JPH0254502B2 - - Google Patents
Info
- Publication number
- JPH0254502B2 JPH0254502B2 JP57134313A JP13431382A JPH0254502B2 JP H0254502 B2 JPH0254502 B2 JP H0254502B2 JP 57134313 A JP57134313 A JP 57134313A JP 13431382 A JP13431382 A JP 13431382A JP H0254502 B2 JPH0254502 B2 JP H0254502B2
- Authority
- JP
- Japan
- Prior art keywords
- ion
- sensitive
- glass
- electrode
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000002500 ions Chemical class 0.000 claims description 42
- 239000012528 membrane Substances 0.000 claims description 15
- 229910052751 metal Inorganic materials 0.000 claims description 15
- 239000002184 metal Substances 0.000 claims description 15
- 150000004703 alkoxides Chemical class 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 11
- 230000007935 neutral effect Effects 0.000 claims description 6
- 230000003301 hydrolyzing effect Effects 0.000 claims description 5
- 239000011159 matrix material Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 239000004014 plasticizer Substances 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 10
- 239000007787 solid Substances 0.000 description 7
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 6
- 239000011521 glass Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 108010067973 Valinomycin Proteins 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- FCFNRCROJUBPLU-UHFFFAOYSA-N compound M126 Natural products CC(C)C1NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC1=O FCFNRCROJUBPLU-UHFFFAOYSA-N 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 4
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- FCFNRCROJUBPLU-DNDCDFAISA-N valinomycin Chemical compound CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC1=O FCFNRCROJUBPLU-DNDCDFAISA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 3
- -1 alkoxy metals Chemical class 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229920000620 organic polymer Polymers 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229910021607 Silver chloride Inorganic materials 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229910001414 potassium ion Inorganic materials 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000004043 responsiveness Effects 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- HSYWOEKSALFBEK-UHFFFAOYSA-N 2,2-dioctyldecanedioic acid Chemical compound CCCCCCCCC(CCCCCCCC)(C(O)=O)CCCCCCCC(O)=O HSYWOEKSALFBEK-UHFFFAOYSA-N 0.000 description 1
- FNSVFYNYEORBIV-UHFFFAOYSA-N 2,2-dioctylhexanedioic acid Chemical compound CCCCCCCCC(C(O)=O)(CCCC(O)=O)CCCCCCCC FNSVFYNYEORBIV-UHFFFAOYSA-N 0.000 description 1
- 229910000497 Amalgam Inorganic materials 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- RMIXHJPMNBXMBU-QIIXEHPYSA-N Nonactin Chemical compound C[C@H]([C@H]1CC[C@H](O1)C[C@@H](OC(=O)[C@@H](C)[C@@H]1CC[C@@H](O1)C[C@@H](C)OC(=O)[C@H](C)[C@H]1CC[C@H](O1)C[C@H](C)OC(=O)[C@H]1C)C)C(=O)O[C@H](C)C[C@H]2CC[C@@H]1O2 RMIXHJPMNBXMBU-QIIXEHPYSA-N 0.000 description 1
- RMIXHJPMNBXMBU-UHFFFAOYSA-N Nonactin Natural products CC1C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(C)CC2CCC1O2 RMIXHJPMNBXMBU-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 150000003983 crown ethers Chemical class 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 229910052976 metal sulfide Inorganic materials 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000007784 solid electrolyte Substances 0.000 description 1
- 125000001174 sulfone group Chemical group 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
- G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Description
【発明の詳細な説明】
この発明は、イオン選択性電極に関する。さら
に詳しくは、試料による汚染が減少され耐久性に
富んだイオン感応性膜を有するイオン選択性電極
及びその製造法に関する。DETAILED DESCRIPTION OF THE INVENTION This invention relates to an ion selective electrode. More specifically, the present invention relates to an ion-selective electrode having an ion-sensitive membrane with reduced sample contamination and high durability, and a method for manufacturing the same.
