JPH0315882B2 - - Google Patents
Info
- Publication number
- JPH0315882B2 JPH0315882B2 JP5501987A JP5501987A JPH0315882B2 JP H0315882 B2 JPH0315882 B2 JP H0315882B2 JP 5501987 A JP5501987 A JP 5501987A JP 5501987 A JP5501987 A JP 5501987A JP H0315882 B2 JPH0315882 B2 JP H0315882B2
- Authority
- JP
- Japan
- Prior art keywords
- toothbrush
- porous
- medicinal
- brush
- porous substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000126 substance Substances 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 9
- 150000004676 glycans Chemical class 0.000 claims description 9
- 229920001282 polysaccharide Polymers 0.000 claims description 9
- 239000005017 polysaccharide Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 230000007721 medicinal effect Effects 0.000 description 7
- 229920001661 Chitosan Polymers 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 231100000405 induce cancer Toxicity 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 231100001081 no carcinogenicity Toxicity 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Landscapes
- Brushes (AREA)
Description
【発明の詳細な説明】
〔産業上の利用分野〕
この発明は、各種薬効を有する歯ブラシに関す
るものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a toothbrush having various medicinal effects.
従来の歯ブラシは、それ自体は薬効を有さず、
歯を磨く際には必ず歯みがきをつけるものとされ
てきた。従つて、歯ブラシ自体に各種薬効を付与
することができれば、歯みがきが不要になり非常
に便利になる。しかし、歯ブラシの刷毛に薬効を
付与し、しかも長時間薬効を安定して持続させる
ことは困難であつた。さらに発がん性がないこ
と、炎症やアレルギーを起こさないこと等安全性
の点からも現実は困難であつた。
Conventional toothbrushes have no medicinal properties in and of themselves;
It has been said that you should always apply toothpaste when brushing your teeth. Therefore, if a toothbrush itself could be endowed with various medicinal effects, brushing the teeth would become unnecessary and would be extremely convenient. However, it has been difficult to impart medicinal efficacy to toothbrush brushes and to maintain the medicinal efficacy stably for a long period of time. Furthermore, it has been difficult to achieve safety in terms of safety, such as non-carcinogenicity and non-inflammation and allergy-inducing properties.
そこで、この発明はそれ自体薬効を有しかつ長
時間持続し、しかも安全性を有する歯ブラシを提
供することを目的としている。
Therefore, it is an object of the present invention to provide a toothbrush that has medicinal effects in itself, lasts for a long time, and is safe.
この発明は、歯ブラシにおいて、多糖類、タン
パク質あるいはこれらの誘導体からなる多孔性質
物質を少なくとも刷毛組成の一部に有し、多孔性
物質には適宜薬剤を固定してあり、この刷毛を少
なくとも植毛の一部に含むものである。
This invention provides a toothbrush that has at least a part of the brush composition made of a porous substance made of polysaccharide, protein, or a derivative thereof, and has an appropriate drug immobilized on the porous substance. This is included in part.
この発明は、歯ブラシの刷毛組成の少なくとも
一部に多孔性物質を有し、この多孔生物質に適宜
薬剤を固定しているので、歯ブラシに薬効を付与
することができ、長時間徐々に薬剤を放出させる
ことができる。
This invention has a porous substance in at least a part of the brush composition of the toothbrush, and the medicinal agent is appropriately immobilized on this porous biomaterial, so that the medicinal effect can be imparted to the toothbrush, and the medicinal agent can be gradually applied over a long period of time. can be released.
多孔性物質は多糖類、タンパク質あるいはこれ
らの誘導体から構成されており、これらの多糖類
等は天然由来の高分子であるので高い安全性を有
する。 The porous substance is composed of polysaccharides, proteins, or derivatives thereof, and these polysaccharides are naturally derived polymers and therefore have high safety.
次に、この発明の一実施例を図面に基づき説明
する。
Next, one embodiment of the present invention will be described based on the drawings.
この発明に係る歯ブラシは、多糖類、タンパク
質あるいはこれらの誘導体からなる多孔性物質を
少なくとも刷毛組成の一部に有し、多孔性物質に
は適宜薬剤を固定してあり、この刷毛を少なくと
も植毛の一部に含むものである。 The toothbrush according to the present invention has a porous substance made of polysaccharide, protein, or a derivative thereof in at least a part of the brush composition, and an appropriate drug is immobilized on the porous substance, and the brush is made of at least a flocked material. This is included in part.
この発明における多糖類としては、キチン、キ
トサン、セルロース、デキストラン、アガロー
ス、デンプン等の一種あるいは二種が好ましい。
特にキトサンやジヤガイモデンプン由来の多孔性
物質は有効である。これらの誘導体としては、例
えばこれらのイオン交換性の誘導体、疏水性基を
もつ誘導体、タンニンを結合させた融合体であ
る。 The polysaccharide used in this invention is preferably one or two of chitin, chitosan, cellulose, dextran, agarose, starch, and the like.
Porous materials derived from chitosan and potato starch are particularly effective. Examples of these derivatives include ion-exchangeable derivatives, derivatives with hydrophobic groups, and tannin-bonded fusion products.
