JPH024301B2 - - Google Patents
Info
- Publication number
- JPH024301B2 JPH024301B2 JP60162048A JP16204885A JPH024301B2 JP H024301 B2 JPH024301 B2 JP H024301B2 JP 60162048 A JP60162048 A JP 60162048A JP 16204885 A JP16204885 A JP 16204885A JP H024301 B2 JPH024301 B2 JP H024301B2
- Authority
- JP
- Japan
- Prior art keywords
- low
- acid
- adsorbent
- density lipoprotein
- adsorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010007622 LDL Lipoproteins Proteins 0.000 claims description 70
- 102000007330 LDL Lipoproteins Human genes 0.000 claims description 70
- 239000003463 adsorbent Substances 0.000 claims description 70
- 229920000447 polyanionic polymer Polymers 0.000 claims description 31
- 210000001124 body fluid Anatomy 0.000 claims description 13
- 239000010839 body fluid Substances 0.000 claims description 13
- 239000002738 chelating agent Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 description 43
- 238000001179 sorption measurement Methods 0.000 description 33
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 27
- 239000000243 solution Substances 0.000 description 22
- 230000001172 regenerating effect Effects 0.000 description 19
- 238000011069 regeneration method Methods 0.000 description 15
- 235000012000 cholesterol Nutrition 0.000 description 14
- 239000007788 liquid Substances 0.000 description 13
- 102000004895 Lipoproteins Human genes 0.000 description 12
- 108090001030 Lipoproteins Proteins 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 230000008929 regeneration Effects 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 229920002554 vinyl polymer Polymers 0.000 description 10
- 239000000499 gel Substances 0.000 description 9
- -1 vinyl anions Chemical class 0.000 description 9
- 229920002125 Sokalan® Polymers 0.000 description 7
- 229920001577 copolymer Polymers 0.000 description 7
- 239000003446 ligand Substances 0.000 description 7
- 239000004584 polyacrylic acid Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 208000000563 Hyperlipoproteinemia Type II Diseases 0.000 description 6
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 description 6
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 description 6
- 201000001386 familial hypercholesterolemia Diseases 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 238000009739 binding Methods 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
- 239000000969 carrier Substances 0.000 description 5
- 125000000524 functional group Chemical group 0.000 description 5
- 229920000669 heparin Polymers 0.000 description 5
- 239000000178 monomer Substances 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000003431 cross linking reagent Substances 0.000 description 4
- 229960002897 heparin Drugs 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 235000011121 sodium hydroxide Nutrition 0.000 description 4
- KOMNUTZXSVSERR-UHFFFAOYSA-N 1,3,5-tris(prop-2-enyl)-1,3,5-triazinane-2,4,6-trione Chemical compound C=CCN1C(=O)N(CC=C)C(=O)N(CC=C)C1=O KOMNUTZXSVSERR-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 3
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 230000004154 complement system Effects 0.000 description 3
- 230000007717 exclusion Effects 0.000 description 3
- 238000010559 graft polymerization reaction Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 235000011007 phosphoric acid Nutrition 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- XFCMNSHQOZQILR-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOC(=O)C(C)=C XFCMNSHQOZQILR-UHFFFAOYSA-N 0.000 description 2
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical compound NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 239000004593 Epoxy Substances 0.000 description 2
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical group OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 238000001042 affinity chromatography Methods 0.000 description 2
- 239000011543 agarose gel Substances 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 description 2
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 2
- 150000001735 carboxylic acids Chemical class 0.000 description 2
- 238000013375 chromatographic separation Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000003700 epoxy group Chemical group 0.000 description 2
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000003527 fibrinolytic agent Substances 0.000 description 2
- 230000003480 fibrinolytic effect Effects 0.000 description 2
- 238000004388 gamma ray sterilization Methods 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000012052 hydrophilic carrier Substances 0.000 description 2
- 239000012051 hydrophobic carrier Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 150000004804 polysaccharides Chemical class 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical compound OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 125000000542 sulfonic acid group Chemical group 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229920001567 vinyl ester resin Polymers 0.000 description 2
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- RBNPOMFGQQGHHO-UHFFFAOYSA-N -2,3-Dihydroxypropanoic acid Natural products OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 description 1
- SHXHPUAKLCCLDV-UHFFFAOYSA-N 1,1,1-trifluoropentane-2,4-dione Chemical compound CC(=O)CC(=O)C(F)(F)F SHXHPUAKLCCLDV-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- NDGWHQSOYIQHAS-UHFFFAOYSA-N 1-(furan-2-yl)-3-phenylpropane-1,3-dione Chemical compound C=1C=COC=1C(=O)CC(=O)C1=CC=CC=C1 NDGWHQSOYIQHAS-UHFFFAOYSA-N 0.000 description 1
- OOSZCNKVJAVHJI-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]piperazine Chemical compound C1=CC(F)=CC=C1CN1CCNCC1 OOSZCNKVJAVHJI-UHFFFAOYSA-N 0.000 description 1
- SAMJGBVVQUEMGC-UHFFFAOYSA-N 1-ethenoxy-2-(2-ethenoxyethoxy)ethane Chemical compound C=COCCOCCOC=C SAMJGBVVQUEMGC-UHFFFAOYSA-N 0.000 description 1
- FPSURBCYSCOZSE-UHFFFAOYSA-N 1-ethenoxybutan-1-ol Chemical compound CCCC(O)OC=C FPSURBCYSCOZSE-UHFFFAOYSA-N 0.000 description 1
- CVBUKMMMRLOKQR-UHFFFAOYSA-N 1-phenylbutane-1,3-dione Chemical compound CC(=O)CC(=O)C1=CC=CC=C1 CVBUKMMMRLOKQR-UHFFFAOYSA-N 0.000 description 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2,2'-azo-bis-isobutyronitrile Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- BJELTSYBAHKXRW-UHFFFAOYSA-N 2,4,6-triallyloxy-1,3,5-triazine Chemical compound C=CCOC1=NC(OCC=C)=NC(OCC=C)=N1 BJELTSYBAHKXRW-UHFFFAOYSA-N 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- RFPMBNQRCCSCMH-UHFFFAOYSA-N 2-[5-[bis(carboxymethyl)amino]pentyl-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CCCCCN(CC(O)=O)CC(O)=O RFPMBNQRCCSCMH-UHFFFAOYSA-N 0.000 description 1
- VRVRGVPWCUEOGV-UHFFFAOYSA-N 2-aminothiophenol Chemical compound NC1=CC=CC=C1S VRVRGVPWCUEOGV-UHFFFAOYSA-N 0.000 description 1
- LSTRKXWIZZZYAS-UHFFFAOYSA-N 2-bromoacetyl bromide Chemical compound BrCC(Br)=O LSTRKXWIZZZYAS-UHFFFAOYSA-N 0.000 description 1
- SLAMLWHELXOEJZ-UHFFFAOYSA-N 2-nitrobenzoic acid Chemical compound OC(=O)C1=CC=CC=C1[N+]([O-])=O SLAMLWHELXOEJZ-UHFFFAOYSA-N 0.000 description 1
- BXAAQNFGSQKPDZ-UHFFFAOYSA-N 3-[1,2,2-tris(prop-2-enoxy)ethoxy]prop-1-ene Chemical compound C=CCOC(OCC=C)C(OCC=C)OCC=C BXAAQNFGSQKPDZ-UHFFFAOYSA-N 0.000 description 1
- UWRBFYBQPCJRRL-UHFFFAOYSA-N 3-[bis(carboxymethyl)amino]propanoic acid Chemical compound OC(=O)CCN(CC(O)=O)CC(O)=O UWRBFYBQPCJRRL-UHFFFAOYSA-N 0.000 description 1
- DOHOPUBZLWVZMZ-UHFFFAOYSA-N 3-chloro-2-hydroxybenzaldehyde Chemical compound OC1=C(Cl)C=CC=C1C=O DOHOPUBZLWVZMZ-UHFFFAOYSA-N 0.000 description 1
- KQLRFWVNJUCXQT-UHFFFAOYSA-N 3-formyl-4-hydroxybenzenesulfonic acid Chemical compound OC1=CC=C(S(O)(=O)=O)C=C1C=O KQLRFWVNJUCXQT-UHFFFAOYSA-N 0.000 description 1
- UUEWCQRISZBELL-UHFFFAOYSA-N 3-trimethoxysilylpropane-1-thiol Chemical compound CO[Si](OC)(OC)CCCS UUEWCQRISZBELL-UHFFFAOYSA-N 0.000 description 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- YCPXWRQRBFJBPZ-UHFFFAOYSA-N 5-sulfosalicylic acid Chemical compound OC(=O)C1=CC(S(O)(=O)=O)=CC=C1O YCPXWRQRBFJBPZ-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 1
- WXBUDEYZZBHQBC-UHFFFAOYSA-N CC(O)=O.CC(O)=O.NC1=CC=CC=C1 Chemical compound CC(O)=O.CC(O)=O.NC1=CC=CC=C1 WXBUDEYZZBHQBC-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 150000000703 Cerium Chemical class 0.000 description 1
- XXAXVMUWHZHZMJ-UHFFFAOYSA-N Chymopapain Chemical compound OC1=CC(S(O)(=O)=O)=CC(S(O)(=O)=O)=C1O XXAXVMUWHZHZMJ-UHFFFAOYSA-N 0.000 description 1
- 102000000989 Complement System Proteins Human genes 0.000 description 1
- 108010069112 Complement System Proteins Proteins 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- RBNPOMFGQQGHHO-UWTATZPHSA-N D-glyceric acid Chemical compound OC[C@@H](O)C(O)=O RBNPOMFGQQGHHO-UWTATZPHSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010093096 Immobilized Enzymes Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- OHHLQFCWNFSQEY-UHFFFAOYSA-N O.O.O.O.[Na].[Na].[Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O Chemical compound O.O.O.O.[Na].[Na].[Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O OHHLQFCWNFSQEY-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920000805 Polyaspartic acid Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 108010020346 Polyglutamic Acid Proteins 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 238000007259 addition reaction Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- XYLMUPLGERFSHI-UHFFFAOYSA-N alpha-Methylstyrene Chemical compound CC(=C)C1=CC=CC=C1 XYLMUPLGERFSHI-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- SXYCCJAPZKHOLS-UHFFFAOYSA-N chembl2008674 Chemical compound [O-][N+](=O)C1=CC=C2C(N=NC3=C4C=CC=CC4=CC=C3O)=C(O)C=C(S(O)(=O)=O)C2=C1 SXYCCJAPZKHOLS-UHFFFAOYSA-N 0.000 description 1
- ZQWICJYATMSSSD-UHFFFAOYSA-M chembl2028584 Chemical compound [Na+].C1=CC=C2C(N=NC3=C4C=CC=CC4=CC=C3O)=C(O)C=C(S([O-])(=O)=O)C2=C1 ZQWICJYATMSSSD-UHFFFAOYSA-M 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- HNEGQIOMVPPMNR-IHWYPQMZSA-N citraconic acid Chemical compound OC(=O)C(/C)=C\C(O)=O HNEGQIOMVPPMNR-IHWYPQMZSA-N 0.000 description 1
- 229940018557 citraconic acid Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000024203 complement activation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- AZSFNUJOCKMOGB-UHFFFAOYSA-N cyclotriphosphoric acid Chemical compound OP1(=O)OP(O)(=O)OP(O)(=O)O1 AZSFNUJOCKMOGB-UHFFFAOYSA-N 0.000 description 1
- 238000005695 dehalogenation reaction Methods 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 1
- DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229940052303 ethers for general anesthesia Drugs 0.000 description 1
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 description 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 description 1
- JMANVNJQNLATNU-UHFFFAOYSA-N glycolonitrile Natural products N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
- 229960001008 heparin sodium Drugs 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940027941 immunoglobulin g Drugs 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002505 iron Chemical class 0.000 description 1
- ZFSLODLOARCGLH-UHFFFAOYSA-N isocyanuric acid Chemical group OC1=NC(O)=NC(O)=N1 ZFSLODLOARCGLH-UHFFFAOYSA-N 0.000 description 1
- 238000005339 levitation Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 150000004002 naphthaldehydes Chemical class 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- RGHXWDVNBYKJQH-UHFFFAOYSA-N nitroacetic acid Chemical compound OC(=O)C[N+]([O-])=O RGHXWDVNBYKJQH-UHFFFAOYSA-N 0.000 description 1
- LJDZFAPLPVPTBD-UHFFFAOYSA-N nitroformic acid Chemical class OC(=O)[N+]([O-])=O LJDZFAPLPVPTBD-UHFFFAOYSA-N 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical class C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000172 poly(styrenesulfonic acid) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 108010064470 polyaspartate Proteins 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229940005642 polystyrene sulfonic acid Drugs 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- DBCAVMLQRAABFF-UHFFFAOYSA-M potassium;carbonic acid;hydrogen carbonate Chemical compound [K+].OC(O)=O.OC([O-])=O DBCAVMLQRAABFF-UHFFFAOYSA-M 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003761 preservation solution Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- AOHJOMMDDJHIJH-UHFFFAOYSA-N propylenediamine Chemical compound CC(N)CN AOHJOMMDDJHIJH-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229940005657 pyrophosphoric acid Drugs 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 125000005372 silanol group Chemical group 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010557 suspension polymerization reaction Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000006276 transfer reaction Methods 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
- GQIUQDDJKHLHTB-UHFFFAOYSA-N trichloro(ethenyl)silane Chemical compound Cl[Si](Cl)(Cl)C=C GQIUQDDJKHLHTB-UHFFFAOYSA-N 0.000 description 1
- BPSIOYPQMFLKFR-UHFFFAOYSA-N trimethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound CO[Si](OC)(OC)CCCOCC1CO1 BPSIOYPQMFLKFR-UHFFFAOYSA-N 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 229940048102 triphosphoric acid Drugs 0.000 description 1
- 229920006163 vinyl copolymer Polymers 0.000 description 1
- 239000005050 vinyl trichlorosilane Substances 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
- Materials For Medical Uses (AREA)
Description
ãçºæã®è©³çŽ°ãªèª¬æã
ïŒç£æ¥äžã®å©çšåéïŒ
æ¬çºæã¯ãè¡æŒ¿è質ã®å¢å ã«èµ·å ããåçš®çŸæ£
ãšå¯æ¥ãªé¢ä¿ãæã€ãšèããããŠããäœæ¯éãªã
èçœè³ªãéžæçã«åžçé€å»ããäœæ¯éãªãèçœè³ª
åžçæã®åçæ¹æ³ã«é¢ããã
ãšå¯æ¥ãªé¢ä¿ãæã€ãšèããããŠããäœæ¯éãªã
èçœè³ªãéžæçã«åžçé€å»ããäœæ¯éãªãèçœè³ª
åžçæã®åçæ¹æ³ã«é¢ããã
åšç¥ã®åŠããè¡æ¶²äžã®è質ãç¹ã«äœæ¯éãªãè
çœè³ªã®å¢å ã¯ãåè硬åã®åå ãããã¯é²è¡ãšå¯
æ¥ãªé¢ä¿ãæã€ãŠãããšèããããŠãããåè硬
åãé²ããšå¿çæ¢å¡ãè³æ¢å¡ç埪ç°åšç³»ã®é節ãª
çç¶ã«é¥ãå¯èœæ§ãéåžžã«é«ããªããæ»äº¡çãé«
ãã
çœè³ªã®å¢å ã¯ãåè硬åã®åå ãããã¯é²è¡ãšå¯
æ¥ãªé¢ä¿ãæã€ãŠãããšèããããŠãããåè硬
åãé²ããšå¿çæ¢å¡ãè³æ¢å¡ç埪ç°åšç³»ã®é節ãª
çç¶ã«é¥ãå¯èœæ§ãéåžžã«é«ããªããæ»äº¡çãé«
ãã
ããã§ãè¡æ¶²ãè¡æŒ¿çã®äœæ¶²æåããäœæ¯éãª
ãèçœè³ªãéžæçã«åžçé€å»ããããšã«ãã€ãŠã
äžèšã®åŠãçŸæ£ã®é²è¡ãé²æ¢ããçç¶ã軜æžãã
ããããã«ã¯æ²»ããæ©ããããšãæåŸ ãããŠã
ãã
ãèçœè³ªãéžæçã«åžçé€å»ããããšã«ãã€ãŠã
äžèšã®åŠãçŸæ£ã®é²è¡ãé²æ¢ããçç¶ã軜æžãã
ããããã«ã¯æ²»ããæ©ããããšãæåŸ ãããŠã
ãã
ïŒåŸæ¥ã®æè¡ïŒ
äžèšç®çã«äœ¿çšå¯èœãªæ¢åã®æè¡ã«ã¯ãã¢ã¬ã
ãŒã¹ã²ã«ã«ãããªã³ãåºå®åããåžçæã«ããåž
çïŒLupienãâãet.al.ïŒïŒ¡ new
approach tn the management of familial
hypercholesterolemia.Removal of plasmaâ
cholesterol based on the principle of affinity
chromatography.LancetãïŒïŒ1261ã1264ã
1976.ïŒããã³ã¬ã©ã¹ããŠããŒãŸãã¯ã¬ã©ã¹ããŒ
ãºãçšããã¯ãããã°ã©ãã€ãŒïŒCarlsonãL.
A.ïŒChromatographic separation of serum
lipoproteins on glass powder colums.
Description of the method and some
applications.Clin.Chim.ActaãïŒïŒ528ã538ã
1960.ïŒãããã
ãŒã¹ã²ã«ã«ãããªã³ãåºå®åããåžçæã«ããåž
çïŒLupienãâãet.al.ïŒïŒ¡ new
approach tn the management of familial
hypercholesterolemia.Removal of plasmaâ
cholesterol based on the principle of affinity
chromatography.LancetãïŒïŒ1261ã1264ã
1976.ïŒããã³ã¬ã©ã¹ããŠããŒãŸãã¯ã¬ã©ã¹ããŒ
ãºãçšããã¯ãããã°ã©ãã€ãŒïŒCarlsonãL.
A.ïŒChromatographic separation of serum
lipoproteins on glass powder colums.
Description of the method and some
applications.Clin.Chim.ActaãïŒïŒ528ã538ã
1960.ïŒãããã
ãŸããæè¿ã«ãªã€ãŠãäœå€åŸªç°ã«ããäœæ¯éãª
ãèçœè³ªã®åžçé€å»ã«é©ããæ¹è¯çºæïŒç¹éæ59
â102436ïŒããäœæ¯éãªãèçœè³ªã®åžçèœåãã
ãã«é«ããåžçæã®çºæïŒç¹é¡æ58â80777ãç¹
é¡æ58â80778ïŒããªãããããã«ãªããæè¡ç
ã«ã¯é²æ©ããŠããã
ãèçœè³ªã®åžçé€å»ã«é©ããæ¹è¯çºæïŒç¹éæ59
â102436ïŒããäœæ¯éãªãèçœè³ªã®åžçèœåãã
ãã«é«ããåžçæã®çºæïŒç¹é¡æ58â80777ãç¹
é¡æ58â80778ïŒããªãããããã«ãªããæè¡ç
ã«ã¯é²æ©ããŠããã
ãŸãããããã®åžçæã§äœæ¶²ãåŠçããäœæ¯é
ãªãèçœè³ªãåžçé€å»ããåŸã該åžçæããäœæ¯
éãªãèçœè³ªãè±çãããåžçæãåçããå䜿
çšããããšããè©Šã¿ããªãããŠããã
ãªãèçœè³ªãåžçé€å»ããåŸã該åžçæããäœæ¯
éãªãèçœè³ªãè±çãããåžçæãåçããå䜿
çšããããšããè©Šã¿ããªãããŠããã
äŸãã°ããããªã³ãåºå®åããåžçæã®å Žå
ã¯ãïŒïŒ å¡©åãããªãŠã ã«ããããªãèçœãæŽæµ
ããæ¹æ³ïŒDdwin A.Burgstaler et.al.ïŒ
Labolatory StudyãRemoval of plasma
lipoproteins from circulating blood with ïœ
HeparinâAgarose column.Mayo Clin Proc
55ïŒ180â184ã1980ïŒã§ãããã¬ã©ã¹ãçšããå Ž
åã«ã¯ãpotassium bicarbonateâcarbonate
bufferïŒPH8.8ã9.6ã9.8ããã³CO3ïŒã§ãªãèçœã
溶åºããæ¹æ³ïŒCarlsonãL.A.ïŒ
Chromatographic separation of serum
lipoproteins on glass powder column.
Description of the method and some
applications.Clin.Chim.ActaãïŒïŒ528ã538ã
1960.ïŒãããã
ã¯ãïŒïŒ å¡©åãããªãŠã ã«ããããªãèçœãæŽæµ
ããæ¹æ³ïŒDdwin A.Burgstaler et.al.ïŒ
Labolatory StudyãRemoval of plasma
lipoproteins from circulating blood with ïœ
HeparinâAgarose column.Mayo Clin Proc
55ïŒ180â184ã1980ïŒã§ãããã¬ã©ã¹ãçšããå Ž
åã«ã¯ãpotassium bicarbonateâcarbonate
bufferïŒPH8.8ã9.6ã9.8ããã³CO3ïŒã§ãªãèçœã
溶åºããæ¹æ³ïŒCarlsonãL.A.ïŒ
Chromatographic separation of serum
lipoproteins on glass powder column.
Description of the method and some
applications.Clin.Chim.ActaãïŒïŒ528ã538ã
1960.ïŒãããã
ïŒçºæã解決ããããšããåé¡ç¹ïŒ
ããããªããããããã®åžçæåçæ¹æ³ã¯ãåŸ
æ¥ã®åžçæ§èœãããŸãé«ããªãåžçæã«å¯Ÿããå
çæ段ãšããŠã¯å åã§ãã€ããšããŠããæè¿ã®äœ
æ¯éãªãèçœè³ªåžçæ§èœã®åäžããããªã¢ããªã³
ç³»åžçæã«å¯ŸããŠãäžèšãããããªåžçæåçæ¹
æ³ãé©çšããŠã¿ãŠããåžçæã¯å åã«ã¯åçãã
ããæ¹è¯ãæãŸããŠããã
æ¥ã®åžçæ§èœãããŸãé«ããªãåžçæã«å¯Ÿããå
çæ段ãšããŠã¯å åã§ãã€ããšããŠããæè¿ã®äœ
æ¯éãªãèçœè³ªåžçæ§èœã®åäžããããªã¢ããªã³
ç³»åžçæã«å¯ŸããŠãäžèšãããããªåžçæåçæ¹
æ³ãé©çšããŠã¿ãŠããåžçæã¯å åã«ã¯åçãã
ããæ¹è¯ãæãŸããŠããã
ïŒåé¡ç¹ã解決ããããã®æ段ïŒ
æ¬çºæè
ãã¯ãäžèšããåé¡ã解決ãã簡䟿ã§
å®å šãªãå¹çã®è¯ãåžçæåçæ¹æ³ãæäŸããã
ãéæç 究ããçµæã溶é¢æ¶²ãšããŠéå±ã€ãªã³ãš
åå¿ããŠéå±ãã¬ãŒããäœãæ§è³ªã®ããç©è³ªãå«
ã液äœãçšããããšã«ãããé©ãã»ã©é«ãå¹çã§
ç°¡åã«ããããå®å šã«åžçæã®åçãã§ããããš
ãèŠåºããæ¬çºæãå®æããã«è³ã€ãã
å®å šãªãå¹çã®è¯ãåžçæåçæ¹æ³ãæäŸããã
ãéæç 究ããçµæã溶é¢æ¶²ãšããŠéå±ã€ãªã³ãš
åå¿ããŠéå±ãã¬ãŒããäœãæ§è³ªã®ããç©è³ªãå«
ã液äœãçšããããšã«ãããé©ãã»ã©é«ãå¹çã§
ç°¡åã«ããããå®å šã«åžçæã®åçãã§ããããš
ãèŠåºããæ¬çºæãå®æããã«è³ã€ãã
ããªãã¡ãæ¬çºæã¯ãäœæ¶²äžã®äœæ¯éãªãèçœ
質ãåžçãããè¡šé¢ã«ããªã¢ããªã³éšãæããäœ
æ¯éãªãèçœè³ªåžçæããå°ãªããšãïŒçš®é¡ã®ã
ã¬ãŒãåå€ãå«ã溶液ã§æŽæµããããšãç¹åŸŽãšã
ãäœæ¯éãªãèçœè³ªåžçæã®åçæ¹æ³ã§ããã
質ãåžçãããè¡šé¢ã«ããªã¢ããªã³éšãæããäœ
æ¯éãªãèçœè³ªåžçæããå°ãªããšãïŒçš®é¡ã®ã
ã¬ãŒãåå€ãå«ã溶液ã§æŽæµããããšãç¹åŸŽãšã
ãäœæ¯éãªãèçœè³ªåžçæã®åçæ¹æ³ã§ããã
æ¬çºæã§å¯Ÿè±¡ãšããåžçç©è³ªã¯ãäœæ¯éãªãè
çœè³ªã§ãããããã詳现ã«èª¬æãããšãååéã
2.2Ã106ãã3.5Ã106ãæ°Žåå¯åºŠã1.003ãã1.034
ïŒïœ/mlïŒãæµ®äžä¿æ°ïŒ1.063ïŒãïŒãã20Ã10-13
cmã»sec-1ã»dyh-1ã»g-1ãçŽåŸã20.0ãã30.0nïœ
ã®ãªãèçœïŒSCANUãA.M.ïŒplasma
lipoproteinsïŒan introduction.âThe
Biochemistry of Atherosclerosisâed.by
SCANU â§M.ã1979ãP.3ãïŒãã«ããïŒã
èšãã
çœè³ªã§ãããããã詳现ã«èª¬æãããšãååéã
2.2Ã106ãã3.5Ã106ãæ°Žåå¯åºŠã1.003ãã1.034
ïŒïœ/mlïŒãæµ®äžä¿æ°ïŒ1.063ïŒãïŒãã20Ã10-13
cmã»sec-1ã»dyh-1ã»g-1ãçŽåŸã20.0ãã30.0nïœ
ã®ãªãèçœïŒSCANUãA.M.ïŒplasma
lipoproteinsïŒan introduction.âThe
Biochemistry of Atherosclerosisâed.by
SCANU â§M.ã1979ãP.3ãïŒãã«ããïŒã
èšãã
次ã«ãæ¬çºæã§å¯Ÿè±¡ãšããåžçæã®æ§æèŠä»¶ã«
ã€ããŠè©³çŽ°ã«èª¬æããã
ã€ããŠè©³çŽ°ã«èª¬æããã
æ¬çºæã§èšãäœæ¯éãªãèçœè³ªåžçæã®ããªã¢
ããªã³éšãšã¯ãïŒååã®ååéã600以äžã§ããã
ïŒååäžã«è² é»è·ã瀺ãå®èœåºãããªãã¡ãã«ã«
ããã·ã«åºïŒCOOHãCOO-ïŒãã¹ã«ãã³é žåº
ïŒSO3HãSO3 -ïŒãªã©è¡æŒ¿äžã§è² é»è·ã瀺ãå®èœ
åºãå€æ°åæã€ãã®ãèšããäŸç€ºãããšãããªã¢
ã¯ãªã«é žãããªããã«ã¹ã«ãã³é žãããªããã«ãª
ã³é žãããªã¡ã¿ã¯ãªã«é žçã®ããã«ç³»åæããªã¢
ããªã³ãããªã¹ãã¬ã³ã¹ã«ãã³é žãããªâαâã¡
ãã«ã¹ãã¬ã³ã¹ã«ãã³é žãããªã¹ãã¬ã³ãªã³é žç
ã®ã¹ãã¬ã³ç³»ããªã¢ããªã³ãããã«ç³»ã¢ããªã³ã®
å ±éåäœãäŸãã°ãã¹ãã¬ã³ãã¬ã€ã³é žå ±éåäœ
ã®ãããªããªã¢ããªã³ãããªã°ã«ã¿ãã³é žãããª
ã¢ã¹ãã©ã®ã³é žçã®åæããããç³»ããªã¢ããª
ã³ãpoly ãpoly çã®åææ žé žç³»ããªã¢ããª
ã³ãããªãªã³é žãããªãã¹ããšã€ããšã¹ãã«ãã¢
ã«ã®ã³é žããããªã³çã®å€©ç¶ããªã¢ããªã³ããã
ãããã
ããªã³éšãšã¯ãïŒååã®ååéã600以äžã§ããã
ïŒååäžã«è² é»è·ã瀺ãå®èœåºãããªãã¡ãã«ã«
ããã·ã«åºïŒCOOHãCOO-ïŒãã¹ã«ãã³é žåº
ïŒSO3HãSO3 -ïŒãªã©è¡æŒ¿äžã§è² é»è·ã瀺ãå®èœ
åºãå€æ°åæã€ãã®ãèšããäŸç€ºãããšãããªã¢
ã¯ãªã«é žãããªããã«ã¹ã«ãã³é žãããªããã«ãª
ã³é žãããªã¡ã¿ã¯ãªã«é žçã®ããã«ç³»åæããªã¢
ããªã³ãããªã¹ãã¬ã³ã¹ã«ãã³é žãããªâαâã¡
ãã«ã¹ãã¬ã³ã¹ã«ãã³é žãããªã¹ãã¬ã³ãªã³é žç
ã®ã¹ãã¬ã³ç³»ããªã¢ããªã³ãããã«ç³»ã¢ããªã³ã®
å ±éåäœãäŸãã°ãã¹ãã¬ã³ãã¬ã€ã³é žå ±éåäœ
ã®ãããªããªã¢ããªã³ãããªã°ã«ã¿ãã³é žãããª
ã¢ã¹ãã©ã®ã³é žçã®åæããããç³»ããªã¢ããª
ã³ãpoly ãpoly çã®åææ žé žç³»ããªã¢ããª
