JPH0340008B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a tobacco and tobacco composition, and more specifically, although it contains alcohol, it does not cause irritation to the oral mucous membranes, which is characteristic of alcohol, and is effective against tobacco tobacco and has the sterilizing and disinfecting effects inherent to alcohol. The present invention relates to tobacco and tobacco compositions. It has been well known that ethanol and propanol have sterilizing and disinfecting effects. However, these alcohols have the fatal drawback of strongly irritating the skin, oral mucous membranes, etc. when put into the mouth or when disinfecting wounds. As a result of intensive research in view of the current situation, the present inventors have discovered that the specific compound below has the effect of eliminating the irritation of alcohol without impairing its original bactericidal and disinfecting effect, and furthermore, The blended alcohol composition removes tobacco and garlic,
They also found that it is effective in removing bad breath and preventing tooth decay, and completed the present invention. The present invention was completed based on these new findings, and the gist thereof is to add a) polyoxyethylene mono to ethanol and/or propanol, which is acceptable as a food additive or pharmaceutical additive. Oleate, glycerin monofatty acid ester, propylene glycol fatty acid ester,
A polyhydric alcohol derivative selected from propylene glycol fatty acid ester, polyoxyethylene sorbitan monooleate, sucrose fatty acid ester, polyoxyethylene nonylphenol ether, and trimethylolpropane fatty acid ester,
The present invention relates to a tobacco and chicken composition characterized in that it contains at least one member selected from the group consisting of b) an amino acid having one or two carboxyl groups, and c) benzyl benzoate. Ethanol and propanol used as main components in the composition of the present invention include anhydrous ethanol containing 99.5 V/V% or more of ethanol listed in the Japanese Pharmacopoeia, which is conventionally known as a sterilizing agent;
Examples include disinfectant ethanol, isopropanol and n-propanol. In addition, the compounds that can be blended with the above-mentioned alcohol and achieve the desired effect of the present invention were selected by the present inventor from a wide range of compounds through intensive research, and include a specific polyhydric alcohol derivative, one or two It belongs to the group consisting of amino acids having a carboxyl group and benzyl benzoate. Specific examples of the above-mentioned polyhydric alcohol derivatives and amino acids include the following compounds. <Polyhydric alcohol derivatives> From polyoxyethylene monooleate, glycerin monofatty acid ester, propylene glycol fatty acid ester, polyoxyethylene sorbitan monooleate, sucrose fatty acid ester, polyoxyethylene nonylphenol ether, and trimethylolpropane fatty acid ester At least one type selected. <Amino acids> Glycine, alanine, phenylalanine, arginine, glutamic acid, aspartic acid, histidine, etc. The above-mentioned compounds may be blended alone or in combination with alcohol in the form (solid or liquid) in which they are normally obtained to form the alcohol composition of the present invention. The blending ratio varies slightly depending on the type and form of the compound used, but for liquids,
It is in the range of 0.1 to 25 V/V%, preferably 1 to 20 V/V% relative to alcohol, and in the case of solids, it is preferably 0.05 W/V% to 25 W/V% or up to its saturated solubility. 0.1W/V
% or more and up to 10 W/V% or up to its saturation solubility. The upper limit of the above compounding ratio is not particularly critical, and the intended effect of the present invention can be achieved even if it is used beyond this limit, but normally, the more the above compound is blended, the more the resultant composition will be reduced. This results in a decrease in the alcohol content, which has the disadvantage of requiring a large amount of the composition for use.Also, if the solubility is low, there is a risk that a portion of the composition will precipitate as insoluble matter, which may interfere with the desired effect of the present invention. There is a risk that it will not contribute and be wasted. Furthermore, the composition of the present invention may contain polyhydric alcohols other than the above polyhydric alcohol derivatives. Examples of the polyhydric alcohols include ethylene glycol, propylene glycol, 1,3-butanediol, polyoxyalkylene glycol, polyoxyalkylene triol, glycerin, pentaerythritol, sorbitol, glucose, mannitol, ftectose, and sucrose. can be mentioned. The composition of the present invention thus obtained can be applied directly to the oral cavity in liquid form. In addition, the composition of the present invention contains this as an active ingredient,
It is combined with ordinary pharmaceutical carriers (excipients, diluents), etc., and if necessary, coloring agents, fragrances, flavoring agents, sweeteners, and other pharmaceuticals are added and then shaped into various pharmaceutical forms such as granules and tablets. , lozenges, pastes, gargles (liquids, suspensions, etc.), and toothpaste forms,
