JPH0331468B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a radiopharmaceutical liquid dispensing device, particularly a radiopharmaceutical liquid dispensing device for dispensing a medical radiochemical liquid from a container to a syringe.
The present invention relates to a radiopharmaceutical liquid dispensing device that has a function of injecting a radiochemical liquid dispensed into a syringe into a mixing container and stirring it as necessary.

[Conventional technology]

In recent years, radiological diagnosis, in which radioisotopes (RI) are administered into a patient's body and used as a tracer, has become popular. In this case, since radioactivity is emitted from the chemical solution itself, there is an extremely high risk that the operator will be exposed to radiation during handling.

FIG. 8 shows a conventional method for dispensing this type of chemical solution. In Figure 8, 1 is a container containing a radioactive drug solution (hereinafter referred to as RI) (vial bottle), 2 is a shield made of lead etc. to prevent radioactivity from being released outside (vial shield), and 3
4 is a syringe for dispensing the required amount of RI, 4 is a shield made of lead etc. that is placed over the cylinder part of syringe 3 to prevent radioactivity from escaping, 5
is a lead glass that allows the scale of the syringe inside to be seen.

The operator holds the syringe 3 equipped with the shield 4 in his hand, sticks the needle into the mouth of the container 1, and inserts the piston 3a.
After pulling the needle and dispensing the required amount of RI, the needle is removed and injected directly into the patient.

In addition, when mixing with other solutions or powders, the RI dispensed into the syringe 3 as described above was injected into the mixing container containing these solutions or powders and stirred. .

[Problem to be solved by the invention]

However, in the conventional dispensing method described above, even though the shields 2 and 4 are installed, they are not perfect, so radioactivity leaks, and since it is manual operation, the operator is exposed to radiation during the dispensing process. It was inevitable.

The present invention provides a radiopharmaceutical liquid dispensing device that automatically performs dispensing operations, injection operations for mixing, and stirring operations, thereby minimizing radiation exposure to the operator.

[Means to solve the problem]

In order to achieve the above object, the radiopharmaceutical solution dispensing device of the present invention includes a container holding means for setting and holding a container containing a medical radiopharmaceutical solution at a predetermined position relative to the needle of a syringe in an inverted state; a syringe holding means that is arranged vertically movably below the container holding means and holds a syringe with a needle facing upward; and a piston end that is arranged vertically movably on the syringe holding means and holds a piston end of the syringe. a holding means, a mixing container setting means installed below the first piston end holding means at a predetermined position with respect to the needle of the syringe with the mixing container erected; and a mixing container setting means for vertically moving the syringe holding means. a first elevating mechanism for inserting and retracting the needle of the syringe into and out of the stopper of the container and the mixing container; and a second elevating mechanism that moves the piston end holding means up and down to inject the medicinal solution into the syringe and to pour out the medicinal solution from the syringe. the elevating mechanism, these syringe holding means, the first
a rotation mechanism that rotates the syringe held by the syringe holding means by half a rotation while maintaining the respective arrangement relationships of the elevating mechanism, the piston end holding means, and the second elevating mechanism; the container holding means; the first elevating mechanism; It includes a second elevating mechanism, a rotation mechanism, and a control unit that controls the operation of the mixing container installation means, and automatically dispenses the radiochemical solution dispensed from the container into the syringe into the mixing container.

In the radiopharmaceutical liquid dispensing device configured as described above, the syringe holding means is provided with a pressure sensor on the mounting table on which the syringe main body is placed, and the needle of the syringe is attached to the container held by the container holding means. When the syringe holding means comes into contact with the mouth, the syringe holding means may be further raised by a predetermined height based on the pressure detected by the pressure sensor.

Further, the container holding means may be provided with a centering mechanism for automatically setting the container at a predetermined central position, so that containers having different diameters can be held by the container holding means.

Furthermore, the mixing container installation means is provided with a centering movable mechanism that moves in any horizontal direction on the installation base on which the mixing container is installed, and aligns the center of the mixing container with the position of the needle tip of the syringe. The mixing container may be caused to perform a stirring motion by a movable mechanism.

