JPH0338860B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Field of Industrial Application The present invention relates to a bladder drug solution continuous infusion catheter that has the function of continuously injecting a drug solution into the bladder.

(B) Prior Art Conventionally, there are bladder catheters that are partially indwelled in the bladder and urethra for use in bladder cleansing or drug treatment. The typical bladder catheter has a triple duct with a total length of approximately 40cm, and has a drug solution outlet and a urine inlet at the tip, a balloon attached near these, and a balloon at the proximal end for inflating the balloon. A distilled water inlet, a urine outlet for discharging urine, and a medicinal solution inlet for injecting a medicinal solution are provided, respectively. The balloon is inflated near the junction between the bladder and urethra, which prevents the catheter from slipping out of the bladder.

Examples of uses of conventional typical bladder or urethral balloon catheters will be described below.

In the case of treatment for urinary tract infections, bladder irrigation with antibacterial agents is conventionally performed for chronic cystitis caused by a catheter, but the effect is temporary and the treatment costs are high. When antibiotics and antibacterial agents are administered systemically, side effects may occur and are difficult to treat. Therefore, there is a need for a simple and inexpensive local treatment method.

In the case of bladder cancer treatment, there are reports that intravesical infusion of anticancer drugs is effective for bladder cancer. It is also said to be effective in preventing recurrence of bladder cancer. The anticancer drug is dissolved in 20 to 30 ml of physiological saline and injected into the bladder. However, the anticancer drug can only be stored in the bladder for about two hours at most due to urine retention, and it is physiologically impossible to tolerate it longer than that.
Therefore, the effective use of the drug solution is only about 2 hours, which increases the treatment cost. Therefore, there is a need for a catheter that can continuously inject a medicinal solution for a long period of time.

Therefore, as a method for injecting drug solution into the bladder for a relatively long period of time, a syringe is connected to the drug solution inlet of the catheter, and the syringe is operated manually, by a spring, or electrically to cause the drug solution to flow out, or by using a drip bottle or A chemical solution was placed in a container and then flowed out by natural dripping or electric power.

When a drug solution is injected into the bladder over a period of several minutes to several hours, the syringe or drip bottle serving as the drug supply source must be connected to the injection needle or catheter for that length of time, which is a problem for both the patient and the practitioner. It caused many inconveniences.

For example, in the case of manual connection injection, the patient and practitioner are restrained and fixed for a certain period of time, which causes great pain both physically and mentally. In reality, the limit is said to be 1 to 2 minutes. Even if electric power or springs are used, it is necessary to secure a power source and install a syringe, which limits the patient's movements.

In the case of continuous infusion of a drug solution through an intravenous drip, a large amount of replacement fluid is required compared to the drug solution. In this case, the drip bottle or container must be placed higher than the patient, and a complicated and long conduit is required to connect the catheter and the drip bottle, which restricts the patient's body movements and hinders treatment. It was also necessary for the personnel to conduct appropriate inspections.

(c) Problems to be Solved by the Invention The problems to be solved by the present invention are to provide a simple structure, easy handling, and safety when injecting a medicinal solution into the human body for a relatively long period of time. The object of the present invention is to obtain a bladder drug solution continuous infusion catheter with high performance.

(d) Means for Solving the Problems The bladder drug solution continuous infusion catheter of the present invention utilizes a conventional general bladder catheter. The basic structure of the bladder catheter is that it has a urine drainage passage along its longitudinal axis, and a urine inlet is provided at the distal end of the urine drainage passage, and a urine outlet is provided at the proximal end of the urine drainage passage. This basic structure is modified as follows as necessary. In the first modification, a balloon is attached to the distal end of the catheter to prevent the catheter from falling off, and distilled water is supplied to the balloon from the proximal end of the catheter to expand and contract the balloon. In the second modification, in order to clean the inside of the bladder or urethra, a medicinal solution is supplied from the proximal end of the catheter, and the medicinal solution flows out from the distal end of the catheter. The third modification is a combination of the first and second modifications.

The bladder drug solution continuous infusion catheter of the present invention is any of the bladder catheters described above, in which a recess is provided in a part of the outer periphery of the proximal end of the catheter, and the recess is surrounded by a balloon made of an elastic material. The periphery of the balloon is airtightly fixed to the outer periphery of the catheter, a thin tube is provided in the tube wall of the catheter along the longitudinal axis, and the distal end side of the thin tube is opened to form a drug solution outlet. The proximal end of the thin tube is communicated with the recess, a drug solution injection part is airtightly fixed to the center of the balloon, a central passage is provided in the center of the drug solution injection part, and the entrance of the central passage is fixed to the center of the balloon. The above problem is solved by a configuration in which a valve is provided on the side and the outlet side is communicated with the recess.

The present invention modifies the above-mentioned bladder drug solution continuous infusion catheter, connects a drug solution injection part to the proximal end side of the catheter further than the attachment position of the balloon, and provides a communication path in the proximal tube wall of the catheter. The above-mentioned problem is also solved by a configuration in which one end of the communication passage is provided and the other end is communicated with the outlet side of the central passage.

The present invention further improves the above-mentioned bladder drug solution continuous infusion catheter, and provides a branch part on a part of the outer periphery of the proximal end of the catheter, a central passage in the central part of the branch part, and a central passage at the proximal end of the thin tube. one end of a balloon made of an elastic material is airtightly fixed to the branching part, and a drug solution injection part is fixed to the other end in an airtight manner, and the drug solution injection part's central passage The above problem is also solved by a configuration in which the outlet side of the balloon is communicated with the balloon.

(E) Example FIGS. 9A to 9D are longitudinal cross-sectional views of typical conventional bladder catheters to which the present invention is applied.
Figures 0 to 13 are cross-sectional views of each figure in Figure 9.

Before describing embodiments of the bladder drug solution continuous infusion catheter of the present invention, the structure and function of a conventional bladder catheter will be briefly explained.

The bladder catheter 1a shown in FIGS. 9A and 10 is provided with a urine conduction passage 11 along its longitudinal axis, and has a urine inlet 111 at its distal end and a urine inlet port 111 at its proximal end. A discharge port 112 is provided respectively. When the catheter 1a is indwelled in the body, a stopper 113 is usually attached, and the stopper 113 is removed as necessary to allow urine to be urinated as needed.

The bladder catheter 1b shown in FIGS. 9B and 11 is obtained by adding an intravesical indwelling balloon 12, a distilled water injection part 13, and a distilled water conduit 14 to the bladder catheter 1a described above.

The intravesical indwelling balloon 12 is provided at a predetermined distance from the distal end of the catheter 1b, and the distilled water injection part 13 is provided in a branched manner at the proximal end of the catheter 1b. A distilled water conduit 14 provided in the tube wall along the longitudinal axis of the catheter 1b communicates between the balloon 12 and the distilled water inlet 14.

A valve 131 is provided at the inlet of the distilled water inlet 13 . When distilled water is injected into the distilled water injection part 13 by opening the valve 131 using a conventional syringe or the like (not shown), the distilled water passes through the distilled water conduit 14 and flows into the balloon 12. Inflate as shown by the two-dot chain line. Valve 131 prevents distilled water from flowing out.

By indwelling the balloon 12 in the bladder near the connection port with the urethra and inflating the balloon, the catheter 1b is prevented from falling out. Catheter 1
When drawing b out of the body, insert the syringe etc. into the valve 13.
If the catheter 1b is inserted into the balloon 1b and distilled water is sucked from inside the balloon 12, the balloon 12 will deflate as it returns, so the catheter 1b can be easily pulled out of the body.

The bladder catheter 1c shown in FIGS. 9c and 12 is the bladder catheter 1a described above provided with a drug solution inlet 15 and a drug solution guide path 16. The drug solution injection part 15 is provided in a branched manner at the proximal end of the catheter 1c. A drug fluid guide path 16 is provided in the tube wall along the longitudinal axis of the catheter 1c. The distal end side of the conduction path 16 opens to the outside to form a chemical liquid outlet 161. The proximal end side of the conduction path 16 communicates with the drug solution injection part 15 .

A valve 151 is provided at the injection port of the chemical liquid injection section 15 . The drug solution is injected through the valve 151 using a conventional syringe (not shown), passes through the drug solution guide path 16, and flows into the bladder from the drug solution outlet 161.

A bladder catheter 1d shown in FIGS. 9D and 13 is a combination of the aforementioned catheters 1b and 1c.

Although the present invention can be applied to any of the catheters 1a to 1d described above, for convenience of explanation, an example applied to the catheter 1a will be described below.

FIG. 1 is a longitudinal sectional view of a bladder drug solution continuous infusion catheter 20 according to a first embodiment of the present invention.
The same reference numbers as in catheter 1a indicate the same parts or parts.

In the catheter 20 of this embodiment, as shown in a partially enlarged view in FIG. 20 in an airtight manner. Balloon 2
A drug solution injector 23 is connected to the central portion of the device 2 . The outlet of the central passage 231 of the drug solution injection part 23 is connected to the annular groove 2.
Connects to 1. A valve 23 is installed on the inlet side of the central passage 231.
2 is provided.

The balloon 22 is preferably made of a wear-resistant, high-toughness material that has high elasticity and is not easily damaged by external forces. In particular, transparent or translucent materials are preferred. For example, commercially available silicone rubber or latex rubber is suitable as such a material.

As shown in FIG. 2, the balloon 22 is attached to the catheter 2
The catheter 20 is in close contact with the outer periphery of the catheter 20, and when the catheter 20 is in operation after the drug solution has been injected, the remaining portion expands away from the outer periphery of the catheter 20, leaving only the periphery 221, as shown in FIG.

The balloon 22 is basically spherical, but can be formed into any shape to match the shape of the part of the human body where it will be used. For example, as shown in FIG. 8, it may be in the shape of a flat ellipsoid.

A capillary tube 24 is provided in the tube wall of the catheter 20 along its longitudinal axis. The thin tube 24 is open at its distal end to form a drug solution outlet 241, and communicates with the annular groove 21 at its proximal end.

The valve 232 is open when a conventional syringe or the like (not shown) is inserted and a medicinal solution is injected, but when the syringe or the like is withdrawn, the valve 232 functions to prevent the medicinal solution from flowing out from the injection port.

Since the thin tube 24 is an important factor for determining the drug solution injection time, which will be described later, it is provided separately from the drug solution guide path 16 of the catheter 1c or 1d described above. Therefore, the drug solution injection section 23 is also provided separately from the drug solution injection section 15 described above. Thin tube 24
The diameter and length of the pipe are the main factors that determine the resistance of the pipe. Since the length of the capillary tube 24 is approximately constant, the line resistance is determined by changing the diameter of the capillary tube 24.

The annular groove 21 is preferably provided along the entire circumference of the catheter 20 to ensure that the medical fluid flows evenly and quickly into the balloon 22 during the initial injection of the medical fluid. However, if the catheter 20 and the balloon 22 are sufficiently separable, or if a sufficient gap is provided between them from the beginning, the annular groove 21 will ensure communication with the thin tube 24. It may also take the form of a localized recess or a bottomed hole to the extent possible.

When the drug solution is injected into the balloon 22, the flow rate flowing out from the thin tube 24 is extremely small compared to the amount injected into the balloon, so the drug solution quickly fills the balloon 22, and the balloon 22 is filled with the drug solution quickly.
expands as shown in FIGS. 3 and 5.

A second embodiment of a bladder catheter 30 according to the present invention is shown in FIG. In FIG. 6, the same reference numbers as in FIG. 1 indicate the same parts or parts.

In this embodiment, the drug solution injection section 23 is directly connected to the proximal end side of the catheter 30, and the drug solution injection section 23 is directly connected to the proximal end side of the catheter 30.
3 central passage 231 and annular groove 2 of catheter 30
1 is a communication path 3 provided in the tube wall of the catheter 30.
1.

The medicinal solution is supplied through the central passage 231 of the medicinal solution inlet 23, the valve 232, the communication passage 31 of the catheter 30, and the annular groove 2.
1 into the balloon 22.

A third embodiment of a bladder catheter 40 according to the present invention is shown in FIG. In FIG. 7, the same reference numbers as in FIG. 1 indicate the same parts or parts.

In this embodiment, the balloon 22 is not directly attached to the catheter 40, but is connected between the branch section 41 provided at the proximal end of the catheter 40 and the drug solution injection section 23. A central passage 411 provided in the central portion of the branch 41 communicates with the thin tube 24 of the catheter 40 .

The drug solution is directly delivered to the balloon 22 from the drug solution injection part 23.
injected into the body.

(F) Action The action will be explained using the catheter 20 shown in FIG. 1 as an example. As shown in FIGS. 1 to 4, a predetermined amount of the drug solution is injected from the drug solution inlet 23. The medicinal solution is fed through the central passage 23 of the medicinal solution injection part 23.
1, flows into the balloon 22 through the valve 232;
The balloon 22 is filled with the air while the balloon 22 is inflated. At the same time, the drug solution flows from inside the balloon 22 through the thin tube 24 and into the bladder from the drug solution outlet 241 provided at the tip of the catheter 20.

However, since the thin tube 24 is actually very thin and long (for example, 0.2 mm in diameter x 400 mm in length), it provides appropriate resistance to the flow of the chemical solution. As a result, the balloon 22 is filled with a predetermined amount of the chemical solution in a short time. Thereafter, the medical solution in the balloon 22 passes through the thin tube 24 and the medical solution outlet 241 and gradually flows into the bladder by the contraction force of the balloon itself.

The valve 232 prevents the medical solution filled in the balloon 22 from flowing backward.

The injection time of the drug solution depends on the injection amount and viscosity of the drug solution,
It is determined by the deflation characteristics of balloon 22, the diameter and length of tubule 24, and intravesical pressure. In reality, it is sufficient to actually measure the dispensing time for each catheter using a standard drug solution.

The catheter 30 shown in FIG. 6 and the catheter 40 shown in FIG. 7 also have substantially the same effect as described above.

(g) Effects The bladder drug solution continuous infusion catheter of the present invention functions as a drug solution container and a drug solution injection device, so it has a simple structure and is easy to handle. Therefore, it becomes possible to continuously inject the medicinal solution into the bladder without restricting the patient's actions and body movements, and the labor and restraint time of the practitioner can be reduced.

[Brief explanation of drawings]

FIG. 1 is a longitudinal sectional view of a bladder drug solution continuous infusion catheter according to a first embodiment of the present invention. Figure 2 is a partially enlarged view of Figure 1. FIG. 3 is a partial longitudinal sectional view showing the operating state of FIG. 2. FIG. 4 is a cross-sectional view taken from the - line in FIG. 1. FIG. 5 is a cross-sectional view taken from the - line in FIG. 1. FIG. 6 is a partially enlarged longitudinal cross-sectional view of a bladder drug solution continuous infusion catheter according to a second embodiment of the present invention. FIG. 7 is a partially enlarged longitudinal cross-sectional view of a bladder drug solution continuous infusion catheter according to a third embodiment of the present invention. FIG. 8 is a plan view showing an example of another shape of the balloon for drug solution injection. FIGS. 9A to 9D are longitudinal cross-sectional views of typical conventional bladder catheters to which the present invention is directed. FIG. 10 is a cross-sectional view taken from the - line in FIG. 9A. FIG. 11 is a cross-sectional view taken along line XI-XI in FIG. 9B. FIG. 12 is a cross-sectional view taken along line XII-XII of FIG. 9C. FIG. 13 is a cross-sectional view taken from the - line in FIG. 9D. 1a, 1b, 1c, 1d: Conventional bladder catheter, 11: Urine conduction path, 111: Urine inlet, 11
2: Urine outlet, 113: Plug, 20, 30, 40:
Bladder drug solution continuous infusion catheter of the present invention, 21:
Annular groove, 22: Balloon, 23: Chemical injection part, 2
4: Thin tube, 221: Periphery, 231: Central passage, 2
32: Valve, 241: Chemical solution outlet, 31: Communication path,
41: Branch, 411: Central passage.

Claims (1)

[Claims] 1. Having a urine drainage passage 11 along the longitudinal axis,
A bladder catheter 1 having a urine inlet 111 at the distal end of the urine conduction passage and a urine outlet 112 at the proximal end.
In a, 1b, 1c, and 1d, a recess 21 is provided in a part of the outer periphery of the proximal end of the catheter, and the recess is surrounded by a balloon 22 made of an elastic material, and the peripheral edge 221 of the balloon is attached to the catheter. A thin tube 24 is provided on the tube wall of the catheter along the longitudinal axis, the tip side of the thin tube is opened to form a drug solution outlet 241, and the proximal end of the thin tube is A drug solution injection part 23 is airtightly fixed to the center part of the balloon, and a central passage 23 is connected to the center part of the drug solution injection part.
1, a valve 23 is provided on the inlet side of the central passage, and the outlet side communicates with the recess. 2 has a urine drainage passage 11 along the longitudinal axis;
A bladder catheter 1 having a urine inlet 111 at the distal end of the urine conduction passage and a urine outlet 112 at the proximal end.
In a, 1b, 1c, and 1d, a recess 21 is provided in a part of the outer periphery of the proximal end of the catheter, and the recess is surrounded by a balloon 22 made of an elastic material, and the peripheral edge 221 of the balloon is attached to the catheter. A thin tube 24 is provided on the tube wall of the catheter along the longitudinal axis, the tip side of the thin tube is opened to form a drug solution outlet 241, and the proximal end of the thin tube is A drug solution injection part 23 is connected to the proximal end side of the catheter further than the balloon attachment position, and a central passage 231 is provided in the center of the drug solution injection part. A valve 23 is provided on the entry side, a communication passage 31 is provided on the proximal tube wall of the catheter, and one end of the communication passage communicates with the recess and the other end communicates with the exit side of the central passage. Continuous infusion catheter for bladder medication. 3 having a urine drainage passage 11 along the longitudinal axis;
A bladder catheter 1 having a urine inlet 111 at the distal end of the urine conduction passage and a urine outlet 112 at the proximal end.
a, 1b, 1c, and 1d, a branch part 41 is provided at a part of the proximal outer periphery of the catheter, a central passage 411 is provided in the central part of the branch part, and the catheter is provided with a central passage 411 along the longitudinal axis. Tube 2 on the tube wall
4, the distal end side of the capillary tube is opened to form a drug solution outlet 241, the proximal end side of the capillary tube is communicated with the central passage, and one end of the balloon 22 made of an elastic material is airtightly connected to the branch section. A liquid medicine injection part 23 is fixed to the other end in an airtight manner, a central passage 231 is provided in the center of the liquid injection part, a valve 23 is provided on the inlet side of the central passage, and the outlet side is connected to the balloon. A bladder drug solution continuous infusion catheter consisting of a communicating structure.