近年、バリノマイシン等のニユートラルキヤリ
アーをイオン感応物質として用いたイオン選択性
電極が種々用いられるようになつてきた。そして
かようなニユートラルキヤリアーをポリ塩化ビニ
ル等の有機高分子化合物に保持させたイオン感応
性固体膜が種々提案されている。しかし、このよ
うな従来の感応膜は、有機高分子化合物をマトリ
ツクスとしているため試料による汚染が問題とな
り、例えば全血等の生体試料分析の際、タン白質
などが沈着して正常なイオン感応が阻害されると
いう問題点があつた。さらに、かような感応膜を
ガラス電極上や電子電導性又はイオン電導性物質
上に被覆して形成する場合には、薄膜で強度のあ
る膜を形成させることが困難であつた。結局、従
来の感応膜においては上記のごとく電極寿命や耐
久性において問題があつた。 In recent years, various ion-selective electrodes using neutral carriers such as valinomycin as ion-sensitive substances have come into use. Various ion-sensitive solid membranes have been proposed in which such neutral carriers are held in organic polymer compounds such as polyvinyl chloride. However, since such conventional sensitive membranes use organic polymer compounds as a matrix, contamination by samples becomes a problem. For example, when analyzing biological samples such as whole blood, proteins and other substances may deposit and disrupt normal ion sensitivity. There was a problem that it was blocked. Furthermore, when forming such a sensitive film by coating it on a glass electrode or an electronically conductive or ionically conductive material, it is difficult to form a thin and strong film. In the end, conventional sensitive films had problems in electrode life and durability as described above.
この発明はこのような従来の問題点を解消すべ
くなされたものである。この発明の発明者らは、
金属アルコキシドを加水分解して得られるガラス
様ゲル体をニユートラルキヤリアー等のイオン感
応物質のマトリツクスとして適用することに想着
し鋭意研究を行なつた結果この発明に到達した。 This invention has been made to solve these conventional problems. The inventors of this invention
The inventors came up with the idea of applying a glass-like gel obtained by hydrolyzing metal alkoxides as a matrix for ion-sensitive substances such as neutral carriers, and as a result of intensive research, they arrived at this invention.
かくしてこの発明によれば、金属アルコキシド
を加水分解して得られるガラス様ゲル体をイオン
感応物質のマトリツクスとして用いてなるイオン
選択性電極が提供される。 Thus, according to the present invention, an ion-selective electrode is provided that uses a glass-like gel obtained by hydrolyzing a metal alkoxide as a matrix of an ion-sensitive substance.
この発明における金属アルコキシドとしてはガ
ラス製造分野やセラミツクス製造分野で知られた
金属のアルコキシドが種々適用でき、具体的には
Si（OCH3）4、Si（OC2H5）4、Ti（OC3H7）4、Ｖ
（OC2H5）3、NaOCH3、Al（OC3H7）3等の低級ア
ルコキシ金属が挙げられ、通常低級アルコキシシ
ランを用いるのが適当である。これら二種以上の
混合物を用いてもよい。 As the metal alkoxide in this invention, various metal alkoxides known in the glass manufacturing field and ceramic manufacturing field can be used, and specifically,
Si ( OCH3 ) 4 , Si( OC2H5 ) 4 , Ti ( OC3H7 ) 4 , V
Examples include lower alkoxy metals such as (OC 2 H 5 ) 3 , NaOCH 3 , and Al(OC 3 H 7 ) 3 , and it is usually appropriate to use lower alkoxysilanes. A mixture of two or more of these may also be used.
一方、この発明におけるイオン感応物質として
は、当該分野で公知のものが種々適用でき具体的
にはニユートラルキヤリアーとして知られたバリ
ノマイシン、ノナクチン、グラミシンジン、クラ
ウンエーテル類などが挙げられ、これ以外に第４
級アンモニウム基、スルホン基等も適用できる。
これらは目的のイオンに応じて適宜選択される。 On the other hand, various ion-sensitive substances known in the art can be used as the ion-sensitive substance in this invention, and specific examples include valinomycin, nonactin, gramicindin, and crown ethers, which are known as neutral carriers. Fourth
Class ammonium groups, sulfone groups, etc. can also be applied.
