JPH0256063B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to feed additive compositions. More specifically, the present invention relates to a feed additive composition that protects substances that are effective for living organisms so that they pass through the rumen of ruminants and are eluted from the abomasum onwards. Ruminants have various microorganisms living symbiotically in their rumen, and by borrowing their functions, they are able to digest and utilize components such as cellulose that are normally not available to higher animals. The existence and function of the rumen is extremely important for ruminants. However, in recent years, physiological and nutritional research on ruminants has pointed out the existence of the rumen as one of the factors that restricts the productivity of ruminants. In other words, substances effective for the living body that we do not want to be broken down in the rumen pass through the rumen, and are broken down and absorbed in the fourth stomach and beyond, thereby making more efficient use of the substances effective for the living body. There is a lot of research going on. In addition, the livestock industry, which is aiming for more efficient management, is hoping for the development of a technology that allows it to pass through the rumen, and several methods have been proposed, but none of them are sufficiently effective. do not have. For example, also German patent no.
No. 2212568 describes coating biologically active substances with coatings consisting of aliphatic monocarboxylic acids having 14 to 22 carbon atoms or ricinoleic acid or mixtures of such acids or salts of such acids or mixtures of such acids. The ivy particle shape is shown. Japanese Patent Publication No. 56-1057 also describes biologically active substances as saturated linear or branched substituted or unsubstituted aliphatic monocarboxylic acids having at least 14 carbon atoms or salts thereof; coated with a matrix consisting of a mixture of a saturated acid or its salt and an unsaturated linear or branched substituted or unsubstituted aliphatic monocarboxylic acid having at least 14 carbon atoms or its salt. It shows. JP-A-56-154956 also discloses that a biologically effective substance is provided with a coating containing a salt of an aliphatic monocarboxylic acid having 14 to 22 carbon atoms or a mixture of several of said acids. It shows something in the form of particles. Furthermore, JP-A-58-175449 describes biologically active substances as linear or branched saturated or unsaturated monocarboxylic acids having 14 to 22 carbon atoms, hydrogenated vegetable fats and hydrogenated animal fats. This figure shows one surrounded by a protective substance coating containing one or more substances selected from sexual fats and chitosan. However, German Patent No. 2212568,
In No. 56-1057, it is expected that the disintegration of the coating substance will occur after the small intestine, so there are restrictions on the time available for digestion and absorption, which has the disadvantage that sufficient digestion and absorption will not occur. are doing. Furthermore, in order to overcome the above-mentioned drawbacks, JP-A-56-154956 and JP-A-58-175449 use a coating material that disintegrates in the abomasum and elutes substances that are effective for living organisms. However, the disintegration effect of the coating material within the abomasum is not sufficient, and the effect cannot be said to be stable. That is, the reality is that there is still no satisfactory feed additive that passes through the rumen and dissolves from the abomasum onwards. As a result of various studies under the above circumstances, the present inventors unexpectedly found that a linear or branched saturated or unsaturated monocarboxylic acid having 14 or more carbon atoms or a salt thereof, or a melting point of 40°C or more In addition to at least 10% by weight of at least one substance selected from animal fats and oils, vegetable oils and fats with a melting point of 40°C or higher, or waxes with a melting point of 40°C or higher (hereinafter, this substance is abbreviated as a protective substance), The present inventors have completed the present invention by discovering that a granulated feed additive composition containing at least 20% by weight of calcium carbonate has excellent performance without the above-mentioned drawbacks. The present invention will be explained in more detail below. The animals targeted by the feed additive of the present invention are ruminants, typical examples of which are beef cattle, dairy cattle, calves, sheep, and goats. In the present invention, substances that are effective for living organisms include nutrients, feed containing nutrients, and drugs, which are not consumed by microorganisms in the rumen but are absorbed into the ruminant's own body from the abomasum onwards. For example, amino acids, amino acid derivatives,
proteins, vitamins, enzymes, carbohydrates, veterinary drugs,
Representative examples of hormones include amino acids such as methionine, lysine, threonine, leucine, isoleucine, tryptophan, phenylalanine, valine, and glycine, and amino acid derivatives such as N-acyl amino acids such as N-stearoylmethionine or N-oleoylmethionine, calcium salt of N-hydroxymethylmethionine, lysine hydrochloride, methionine hydroxy analogue, sodium glutamate, protein, and can also be applied to feather powder, fishmeal, casein, corn protein or potato protein. Furthermore, vitamins include vitamin A ₁ , vitamin A palmitate, vitamin A acetate, β-carotene, vitamin D ₂ , vitamin D ₃ , vitamin E, menadione sodium bisulfite, vitamin B group (thiamine, thiamine hydrochloride, riboflavin). , nicotinic acid, nicotinamide, calcium pantothenate, choline pantothenate, pyridoxine hydrochloride, choline chloride, cyanocobalamin, biotin, folic acid, para-aminobenzoic acid); Enzymes include protease agents, amylase agents, mixed enzyme agents, and lipase agents. Carbohydrates include starch, glucose, and sucrose. Veterinary drugs include antibiotics such as tetracyclines, aminoglycosides, macrolides, polypeptides, polysaccharides, and polyethers, and anthelmintics such as Negufuon. Deworming agent, piperazine salt, etc.
Hormones include estrous hormones such as estrogen, stilbestrol, and hexestrol;
Examples include thyroid hormones such as thyroprotein and goitolodiene. Generally, one type of these is used, but a mixture of two or more types can also be used. The calcium carbonate used in the present invention is heavy,
It may be of any light type and is contained in an amount of 20% by weight or more based on the total amount of the feed additive composition of the present invention. If it is less than 20% by weight, it will be difficult to control the solubility of substances that are effective for living organisms, and sufficient effects will not be obtained.
Furthermore, if this amount is increased excessively, the amount of the active ingredient will decrease and sufficient effects will not be obtained in carrying out the present invention. In addition, the amount of protective substances is 10% by weight or more. If the amount is less than 10% by weight, there will be a problem in the stability of substances that are effective for living organisms in the rumen, and sufficient effects will not be obtained. Furthermore, if the amount is increased excessively, there are problems such as a decrease in the amount of the active ingredient and difficulty in dissolving it in the abomasum, making it impossible to obtain sufficient effects. Methods for producing the feed additive composition of the present invention include rolling granulation method, extrusion granulation method, compression granulation method such as tablet molding, melt granulation method, spray granulation method, flow granulation method, Examples include methods of forming into pellets, particles, and tablets using granulation techniques such as crushing granulation and stirring granulation. Further, a binder or the like may be added depending on the case. The feed additive composition of the present invention is usually used by directly adding it to feed, but it can also be added and mixed in advance, for example, during the production of compound feed. As described above, the feed additive of the present invention has an excellent property of passing through the rumen of ruminants and eluting from the abomasum onwards, and the calcium carbonate contained is itself effective as a calcium source. Therefore, it is extremely useful industrially. Hereinafter, the present invention will be explained in more detail with reference to Examples. In addition, parts in the examples are parts by weight, and % is weight %. Examples 1 to 4 Comparative Examples 1 and 2 After uniformly mixing materials having the compositions shown in Table 1 using a ribbon mixer, pellets having a diameter of 2 mm and a length of 3 mm were produced using a pelletizer.
Using the obtained pelleted feed additive composition, a dissolution test of DL-methionine under artificial ruminal fluid and artificial abomasal fluid was conducted. 0.1M sodium phosphate buffer was used as the artificial ruminal fluid, and 0.1N hydrochloric acid was used as the artificial abomasal fluid. For the dissolution test, 5 g of the pellets prepared above were immersed in an Erlenmeyer flask containing 100 ml of artificial ruminal fluid or artificial abomasal fluid, kept at 39°C with a shaking device, and after shaking for a predetermined period of time, each eluted DL- Methionine was measured by iodometry. The shaking time was 10 hours for the artificial ruminal fluid and 3 hours for the artificial abomasal fluid. Table 1 shows the blending ratios and dissolution test results for each Example and each Comparative Example. Example 5 Pellets were produced in the same manner as in Examples 1 to 4 using 25% by weight of DL-methionine, 25% by weight of stearic acid, and 50% by weight of calcium carbonate, and a dissolution test was conducted. The amount of methionine eluted was 17% under artificial ruminal fluid and 84% under artificial abomasal fluid. Examples 6 and 7 Pellets containing nicotinic acid amide were produced in the same manner as in Examples 1 to 5. The N content of the eluted nicotinic acid amide was measured by the Kjeldahl method. The blending ratios and results are shown in Table 2.

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Claims (1)

[Claims] 1. A feed additive composition containing at least one substance that is effective for living organisms, containing 20% by weight or more of calcium carbonate, and a linear or branched saturated or unsaturated monomer having 14 or more carbon atoms. Granules containing 10% by weight or more of at least one substance selected from carboxylic acids or salts thereof, animal fats and oils with a melting point of 40°C or higher, vegetable oils and fats with a melting point of 40°C or higher, or waxes with a melting point of 40°C or higher. A feed additive composition characterized by: