lauryl alcohol and oleyl alcohol with ethylene oxide,
It is a nonionic surfactant obtained by adding alkylene oxide such as propylene oxide. Among these, HLBs having a high hydrophilicity of 15 or more are preferable, and for example, polyethylene glycol lauryl ether, polyethylene glycol oleyl ether, etc. are preferable.

The emulsion of the present invention is an O/W type polyisobutylene emulsion containing polyisobutylene and the above two types of emulsifiers and having a solid content of 1% to 75% by weight. Other emulsifiers, known oxidation stabilizers, fillers, etc. may be included as long as they are stable as emulsions.

Further, the emulsion of the present invention uses the above-mentioned two types of emulsifiers in combination, and can be manufactured by a conventionally known manufacturing method. For example, after heating to an appropriate temperature and mixing polyisobutylene and the two types of emulsifiers, water can be gradually added to form an emulsion.

The isobutylene emulsion of the present invention can be used as an emulsion in general adhesives, etc.
Since it is hygienically safe, it is suitable for use as a bulging agent.

In order to apply a hot or cold compress, the agent is applied to a stretchable or non-woven fabric in advance, spread and covered with a protective film, and when it is ready for use, the protective film is peeled off and applied to the affected area. It is to be pasted. In addition, as a bulging agent, polyisobutylene emulsion alone or a mixture thereof with a polymer solution or emulsion such as gelatin, gum arabic, polyvinyl alcohol, methyl cellulose, etc., and kaolin, Mix heat absorbing agents such as bentonite, water retaining agents such as urea, glycerin, propylene glycol, sorbitol aqueous solution, or moisture absorbing agents made of alkaline earth metal salts such as magnesium chloride, and if necessary, add rosin, ester gum, etc. A tackifier can be produced by mixing a tackifier resin, forming a paste, and applying the paste to a base material such as cloth.

The patch containing the polyisobutylene emulsion of the present invention produced in this manner has appropriate adhesion to the skin, has little sagging, and has improved moisture evaporation prevention and water retention properties, as well as the above-mentioned properties. As such, it is suitable as a hygienically safe bulging agent.

Next, the present invention will be explained in detail with reference to Examples.

Example The following polyisobutylene (1000g), sucrose fatty acid ester (100g) and polyethylene glycol lauryl ether (50g) were placed in a kneader No. 3 heated to about 70°C, and stirred for 30 to 60 minutes to make them uniform. .

Polyisobutylene: Viscosity average molecular weight (Flory method) 60,000 Sucrose fatty acid ester: Product name DK Ester F-160 (HLB16) (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) Polyethylene glycol lauryl ether: Product name Neugen YX-400 (HLB20) ( (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) Next, while stirring, a total of 1150 ml of water was gradually added to produce an emulsion with a solid content of 50% by weight.

Even if you leave this emulsion for several days,
It was stable without phase separation.

Of the above emulsifiers, DK ester F-
160 is approved as a food additive, and Neugen YX-400 is approved by the US FDA (Food and Drug Administration).
Since it passes the standards, the obtained emulsion is also sanitary and safe, making it ideal for medical use.

Comparative Example DK Ester F-160 (150 g) and Neugen YX-400 (100 g) were used alone as emulsifiers, but the same procedure as in Example was carried out, and they were mixed with polyisobutylene and water was added, but no stable emulsion was obtained. I couldn't get it.

Claims (1)

[Claims] 1. As a solid content, (a) per 100 parts by weight of polyisobutylene having a viscosity average molecular weight of 10,000 to 70,000, (b) 7.5 parts to 20 parts by weight of sucrose fatty acid ester, and (c) polyalkylene glycol. Very stable O/W polyisobutylene emulsion containing 2 to 10 parts by weight of monoalkyl (or alkenyl) ether. 2. The polyisobutylene emulsion according to claim 1, wherein the polyalkylene glycol monoalkyl (or alkenyl) ether is polyethylene glycol lauryl ether. 3. The polyisobutylene emulsion according to claim 1, wherein the polyalkylene glycol monoalkyl (or alkenyl) ether is polyethylene glycol oleyl ether.