[Operation] According to a preset program, the syringe is first raised by the first elevating mechanism and the needle of the syringe is inserted into the mouth of the container set at the top, and then the second
The elevating mechanism lowers the piston of the syringe to extract the necessary amount of RI, and in this state, the elevating mechanism first lowers the syringe and pulls out the needle of the syringe from the mouth of the container. Then, the rotation mechanism rotates the syringe half a turn, the first elevating mechanism lowers the syringe, inserts the needle of the syringe into the mouth of the mixing container set at the bottom, and then the second elevating mechanism lowers the syringe piston. lower it and inject the RI into the mixing container. In this state, the syringe is raised by the first elevating mechanism, and further rotated by a half turn by the rotation mechanism to return to its original state. If necessary, the mixing container is stirred by the centering movable mechanism. By performing this kind of operation, the required amount of RI can be dispensed automatically.
Opportunities for radiation exposure to the operator can be minimized.

An embodiment of the present invention will be described below with reference to the drawings.

〔Example〕

Fig. 1 is a schematic perspective view showing the main parts of the present invention, Fig. 2 is a configuration explanatory view explaining the structure of the main parts in the background, and Fig. 3 is a perspective view showing the elevating mechanism. , FIG. 4 is an explanatory diagram of the X-Y movement mechanism of the container holder, FIG. 5 is an explanatory diagram of the centering mechanism of one embodiment of the container holder, and FIG. 6 is an explanatory diagram of the centering mechanism of another embodiment of the container holder. 7 shows a front view of FIG. 6.

In FIG. 1, 11 is a housing, and the housing 1
A container holder 12 is provided on the upper part of the container 1 . The container holder 12 holds a container 13 containing RI (a vial bottle and a vial shield) in an inverted state, and the center is always set at a predetermined position even if the diameter of the container 13 is different. It includes a centering mechanism 14 and a centering movable mechanism section 15 that moves the centering mechanism 14. In the center of the housing 11, the rotary plate 16 is rotated half a turn.
That is, a rotation mechanism 17 that rotates 180 degrees is provided. The rotation mechanism 17 uses a motor 18 fixed to the housing 11 as a drive source, and the rotation of the rotary plate 16 is controlled by a timing belt 19 and a pulley 20. A notch 21 is provided in the center of the rotary plate 16, and a syringe holder 22 moves freely up and down in the notch 21.
is installed. The needle 2 is attached to the syringe holding part 22.
It is adapted to hold a syringe 24 with 3 facing upward. 25 is a shield made of lead that covers the cylinder portion of the syringe 24; 26 is a lead glass provided so that the scale of the syringe 24 can be seen; 27 is the syringe 2;
This is a piston end holding part that holds the end of the piston 28 of No. 4. Shield 2 attached to syringe 24
5 has an iron plate on the back, and the syringe holding part 2
A magnet is embedded in the part of 2 that faces this, allowing the syringe to be easily attached and detached. Reference numeral 22a denotes a syringe mounting table, which is bifurcated so that the piston 28 of the syringe 24 can be inserted into the syringe mounting table 22a. A pressure sensor (not shown) is embedded in each of the forks, and when pressure is applied to the syringe 24, the pressure sensor detects the applied pressure.

A centering movable mechanism 29 similar to the centering movable mechanism 15 used in the container holder 12 is provided at the lower end of the casing 11, and the centering movable mechanism 29 is provided with a mixing container (a vial and a vial shield). Installation board 3 for installing 30
2 is provided. A hole is formed in the installation plate 32, and the mixing container 30 is installed in the hole formed in the installation plate 32.
By pulling out the installation plate 32 from the installation plate guide 32-a, the mixing container 30 can be easily taken out. If the mixing containers 30 have different diameters, it is possible to use a variety of mixing containers by preparing several types with holes that match the diameters of the mixing containers 30. becomes. A needle position detection sensor 33 is provided directly above the mixing container 30, and the centering movable mechanism 29 moves according to the position of the needle 23 of the syringe 24 detected by the needle position detection sensor 33. ing. Note that 42 and 45 are pulse motors.

Next, in FIG. 2 illustrating the structure of the main part of the back side, 34 is a rack fixed to the rotating plate 16, and has a groove in the center as will be described later. 35 is a grooved rail fixed to the rotating plate 16, 36 is a grooved rack fixed to the panel of the syringe holding part 22, and 37 is a grooved rail fixed to the panel of the syringe holding part 22. be.
38a to 38d are rotatable wheels provided on the panel of the syringe holder 22, and are engaged with the grooves of the rack 34 or the grooves of the rail 35. 39a-39d
is a rotatable wheel provided on the panel of the piston end holding portion 27, and is connected to the groove of the rack 36 or the rail 37.
is engaged with the groove of 40 and 41 are pulse motors, and 42 is a limit switch.