ã³ãããªãªã³é žãããªãã¹ããšã€ããšã¹ãã«ãã¢
ã«ã®ã³é žããããªã³çã®å€©ç¶ããªã¢ããªã³ããã
ãããã
äžã§ãåæããªã¢ããªã³ã¯ããã®ååŠçå®å®æ§
ã«åªããé«å§èžæ°æ» èãγç·æ» èããšãã¬ã³ãªã
ãµã€ãæ» èçã«å¯ŸããŠãå®å®ãªãã®ãåŸæãããŸ
ããååéã®èª¿ç¯ãæ¯èŒç簡䟿ã«è¡ãªããçã®ç¹
ã§å€©ç¶ã®ç©ããåªããæšå¥šã§ããããŸããåæã«
ããåŸãããããªã¢ããªã³ã®å Žåã倩ç¶ã®å€ç³é¡
ã«ã¿ããããããªè£äœã®æŽ»æ§åãèµ·ããé£ãããª
ã¢ããªã³ã容æã«åŸããããã奜ãŸããããã
ã«ãããã«ç³»ã¢ããªã³ã®ããã«ãæ äœã«å¯ŸããŠçŽ
æ¥ã°ã©ããéåãè¡ãããã®ã¯ãæ äœã«å¯ŸããŠå
åéã®å€§ããããªã¢ããªã³ãé«ä¿æéã§åºå®ãã
ããšãã§ããç¹ã§ããã奜ãŸããçµæãäžããã
ã«åªããé«å§èžæ°æ» èãγç·æ» èããšãã¬ã³ãªã
ãµã€ãæ» èçã«å¯ŸããŠãå®å®ãªãã®ãåŸæãããŸ
ããååéã®èª¿ç¯ãæ¯èŒç簡䟿ã«è¡ãªããçã®ç¹
ã§å€©ç¶ã®ç©ããåªããæšå¥šã§ããããŸããåæã«
ããåŸãããããªã¢ããªã³ã®å Žåã倩ç¶ã®å€ç³é¡
ã«ã¿ããããããªè£äœã®æŽ»æ§åãèµ·ããé£ãããª
ã¢ããªã³ã容æã«åŸããããã奜ãŸããããã
ã«ãããã«ç³»ã¢ããªã³ã®ããã«ãæ äœã«å¯ŸããŠçŽ
æ¥ã°ã©ããéåãè¡ãããã®ã¯ãæ äœã«å¯ŸããŠå
åéã®å€§ããããªã¢ããªã³ãé«ä¿æéã§åºå®ãã
ããšãã§ããç¹ã§ããã奜ãŸããçµæãäžããã
ãŸããåžçç®çç©è³ªã§ããäœæ¯éãªãèçœè³ª
ã¯ãçŽåŸãçŽ200â«ãšãã巚倧ãªãªãèçœã§ãã
ãããããªã¢ããªã³éšã®æ§é ã¯éç¶æ§é ã§ããã
ãšã奜ãŸãããåžçæè¡šé¢ããé·ã䌞ã³ãŠããæ¹
ã奜ãŸããããŸããããªã¢ããªã³éšäžã®è² é»è·å¯
床ã¯ãååé300åœãã«å°ãªããšãïŒåããã®ã
奜ãŸãããããã«å¥œãŸããã¯ãååé200åœãã«
ïŒå以äžã§ãããååé70ãã150ã®åäœã«ïŒå
ããã®ãæãŸãããããã§èšãååéã«ã¯ãè² é»
è·ã瀺ãå®èœåºã®ååéãå«ããããªã¢ããªã³éš
ã®ååéã¯ãå°ãããªããšäœæ¯éãªãèçœè³ªãã
ãŸãåžçããªããªãã®ã§ãå°ãªããšã600ã¯å¿ èŠ
ã§ããã奜ãŸããã®ã¯2500以äžã§ãããïŒäžãã
500äžã®ç¯å²ã奜ãŸããã
ã¯ãçŽåŸãçŽ200â«ãšãã巚倧ãªãªãèçœã§ãã
ãããããªã¢ããªã³éšã®æ§é ã¯éç¶æ§é ã§ããã
ãšã奜ãŸãããåžçæè¡šé¢ããé·ã䌞ã³ãŠããæ¹
ã奜ãŸããããŸããããªã¢ããªã³éšäžã®è² é»è·å¯
床ã¯ãååé300åœãã«å°ãªããšãïŒåããã®ã
奜ãŸãããããã«å¥œãŸããã¯ãååé200åœãã«
ïŒå以äžã§ãããååé70ãã150ã®åäœã«ïŒå
ããã®ãæãŸãããããã§èšãååéã«ã¯ãè² é»
è·ã瀺ãå®èœåºã®ååéãå«ããããªã¢ããªã³éš
ã®ååéã¯ãå°ãããªããšäœæ¯éãªãèçœè³ªãã
ãŸãåžçããªããªãã®ã§ãå°ãªããšã600ã¯å¿ èŠ
ã§ããã奜ãŸããã®ã¯2500以äžã§ãããïŒäžãã
500äžã®ç¯å²ã奜ãŸããã
ããªã¢ããªã³éšãæã€å€æ°åã®è² é»è·ã瀺ãå®
èœåºããäœæ¯éãªãèçœè³ªã®å€æ°ç¹ãèªèããã
ãšã«ããã匷ãã¯ãŒãã³åã§äœæ¯éãªãèçœè³ªã
çµåãããšèããããã
èœåºããäœæ¯éãªãèçœè³ªã®å€æ°ç¹ãèªèããã
ãšã«ããã匷ãã¯ãŒãã³åã§äœæ¯éãªãèçœè³ªã
çµåãããšèããããã
è² é»è·ã瀺ãå®èœåºã®äžã§ã¯ãã«ã«ããã·ã«åº
ïŒCOOHãCOO-ïŒãç¹ã«å¥œãŸããçµæãäžããã
ã¹ã«ãã³é žåºïŒSO3HãSO3 -ïŒã«æ¯ã¹ãŠåŒ±é žã§ã
ããããã¢ã«ããã³ã®ãããªæçšèçœè³ªã«å¯Ÿãã
åžçæ§ãå°ããããŸããè¡æ¶²ååºç³»èçœã®åžçã
å°ãªãã掻æ§åãèµ·ããé£ããããã«ãè£äœç³»è
çœãåžçãé£ãã
ïŒCOOHãCOO-ïŒãç¹ã«å¥œãŸããçµæãäžããã
ã¹ã«ãã³é žåºïŒSO3HãSO3 -ïŒã«æ¯ã¹ãŠåŒ±é žã§ã
ããããã¢ã«ããã³ã®ãããªæçšèçœè³ªã«å¯Ÿãã
åžçæ§ãå°ããããŸããè¡æ¶²ååºç³»èçœã®åžçã
å°ãªãã掻æ§åãèµ·ããé£ããããã«ãè£äœç³»è
çœãåžçãé£ãã
åèšããããªã¢ããªã³éšã®äžã§ã¯ãããªã¢ã¯ãª
ã«é žãããªã¡ã¿ã¯ãªã«é žã®ãããªããªã«ã«ãã³é ž
ãç¹ã«å®å®ã§ãããæšå¥šã§ããã
ã«é žãããªã¡ã¿ã¯ãªã«é žã®ãããªããªã«ã«ãã³é ž
ãç¹ã«å®å®ã§ãããæšå¥šã§ããã
è² é»è·ã®å¯åºŠã¯åžçæïŒmlåœã1ÎŒeqãã1meq
ã®ç¯å²ãäœæ¯éãªãèçœè³ªã®åžçæ§èœãè¯ããåž
çéžææ§ãè¯ããååºç·æº¶ç³»ãè£äœç³»ãžã®åœ±é¿ã
å°ãªãé©åœãªç¯å²ã§ããã1ÎŒeqïŒmlããè² é»è·
å¯åºŠãäœããªããšãäœæ¯éãªãèçœè³ªã®åžçèœå
ãå®çšæ§èœã«æºããã1meqãè¶ãããšééžæç
ãªåžçãå¢ããååºç·æº¶ç³»ãè£äœç³»ã«æªåœ±é¿ãäž
ããããã奜ãŸããç¯å²ã¯5ÎŒeqïŒmlãã
700ÎŒeqïŒmlãããã«å¥œãŸããã®ã¯10ÎŒeqïŒmlãã
500ÎŒeqïŒmlã§ããã
ã®ç¯å²ãäœæ¯éãªãèçœè³ªã®åžçæ§èœãè¯ããåž
çéžææ§ãè¯ããååºç·æº¶ç³»ãè£äœç³»ãžã®åœ±é¿ã
å°ãªãé©åœãªç¯å²ã§ããã1ÎŒeqïŒmlããè² é»è·
å¯åºŠãäœããªããšãäœæ¯éãªãèçœè³ªã®åžçèœå
ãå®çšæ§èœã«æºããã1meqãè¶ãããšééžæç
ãªåžçãå¢ããååºç·æº¶ç³»ãè£äœç³»ã«æªåœ±é¿ãäž
ããããã奜ãŸããç¯å²ã¯5ÎŒeqïŒmlãã
700ÎŒeqïŒmlãããã«å¥œãŸããã®ã¯10ÎŒeqïŒmlãã
500ÎŒeqïŒmlã§ããã
è² é»è·å¯åºŠã®æž¬å®ã¯ãéåžžã®éœã€ãªã³äº€ææš¹è
ã®ã€ãªã³äº€æ容é枬å®æ¹æ³ã«æºããŠè¡ãªãããšã
ã§ããã
ã®ã€ãªã³äº€æ容é枬å®æ¹æ³ã«æºããŠè¡ãªãããšã
ã§ããã
æ¬çºæã§èšãäœæ¯éãªãèçœè³ªåžçæã補é ã
ãæ¹æ³ã¯ãäŸãã°ãæ äœã掻æ§åããããªã¢ããª
ã³ãå ±æçµåãããæ¹æ³ãæ äœã«ã¢ããªã³ã¢ãã
ãŒãã°ã©ããéåãããããªã¢ããªã³ã®ã°ã©ãã
éã圢æãããæ¹æ³ãªã©ãæããããã
ãæ¹æ³ã¯ãäŸãã°ãæ äœã掻æ§åããããªã¢ããª
ã³ãå ±æçµåãããæ¹æ³ãæ äœã«ã¢ããªã³ã¢ãã
ãŒãã°ã©ããéåãããããªã¢ããªã³ã®ã°ã©ãã
éã圢æãããæ¹æ³ãªã©ãæããããã
æ
äœã¯ãããªã¢ããªã³ãåºå®ã§ããã°ããã芪
æ°Žæ§æ äœãçæ°Žæ§æ äœãããã䜿çšã§ããããç
æ°Žæ§æ äœãçšããå Žåã«ã¯ãæã«æ äœãžã®ã¢ã«ã
ãã³ã®éç¹ç°çåžçãçããããã芪氎æ§æ äœã®
æ¹ã奜ãŸããçµæãäžããã
æ°Žæ§æ äœãçæ°Žæ§æ äœãããã䜿çšã§ããããç
æ°Žæ§æ äœãçšããå Žåã«ã¯ãæã«æ äœãžã®ã¢ã«ã
ãã³ã®éç¹ç°çåžçãçããããã芪氎æ§æ äœã®
æ¹ã奜ãŸããçµæãäžããã
äžæº¶æ§æ
äœã®åœ¢ç¶ã¯ãç²åç¶ãç¹ç¶ç¶ãäžç©ºç³ž
ç¶ãèç¶çãããã®å ¬ç¥ã®åœ¢ç¶ãçšããããšãã§
ããããããªã¢ããªã³ã®ä¿æéãåžçæãšããŠã®
åæ±ãæ§ããã¿ãŠãç²åç¶ãç¹ç¶ç¶ã®ãã®ã奜ãŸ
ããã
ç¶ãèç¶çãããã®å ¬ç¥ã®åœ¢ç¶ãçšããããšãã§
ããããããªã¢ããªã³ã®ä¿æéãåžçæãšããŠã®
åæ±ãæ§ããã¿ãŠãç²åç¶ãç¹ç¶ç¶ã®ãã®ã奜ãŸ
ããã
æ
äœã¯ãããªã¢ããªã³ãåºå®ã§ããã°ãã©ã®ã
ããªæ質ã®ãã®ãçšããŠãããã䜿çšã§ããæ äœ
ãšããŠã¯ãã»ã«ããŒã¹ç³»ã²ã«ãããã¹ãã©ã³ç³»ã²
ã«ãã¢ã¬ããŒã¹ç³»ã²ã«ãããªã¢ã¯ãªã«ã¢ããç³»ã²
ã«ãå€å質ã¬ã©ã¹ãããã«ããªããŒã²ã«çã®ææ©
ãŸãã¯ç¡æ©ã®å€åäœã䜿çšã§ããéåžžã®ã¢ãã€ã
ãã€ãŒã¯ãããã°ã©ãã€ãŒã«çšããããæ äœçšã®
ææã¯å šãŠçšããããšãã§ãããã被åžçç©è³ªã§
ããäœæ¯éãªãèçœè³ªãçŽåŸ200ã300â«ãååé
ã2.2Ã106ã3.5Ã106ãšå€§ããã®ã§ãæ äœã®æé€
éçååéã¯220äžä»¥äžãåã®çŽåŸã¯200â«ä»¥äžã
ãæ¹ãåžçå¹çãé«ãã
ããªæ質ã®ãã®ãçšããŠãããã䜿çšã§ããæ äœ
ãšããŠã¯ãã»ã«ããŒã¹ç³»ã²ã«ãããã¹ãã©ã³ç³»ã²
ã«ãã¢ã¬ããŒã¹ç³»ã²ã«ãããªã¢ã¯ãªã«ã¢ããç³»ã²
ã«ãå€å質ã¬ã©ã¹ãããã«ããªããŒã²ã«çã®ææ©
ãŸãã¯ç¡æ©ã®å€åäœã䜿çšã§ããéåžžã®ã¢ãã€ã
ãã€ãŒã¯ãããã°ã©ãã€ãŒã«çšããããæ äœçšã®
ææã¯å šãŠçšããããšãã§ãããã被åžçç©è³ªã§
ããäœæ¯éãªãèçœè³ªãçŽåŸ200ã300â«ãååé
ã2.2Ã106ã3.5Ã106ãšå€§ããã®ã§ãæ äœã®æé€
éçååéã¯220äžä»¥äžãåã®çŽåŸã¯200â«ä»¥äžã
ãæ¹ãåžçå¹çãé«ãã
åèšããæ
äœã®äžã§ããç¹ã«ããã«ã¢ã«ã³ãŒã«
åäœãäž»æ§ææåãšããæ¶æ©å ±éåäœãããªãæ
äœã¯ããã®èŠªæ°Žæ§ã®ãããè¡æŒ¿äžã®ã¿ã³ãã¯è³ªç
溶質ãšã®çžäºäœçšãå°ãããéç¹ç°åžçãæå°é
ã«äœäžãããããŸããè¡æŒ¿äžã®è£äœç³»ãååºç³»ãš
çžäºäœçšããªãçã®æ¥µããŠåªããç¹æ§ãæããã
ç©ççç¹æ§ã®é¢ã§ããåªããååŸååžã瀺ããè