It can be in the form of chewing gum or the like. The carrier and other additives used in the above may be any of the commonly used ones, and specific examples include starch, calcium carbonate, sodium bicarbonate, crystalline cellulose, particulate anhydrous silica, kaolin, bentonite, and talc. , stearate, carboxymethylcellulose (CMC), methylcellulose, gelatin, polyvinylpyrrolidone, alginate, calcium phosphate, porous magnesium aluminate metasilicate,
Examples include pinyl acetate resin, menthol, thymol, cinnamon oil, cinnamon oil, peppermint oil, and saccharin. Preparation methods for the above-mentioned various forms of preparations can follow conventional methods. For example, granules, tablets, etc. are prepared by mixing the composition of the present invention with excipients, etc., and then coating with polypynyl alcohol or the like to prevent the volatilization of the alcohol, which is the active ingredient, and, if necessary, calcium stearate. You can add luster with etc. A gargle can be prepared by adding and mixing a sweetener, a coloring agent, a flavoring agent, etc. to the composition of the present invention, and diluting the mixture appropriately with water. Pastes and toothpastes are
It is prepared by mixing a binder or sizing agent such as CMC with the composition of the present invention, and kneading the mixture with fillers, extenders, and other additives. Chewing gum is a porous material such as porous magnesium aluminate metasilicate made by softening a chewing gum base material such as vinyl acetate resin in advance with ethanol, and mixing and impregnating this with the composition of the present invention and, if necessary, a sweetener, flavoring agent, etc. After kneading, the molded product is molded into a plate shape, the surface of the molded product is covered with a polyvinyl alcohol film, etc., and the product is cut into an appropriate size. The content of the composition of the present invention in the preparations prepared in the above various forms depends on the form of the preparation, the method of use, the amount of application,
It is determined as appropriate depending on the desired effect and there is no particular limitation, but it is usually about 50% by weight or more, preferably about 60 to 90% by weight per unit of the preparation. Each preparation thus prepared is applied as follows depending on its form. For example, solid drugs such as tablets can be placed in the mouth and chewed.
It can have the effect of cleaning and sterilizing the oral cavity, preventing cavities, cleaning teeth from tobacco and chicken, and removing bad breath from garlic odor. Such solid agents are usually about 1 to 3 g.
The unit form may be applied as appropriate when desired effects are required. Use liquids such as gargles at a time.
By diluting 30ml appropriately and gargling 3 times at a time, around 3 times a day, it will have an oral cleaning effect.
For example, it can be effective in curing tonsilloma, etc., cleaning teeth, removing tobacco and bitterness, removing bad breath, and preventing tooth decay. The drug in the form of toothpaste is usually applied by applying about 2 to 3 g at a time to a toothbrush or the like and brushing the teeth three or more times a day, and is effective in preventing cavities and removing tobacco residue, and can also remove bad breath. . Furthermore, by chewing one or two pieces of chewing gum at a time several times a day, the medicine in the form of chewing gum can produce the same effects as toothpaste. Various test examples conducted on the composition of the present invention are listed below. The composition of the present invention used in each test was prepared using disinfectant ethanol (ethanol) listed in the Japanese Pharmacopoeia.
Each of the following compounds No. 1 to 15 was added and dissolved in a predetermined amount to 100 ml of 830 ml of the sample (prepared by adding purified water to make a total volume of 1000 ml). In the above preparation, compounds that were not completely dissolved were heated to 80° C. in a hot water bath and then allowed to cool to remove precipitates and used in the form of a saturated liquid. <Test compound> No. Type 1 Propylene glycol monooleate 2 Polyoxyethylene monooleate 3 Polyoxyethylene nonylphenol ether 4 Glycerin monooleate 5 Trimethylolpropane fatty acid ester 6 Polyoxyethylene sorbitan monooleate 7 Yosaccharide fatty acid ester 8 Katspring Shugar (manufactured by Hayashibara Biochemical Research Institute) 9 Glycine 10 Alanine 11 L-aspartic acid 12 Glutamic acid 13 Alginic acid 14 L-Arginine/L-glutamate 15 Benzyl benzoate Above test compound No. 4 , 7 and 9-13 are as follows. Test Compound No. Solubility (%) 4 0.16 5 0.54 9 0.40 10 0.49 11 0.17 12 0.16 13 0.10 Test Taste test (mouth irritation test) Composition of the present invention containing each of the above test compounds (numbers indicate test compound No. Approximately 5 ml of each (corresponding to . Each person conducted the test three times for each composition, and the results were determined according to the following criteria, and the average value for 10 people is shown in Table 1 below. ...Strong stimulation...Stimulation +...Slight stimulation ±...Very little stimulation -...No stimulation

[Table] However, * indicates saturation.
From Table 1 above, it can be seen that test compounds Nos. 1 to 15 can eliminate the oral irritation of alcohol by mixing and dissolving them in disinfectant ethanol. Test Wound Irritation Test It is well known that when alcohol is applied to a wound to disinfect it, the alcohol irritates the wound, so-called seeping into the wound. This test was conducted to determine whether the sample composition of the present invention has irritation to wounds. The wound on the finger or foot was wiped five times using absorbent cotton soaked with about 0.5 to 1 ml of the sample composition of the present invention, and irritation to the wound was observed. The results are shown in Table 2 below.

[Table] The same test was carried out using 5 ml of isopropanol and 50 ml of purified water.
The results of compositions No. 16 to 20 of the present invention, in which a predetermined amount of the test compound was blended with a mixture of
Shown in the table.

[Table] From Tables 2 and 3 above, the composition of the present invention is
The irritation to wounds has also been eliminated, and it can be seen that it does not stain. Test Bactericidal effect test The bactericidal effect of the composition of the present invention on the following various microorganisms was investigated. <Test microorganisms> A...Streptococcus mutans B...Staphylococcus aureus C...Mycobacterium tuberculosis D...Escherichia coli E...Diprococcus pneumoniae (Diplococcus pneumoniae) F...Salmonella typhi 10 ml of each of the compositions of the present invention was placed in a test tube,
Add 1 ml of the culture solution of each of the above test microorganisms to this, and after 15 seconds, remove one platinum loop from the test tube and transfer it to the medium in another first test tube. One platinum loop was taken from the first in vitro culture medium in which the test microorganism was cultured, and transferred to the medium in the second, third, etc. test tubes, and each test tube was sequentially cultured at 37°C for 2 days. The presence or absence of growth of microorganisms is examined using the method, and the time (seconds) during which growth is inhibited, that is, the sterilization time (seconds), is determined. The results are shown in Table 4 below as the average value obtained by repeating the same test three times. The compounding amount of each test compound in the composition of the present invention is a certain amount (5 to 15 ml, 5
g or saturated dissolution amount).

【table】

[Table] When alcohol is used alone in the above test, the sterilization time for test microorganism A is 30 seconds for disinfectant ethanol, 60 seconds for 99.5% (V/V) ethyl alcohol, or absolute ethanol, and 50 seconds for 99.5% (V/V) ethyl alcohol, or absolute ethanol. %
The time was 30 seconds for isopropyl alcohol and 45 seconds for 50% n-propyl alcohol. From Table 4 above, it is clear that all of the compositions of the present invention have strong bactericidal activity against the test microorganisms. Test Tobacco tart removal effect test One end of a glass tube with an inner diameter of 18 mm is closed with paper, and from the other end all the smoke generated by the combustion of three cigarettes "pieces" is passed through the paper through the glass tube. The paper will turn brown. Cut this browned paper into a circular piece with a diameter of 15 mm to use as a test piece. The above test piece was placed in a test tube with an inner diameter of 20 mm, and 5 ml of the composition of the present invention was added thereto and shaken at a rate of 120 times per minute with an amplitude of 50 mm.After 20 minutes, the degree of decolorization of the test piece and the degree of coloration of the liquid were observed. The results are shown in Table 5 below. Table 5 also shows the results when alcohol was used alone as a control, and for comparison, methyl p-aminobenzoate and ethyl salicylate, which have been proposed to be effective against yuri, were used.

【table】

[Table] From Table 5 above, it is clear that the composition of the present invention has a tobacco and bitter effect. Test: Deodorizing effect test A person who can smell a strong garlic odor immediately after eating commercially available dumplings was asked to brush their teeth with a toothbrush for 1 minute using 3 ml of the composition of the present invention. As a result, no garlic odor was observed at a distance of 10 cm. Similarly, for people who eat commercially available dumplings and feel a strong garlic odor, 30 ml of the composition of the present invention
After gargling three times, I could not detect any garlic odor even when I came within 10 cm of the garlic. From the above test, it is clear that the composition of the present invention has a bad breath removal effect. Prescription examples of the composition of the present invention will be given below as examples. Example 1 Disinfectant ethanol 1000ml L-alanine 5g Add L-alanine to disinfectant ethanol and place in hot water bath
The mixture is heated to 80° C. to dissolve it, and after cooling to room temperature, the insoluble matter is removed to obtain the composition of the present invention in the form of a liquid. Example 2 Ethanol for disinfection 1000 ml Sugar fatty acid ester 5 g The composition of the present invention in liquid form was obtained in the same manner as in Example 1. Example 3 i-propanol 100g saccharin 0.5g erythrosine 0.01g menthol 0.02g benzyl benzoate 10g The above chemicals are mixed to obtain the composition of the present invention in the form of a mouthwash. If you dilute this drug appropriately with water and wash your mouth by gargling, etc., it will sterilize the microorganisms in your mouth that cause cavities, and it will not only eliminate bacterial contaminants caused by cigarette tar and bad breath caused by garlic and other substances, but also remove tonsils. It has the effect of preventing glandular swelling. Example 4 Chlorhexidine 4g Menthol 2g Thymol 2.5g Chlorophyte oil 1.6g Cinnamon oil 8g Disinfectant ethanol 1000ml Propylene glycol monooleate 50g The above ingredients were mixed and dissolved to obtain the mouthwash detergent of the present invention. This can provide the same effects as the mouthwash obtained in Example 3. Example 5 Disinfectant ethanol 100g Polyoxyethylene glycol 2g Glycerin monooleate 3g Fine-particle anhydrous silica 70g Satucharin 0.5g Peppermint oil 0.5g The above chemicals are uniformly kneaded to obtain the composition of the present invention in the form of a sticky paste. During dental treatment, if a rotating brush attached to a dental engine is dipped in water and brushed while rotating, it will remove the tobacco tar attached to the teeth and make the teeth clean. It is effective in sterilizing parasitic microorganisms such as Streptococcus smutans, preventing tooth decay, and eliminating bad breath. Example 6 99.5% (V/V) ethyl alcohol 75g Glycerin 15g CMC 20g Alanine 2g Fructose 5g Calcium carbonate 100g Calcium phosphate dihydrate 100g Menthol 0.5g Sodium benzoate 0.5g Water 25ml CMC was dispersed in glycerin in advance, and then Mix with water to form a viscous paste, add ethyl alcohol to this, dissolve alanine, fructose, and sodium benzoate, and then knead calcium carbonate and calcium phosphate dihydrate to form a uniform paste. Finally, a flavoring agent is added and mixed to obtain the composition of the present invention in the form of a toothpaste. This toothpaste is effective in preventing tooth decay and removing contaminants from cigarette tar and bad breath from garlic and other substances. Example 7 Ethanol for disinfection 200g Glycerin monooleate 10g Fructose 5g Vanilla flavoring 5ml Porous aluminometasilicate 1000g Magnesium (inocillin) Vinyl acetate resin 1000g Ethanol for disinfection, glycerin monooleate, and fragrance were combined with magnesium aluminate metasilicate. The porous interior of mixed magnesium aluminate metasilicate is saturated with absorption, and this is separately kneaded into vinyl acetate resin softened with disinfectant ethanol. The composition of the present invention in the form of chewing gum is obtained by covering with a vinyl alcohol film or the like to prevent volatilization of disinfectant ethanol and cutting it into an appropriate size. By chewing this chewing gum, you can prevent tooth decay, remove tooth stains caused by tobacco tar, and eliminate bad breath caused by garlic and other substances. Example 8 Ethanol for disinfection 200g Polyoxyethylene monooleate 10g Alginic acid 0.2g Porous aluminometasilicic acid 1500g Magnesium (Neusilin) Menthol 0.1g MPM 50g MPM is 2-methyl-5-vinylpyridine-methylthiacrylate and methacrylic acid (manufactured by Tanabe Seiyaku Co., Ltd.). Disinfectant ethanol, polyoxyethylene monooleate, alginic acid, and menthol are mixed and dissolved to form a homogeneous liquid, and porous magnesium aluminate metasilicate is mixed with this and the porous interior is impregnated. After kneading a viscous liquid in which MPM is dissolved in a small amount of alcohol, this is coated with polyvinyl alcohol to prevent the ethanol from volatilizing into granules or tablets, and the surface is made glossy with calcium stearate. The composition of the present invention is obtained in the form of granules or tablets. This has the effect of preventing cavities by constantly chewing, cleaning teeth contaminated with tobacco tar, and removing garlic odor.

Claims (1)

[Scope of Claims] 1. Polyoxyethylene monooleate, glycerin monofatty acid ester, propylene glycol fatty acid ester, polyoxyethylene sorbitan monooleate, which are acceptable as food additives or pharmaceutical additives, are added to ethanol and/or propanol. ate, a polyhydric alcohol derivative selected from sucrose fatty acid ester, polyoxyethylene nonylphenol ether, and trimethylolpropane fatty acid ester, an amino acid having one or two carboxyl groups, and at least one selected from the group consisting of benzyl benzoate. A tobacco and nitori composition characterized by containing one of the following. 2. The composition according to claim 1, wherein the amino acid having one or two carboxyl groups is selected from glycine, alanine, phenylalanine, arginine, glutamic acid, aspartic acid and histidine. 3. The composition according to claim 1, which is used in the form of a liquid, a gargle, a paste, a toothpaste, and a chewing gum.