The rack 34, the rail 35, the wheels 38a to 38d, and the pulse motor 40 constitute an elevating mechanism (first elevating mechanism) for the syringe holder 22.
The main part is shown enlarged in FIG. That is, the four rotatable wheels 38a to 38d provided on the panel of the syringe holder 22 are connected to the groove 43a of the rack 34.
is engaged with the groove 43b of the rail 35, and on the other hand,
A pinion 44 connected to a pulse motor 40 fixed to the panel of the syringe holding part 22 via a built-in speed reducer meshes with the teeth of the rack 34, so that the rotation of the pulse motor 40 causes the syringe holding part to rotate. 22 goes up and down. Similarly, Rack 36,
The rail 37, the wheels 39a to 39d, and the pulse motor 41 constitute an elevating mechanism (second elevating mechanism) for the piston end holder 27 relative to the syringe holder 22. The elevating mechanism having the above-mentioned structure is characterized in that it moves smoothly and generates extremely little noise compared to a mechanism using a worm gear or the like.

Furthermore, in FIG. 2, 46 is a container holding plate;
7 is a moving plate, 48 is a needle position detection sensor section, 49,
50 is a pulse motor fixed to the top plate 51 of the casing for moving the moving plate 47; 52 is a mixing container holding plate; 53 is a moving plate; 54 and 55 are movable motors fixed to the bottom plate 56 of the casing. This is a pulse motor for moving the plate 53. The mixing container holding plate 52
The installation plate 32 described in FIG. 1 is fixed on top via an installation plate guide 32-a. The needle 23 attached to the syringe does not always align with the axis of the syringe. Therefore, if the needle tip is attached with the needle tip deviated from the axis, the syringe will be deviated from the mouth of the container 13 even if the syringe is raised as it is. Therefore, it is necessary to detect the position of the needle tip and move the container to match it.

FIG. 4 shows the moving mechanism, that is, the centering moving mechanism. Arms 57a, 57b, and 57c are rotatably provided on the top plate 51 of the casing, and their rotation axes are connected to pulse motors 49 and 50 shown in FIG. 2, and pulse motor 42 shown in FIG. 1, respectively. has been done. Arms 57a, 57
b, 57c have rotatable wheels 58a, 57c, respectively.
58b, 58c are attached, and these wheels engage with long holes 59a, 59b, 59c formed in the moving plate 47 (see FIG. 1). The moving plate 47 rides on rollers 60a, 60b, 60c arranged on the top plate 51 of the casing, is biased in the direction of arrow P by a spring or the like (not shown), and moves the limit switches 61a, 61.
The initial position is set by b and 61c. When aligning the tip of the needle 23 of the syringe with the opening of the container, the arm 57c is driven by the pulse motor 42.
is rotated to move the movable plate 47 by a predetermined amount in the X direction, and further, by driving the pulse motors 49 and 50, the arms 57a and 57b are rotated to move the movable plate 47 by a predetermined amount in the Y direction.

The centering movable mechanism section 29 provided on the housing bottom plate 56 shown in FIG. 2 is also completely similar to the centering movable mechanism section 15 described above. The centering movable mechanism section 29 can stir the mixing container 30 according to a program.

FIG. 5 shows an explanatory diagram of the centering mechanism provided in the container holding part, and shows the motor mounting plate 71.
A motor 72 is fixed to the shaft of the motor 72, and a worm 73 is fixed to the shaft of the motor 72. A gear 76 is fixed to a shaft 75 of a worm wheel 74 that meshes with the worm 73, and two movable shafts 77 and 78 are respectively engaged with the gear 76 via gear grooves. These two movable shafts 77, 7
8 is pivotally supported by a fixed plate 79, and the fixed plate 79 is fixed to the motor mounting plate 71. A shaft support plate 80 fixing one end 77a of the movable shaft 77
supports another movable shaft 78 in a movable manner,
A clamping plate 81 is attached to the shaft support plate 80,
The tip of the clamping plate 81 is formed into a dogleg shape. Similarly, a shaft support plate 82 fixing one end 78a of the movable shaft 78 movably supports the other movable shaft 77, and is attached to the shaft support plate 82.
The tip of the clamping plate 83 is formed into a dogleg shape.
By rotating the motor 72, the movable shaft 7
7 and 78 always move in opposite directions with respect to the fixed plate 79 by the same amount of movement. Therefore, two clamping plates 8
If the container 13 is placed between 1 and 83, the container 13
Regardless of the diameter of the clamping plates 81 and 83, they are guided to the doglegged ends of the clamping plates 81 and 83, and centering is always possible. That is, the center of the container 13 can always be set at the center of the hole 84 into which the needle 15 of the syringe enters.