ç±æ§ãæããç±æ» èãå¯èœãªããããããã«ã¯å
æé«ååã®ç¹æ§ã§ããç©ççæ©æ¢°ç匷床ã«åªããŠ
ãããå šè¡çšåžçæã®æ äœãšããŠçšããå Žåã«
ããè¡çæåãšã®çžäºäœçšãå°ãªããè¡æ 圢æã
è¡çæåã®éç¹ç°ç²çãæ®è¡çãæå°éã«ããã
ãçã®æ¥µããŠåªããç¹æ§ã䜵ãæã€ãŠããã
åäœãäž»æ§ææåãšããæ¶æ©å ±éåäœãããªãæ
äœã¯ããã®èŠªæ°Žæ§ã®ãããè¡æŒ¿äžã®ã¿ã³ãã¯è³ªç
溶質ãšã®çžäºäœçšãå°ãããéç¹ç°åžçãæå°é
ã«äœäžãããããŸããè¡æŒ¿äžã®è£äœç³»ãååºç³»ãš
çžäºäœçšããªãçã®æ¥µããŠåªããç¹æ§ãæããã
ç©ççç¹æ§ã®é¢ã§ããåªããååŸååžã瀺ããè
ç±æ§ãæããç±æ» èãå¯èœãªããããããã«ã¯å
æé«ååã®ç¹æ§ã§ããç©ççæ©æ¢°ç匷床ã«åªããŠ
ãããå šè¡çšåžçæã®æ äœãšããŠçšããå Žåã«
ããè¡çæåãšã®çžäºäœçšãå°ãªããè¡æ 圢æã
è¡çæåã®éç¹ç°ç²çãæ®è¡çãæå°éã«ããã
ãçã®æ¥µããŠåªããç¹æ§ã䜵ãæã€ãŠããã
ããã«ã¢ã«ã³ãŒã«åäœãäž»æ§ææåãšããæ¶æ©
éåäœã¯ãæ°Žé žåºãæããã¢ãããŒã®éåãŸãã¯
ããªããŒã®ååŠåå¿ã«ããæ°Žé žåºã®å°å ¥ã«ããå
æã§ãããäž¡è ã䜵çšããŠåæããããšãã§ã
ããéåæ¹æ³ãšããŠã¯ãã©ãžã«ã«éåæ³ãçšãã
ããšãã§ãããæ¶æ©å€ã¯éåæå ±éåã«ããå°å ¥
ããŠããããããŸãããªããŒã®ååŠåå¿ïŒããªã
ãŒéãããªããŒãšæ¶æ©å€ïŒã§å°å ¥ããŠããããäž¡
è ã䜵çšããŠãããã
éåäœã¯ãæ°Žé žåºãæããã¢ãããŒã®éåãŸãã¯
ããªããŒã®ååŠåå¿ã«ããæ°Žé žåºã®å°å ¥ã«ããå
æã§ãããäž¡è ã䜵çšããŠåæããããšãã§ã
ããéåæ¹æ³ãšããŠã¯ãã©ãžã«ã«éåæ³ãçšãã
ããšãã§ãããæ¶æ©å€ã¯éåæå ±éåã«ããå°å ¥
ããŠããããããŸãããªããŒã®ååŠåå¿ïŒããªã
ãŒéãããªããŒãšæ¶æ©å€ïŒã§å°å ¥ããŠããããäž¡
è ã䜵çšããŠãããã
äžäŸãããããšãããã«ç³»ã¢ãããŒãšããã«ç³»
ãŸãã¯ã¢ãªã«ç³»æ¶æ©å€ãšã®å ±éåã«ããäœãããš
ãã§ããããã®å Žåã®ããã«ç³»ã¢ãããŒãšããŠ
ã¯ãé ¢é žããã«ãããããªã³é žããã«çã®ã«ã«ã
ã³é žã®ããã«ãšã¹ãã«é¡ãã¡ãã«ããã«ãšãŒã
ã«ããšãã«ããã«ãšãŒãã«çã®ããã«ãšãŒãã«é¡
ãäŸç€ºããããšãã§ããã
ãŸãã¯ã¢ãªã«ç³»æ¶æ©å€ãšã®å ±éåã«ããäœãããš
ãã§ããããã®å Žåã®ããã«ç³»ã¢ãããŒãšããŠ
ã¯ãé ¢é žããã«ãããããªã³é žããã«çã®ã«ã«ã
ã³é žã®ããã«ãšã¹ãã«é¡ãã¡ãã«ããã«ãšãŒã
ã«ããšãã«ããã«ãšãŒãã«çã®ããã«ãšãŒãã«é¡
ãäŸç€ºããããšãã§ããã
æ¶æ©å€ãšããŠã¯ãããªã¢ãªã«ã€ãœã·ã¢ãã¬ãŒ
ããããªã¢ãªã«ã·ã¢ãã¬ãŒãçã®ã¢ãªã«ååç©
é¡ããšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¢ã¯ãªã¬ãŒãããž
ãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¢ã¯ãªã¬ãŒãçã®ãž
ïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒãé¡ããã¿ã³ãžãªãŒã«ããã«
ãšãŒãã«ããžãšãã¬ã³ã°ãªã³ãŒã«ãžããã«ãšãŒã
ã«ãããã©ããã«ã°ãªãªãã¶ãŒã«çã®ããªããã«
ãšãŒãã«é¡ããžã¢ãªãªãã³ãã³ã¿ãšãªã¹ãªããã
ããã©ã¢ãªããã·ãšã¿ã³ã®ãããªããªã¢ãªã«ãšãŒ
ãã«é¡ãã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãçã®ã°ãªã·ãž
ã«ã¢ã¯ãªã¬ãŒãé¡ãçšããããšãã§ããããŸãã
å¿ èŠã«å¿ããŠãä»ã®ã³ã¢ãããŒãå ±éåãããã®
ãçšããããšãã§ããã
ããããªã¢ãªã«ã·ã¢ãã¬ãŒãçã®ã¢ãªã«ååç©
é¡ããšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¢ã¯ãªã¬ãŒãããž
ãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¢ã¯ãªã¬ãŒãçã®ãž
ïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒãé¡ããã¿ã³ãžãªãŒã«ããã«
ãšãŒãã«ããžãšãã¬ã³ã°ãªã³ãŒã«ãžããã«ãšãŒã
ã«ãããã©ããã«ã°ãªãªãã¶ãŒã«çã®ããªããã«
ãšãŒãã«é¡ããžã¢ãªãªãã³ãã³ã¿ãšãªã¹ãªããã
ããã©ã¢ãªããã·ãšã¿ã³ã®ãããªããªã¢ãªã«ãšãŒ
ãã«é¡ãã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãçã®ã°ãªã·ãž
ã«ã¢ã¯ãªã¬ãŒãé¡ãçšããããšãã§ããããŸãã
å¿ èŠã«å¿ããŠãä»ã®ã³ã¢ãããŒãå ±éåãããã®
ãçšããããšãã§ããã
ããã«ç³»å
±éåäœã®å Žåã«ã¯ãã«ã«ãã³é
žã®ã
ãã«ãšã¹ãã«ãšã€ãœã·ã¢ãã¬ãŒãç°ãæãããã
ã«ååç©ïŒã¢ãªã«ååç©ïŒãå ±éåããå ±éåäœ
ãæ¶æ°Žå解ããŠåŸãããããªããã«ã¢ã«ã³ãŒã«ã®
ããªã¢ãªã«ã€ãœã·ã¢ãã¬ãŒãæ¶æ©äœãã匷床ãå
åŠçå®å®æ§ã®é¢ã§ç¹ã«è¯å¥œãªæ äœãäžããã
ãã«ãšã¹ãã«ãšã€ãœã·ã¢ãã¬ãŒãç°ãæãããã
ã«ååç©ïŒã¢ãªã«ååç©ïŒãå ±éåããå ±éåäœ
ãæ¶æ°Žå解ããŠåŸãããããªããã«ã¢ã«ã³ãŒã«ã®
ããªã¢ãªã«ã€ãœã·ã¢ãã¬ãŒãæ¶æ©äœãã匷床ãå
åŠçå®å®æ§ã®é¢ã§ç¹ã«è¯å¥œãªæ äœãäžããã
ããªã¢ããªã³ãäžæº¶æ§æ
äœã®è¡šé¢ã«åºå®ããæ¹
æ³ã¯ãå ±æçµåãã€ãªã³çµåãç©çåžçãå åã
ããã¯éåäœè¡šé¢ãžã®æ²æ®¿äžæº¶åçããããå ¬ç¥
ã®æ¹æ³ãçšããããšãã§ããããåºå®åããåå
ç©ã®æº¶åºæ§ããèãããšãå ±æçµåã«ãããåº
å®ãäžæº¶åããŠçšããããšã奜ãŸããããã®ãã
éåžžåºå®åé µçŽ ãã¢ãã€ããã€ãŒã¯ãããã°ã©ã
ã€ãŒã§çšããããå ¬ç¥ã®æ äœã®æŽ»æ§åæ¹æ³ããªã¬
ã³ããšã®çµåæ¹æ³ãããã³æ äœãŸãã¯æŽ»æ§åæ äœ
ãå¹¹ããªããŒãšããããªã¢ããªã³ãæãšããã°ã©
ããéåã®ææ³ãçšããããšãã§ããã
æ³ã¯ãå ±æçµåãã€ãªã³çµåãç©çåžçãå åã
ããã¯éåäœè¡šé¢ãžã®æ²æ®¿äžæº¶åçããããå ¬ç¥
ã®æ¹æ³ãçšããããšãã§ããããåºå®åããåå
ç©ã®æº¶åºæ§ããèãããšãå ±æçµåã«ãããåº
å®ãäžæº¶åããŠçšããããšã奜ãŸããããã®ãã
éåžžåºå®åé µçŽ ãã¢ãã€ããã€ãŒã¯ãããã°ã©ã
ã€ãŒã§çšããããå ¬ç¥ã®æ äœã®æŽ»æ§åæ¹æ³ããªã¬
ã³ããšã®çµåæ¹æ³ãããã³æ äœãŸãã¯æŽ»æ§åæ äœ
ãå¹¹ããªããŒãšããããªã¢ããªã³ãæãšããã°ã©
ããéåã®ææ³ãçšããããšãã§ããã
掻æ§åæ¹æ³ãäŸç€ºãããšãããã²ã³åã·ã¢ã³
æ³ããšãã¯ãã«ãããªã³æ³ããã¹ãšããã·ãæ³ã
ããã²ã³åããªã¢ãžã³æ³ãããã¢ã¢ã»ãã«ããã
ãæ³ããšãã«ã¯ãããã«ããŒãæ³ãïŒïŒ1â²âã«ã«
ããã«ãžã€ãããŸãŒã«æ³çããããããšãã§ã
ããæ¬çºæã®æŽ»æ§åæ¹æ³ã¯ããªã¬ã³ãã®ã¢ãã
åºãæ°Žé žåºãã«ã«ããã·ã«åºãããªãŒã«åºçã®æŽ»
æ§æ°ŽçŽ ãæããæ±æ žåå¿åºãšçœ®æããã³ïŒãŸãã¯
ä»å åå¿ã§ããã°ãããäžèšã®äŸç€ºã«éå®ããã
ãã®ã§ã¯ãªãããååŠçå®å®æ§ãç±çå®å®æ§çã
èæ ®ãããšããšããã·ããçšããæ¹æ³ã奜ãŸã
ããç¹ã«ãšãã¯ãã«ãããªã³æ³ãæšå¥šã§ããã
æ³ããšãã¯ãã«ãããªã³æ³ããã¹ãšããã·ãæ³ã
ããã²ã³åããªã¢ãžã³æ³ãããã¢ã¢ã»ãã«ããã
ãæ³ããšãã«ã¯ãããã«ããŒãæ³ãïŒïŒ1â²âã«ã«
ããã«ãžã€ãããŸãŒã«æ³çããããããšãã§ã
ããæ¬çºæã®æŽ»æ§åæ¹æ³ã¯ããªã¬ã³ãã®ã¢ãã
åºãæ°Žé žåºãã«ã«ããã·ã«åºãããªãŒã«åºçã®æŽ»
æ§æ°ŽçŽ ãæããæ±æ žåå¿åºãšçœ®æããã³ïŒãŸãã¯
ä»å åå¿ã§ããã°ãããäžèšã®äŸç€ºã«éå®ããã
ãã®ã§ã¯ãªãããååŠçå®å®æ§ãç±çå®å®æ§çã
èæ ®ãããšããšããã·ããçšããæ¹æ³ã奜ãŸã
ããç¹ã«ãšãã¯ãã«ãããªã³æ³ãæšå¥šã§ããã
ãŸããã·ãªã«ç³»ãã¬ã©ã¹ç³»çã®ã·ã©ããŒã«åºã
æã€æ äœã«ã€ããŠã¯ãγâã°ãªã·ããã·ãããã«
ããªã¡ããã·ã·ã©ã³ãγâã¢ãããããã«ããªãš
ããã·ã·ã©ã³ãγâã¡ã«ã«ãããããã«ããªã¡ã
ãã·ã·ã©ã³ãããã«ããªã¯ããã·ã©ã³çã®åçš®ã·
ã©ã³ã«ãããªã³ã°å€ã奜ãŸããçšããããã
æã€æ äœã«ã€ããŠã¯ãγâã°ãªã·ããã·ãããã«
ããªã¡ããã·ã·ã©ã³ãγâã¢ãããããã«ããªãš
ããã·ã·ã©ã³ãγâã¡ã«ã«ãããããã«ããªã¡ã
ãã·ã·ã©ã³ãããã«ããªã¯ããã·ã©ã³çã®åçš®ã·
ã©ã³ã«ãããªã³ã°å€ã奜ãŸããçšããããã
ã°ã©ããéåæ³ãäŸç€ºãããšãé£é移ååå¿ã
å©çšããæ¹æ³ãæŸå°ç·ã玫å€ç·ãªã©ã«ããè±æ°Ž
çŽ ãè±ããã²ã³ãªã©ã®åå¿ãå©çšããæ¹æ³ãéé ž
åç©ã®åœ¢æãå©çšããæ¹æ³ãªã©ãããããããã
æ°Žé žåºãããªãŒã«ãã¢ã«ããããã¢ãã³ãªã©ã®é