These are appropriately selected depending on the target ion.
この発明の感応膜は、かようなイオン感応物質
を、前記金属アルコキシドを加水分解して生成す
る水酸化金属化合物又はその縮合物からなるガラ
ス様ゲル体に保持させたものである。かようなゲ
ル体は、ガラス様であり従来の有機高分子化合物
に比して化学的に安定でありタン白質などを沈着
し難く、汚染が少ない。従つてイオン感応物質の
イオン感応性が汚染によつて阻害されにくく電極
寿命や耐久性が従来よりも優れたものである。 The sensitive membrane of the present invention has such an ion-sensitive substance held in a glass-like gel body made of a metal hydroxide compound or a condensate thereof produced by hydrolyzing the metal alkoxide. Such a gel body is glass-like and chemically stable compared to conventional organic polymer compounds, is less likely to deposit proteins, and is less contaminated. Therefore, the ion sensitivity of the ion-sensitive material is less likely to be inhibited by contamination, and the electrode life and durability are superior to those of conventional electrodes.
この発明のイオン選択性電極は、通常、金属ア
ルコキシドと、所望のイオン感応物質と可塑剤と
を含む溶液をイオンセンサー基材に塗着し、金属
アルコキシドを加水分解してガラス様ゲル体とす
ることにより得られる。上記溶媒としては通常、
揮発性溶剤又はその含水物を用いるのが適当であ
る。例えば揮発性溶剤としてはメタノールやエタ
ノール、THF等が挙げられる、勿論、混合溶媒
であつてもよい。溶媒のPHは例えば金属アルコキ
シドとして低級アルコキシシランを用いた際には
弱酸性とするのが加水分解の点で適当である。ま
た可塑剤としてはジブチルフタレート、ジオクチ
ルセバシン酸、ジオクチルアジピン酸等の公知の
ものが任意に用いられる。 The ion-selective electrode of the present invention usually involves coating an ion sensor substrate with a solution containing a metal alkoxide, a desired ion-sensitive substance, and a plasticizer, and hydrolyzing the metal alkoxide to form a glass-like gel body. It can be obtained by The above solvent is usually
It is suitable to use volatile solvents or their hydrated forms. For example, volatile solvents include methanol, ethanol, THF, etc. Of course, mixed solvents may also be used. For example, when a lower alkoxysilane is used as the metal alkoxide, it is appropriate to make the pH of the solvent weakly acidic from the viewpoint of hydrolysis. Further, as the plasticizer, known ones such as dibutyl phthalate, dioctyl sebacic acid, dioctyl adipic acid, etc. can be used as desired.
このような溶液はイオンセンサー基材に塗着さ
れる。被膜の厚みは金属アルコキシドの濃度によ
つて適宜決定される。塗着された金属アルコキシ
ドは加水分解によつてガラス様ゲル体を形成す
る。かような加水分解は通常、溶媒の蒸散と共に
常温下で進行する。例えば、低級アルコキシシラ
ンを用いた際には常温放置と共に加水分解が進行
し、生成するSi（OH）4によつてガラス様ゲル体が
形成される。このようにしてガラス様ゲル体をイ
オン感応物質のマトリツクスとするイオン感応性
膜を形成させることができる。 Such a solution is applied to the ion sensor substrate. The thickness of the coating is appropriately determined depending on the concentration of metal alkoxide. The applied metal alkoxide forms a glass-like gel body by hydrolysis. Such hydrolysis usually proceeds at room temperature with evaporation of the solvent. For example, when lower alkoxysilane is used, hydrolysis progresses as it is left at room temperature, and a glass-like gel body is formed by the generated Si(OH) 4 . In this way, it is possible to form an ion-sensitive membrane using a glass-like gel as a matrix of an ion-sensitive substance.