FIG. 6 shows an explanatory view of another centering mechanism, and FIG. 7 is a front view thereof. Figure 6,
In FIG. 7, a motor mounting plate 92 is attached to a mounting plate 91.
A motor 93 is fixed via. A pulley 94 is fixed to a shaft 98 of the motor 92, and a timing belt 95 is wound around the pulley 94. The timing belt 95 has four pulleys 9 rotatably attached to a mounting plate 91.
6 is hung on a belt so that it rotates. 4
A blade 97 is fixed to each pulley 96.

When the motor 93 rotates, the four pulleys 96 are rotated at a constant speed by the timing belt 95, so that the blades 97 fixed to each pulley 96 swing around the pulley 96. Therefore, the container 1 is placed in the four blades 97.
When the container 13 is placed, the center position of the container 13 is always set at a constant position by the four blades 97.

Next, the operation of this embodiment will be explained. First, the container 13 containing RI is placed upside down on the container holding plate 46, and the mixing container 30 is placed on the installation plate 32 and set on the installation plate guide 32-a.
The centering mechanism 14 is activated to center the container 13. Next, the syringe holder 22 with the syringe set therein is raised by the first elevating mechanism. When the needle tip of the syringe 24 reaches the upper chain line A shown in the needle position detection sensor section 48 in FIG. 2, the syringe holding section 22 temporarily stops. Therefore, the needle position is detected by the sensor disposed at the level of the lower chain line B shown in the needle position detection sensor section 48, and the pulse motors 42, 49, 50 are operated correspondingly to adjust the position of the movement plan 47. will be held. After the needle position matches the position of the opening of the container 13, the syringe holding part 22 is raised again by the first elevating mechanism, and the needle 2
3 comes into contact with the mouth of the container 13. At this time, a pressure sensor (not shown) embedded in the bifurcation of the syringe mounting table 22a detects the contact between the needle 23 and the opening of the container 13, and based on this detection, the syringe holder 22 stops at that position again. do. Then, the syringe holder 22 is raised by a certain height by the first lifting mechanism, and the needle 23 is inserted into the mouth of the container 13. When the needle 23 rises by a certain height based on the detection of the pressure sensor, the needle 23 moves at the same pitch as the thickness of the plug provided at the mouth of the container 13, and the RI of the container 13 increases. This function makes the most effective use of liquid and works to ensure that there is no residual liquid in the container 13. Next, the second elevating mechanism is activated, and the piston end holder 27 that holds the end of the piston of the syringe 24 is lowered to dispense the required amount of RI into the syringe 24. In this state, the first elevating mechanism is operated to lower the syringe holder 22, the needle 24 comes out of the opening of the container 13, and when it descends to a certain position, it stops. Next, the rotation mechanism 17 is activated, and the rotating plate 16 rotates half a rotation and then stops. That is, the needle 23 of the syringe 24 is directed downward. The syringe holding part 22 is lowered by the first elevating mechanism, the position of the needle tip is detected by the needle position detection sensor part 33 in the same way as when dispensing from the container 13, and the centering movable mechanism part 29 is moved. The needle 23 is operated to match the position of the needle 23 with the opening of the mixing container 30. Then, the syringe holding part 2 is lifted up by the first lifting mechanism.
2 is lowered again and the needle tip is inserted into the opening of the mixing container 30. Next, the second elevating mechanism is activated, and the piston end holder 27 that holds the end of the piston of the syringe 24 is lowered to inject the RI dispensed into the syringe 24 into the mixing container 30. In the state
The first elevating mechanism operates, the syringe holding part 22 rises, the needle 23 comes out of the mouth of the mixing container 30,
After the syringe holding part 22 rises to a certain height, it stops. Next, the rotation mechanism 17 is operated, and the rotation plate 1
Turn 6 half a turn and stop. In other words, it returns to the initial state. Thereafter, the centering movable mechanism section 29 is operated as necessary to cause the mixing container 30 to perform a stirring motion. When the stirring movement is performed for a certain period of time,
The centering movable mechanism section 29 stops, and one cycle ends.