å æ§åºãæããæ äœã«ãã»ãªãŠã å¡©ãéå¡©ãªã©ã
éå§å€ãšããŠã¢ããªã³ã¢ãããŒãã°ã©ããéåã
ãŠè¡ãæ¹æ³ã簡䟿ã§ãããæšå¥šã§ããããŸããã°
ã©ããéåã®ç³»ã¯ãæ¯èŒçååéã®å€§ããããªã¢
ããªã³ãæ äœã®å éšãŸã§åºå®ã§ããã®ã§å¥œãŸãã
çšããããã
å©çšããæ¹æ³ãæŸå°ç·ã玫å€ç·ãªã©ã«ããè±æ°Ž
çŽ ãè±ããã²ã³ãªã©ã®åå¿ãå©çšããæ¹æ³ãéé ž
åç©ã®åœ¢æãå©çšããæ¹æ³ãªã©ãããããããã
æ°Žé žåºãããªãŒã«ãã¢ã«ããããã¢ãã³ãªã©ã®é
å æ§åºãæããæ äœã«ãã»ãªãŠã å¡©ãéå¡©ãªã©ã
éå§å€ãšããŠã¢ããªã³ã¢ãããŒãã°ã©ããéåã
ãŠè¡ãæ¹æ³ã簡䟿ã§ãããæšå¥šã§ããããŸããã°
ã©ããéåã®ç³»ã¯ãæ¯èŒçååéã®å€§ããããªã¢
ããªã³ãæ äœã®å éšãŸã§åºå®ã§ããã®ã§å¥œãŸãã
çšããããã
æ
äœã«ããªã¢ããªã³ãïŒçš®é¡ä»¥äžçµåããŠãã
ãã€ãããªãã
ãã€ãããªãã
以äžãäœæ¯éãªãèçœè³ªåžçæã®è£œé æ¹æ³ãšã
ãŠãæ äœã掻æ§åããåŸãããªã¢ããªã³ãçµåã
ãæ¹æ³ã«ã€ããŠèª¬æããããããã«éå®ãããã
ã®ã§ã¯ãªãã
ãŠãæ äœã掻æ§åããåŸãããªã¢ããªã³ãçµåã
ãæ¹æ³ã«ã€ããŠèª¬æããããããã«éå®ãããã
ã®ã§ã¯ãªãã
äœæ¯éãªãèçœè³ªåžçåšã¯ãåèšããäœæ¯éãª
ãèçœè³ªåžçæããäœæ¶²ã®å°åºå ¥å£ãåãã容åš
å ã«å å¡«ä¿æãããã®ã§ããã
ãèçœè³ªåžçæããäœæ¶²ã®å°åºå ¥å£ãåãã容åš
å ã«å å¡«ä¿æãããã®ã§ããã
æ¬çºæã«ãããŠãåžçæã¯äœæ¶²ã®å°åºå
¥å£ãå
ãã容åšå ã«å å¡«ä¿æãããŠäœ¿çšãããã®ãäžè¬
çã§ããã
ãã容åšå ã«å å¡«ä¿æãããŠäœ¿çšãããã®ãäžè¬
çã§ããã
第ïŒå³ã«ãããŠãïŒã¯äœæ¯éãªãèçœè³ªåžçæ
ãçŽããŠãªãäœæ¯éãªãèçœè³ªåžçåšã®äžäŸã瀺
ããã®ã§ãããåçïŒã®äžç«¯éå£éšã«ãå åŽã«ã
ã€ã«ã¿ãŒïŒã匵ã€ããããã³ã°ïŒãä»ããŠäœæ¶²å°
å ¥å£ãæãããã€ãããããžåµåããåçïŒã®ä»
端éå£éšã«å åŽã«ãã€ã«ã¿ãŒïŒâ²ã匵ã€ãããã
ã³ã°ïŒâ²ãä»ããŠäœæ¶²å°åºå£ïŒãæãããã€ãã
ïŒãããžåµåããŠå®¹åšã圢æãããã€ã«ã¿ãŒïŒã
ãã³ïŒâ²ã®ééã«äœæ¯éãªãèçœè³ªåžçæãå å¡«
ä¿æãããŠåžçæå±€ïŒã圢æããŠãªããã®ã§ã
ãã
ãçŽããŠãªãäœæ¯éãªãèçœè³ªåžçåšã®äžäŸã瀺
ããã®ã§ãããåçïŒã®äžç«¯éå£éšã«ãå åŽã«ã
ã€ã«ã¿ãŒïŒã匵ã€ããããã³ã°ïŒãä»ããŠäœæ¶²å°
å ¥å£ãæãããã€ãããããžåµåããåçïŒã®ä»
端éå£éšã«å åŽã«ãã€ã«ã¿ãŒïŒâ²ã匵ã€ãããã
ã³ã°ïŒâ²ãä»ããŠäœæ¶²å°åºå£ïŒãæãããã€ãã
ïŒãããžåµåããŠå®¹åšã圢æãããã€ã«ã¿ãŒïŒã
ãã³ïŒâ²ã®ééã«äœæ¯éãªãèçœè³ªåžçæãå å¡«
ä¿æãããŠåžçæå±€ïŒã圢æããŠãªããã®ã§ã
ãã
åžçæå±€ïŒã«ã¯ãäœæ¯éãªãèçœè³ªåžçæãå
ç¬ã§å å¡«ããŠããããä»ã®åžçæãšæ··åãããã¯
ç©å±€ããŠããããä»ã®åžçæãšããŠã¯ãäŸãã°ã
å¹ åºãåžçèœãæãã掻æ§çã®ãããªãã®ãçšã
ãããšãã§ãããããã«ããåžçæã®çžä¹å¹æã«
ããããåºç¯ãªèšåºå¹æãæåŸ ã§ãããåžçæå±€
ïŒã®å®¹ç©ã¯ãäœå€åŸªç°ã«çšããå Žåã50ã400ml
çšåºŠãé©åœã§ããããã®è£ 眮ãäœå€åŸªç°ã§çšãã
å Žåã«ã¯ã倧ç¥æ¬¡ã®äºéãã®æ¹æ³ããããäžã€ã«
ã¯ãäœå ããåãåºããè¡æ¶²ãé å¿åé¢åšããã
ã¯èåè¡æŒ¿åé¢åšã䜿çšããŠãè¡æŒ¿æåãšè¡çæ
åãšã«åé¢ããåŸãè¡æŒ¿æåãè©²è£ çœ®ã«ééã
ããæµåããåŸãè¡çæåãšåãããŠäœå ã«ãã©
ãæ¹æ³ã§ãããä»ã®äžã€ã¯äœå ããåãåºããè¡
液ãçŽæ¥è©²è£ 眮ã«ééãããæµåããæ¹æ³ã§ã
ãã
ç¬ã§å å¡«ããŠããããä»ã®åžçæãšæ··åãããã¯
ç©å±€ããŠããããä»ã®åžçæãšããŠã¯ãäŸãã°ã
å¹ åºãåžçèœãæãã掻æ§çã®ãããªãã®ãçšã
ãããšãã§ãããããã«ããåžçæã®çžä¹å¹æã«
ããããåºç¯ãªèšåºå¹æãæåŸ ã§ãããåžçæå±€
ïŒã®å®¹ç©ã¯ãäœå€åŸªç°ã«çšããå Žåã50ã400ml
çšåºŠãé©åœã§ããããã®è£ 眮ãäœå€åŸªç°ã§çšãã
å Žåã«ã¯ã倧ç¥æ¬¡ã®äºéãã®æ¹æ³ããããäžã€ã«
ã¯ãäœå ããåãåºããè¡æ¶²ãé å¿åé¢åšããã
ã¯èåè¡æŒ¿åé¢åšã䜿çšããŠãè¡æŒ¿æåãšè¡çæ
åãšã«åé¢ããåŸãè¡æŒ¿æåãè©²è£ çœ®ã«ééã
ããæµåããåŸãè¡çæåãšåãããŠäœå ã«ãã©
ãæ¹æ³ã§ãããä»ã®äžã€ã¯äœå ããåãåºããè¡
液ãçŽæ¥è©²è£ 眮ã«ééãããæµåããæ¹æ³ã§ã
ãã
äœæ¶²ã®é液æ¹æ³ãšããŠã¯ãèšåºäžã®å¿
èŠã«å¿
ãããããã¯èšåã®è£ 眮ç¶æ³ã«å¿ããŠãé£ç¶çã«
é液ããŠããããããŸããæç¶çã«é液䜿çšããŠ
ãããã
ãããããã¯èšåã®è£ 眮ç¶æ³ã«å¿ããŠãé£ç¶çã«
é液ããŠããããããŸããæç¶çã«é液䜿çšããŠ
ãããã
æ¬çºæã§èšããã¬ãŒãåå€ãšã¯ãéå±ã€ãªã³ãš
åå¿ããŠéå±ãã¬ãŒãïŒäžã€ã®é äœåãïŒã±æãŸ
ãã¯ãã以äžã§äžå¿éå±ã«é äœããéå±ååãå«
ãç°ç¶æ§é ã圢æããŠããé¯äœïŒãäœãè¬å€ã®ã
ãšãèšããäŸç€ºãããšãããã³é žãã·ãŠãŠé žãã
ã¿ã«é žãã³ãã¯é žããã¬ã€ã³é žãã·ãã©ã³ã³é žã
ã€ã¿ã³ã³é žçã®ã«ã«ãã³é žïŒäºå¡©åºé žïŒããšãã¬
ã³ãžã¢ãã³ããžãšãã¬ã³ããªã¢ãã³ããããã¬ã³
ãžã¢ãã³çã®èèªæã¢ãã³ãαïŒÎ±â²âãžããªãž
ã«ãããšãã³ãããªã³çã®è³éŠæã¢ãã³ãã¢ã©ã
ã³ãã¢ã¹ãã©ã®ã³é žãã°ãªã·ã³ãã°ãªã·ã«ã°ãªã·
ã«ã°ãªã·ã³ãã°ã«ã¿ãã³é žçã®å€©ç¶ã¢ããé žãã
ã³ãããããβâã¢ã©ãã³âïŒïŒ®âãžé ¢é žãã¢
ããå®æ¯éŠé žâïŒïŒ®âãžé ¢é žãã€ãããžé ¢é žã
ã¢ããªã³ãžé ¢é žãïŒïŒïŒâãžã¢ããã·ã¯ããããµ
ã³âïŒNâ²âããã©é ¢é žããšãã¬ã³ãžã¢ãã³ã
ãã©é ¢é žããã³ã¿ã¡ãã¬ã³ãžã¢ãã³ããã©é ¢é ž
çã倩ç¶ã«ååšããªãã¢ããé žãã¯ãšã³é žãã°ã«
ã³ã³é žãã°ãªã»ãªã³é žãã°ãªã³ãŒã«é žããªã³ãŽ
é žãïŒâã¹ã«ããµãªãã«é žãé ç³é žçã®ãªãã·
é žããããªã³é žãããªã¡ã¿ãªã³é žãããªãªã³é žç
ã®çž®åãªã³é žããããé ¢é žãâãããå®æ¯éŠé ž
çã®ãããã«ã«ãã³é žããªããµã«é ¢é žããã«ãã³
é žçã®é žããµãªãã«ã¢ã«ããããïŒâã¯ãã«ãµãª
ãã«ã¢ã«ããããïŒâã¹ã«ããµãªãã«ã¢ã«ããã
çãµãªãã«ã¢ã«ãããããã³ãã®èªå°äœãïŒâãª
ãã·âïŒâãããã¢ã«ããããïŒâãªãã·âïŒâ
ãããã¢ã«ãããçã®ãªãã·ã¢ã«ããããã¢ã»ã
ã«ã¢ã»ãã³ããã³ãŸã€ã«ã¢ã»ãã³ãïŒâããã€ã«
ãã³ãŸã€ã«ã¡ã¿ã³ãããªãã«ãªã«ã¢ã»ãã«ã¢ã»ã
ã³çã®Î²âãžã±ãã³ãïŒâãªãã·ãããªã³ãã«ã
ã³ãŒã«âïŒïŒïŒâãžã¹ã«ãã³é žçã®ããšããŒã«èª
å°äœããšãªãªã¯ãã ãã©ãã¯âããšãªãªã¯ãã
ãã«ãŒãã©ãã¯ïŒ²çã®ïŒ¯ïŒOâ²âãžãªãã·ã¢ãŸè²
çŽ ãã¢ãããã³ãŒã³ããªãŒã«ãâã¢ããããšã
ãŒã«ãã¢ã»ãé ¢é žãšãã«çãæããããããŸãã
ããªã¢ã¯ãªã«é žããããªã¡ã¿ã¯ãªã«é žã®ãããªã
ãªã«ã«ãã³é žããããªã³ãã¢ã«ã®ã³é žçã®å€ç³é¡
ãçšããããšãã§ããã
åå¿ããŠéå±ãã¬ãŒãïŒäžã€ã®é äœåãïŒã±æãŸ
ãã¯ãã以äžã§äžå¿éå±ã«é äœããéå±ååãå«
ãç°ç¶æ§é ã圢æããŠããé¯äœïŒãäœãè¬å€ã®ã
ãšãèšããäŸç€ºãããšãããã³é žãã·ãŠãŠé žãã
ã¿ã«é žãã³ãã¯é žããã¬ã€ã³é žãã·ãã©ã³ã³é žã
ã€ã¿ã³ã³é žçã®ã«ã«ãã³é žïŒäºå¡©åºé žïŒããšãã¬
ã³ãžã¢ãã³ããžãšãã¬ã³ããªã¢ãã³ããããã¬ã³
ãžã¢ãã³çã®èèªæã¢ãã³ãαïŒÎ±â²âãžããªãž
ã«ãããšãã³ãããªã³çã®è³éŠæã¢ãã³ãã¢ã©ã
ã³ãã¢ã¹ãã©ã®ã³é žãã°ãªã·ã³ãã°ãªã·ã«ã°ãªã·
ã«ã°ãªã·ã³ãã°ã«ã¿ãã³é žçã®å€©ç¶ã¢ããé žãã
ã³ãããããβâã¢ã©ãã³âïŒïŒ®âãžé ¢é žãã¢
ããå®æ¯éŠé žâïŒïŒ®âãžé ¢é žãã€ãããžé ¢é žã
ã¢ããªã³ãžé ¢é žãïŒïŒïŒâãžã¢ããã·ã¯ããããµ
ã³âïŒNâ²âããã©é ¢é žããšãã¬ã³ãžã¢ãã³ã
ãã©é ¢é žããã³ã¿ã¡ãã¬ã³ãžã¢ãã³ããã©é ¢é ž
çã倩ç¶ã«ååšããªãã¢ããé žãã¯ãšã³é žãã°ã«
ã³ã³é žãã°ãªã»ãªã³é žãã°ãªã³ãŒã«é žããªã³ãŽ
é žãïŒâã¹ã«ããµãªãã«é žãé ç³é žçã®ãªãã·
é žããããªã³é žãããªã¡ã¿ãªã³é žãããªãªã³é žç
ã®çž®åãªã³é žããããé ¢é žãâãããå®æ¯éŠé ž
çã®ãããã«ã«ãã³é žããªããµã«é ¢é žããã«ãã³