この方法におけるイオンセンサー基材として
は、上記溶液を塗着できる担体、例えばガラス膜
を備えた電極筒を用いるのが適当であり、通常予
め作製した又は市販のガラス電極筒のガラス感応
膜上に塗着してゲル膜を形成し適宜内部極や内部
液を具備させるのが簡便である。勿論予め感応膜
自体を作成しておき、これを電極筒先端に張設し
て作製してもよい。これにより所謂、固体膜型電
極を得ることができる。 As the ion sensor substrate in this method, it is appropriate to use a carrier to which the above solution can be applied, such as an electrode tube equipped with a glass membrane. It is convenient to apply it to form a gel film and provide an internal electrode and an internal liquid as appropriate. Of course, the sensitive membrane itself may be prepared in advance and stretched over the tip of the electrode cylinder. As a result, a so-called solid film type electrode can be obtained.
また、銀、白金等の金属リード線にアマルガム
や固体電解質（例えば、遷移金属のハロゲン化物
や硫化物）等の電子電導性又はイオン電導性の物
質層を被覆しこれを基材として溶液を塗布しゲル
状膜を形成することによりコーテイツドワイヤー
型のイオン選択性被覆型電極を簡便に得ることが
できる。さらにガラス細管内壁に溶液を被覆放置
してゲル化させることによりフロースルー型のイ
オン選択性固体膜電極を簡便に得ることができ
る。また、液膜型電極の多孔性膜として適用して
もよい。 In addition, metal lead wires such as silver or platinum are coated with a layer of electronically conductive or ionically conductive material such as amalgam or solid electrolyte (for example, transition metal halides and sulfides), and a solution is applied using this as a base material. By forming a gel-like membrane, a coated wire type ion-selective coated electrode can be easily obtained. Furthermore, a flow-through type ion-selective solid membrane electrode can be easily obtained by coating the inner wall of a glass capillary with a solution and allowing it to gel. Moreover, it may be applied as a porous membrane of a liquid film type electrode.
上記方法によれば、溶液状の原料を用いている
ため粘度調節等によつて簡便に薄膜のイオン感応
性膜を形状を問わず形成することができる。そし
て、得られた感応膜はガラス様であるが、従来の
ガラス電極のように高温加熱を行なつていないた
めイオン感応物質も分解、変質することはなく、
優れたイオン感応性を示すものである。 According to the above method, since a raw material in the form of a solution is used, a thin ion-sensitive film can be easily formed regardless of the shape by adjusting the viscosity or the like. The resulting sensitive membrane is glass-like, but since it is not heated to high temperatures like conventional glass electrodes, the ion-sensitive material will not decompose or change in quality.
It shows excellent ion sensitivity.
以下、この発明を実施例により説明する。 This invention will be explained below with reference to Examples.
実施例 １
バリノマイシン４mgをTHF0.6mlに溶解した。
Si（OC2H5）4、エタノール、水及び塩酸（1N）を
重量比10：10：４：１の割合で混合した混合物
0.1mlと、ジブチルフタレート0.01mlと上記バリ
ノマイシン溶液とを混合して均一な溶液を得た。
この溶液をNa+イオン選択性電極筒２のイオン感
応面３にハケ塗りし、室温で２時間風乾し均一な
ガラス様ゲル体からなるイオン感応性固体膜４を
形成させた。次いでAg／AgCl／Ag2Sからなる
内部極５及び1N−NaCl水溶液からなる内部液６
を具備させることによりこの発明のイオン選択性
固体膜電極１を得た。Example 1 4 mg of valinomycin was dissolved in 0.6 ml of THF.
A mixture of Si(OC 2 H 5 ) 4 , ethanol, water and hydrochloric acid (1N) in a weight ratio of 10:10:4:1
0.1 ml of dibutyl phthalate, 0.01 ml of dibutyl phthalate, and the above valinomycin solution were mixed to obtain a homogeneous solution.
This solution was brushed onto the ion-sensitive surface 3 of the Na + ion-selective electrode tube 2 and air-dried at room temperature for 2 hours to form an ion-sensitive solid film 4 made of a uniform glass-like gel. Next, an internal electrode 5 consisting of Ag/AgCl/Ag 2 S and an internal liquid 6 consisting of a 1N-NaCl aqueous solution are formed.
The ion-selective solid membrane electrode 1 of the present invention was obtained by providing the following.
この電極のK+イオンに対する応答性を、Ag／
AgClを内部極とし飽和KCl溶液を内部液とする
参照電極を用いて測定した結果（25℃）を第２図
に示す。 The responsiveness of this electrode to K + ions was determined by Ag/
Figure 2 shows the results of measurements (at 25°C) using a reference electrode with AgCl as the internal electrode and saturated KCl solution as the internal solution.
このように、K+イオン濃度10-4〜100の範囲で
直線性を示し、その傾きは30mV／decadeであつ
た。 Thus, linearity was exhibited in the K + ion concentration range of 10 -4 to 100 , and the slope was 30 mV/decade.
このようなこの発明の電極はイオン感応物質の
選択により、種々の陽イオン（Ne+、K+、Cs+、
Tl+等）や陰イオン（Cl-等）の選択性電極とす
ることもできる。 The electrode of the present invention can handle various cations (Ne + , K + , Cs + ,
It can also be used as a selective electrode for Tl +, etc.) or anions (Cl -, etc.).
第１図は、この発明のイオン選択性電極を例示
する構成説明図、第２図はこの発明のイオン選択
性電極の応答性を例示するグラフである。
１…イオン選択性固体膜電極、２…Na+イオン
選択性電極筒、３…イオン感応面、４…イオン感
応性固体膜、５…内部極、６…内部液。
FIG. 1 is a configuration explanatory diagram illustrating the ion-selective electrode of the present invention, and FIG. 2 is a graph illustrating the responsiveness of the ion-selective electrode of the present invention. DESCRIPTION OF SYMBOLS 1... Ion-selective solid membrane electrode, 2... Na + ion-selective electrode cylinder, 3... Ion-sensitive surface, 4... Ion-sensitive solid membrane, 5... Internal electrode, 6... Internal liquid.
Claims (1)
ラス様ゲル体をマトリツクスとしてなり、このガ
ラス様ゲル体にニユートラルキヤリアーからなる
イオン感応物質を保持してなるイオン選択性電
極。 ２ 金属アルコキシドの一種又は二種以上、ニユ
ートラルキヤリアーからなるイオン感応物質及び
可塑剤を含有する溶液をイオンセンサー基材に塗
着し、金属アルコキシドを加水分解してガラス様
ゲル体からなるイオン感応性膜を形成させること
を特徴とするイオン選択性電極の製造法。[Scope of Claims] 1. An ion-selective electrode comprising, as a matrix, a glass-like gel obtained by hydrolyzing a metal alkoxide, and holding an ion-sensitive substance comprising a neutral carrier in the glass-like gel. 2 A solution containing one or more metal alkoxides, an ion-sensitive substance consisting of a neutral carrier, and a plasticizer is applied to the ion sensor substrate, and the metal alkoxide is hydrolyzed to form ions consisting of a glass-like gel body. A method for producing an ion-selective electrode characterized by forming a sensitive membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57134313A JPS5924246A (en) | 1982-07-31 | 1982-07-31 | Ion selective electrode and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57134313A JPS5924246A (en) | 1982-07-31 | 1982-07-31 | Ion selective electrode and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5924246A JPS5924246A (en) | 1984-02-07 |
| JPH0254502B2 true JPH0254502B2 (en) | 1990-11-21 |
Family
ID=15125373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57134313A Granted JPS5924246A (en) | 1982-07-31 | 1982-07-31 | Ion selective electrode and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5924246A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5405220B2 (en) * | 2009-07-10 | 2014-02-05 | 株式会社堀場製作所 | Ion selective electrode |
-
1982
- 1982-07-31 JP JP57134313A patent/JPS5924246A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5924246A (en) | 1984-02-07 |
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