The above operations are executed under the control of a pre-programmed control section (not shown).

In this embodiment configured as described above, the container 13
The RI dispensed into the syringe 24 is automatically dispensed into the syringe 24, and the RI dispensed into the syringe 24 is injected into the mixing container 30, and is automatically stirred as necessary. Chances of radiation exposure are greatly reduced.

〔Effect of the invention〕

As explained above, according to the present invention, by employing a two-stage elevating mechanism and a rotating mechanism,
Dispensing, injecting, and stirring RI are performed automatically and with high precision, minimizing radiation exposure to the operator.

In addition, since a pressure sensor is used in the syringe holder, dispensing can be performed without leaving any RI in the container, allowing for the most effective dispensing.

[Brief explanation of drawings]

Fig. 1 is a schematic perspective view showing the main parts of the present invention, Fig. 2 is a configuration explanatory view showing the structure of the main parts on the back side, and Fig. 3 is a perspective view showing the elevating mechanism. , FIG. 4 is an explanatory diagram of the X-Y moving mechanism of the container holder, FIG. 5 is an explanatory diagram of the centering mechanism of one embodiment of the container holder, and FIG. 6 is an explanatory diagram of the centering mechanism of another embodiment of the container holder. 7 shows a front view of FIG. 6, and FIG. 8 shows a dispensing explanatory diagram explaining a conventional dispensing method. In the figure, 12 is a container holding part, 13 is a container, 14 is a centering mechanism, 15 is a centering movable mechanism part, 17 is a rotation mechanism, 22 is a syringe holding part, 23
is a needle, 24 is a syringe, 27 is a piston end holder,
29 represents a centering movable mechanism, and 30 represents a mixing container.

Claims (1)

[Scope of Claims] 1. Container holding means for setting and holding a container containing a medical radioactive drug solution at a predetermined position relative to the needle of a syringe in an inverted state; and a container holding means that is movable vertically downwardly. a syringe holding means for holding a syringe with a needle facing upward; a piston end holding means provided on the syringe holding means so as to be movable up and down and holding a piston end of the syringe; and a lower part of the piston end holding means. a mixing container setting means that is installed at a predetermined position relative to the needle of the syringe with the mixing container erected; a first elevating mechanism for inserting and retracting the piston end into and out of the stopper; a second elevating mechanism for moving the piston end holding means up and down to inject the drug solution into the syringe and pour out the drug solution from the syringe; a rotation mechanism that rotates the syringe held by the syringe holding means by half a rotation while maintaining the respective arrangement relationships of the first lifting mechanism, the piston end holding means, and the second lifting mechanism; the container holding means and the first lifting mechanism; , a second elevator groove, a rotation mechanism, and a control unit for controlling the operation of the mixing container installation means, and the radiation drug solution dispensed from the container into the syringe is automatically injected into the mixing container. Features of radiopharmaceutical liquid dispensing device. 2. In the radiopharmaceutical liquid dispensing device according to claim 1, the syringe holding means is provided with a pressure sensor on the mounting table on which the syringe body is placed, and the needle of the syringe is placed in contact with the opening of the container held by the container holding means. A radiation drug solution dispensing device that further raises the syringe holding means by a predetermined height based on the pressure detected by the pressure sensor. 3. The radiochemical liquid dispensing device according to claim 1 or 2, wherein the container holding means is provided with a centering mechanism for automatically setting the container at a predetermined central position. 4. In the radiopharmaceutical liquid dispensing device according to any one of claims 1 to 3, the mixing container installation means includes a centering movable mechanism that moves the installation plate on which the mixing container is installed in any horizontal direction, and A radiopharmaceutical solution dispensing device configured to center the mixing container at the previous position and to perform a stirring motion on the mixing container using the centering movable mechanism.