é žçã®é žããµãªãã«ã¢ã«ããããïŒâã¯ãã«ãµãª
ãã«ã¢ã«ããããïŒâã¹ã«ããµãªãã«ã¢ã«ããã
çãµãªãã«ã¢ã«ãããããã³ãã®èªå°äœãïŒâãª
ãã·âïŒâãããã¢ã«ããããïŒâãªãã·âïŒâ
ãããã¢ã«ãããçã®ãªãã·ã¢ã«ããããã¢ã»ã
ã«ã¢ã»ãã³ããã³ãŸã€ã«ã¢ã»ãã³ãïŒâããã€ã«
ãã³ãŸã€ã«ã¡ã¿ã³ãããªãã«ãªã«ã¢ã»ãã«ã¢ã»ã
ã³çã®Î²âãžã±ãã³ãïŒâãªãã·ãããªã³ãã«ã
ã³ãŒã«âïŒïŒïŒâãžã¹ã«ãã³é žçã®ããšããŒã«èª
å°äœããšãªãªã¯ãã ãã©ãã¯âããšãªãªã¯ãã
ãã«ãŒãã©ãã¯ïŒ²çã®ïŒ¯ïŒOâ²âãžãªãã·ã¢ãŸè²
çŽ ãã¢ãããã³ãŒã³ããªãŒã«ãâã¢ããããšã
ãŒã«ãã¢ã»ãé ¢é žãšãã«çãæããããããŸãã
ããªã¢ã¯ãªã«é žããããªã¡ã¿ã¯ãªã«é žã®ãããªã
ãªã«ã«ãã³é žããããªã³ãã¢ã«ã®ã³é žçã®å€ç³é¡
ãçšããããšãã§ããã
åžçæã®ããªã¢ããªã³éšãšã®çžäºäœçšã§åžçæ
ã«åžçãããŠããäœæ¯éãªãèçœè³ªãã«ã«ã·ãŠ
ã ããã°ãã·ãŠã çã®ã«ããªã³æ§ç©è³ªããé«ãæ¿
床ã®ãã¬ãŒãåå€ã®ååšã§åžç平衡ããããåžç
æããè±é¢ããŠãããã®ãšèããããã
ã«åžçãããŠããäœæ¯éãªãèçœè³ªãã«ã«ã·ãŠ
ã ããã°ãã·ãŠã çã®ã«ããªã³æ§ç©è³ªããé«ãæ¿
床ã®ãã¬ãŒãåå€ã®ååšã§åžç平衡ããããåžç
æããè±é¢ããŠãããã®ãšèããããã
ãã¬ãŒãåå€ã®äžã§ã¯ãåžçæãäœå€åŸªç°æ²»ç
ã«å䜿çšãããã®ãšèãããšãã¯ãšã³é žãããªãŠ
ã ããããªã³ãããªãŠã çãå®å šæ§ã®é¢ã§åªããŠ
ããæšå¥šã§ããã
ã«å䜿çšãããã®ãšèãããšãã¯ãšã³é žãããªãŠ
ã ããããªã³ãããªãŠã çãå®å šæ§ã®é¢ã§åªããŠ
ããæšå¥šã§ããã
次ã«ãäœæ¯éãªãèçœè³ªåžçæã®åçæ¹æ³ã«ã€
ããŠäŸãæããŠèª¬æããã
ããŠäŸãæããŠèª¬æããã
åè¿°ã®ããã«ãäœæ¯éãªãèçœè³ªåžçæã¯ãé
åžžã容åšã«å å¡«ããã第ïŒå³ã®ãããªãªãèçœè³ª
åžçåšãšããŠäœ¿çšãããããã®äœæ¯éãªãèçœè³ª
åžçåšã«äœæ¶²ãæµããäœæ¶²äžã®äœæ¯éãªãèçœè³ª
ãåžçãããã䜿çšåŸãåçãå§ããããã§ãã
ããéåžžãå ããäœæ¯éãªãèçœè³ªåžçåšã®äžã«
æ®çããŠããäœæ¶²ãæŽãåºãããã«ãåžçåšå®¹é
ã®ïŒã10å容éã®ççç溶液ïŒäŸãã°ãççé£å¡©
æ°ŽïŒãçšããŠæŽæµããããã®æäœã¯ããã®åŸã«çš
ããåç液ããäœæ¶²ã«å¯ŸããŠå€æ§ãåéçã®æªåœ±
é¿ãåãŒããã®ã§ãªãå Žåã«ã¯ãçç¥ããŠããã
ã€ãããªãã
åžžã容åšã«å å¡«ããã第ïŒå³ã®ãããªãªãèçœè³ª
åžçåšãšããŠäœ¿çšãããããã®äœæ¯éãªãèçœè³ª
åžçåšã«äœæ¶²ãæµããäœæ¶²äžã®äœæ¯éãªãèçœè³ª
ãåžçãããã䜿çšåŸãåçãå§ããããã§ãã
ããéåžžãå ããäœæ¯éãªãèçœè³ªåžçåšã®äžã«
æ®çããŠããäœæ¶²ãæŽãåºãããã«ãåžçåšå®¹é
ã®ïŒã10å容éã®ççç溶液ïŒäŸãã°ãççé£å¡©
æ°ŽïŒãçšããŠæŽæµããããã®æäœã¯ããã®åŸã«çš
ããåç液ããäœæ¶²ã«å¯ŸããŠå€æ§ãåéçã®æªåœ±
é¿ãåãŒããã®ã§ãªãå Žåã«ã¯ãçç¥ããŠããã
ã€ãããªãã
次ã«ãåžçæã®åç液ãäœæ¯éãªãèçœè³ªåžç
åšã«æµãã®ã§ããããæ¬çºæã®åç液ãããªã
ã¡ããã¬ãŒãåå€ãå«ã溶液ã¯ãåžçæã«åžçã
ãŠããäœæ¯éãªãèçœè³ªã®è±çå¹çãéåžžã«é«ã
ã®ã§ãåžçåšå®¹éã®ïŒãïŒå容éæµãã°ãã»ãŒå®
å šã«è±çã§ãããæµéã極端ã«éããªãéãä»»æ
ã«éžæã§ãã枩床ãä»»æã«éžæã§ããã
åšã«æµãã®ã§ããããæ¬çºæã®åç液ãããªã
ã¡ããã¬ãŒãåå€ãå«ã溶液ã¯ãåžçæã«åžçã
ãŠããäœæ¯éãªãèçœè³ªã®è±çå¹çãéåžžã«é«ã
ã®ã§ãåžçåšå®¹éã®ïŒãïŒå容éæµãã°ãã»ãŒå®
å šã«è±çã§ãããæµéã極端ã«éããªãéãä»»æ
ã«éžæã§ãã枩床ãä»»æã«éžæã§ããã
æåŸã«ã次å䜿çšããããšãèããççç溶液
ã«çœ®æãããããŸãã¯ä¿åããããã®æ®ºèå€ã®ã
ããªä¿å液ã«çœ®æãããå¿ èŠã«ãã€ãŠã¯ãççç
溶液ã«çœ®æããŠããã湿ç±æ» èãγç·æ» èçã®æ»
èæäœãè¡ãªã€ãŠãããã
ã«çœ®æãããããŸãã¯ä¿åããããã®æ®ºèå€ã®ã
ããªä¿å液ã«çœ®æãããå¿ èŠã«ãã€ãŠã¯ãççç
溶液ã«çœ®æããŠããã湿ç±æ» èãγç·æ» èçã®æ»
èæäœãè¡ãªã€ãŠãããã
äžèšãããããªæäœã«ããäœæ¯éãªãèçœè³ªåž
çæã¯åçãããã
çæã¯åçãããã
ãŸããå¿
èŠã«ãããäœå€åŸªç°ã§è¡æ¶²äžã®äœæ¯é
ãªãèçœè³ªãåžçé€å»ããŠããæäžã«ãäœæ¯éãª
ãèçœè³ªåžçæãåçã§ããããã®å Žåã«ã¯ãäœ
æ¯éãªãèçœè³ªåžçåšãïŒæ¬ãããã¯ïŒæ¬ä»¥äžäœ¿
çšããäžæ¹ãäœæ¯éãªãèçœè³ªåžççšã«ãä»æ¹ã
åççšã«ãšããå ·åã«ïŒç³»çµ±ã«åããç¡èçã«æ
äœããã®ã奜ãŸããããã ããïŒæ¬ã§éæ¬ çã«è¡
ãªãããšãå¯èœã§ããã
ãªãèçœè³ªãåžçé€å»ããŠããæäžã«ãäœæ¯éãª
ãèçœè³ªåžçæãåçã§ããããã®å Žåã«ã¯ãäœ
æ¯éãªãèçœè³ªåžçåšãïŒæ¬ãããã¯ïŒæ¬ä»¥äžäœ¿
çšããäžæ¹ãäœæ¯éãªãèçœè³ªåžççšã«ãä»æ¹ã
åççšã«ãšããå ·åã«ïŒç³»çµ±ã«åããç¡èçã«æ
äœããã®ã奜ãŸããããã ããïŒæ¬ã§éæ¬ çã«è¡
ãªãããšãå¯èœã§ããã
æ¬çºæã®äœæ¯éãªãèçœè³ªåžçæã®åçæ¹æ³ã
å®æœããã«åœããç¹ã«äœå€åŸªç°ã«ããè¡æ¶²äžã®äœ
æ¯éãªãèçœè³ªãåžçé€å»ããŠããæäžã«äœæ¯é
ãªãèçœè³ªåžçæãåçãããããªå Žåã«ã¯ãäœ
æ¯éãªãèçœè³ªã®åžçåççšè£ 眮ãšããŠãïŒç³»çµ±
ã®æ¶²äœå°å ¥å£ããã³ïŒç³»çµ±ã®æ¶²äœå°åºå£ãæã€å®¹
åšã«ããè¡šé¢ã«ããªã¢ããªã³éšãæããäœæ¯éãª
ãèçœè³ªåžçæããçŽããããŠãªããã®ã䜿çšã
ããšãäœæ¯éãªãèçœè³ªã®åžçåçæäœãéåžžã«
簡䟿ã§ãããç¡èçãªåãæ±ããç°¡åã«ã§ããã
å®æœããã«åœããç¹ã«äœå€åŸªç°ã«ããè¡æ¶²äžã®äœ
æ¯éãªãèçœè³ªãåžçé€å»ããŠããæäžã«äœæ¯é
ãªãèçœè³ªåžçæãåçãããããªå Žåã«ã¯ãäœ
æ¯éãªãèçœè³ªã®åžçåççšè£ 眮ãšããŠãïŒç³»çµ±
ã®æ¶²äœå°å ¥å£ããã³ïŒç³»çµ±ã®æ¶²äœå°åºå£ãæã€å®¹
åšã«ããè¡šé¢ã«ããªã¢ããªã³éšãæããäœæ¯éãª
ãèçœè³ªåžçæããçŽããããŠãªããã®ã䜿çšã
ããšãäœæ¯éãªãèçœè³ªã®åžçåçæäœãéåžžã«
簡䟿ã§ãããç¡èçãªåãæ±ããç°¡åã«ã§ããã
ããªãã¡ã液äœå°å
¥å£ã®äžæ¹ãšæ¶²äœå°åºå£ã®äž
æ¹ãšãäœæ¯éãªãèçœè³ªã®åžççšãšããŠçšãã液
äœå°å ¥å£ã®ä»æ¹ãšæ¶²äœå°åºå£ã®ä»æ¹ãšãäœæ¯éãª
ãèçœè³ªåžçæã®åççšãšããŠçšããããšã«ã
ããäœæ¯éãªãèçœè³ªåžçæã®åžçãåçã簡䟿
ã«ããããç¡èçã«è¡ãªãããšãã§ããéåžžã«äŸ¿
å©ã§ããã
æ¹ãšãäœæ¯éãªãèçœè³ªã®åžççšãšããŠçšãã液
äœå°å ¥å£ã®ä»æ¹ãšæ¶²äœå°åºå£ã®ä»æ¹ãšãäœæ¯éãª
ãèçœè³ªåžçæã®åççšãšããŠçšããããšã«ã
ããäœæ¯éãªãèçœè³ªåžçæã®åžçãåçã簡䟿
ã«ããããç¡èçã«è¡ãªãããšãã§ããéåžžã«äŸ¿
å©ã§ããã
ïŒçºæã®å¹æïŒ
以äžè¿°ã¹ãŠããããã«ãæ¬çºæã®äœæ¯éãªãè
çœè³ªåžçæã®åçæ¹æ³ã«ããã°ãéåžžã«é«ãåžç
èœåã瀺ããé«ãéžææ§ã瀺ãããªã¢ããªã³ç³»åž
çæã®åçãå®å šã«ããã€ç°¡äŸ¿ã«ããããå®å šã«
è¡ãªãããšãã§ããããã«ãªã€ãã®ã§ãäœæ¯éãª
ãèçœè³ªåžçæã®å䜿çšãå¯èœãšãªããïŒæ¬ã®äœ
æ¯éãªãèçœè³ªåžçåšã§å€§éã®äœæ¯éãªãèçœè³ª
ãåžçããããšãå¯èœãšãªã€ãã
çœè³ªåžçæã®åçæ¹æ³ã«ããã°ãéåžžã«é«ãåžç
èœåã瀺ããé«ãéžææ§ã瀺ãããªã¢ããªã³ç³»åž
çæã®åçãå®å šã«ããã€ç°¡äŸ¿ã«ããããå®å šã«
è¡ãªãããšãã§ããããã«ãªã€ãã®ã§ãäœæ¯éãª
ãèçœè³ªåžçæã®å䜿çšãå¯èœãšãªããïŒæ¬ã®äœ
æ¯éãªãèçœè³ªåžçåšã§å€§éã®äœæ¯éãªãèçœè³ª
ãåžçããããšãå¯èœãšãªã€ãã
åçå€ãšããŠãã¬ãŒãåå€ãçšããŠããã®ã§ã
åçå¹çãè¯ããããšãçäœã«å ¥ã€ãŠãå®å šãªã
ã¬ãŒãåå€ãçšããããšã«ãããäœå€åŸªç°æ²»çäž
ã«ãããåçããå¯èœã«ããã
åçå¹çãè¯ããããšãçäœã«å ¥ã€ãŠãå®å šãªã
ã¬ãŒãåå€ãçšããããšã«ãããäœå€åŸªç°æ²»çäž
ã«ãããåçããå¯èœã«ããã
æ¬çºæã¯ã家ææ§é«ã³ã¬ã¹ãããŒã«è¡çæ²»ççš
ã®äœæ¯éãªãèçœè³ªåžçæã®åçã«æå¹ã§ããã
åŸæ¥ã«ãªããå®å šãªåçãã§ãããã€å®å šã§ã
ãã
ã®äœæ¯éãªãèçœè³ªåžçæã®åçã«æå¹ã§ããã
åŸæ¥ã«ãªããå®å šãªåçãã§ãããã€å®å šã§ã
ãã
ïŒå®æœäŸïŒ
以äžãå®æœäŸã«ããæ¬çºæãããã«è©³çŽ°ã«èª¬æ