この発明におけるタンパク質としては、グルテ
ン、絹糸等である。 Proteins in this invention include gluten, silk thread, and the like.
多糖類あるいはその誘導体から多孔性物質を製
造するには、例えばキトサンでは低分子量キトサ
ンを酸性溶液に溶解し、この溶解液を塩基性溶液
中に落下して凝固粒状化している。このようにし
て得られた粒状多孔性キトサンは、粒度が揃つて
おり、均一な微細孔を有し比表面積が大きいの
で、各種薬剤の固定化能が高い。 To produce a porous substance from a polysaccharide or its derivative, for example, chitosan is produced by dissolving low molecular weight chitosan in an acidic solution, and dropping this solution into a basic solution to coagulate it into granules. The granular porous chitosan thus obtained has a uniform particle size, uniform micropores, and a large specific surface area, so it has a high ability to immobilize various drugs.
このような多孔質物質を少なくとも刷毛組成の
一部に有する刷毛を製造するには、多孔性物質
（例えば上記粒状多孔性キトサンでは粒径が１〜
15μｍ、比表面積２〜５m2／ｇのもの）のみある
いはナイロン等の合成樹脂との混合物を成形機か
ら糸状に押し出し、25μｍ程度の線径にする。 In order to manufacture a brush having such a porous material as at least a part of the brush composition, it is necessary to use a porous material (for example, in the case of the above-mentioned granular porous chitosan, the particle size is 1 to 1.
15 μm and a specific surface area of 2 to 5 m 2 /g) or a mixture with a synthetic resin such as nylon is extruded from a molding machine into a thread shape to a wire diameter of about 25 μm.
次にこのようにして製造した刷毛に薬剤を含浸
させ、多孔性物質に薬剤を固定させる。薬剤とし
ては、例えば、歯槽膿漏を予防する水溶性アズレ
ン、歯垢、口臭を防ぐグルコン酸クロルヘキシジ
ン、歯ぐきを強化するビタミンＥ、収れん剤等で
ある。固定手段としては、物理吸着や官能基（ア
ミノ基、カルボキシル基、水酸基、イミダゾール
基、フエノール基、スルフヒドリル基等）による
共有結合である。 Next, the brush thus produced is impregnated with a drug, and the drug is fixed in the porous material. Examples of drugs include water-soluble azulene to prevent alveolar pyorrhea, chlorhexidine gluconate to prevent dental plaque and bad breath, vitamin E to strengthen the gums, and astringents. Immobilization means include physical adsorption and covalent bonding by functional groups (amino group, carboxyl group, hydroxyl group, imidazole group, phenol group, sulfhydryl group, etc.).
図面に示す歯ブラシ１は、このようにして薬効
を付し刷毛２を歯ブラシ１の頭部３に植毛したも
のである。植毛に当つては、薬効を付与し刷毛の
みを使用するほか、ナイロン等の合成毛や豚毛、
白馬毛のような天然毛を加えて混合にしてもよ
い。 The toothbrush 1 shown in the drawings has bristles 2 with medicinal properties implanted in the head 3 of the toothbrush 1 in this way. For hair transplantation, in addition to using only brushes with medicinal properties, synthetic hair such as nylon, pig hair,
Natural hair such as white horse hair may be added to the mixture.
以上のようにして構成された歯ブラシは、使用
中に薬剤が多孔性物質から分離放出されるので、
長時間安定した薬効を持続する。また、多孔性物
質には、多糖類等の天然由来の高分子を使用して
いるので、がんを誘発したり、口内の炎症やアレ
ルギーを引き起すことはない。 In the toothbrush constructed as described above, the drug is separated and released from the porous material during use.
Maintains stable medicinal efficacy for a long time. Furthermore, since the porous material uses naturally derived polymers such as polysaccharides, it does not induce cancer or cause oral inflammation or allergies.
この発明は、多孔性物質を少なくとも刷毛組成
の一部に有し、多孔性物質に薬剤を固定している
ので、歯ブラシ自体に薬効を付与することができ
ると共に長時間その薬効を持続させることができ
る。
This invention has a porous substance in at least a part of the brush composition and fixes the drug to the porous substance, so it is possible to impart medicinal efficacy to the toothbrush itself and maintain the medicinal efficacy for a long time. can.
また、多孔性物質は多糖類、タンパク質あるい
はこれらの誘導体から構成しているので、高い安
全性を有する。 Furthermore, since the porous substance is composed of polysaccharides, proteins, or derivatives thereof, it has high safety.
図面はこの発明に係る歯ブラシの一実施例を示
す斜視図。
１……歯ブラシ、２……刷毛。
The drawing is a perspective view showing an embodiment of the toothbrush according to the present invention. 1...Toothbrush, 2...Brush.
Claims (1)
からなる多孔性物質を少なくとも刷毛組成の一部
に有し、多孔性物質には適宜薬剤を固定してあ
り、この刷毛を少なくとも植毛の一部に含むこと
を特徴とする歯ブラシ。1 At least a part of the brush composition includes a porous substance made of polysaccharide, protein, or a derivative thereof, and an appropriate drug is immobilized on the porous substance, and this brush is included in at least a part of the flocked hair. A distinctive toothbrush.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5501987A JPS63220804A (en) | 1987-03-10 | 1987-03-10 | Toothbrush |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5501987A JPS63220804A (en) | 1987-03-10 | 1987-03-10 | Toothbrush |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63220804A JPS63220804A (en) | 1988-09-14 |
| JPH0315882B2 true JPH0315882B2 (en) | 1991-03-04 |
Family
ID=12986954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5501987A Granted JPS63220804A (en) | 1987-03-10 | 1987-03-10 | Toothbrush |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63220804A (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5520924A (en) * | 1993-07-09 | 1996-05-28 | Mizu Systems Corporation | Methods and articles for administering drug to the oral cavity |
| US5605756A (en) * | 1993-09-14 | 1997-02-25 | Gmz Holding Company | Disposable toothbrush having mint flavored toothpaste composition bonded to bristles thereof |
| BRPI0906452A2 (en) * | 2008-02-08 | 2015-07-14 | Colgate Palmolive Co | Composition, device, method for producing or inhibiting the formation of dental caries, reducing, repairing or inhibiting pre-carious enamel lions, reducing or inhibiting demineralization and promoting tooth remineralization, reducing tooth hypersensitivity, reducing or inhibiting tooth decay. gingivitis, promote healing of wounds or cuts in the mouth, reduce levels of acid-producing bacteria, increase relative levels of arginolytic bacteria, inhibit composition formation, device, method to reduce or inhibit formation of dental caries, reduce , repair or inhibit pre-caries enamel lions, reduce or inhibit demineralization and promote tooth remineralization, reduce tooth hypersensitivity, reduce or inhibit gingivitis, promote wound healing or cuts in the mouth, reduce levels of acid-producing bacteria, increase relative levels of arginolytic bacteria, inhibit microbial biofilm formation o In the oral cavity, raise and / or maintain plaque ph to at least 5.5 ph levels, reduce plaque buildup, treat, relieve or reduce dry mouth, clean teeth and oral cavity, reduce erosion, teeth whitening, immunizing teeth against cariogenic bacteria, and / or promoting systemic health, including cardiovascular health, and use of a basic amino acid |
| CN107307579A (en) * | 2017-06-21 | 2017-11-03 | 青岛容商天下网络有限公司 | Degradable chitosan toothbrush of automatically cleaning and preparation method thereof |
| EP4422457A4 (en) * | 2021-10-28 | 2025-12-24 | Tfh Publications Inc | PET TOOTHBRUSH |
-
1987
- 1987-03-10 JP JP5501987A patent/JPS63220804A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63220804A (en) | 1988-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4795421A (en) | Oral hygiene swab | |
| ES2241134T3 (en) | BIOFUNCTIONAL POLYMERS PREPARED IN A SUPERCRITICAL FLUID. | |
| CN111093595B (en) | Compositions and medical devices comprising antimicrobial particles | |
| RU2697881C2 (en) | Stabilizing zinc oxide film in compositions for oral care | |
| US20020081555A1 (en) | Systems for treating teeth | |
| CA2129422A1 (en) | Improved Flavored Dental Cleaning Article and Method | |
| CN104870179B (en) | Buffer microcapsule compositions and methods | |
| ATE82118T1 (en) | SOLID AND POROUS UNIT FORM CONTAINING MICROPARTICLES AND/OR NANOPARTICLES AND PROCESS FOR THEIR MANUFACTURE. | |
| JPH07500035A (en) | Water-based gel wound dressings and packaging | |
| FI972546A0 (en) | Cross-linked microparticles and their use as therapeutic aids | |
| ZA200505363B (en) | Oral care compositions and methods | |
| DE68915132D1 (en) | Process for the treatment of periodontitis by protracted drug delivery of medicinal products in the tooth cavity, composition thereof and device for administration. | |
| CA2711974A1 (en) | Edible film-strips with modified release active ingredients | |
| CA2711932A1 (en) | Edible film-strips for immediate release of active ingredients | |
| CA2296654A1 (en) | Tannic acid-polymer compositions for controlled release of pharmaceutical agents, particularly in the oral cavity | |
| JP2004536032A5 (en) | ||
| Thangavelu et al. | An overview of chitosan and its role in periodontics | |
| Shirbhate et al. | Injectable and self-invigorating hydrogel applications in dentistry and periodontal regeneration: A literature review | |
| JPH0315882B2 (en) | ||
| Priyadarsini et al. | Application of nanoparticles in dentistry: Current trends | |
| CN102885698A (en) | Ultra-micro colloidal powder with core- shell structure and preparation method and application thereof | |
| KR102800110B1 (en) | Buffer microencapsulation composition and method | |
| ES2828973T3 (en) | Personal dental care product for caries treatment | |
| US6030213A (en) | Device and method for local application of a medicament to a gingiva | |
| DE69002822D1 (en) | PHARMACEUTICAL PREPARATION FOR ORAL ADMINISTRATION IN LIQUID FORM. |