ããã
ããã
å®æœäŸ ïŒ
第ïŒå³ã«ç€ºãäœæ¯éãªãèçœè³ªåžçåšãçšãã
äœæ¯éãªãèçœè³ªã®åžçãåçãååžçå®éšãè¡
ãªã€ãã
äœæ¯éãªãèçœè³ªã®åžçãåçãååžçå®éšãè¡
ãªã€ãã
äœæ¯éãªãèçœè³ªåžçåšã«ã¯å
åŸ0.8cmãé·ã
2.0cmãå 容ç©1.0mlã®äžã«äœæ¯éãªãèçœè³ªåžç
æ1.0mlãè©°ãããã®ãçšããã
2.0cmãå 容ç©1.0mlã®äžã«äœæ¯éãªãèçœè³ªåžç
æ1.0mlãè©°ãããã®ãçšããã
äœæ¯éãªãèçœè³ªåžçæã¯ã以äžã«è¿°ã¹ãæ¹æ³
ã§è£œé ããã
ã§è£œé ããã
é
¢é
žããã«1000ïœãããªã¢ãªã«ã€ãœã·ã¢ãã¬ãŒ
ã414ïœãé ¢é žãšãã«1000ïœãããã¿ã³1000ïœã
ããªé ¢é žããã«ïŒéå床500ïŒ70ïœããã³ïŒïŒ
2â²âã¢ãŸãã¹ã€ãœããããããªã«36ïœãããªãå
äžæ··å液ãšãããªããã«ã¢ã«ã³ãŒã«ïŒééïŒ ããª
ã³é žäºæ°ŽçŽ ãããªãŠã äºæ°Žåç©0.05ééïŒ ããã³
ãªã³é žæ°ŽçŽ äºãããªãŠã åäºæ°Žåç©1.5ééïŒ ã
溶解ããæ°ŽïŒãšããã©ã¹ã³ã«å ¥ããååæ¹æã
ãåŸã65âã§18æéãããã«75âã§ïŒæéå ç±æ¹
æããŠæžæ¿éåãè¡ããç²ç¶å ±éåäœãåŸããé
åäžãæ¹æé床ã¯ç²åŸãå°ããã«ãªãããã«ã³ã³
ãããŒã«ãããéãæ°ŽæŽãã€ãã§ã¢ã»ãã³æœåº
åŸãã«ã»ã€ãœãŒã465ïœããã³ã¡ã¿ããŒã«20ã
ããªã溶液äžã§ã40âã§18æéãå ±éåäœã®ãšã¹
ãã«äº€æåå¿ãè¡ã€ããåŸãããç²åã®å¹³åç²åŸ
ã¯40ÎŒmã§ãã€ãã
ã414ïœãé ¢é žãšãã«1000ïœãããã¿ã³1000ïœã
ããªé ¢é žããã«ïŒéå床500ïŒ70ïœããã³ïŒïŒ
2â²âã¢ãŸãã¹ã€ãœããããããªã«36ïœãããªãå
äžæ··å液ãšãããªããã«ã¢ã«ã³ãŒã«ïŒééïŒ ããª
ã³é žäºæ°ŽçŽ ãããªãŠã äºæ°Žåç©0.05ééïŒ ããã³
ãªã³é žæ°ŽçŽ äºãããªãŠã åäºæ°Žåç©1.5ééïŒ ã
溶解ããæ°ŽïŒãšããã©ã¹ã³ã«å ¥ããååæ¹æã
ãåŸã65âã§18æéãããã«75âã§ïŒæéå ç±æ¹
æããŠæžæ¿éåãè¡ããç²ç¶å ±éåäœãåŸããé
åäžãæ¹æé床ã¯ç²åŸãå°ããã«ãªãããã«ã³ã³
ãããŒã«ãããéãæ°ŽæŽãã€ãã§ã¢ã»ãã³æœåº
åŸãã«ã»ã€ãœãŒã465ïœããã³ã¡ã¿ããŒã«20ã
ããªã溶液äžã§ã40âã§18æéãå ±éåäœã®ãšã¹
ãã«äº€æåå¿ãè¡ã€ããåŸãããç²åã®å¹³åç²åŸ
ã¯40ÎŒmã§ãã€ãã
ãã®ã²ã«ãå
åŸ7.5mmãé·ã120cmã®ã¹ãã³ã¬ã¹
補ã«ã©ã ã«å å¡«ããŠãçš®ã ã®ååéãæã€ããã¹
ãã©ã³ãããªãšãã¬ã³ã°ãªã³ãŒã«ã®æ°Žæº¶æ¶²ããã³
ã¢ã«ããã³ãã€ã ãã°ãããªã³ïŒ§ãã€ã ãã°ãã
ãªã³ïŒãβâãªããããã€ã³ãã¿ãã³ãã¢ã¶ã€
ã¯ããŠã€ã«ã¹ã®ãªã³é žç·©è¡å¡©æº¶æ¶²ã枬å®ãããšã
ããããããååéã®å€§ããé ã«æº¶åºããããã
ãã¹ãã©ã³ã®æé€éçååéã¯çŽïŒÃ106ãã¿ã³
ãã¯è³ªã®æé€éçååéã¯çŽïŒÃ107ã§ãã€ãã
ãŸãã0.3Må¡©åãããªãŠã ããã³0.1Mãªã³é žã
ããªãŠã ãå«ã氎溶液ã溶åªãšããŠãããâγâ
ã°ãããªã³ãããâã¢ã«ããã³ã®æº¶æ¶²ãæµãããš
ãããã»ãšãã©100ïŒ ã®ååçã§ååãããã²ã«
ã®éç¹ç°çåžçã¯éåžžã«å°ãªãã€ãããµã³ãã«ã®
枬å®ã¯ãã¹ãŠæµéïŒmlïŒminã§å®æœããã
補ã«ã©ã ã«å å¡«ããŠãçš®ã ã®ååéãæã€ããã¹
ãã©ã³ãããªãšãã¬ã³ã°ãªã³ãŒã«ã®æ°Žæº¶æ¶²ããã³
ã¢ã«ããã³ãã€ã ãã°ãããªã³ïŒ§ãã€ã ãã°ãã
ãªã³ïŒãβâãªããããã€ã³ãã¿ãã³ãã¢ã¶ã€
ã¯ããŠã€ã«ã¹ã®ãªã³é žç·©è¡å¡©æº¶æ¶²ã枬å®ãããšã
ããããããååéã®å€§ããé ã«æº¶åºããããã
ãã¹ãã©ã³ã®æé€éçååéã¯çŽïŒÃ106ãã¿ã³
ãã¯è³ªã®æé€éçååéã¯çŽïŒÃ107ã§ãã€ãã
ãŸãã0.3Må¡©åãããªãŠã ããã³0.1Mãªã³é žã
ããªãŠã ãå«ã氎溶液ã溶åªãšããŠãããâγâ
ã°ãããªã³ãããâã¢ã«ããã³ã®æº¶æ¶²ãæµãããš
ãããã»ãšãã©100ïŒ ã®ååçã§ååãããã²ã«
ã®éç¹ç°çåžçã¯éåžžã«å°ãªãã€ãããµã³ãã«ã®
枬å®ã¯ãã¹ãŠæµéïŒmlïŒminã§å®æœããã
ã€ãã«ãšã¹ãã«äº€æãããæ°Žã§ååã«æŽæµãã
也ç¥ããã²ã«150ïœããžã¡ãã«ã¹ã«ããã·ã1800
mlããã³ãšãã¯ãã«ãããªã³1200mlãããªã溶液
äžã«æžæ¿ãã50ïŒ æ°Žé žåãããªãŠã 氎溶液150ml
ãå ãã30âã«ãŠïŒæéæ¹æäžåå¿ããããåå¿
çµäºåŸã¬ã©ã¹ãã€ã«ã¿ãŒã§éããïŒã®ãžã¡ã
ã«ã¹ã«ããã·ããã€ãã§20ã®æ°Žã§æŽæµããŠãšã
ãã·åºçµåã²ã«ãåŸãã
也ç¥ããã²ã«150ïœããžã¡ãã«ã¹ã«ããã·ã1800
mlããã³ãšãã¯ãã«ãããªã³1200mlãããªã溶液
äžã«æžæ¿ãã50ïŒ æ°Žé žåãããªãŠã 氎溶液150ml
ãå ãã30âã«ãŠïŒæéæ¹æäžåå¿ããããåå¿
çµäºåŸã¬ã©ã¹ãã€ã«ã¿ãŒã§éããïŒã®ãžã¡ã
ã«ã¹ã«ããã·ããã€ãã§20ã®æ°Žã§æŽæµããŠãšã
ãã·åºçµåã²ã«ãåŸãã
該ã²ã«ã®ãšããã·åºçµåéã¯ïŒmlã«ã€ã
0.11mmolã§ãã€ãã該ãšããã·åºçµåã²ã«ãçš
ããããªã¢ã¯ãªã«é žïŒééå¹³åååéïŒÃ104ã
ç±³åœã¢ã«ããªãã瀟補ïŒããªã¬ã³ããšããŠçµåã
ããåžçæãäœæããã
0.11mmolã§ãã€ãã該ãšããã·åºçµåã²ã«ãçš
ããããªã¢ã¯ãªã«é žïŒééå¹³åååéïŒÃ104ã
ç±³åœã¢ã«ããªãã瀟補ïŒããªã¬ã³ããšããŠçµåã
ããåžçæãäœæããã
ããªã¢ã¯ãªã«é
ž4.5ïœãèžçæ°Žã§500mlã«ããã
ãããªã¬ã³ã液ãšããããã®ãªã¬ã³ã液ã«åèšãš
ããã·åºçµåã²ã«100mlãå ãã50âã§16æéã
æ¯ãšãããªãããªã¬ã³ãã®çµååå¿ãè¡ãªã€ãã
ãããªã¬ã³ã液ãšããããã®ãªã¬ã³ã液ã«åèšãš
ããã·åºçµåã²ã«100mlãå ãã50âã§16æéã
æ¯ãšãããªãããªã¬ã³ãã®çµååå¿ãè¡ãªã€ãã
ãã®åŸãå
åã«æ°ŽæŽããåžåŒè±æ°ŽããåŸã0.1
èŠå®ã®æ°Žé žåãããªãŠã 溶液äžã«30åé浞ããã
ãªã¢ã¯ãªã«é žããããªãŠã åã«ãããã®åŸãå å
éã®æ°ŽæŽãè¡ãªããäœæ¯éãªãèçœè³ªåžçæãšã
ãã
èŠå®ã®æ°Žé žåãããªãŠã 溶液äžã«30åé浞ããã
ãªã¢ã¯ãªã«é žããããªãŠã åã«ãããã®åŸãå å
éã®æ°ŽæŽãè¡ãªããäœæ¯éãªãèçœè³ªåžçæãšã
ãã
åžçå®éšã¯ã家ææ§é«ã³ã¬ã¹ãããŒã«è¡çæ£è
ã®è¡æŒ¿ãçšããŠè¡ãªã€ãã
ã®è¡æŒ¿ãçšããŠè¡ãªã€ãã
å
ããäœæ¯éãªãèçœè³ªåžçåšãççé£å¡©æ°Žã§
ãã©ã€ãã³ã°ããŠããã次ã«ã家ææ§é«ã³ã¬ã¹ã
ããŒã«è¡çæ£è è¡æŒ¿ã0.17mlïŒminã®æµéã§äœæ¯
éãªãèçœè³ªåžçåšã«æµãããåžçåšããæµåºã
ãŠããæåã®ççé£å¡©æ°ŽïŒmlãæšãŠããã®åŸã«åº
ãŠããè¡æŒ¿ã¯ãïŒmlãã€è©Šéšç®¡ã«åããŠè¡ã€ãã
è¡æŒ¿ã12mlæµãããšããã§ãåç液ãšããŠã¯ãšã³
é žäžãããªãŠã ã»äºæ°Žåç©ã®29.4ïœïŒdl溶液ïŒå¡©
é žã§PHãïŒã«èª¿æŽããïŒãçšããè¡æŒ¿ãšåãæµé
ã§ïŒmlæµããããã®åŸãççé£å¡©æ°ŽïŒmlã§ãåç
液ãæŽæµããåŸãåã³å®¶ææ§é«ã³ã¬ã¹ãããŒã«è¡
çæ£è è¡æŒ¿ãåæµéã§12mlæµããååžçãã¹ãã
è¡ãªã€ãã
ãã©ã€ãã³ã°ããŠããã次ã«ã家ææ§é«ã³ã¬ã¹ã
ããŒã«è¡çæ£è è¡æŒ¿ã0.17mlïŒminã®æµéã§äœæ¯
éãªãèçœè³ªåžçåšã«æµãããåžçåšããæµåºã
ãŠããæåã®ççé£å¡©æ°ŽïŒmlãæšãŠããã®åŸã«åº
ãŠããè¡æŒ¿ã¯ãïŒmlãã€è©Šéšç®¡ã«åããŠè¡ã€ãã
è¡æŒ¿ã12mlæµãããšããã§ãåç液ãšããŠã¯ãšã³
é žäžãããªãŠã ã»äºæ°Žåç©ã®29.4ïœïŒdl溶液ïŒå¡©
é žã§PHãïŒã«èª¿æŽããïŒãçšããè¡æŒ¿ãšåãæµé
ã§ïŒmlæµããããã®åŸãççé£å¡©æ°ŽïŒmlã§ãåç
液ãæŽæµããåŸãåã³å®¶ææ§é«ã³ã¬ã¹ãããŒã«è¡
çæ£è è¡æŒ¿ãåæµéã§12mlæµããååžçãã¹ãã
è¡ãªã€ãã
åžçãåçãååžçãã¹ãã®éã®æµåºæ¶²å
šãŠã«
ã€ããŠããã®ã³ã¬ã¹ãããŒã«æ¿åºŠã枬å®ããçµæ
ã第ïŒå³ã§ããã暪軞ãæµåºæ¶²ã®éã§ããã瞊軞
ã¯åã ã®æµåºæ¶²äžã®ã³ã¬ã¹ãããŒã«ã®æ¿åºŠã§ã
ããå ãã第ïŒåç®ã®åžçãã¹ãã§ããããã³ã¬
ã¹ãããŒã«ïŒå®¶ææ§é«ã³ã¬ã¹ãããŒã«è¡çæ£è è¡
挿ãªã®ã§ãã»ãšãã©ãäœæ¯éãªãèçœè³ªã³ã¬ã¹ã
ããŒã«ã§ããïŒåžçéã¯ã第ïŒå³äžãæç·éšã®
é¢ç©ã§è¡šããããèšç®ãããš25mgãšãªãã次ã«ã
åç液ã§æµåºããã³ã¬ã¹ãããŒã«éã¯ã第ïŒå³
äžãæç·éšã®é¢ç©ã§è¡šããããèšç®ãããšæ
ç·éšã®é¢ç©ã«äžèŽããåžçãããã³ã¬ã¹ãããŒã«
ã®å šãŠãåç液ã§è±çããåžçåšå€ã«æµåºããã
ãšããããã次ã«ãïŒåç®ã®åžçãã¹ãã«ããã³
ã¬ã¹ãããŒã«åžçéã¯ã第ïŒå³äžãæç·éšã®é¢
ç©ã§è¡šãããããããããæç·éšã«äžèŽããã®
ã§ãäœæ¯éãªãèçœè³ªåžçæã¯ãåç液ã§å®å šã«
åçããããšããããã
ã€ããŠããã®ã³ã¬ã¹ãããŒã«æ¿åºŠã枬å®ããçµæ
ã第ïŒå³ã§ããã暪軞ãæµåºæ¶²ã®éã§ããã瞊軞
ã¯åã ã®æµåºæ¶²äžã®ã³ã¬ã¹ãããŒã«ã®æ¿åºŠã§ã
ããå ãã第ïŒåç®ã®åžçãã¹ãã§ããããã³ã¬
ã¹ãããŒã«ïŒå®¶ææ§é«ã³ã¬ã¹ãããŒã«è¡çæ£è è¡
挿ãªã®ã§ãã»ãšãã©ãäœæ¯éãªãèçœè³ªã³ã¬ã¹ã
ããŒã«ã§ããïŒåžçéã¯ã第ïŒå³äžãæç·éšã®
é¢ç©ã§è¡šããããèšç®ãããš25mgãšãªãã次ã«ã
åç液ã§æµåºããã³ã¬ã¹ãããŒã«éã¯ã第ïŒå³
äžãæç·éšã®é¢ç©ã§è¡šããããèšç®ãããšæ
ç·éšã®é¢ç©ã«äžèŽããåžçãããã³ã¬ã¹ãããŒã«
ã®å šãŠãåç液ã§è±çããåžçåšå€ã«æµåºããã
ãšããããã次ã«ãïŒåç®ã®åžçãã¹ãã«ããã³
ã¬ã¹ãããŒã«åžçéã¯ã第ïŒå³äžãæç·éšã®é¢
ç©ã§è¡šãããããããããæç·éšã«äžèŽããã®
ã§ãäœæ¯éãªãèçœè³ªåžçæã¯ãåç液ã§å®å šã«
åçããããšããããã
æ¯èŒäŸ ïŒ
åç液ãšããŠïŒïŒ
é£å¡©æ°Žãçšããããšä»¥å€ã¯ã
å šãŠå®æœäŸïŒãšåæ§ã«è¡ãªã€ããšãããåç液ã
ãè±çããã³ã¬ã¹ãããŒã«ã¯ã第ïŒåç®ã®ã³ã¬ã¹
ãããŒã«åžçéã®73ïŒ ã§ããã第ïŒåç®ã®ã³ã¬ã¹
ãããŒã«åžçéã第ïŒåç®ã®68ïŒ ãšå°ãªãã€ãã
å šãŠå®æœäŸïŒãšåæ§ã«è¡ãªã€ããšãããåç液ã
ãè±çããã³ã¬ã¹ãããŒã«ã¯ã第ïŒåç®ã®ã³ã¬ã¹
ãããŒã«åžçéã®73ïŒ ã§ããã第ïŒåç®ã®ã³ã¬ã¹
ãããŒã«åžçéã第ïŒåç®ã®68ïŒ ãšå°ãªãã€ãã
ããªãã¡ãïŒïŒ
é£å¡©æ°Žã§ã¯ãäœæ¯éãªãèçœè³ª
åžçæã®å®å šãªåçã¯ã§ããªãã€ãã
åžçæã®å®å šãªåçã¯ã§ããªãã€ãã
å®æœäŸ ïŒ
åç液ãšããŠããšãã¬ã³ãžã¢ãã³åé
¢é
žåãã
ãªãŠã åæ°Žå¡©ã®4.52ïœïŒdl溶液ïŒå¡©é žã§PHã7.0
ã«èª¿æŽïŒãçšããããšä»¥å€ã¯ãå šãŠå®æœäŸïŒãšå
æ§ã«è¡ãªã€ããšããã第ïŒåç®ã®ã³ã¬ã¹ãããŒã«
åžçéãåç液ã«ããã³ã¬ã¹ãããŒã«ã®è±çéã
第ïŒåç®ã®ã³ã¬ã¹ãããŒã«åžçéã¯ãå šãŠäžèŽã
ããããªãã¡ãäœæ¯éãªãèçœè³ªåžçæã¯å®å šã«
åçãããã
ãªãŠã åæ°Žå¡©ã®4.52ïœïŒdl溶液ïŒå¡©é žã§PHã7.0
ã«èª¿æŽïŒãçšããããšä»¥å€ã¯ãå šãŠå®æœäŸïŒãšå
æ§ã«è¡ãªã€ããšããã第ïŒåç®ã®ã³ã¬ã¹ãããŒã«
åžçéãåç液ã«ããã³ã¬ã¹ãããŒã«ã®è±çéã
第ïŒåç®ã®ã³ã¬ã¹ãããŒã«åžçéã¯ãå šãŠäžèŽã
ããããªãã¡ãäœæ¯éãªãèçœè³ªåžçæã¯å®å šã«
åçãããã
å®æœäŸ ïŒ
åç液ãšããŠãååé2000ã®ããªã¢ã¯ãªã«é
žã®
0.72ïœïŒdl溶液ïŒæ°Žé žåãããªãŠã ã§PHã7.0ã«
調æŽïŒãçšããããšä»¥å€ã¯ãå šãŠå®æœäŸïŒãšåæ§
ã«è¡ãªã€ããšããã第ïŒåç®ã®ã³ã¬ã¹ãããŒã«åž
çéãåç液ã«ããã³ã¬ã¹ãããŒã«è±çéã第ïŒ
åç®ã®ã³ã¬ã¹ãããŒã«åžçéã¯å®å šã«äžèŽããäœ
æ¯éãªãèçœè³ªåžçæãåç液ã«ãããå®å šã«å
çãããããšãããã€ãã
0.72ïœïŒdl溶液ïŒæ°Žé žåãããªãŠã ã§PHã7.0ã«
調æŽïŒãçšããããšä»¥å€ã¯ãå šãŠå®æœäŸïŒãšåæ§
ã«è¡ãªã€ããšããã第ïŒåç®ã®ã³ã¬ã¹ãããŒã«åž
çéãåç液ã«ããã³ã¬ã¹ãããŒã«è±çéã第ïŒ
åç®ã®ã³ã¬ã¹ãããŒã«åžçéã¯å®å šã«äžèŽããäœ
æ¯éãªãèçœè³ªåžçæãåç液ã«ãããå®å šã«å
çãããããšãããã€ãã
第ïŒå³ã¯è¡šé¢ã«ããªã¢ããªã³éšãæããäœæ¯é
ãªãèçœè³ªåžçæãå å¡«ããŠãªãäœæ¯éãªãèçœ
質åžçåšã瀺ãæé¢æš¡åŒå³ã第ïŒå³ã¯å®æœäŸïŒã®
å®éšçµæã瀺ãã°ã©ãã§ããã ïŒâŠâŠäœæ¯éãªãèçœè³ªåžçåšãïŒâŠâŠåçã
ïŒïŒïŒâ²âŠâŠãã€ã«ã¿ãŒãïŒâŠâŠãããã³ã°ãïŒ
âŠâŠäœæ¶²å°å ¥å£ãïŒïŒïŒâŠâŠãã€ãããïŒâŠâŠåž
çæå±€ã
ãªãèçœè³ªåžçæãå å¡«ããŠãªãäœæ¯éãªãèçœ
質åžçåšã瀺ãæé¢æš¡åŒå³ã第ïŒå³ã¯å®æœäŸïŒã®
å®éšçµæã瀺ãã°ã©ãã§ããã ïŒâŠâŠäœæ¯éãªãèçœè³ªåžçåšãïŒâŠâŠåçã
ïŒïŒïŒâ²âŠâŠãã€ã«ã¿ãŒãïŒâŠâŠãããã³ã°ãïŒ
âŠâŠäœæ¶²å°å ¥å£ãïŒïŒïŒâŠâŠãã€ãããïŒâŠâŠåž
çæå±€ã
Claims (1)
- ïŒ äœæ¶²äžã®äœæ¯éãªãèçœè³ªãåžçãããè¡šé¢
ã«ããªã¢ããªã³éšãæããäœæ¯éãªãèçœè³ªåžç
æããå°ãªããšãïŒçš®é¡ã®ãã¬ãŒãåå€ãå«ã溶
液ã§æŽæµããããšãç¹åŸŽãšããäœæ¯éãªãèçœè³ª
åžçæã®åçæ¹æ³ã
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60162048A JPS6222659A (ja) | 1985-07-24 | 1985-07-24 | äœæ¯éãªãèçœè³ªåžçæã®åçæ¹æ³ |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60162048A JPS6222659A (ja) | 1985-07-24 | 1985-07-24 | äœæ¯éãªãèçœè³ªåžçæã®åçæ¹æ³ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6222659A JPS6222659A (ja) | 1987-01-30 |
| JPH024301B2 true JPH024301B2 (ja) | 1990-01-26 |
Family
ID=15747101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60162048A Granted JPS6222659A (ja) | 1985-07-24 | 1985-07-24 | äœæ¯éãªãèçœè³ªåžçæã®åçæ¹æ³ |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6222659A (ja) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0419002U (ja) * | 1990-06-07 | 1992-02-18 | ||
| JPH0480103U (ja) * | 1990-11-26 | 1992-07-13 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2777604B2 (ja) * | 1988-08-29 | 1998-07-23 | æã¡ãã£ã«ã«æ ªåŒäŒç€Ÿ | äœæ¶²åŠççšåžçæ |
| JP2001289215A (ja) | 2000-04-03 | 2001-10-19 | Aoyama Seisakusho Co Ltd | é²æ°Žã°ãã¡ãã |
-
1985
- 1985-07-24 JP JP60162048A patent/JPS6222659A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0419002U (ja) * | 1990-06-07 | 1992-02-18 | ||
| JPH0480103U (ja) * | 1990-11-26 | 1992-07-13 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6222659A (ja) | 1987-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0143369B1 (en) | A porous adsorbent for adsorbing low density lipoproteins | |
| JP2543693B2 (ja) | äœæ¯éãªãèçœè³ªã®åžçæããã³ãã®è£œé æ¹æ³ | |
| JPH024301B2 (ja) | ||
| JPH0513696B2 (ja) | ||
| JPH0436300A (ja) | å€æ§ïœïœïœã®åžçäœããã³ãããçšããå€æ§ïœïœïœã®é€å»è£ 眮 | |
| JPS6319214B2 (ja) | ||
| JPH0114791B2 (ja) | ||
| JPS5827559A (ja) | äœå¯åºŠãªãèçœè³ªåžçå€ | |
| JPH0424065B2 (ja) | ||
| JPS6227967A (ja) | äœæ¯éãªãèçœè³ªåžçæã®åçæ¹æ³ | |
| JPS6259976B2 (ja) | ||
| JPH01315338A (ja) | äœæ¯éãªãèçœè³ªåžçæ | |
| JPS6226073A (ja) | çŽæ¥è¡æ¶²æœ æµåžçæ¹æ³ããã³ãã®è£ 眮 | |
| JPH043988B2 (ja) | ||
| JPS6259975B2 (ja) | ||
| JPS62244442A (ja) | äœæ¯éãªãèçœè³ªåžçæããã³ãã®è£œé æ¹æ³ | |
| JPS59139937A (ja) | äœæ¯éãªãèçœåžçæ | |
| JPS6222658A (ja) | äœæ¯éãªãèçœè³ªåžçè£ çœ® | |
| JPH088928B2 (ja) | äœæ¯éãªãèçœè³ªãé€å»ããè¡æŒ¿ã補é ããè£ çœ® | |
| JP2726662B2 (ja) | åžçäœããã³ãããçšããé€å»è£ 眮 | |
| JPH06178807A (ja) | äžç¹åžåè¡æ¶²æµåçšåžçæ | |
| JPS6359344B2 (ja) | ||
| JPH06237995A (ja) | è¡æ¶²æµååžçæ | |
| JPS6222657A (ja) | äœæ¯éãªãèçœè³ªåžçæããã³ãã®è£œé æ¹æ³ | |
| JPH0616842B2 (ja) | 掻æ§åè£äœæåã®åžçäœ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |