JPH0351390B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a health food mainly containing millet extract, and more particularly to a health food that promotes hair growth and growth, prevents hair loss, and keeps hair healthy. The causes of alopecia and abnormal hair growth are thought to be blood circulation disorders in capillaries, aging and abnormalities in hair follicles and epidermis, and various hormonal disorders, but many things are still unknown and it is difficult to completely cure them. If it occurs in the body part, it is accompanied by cosmetic and mental pain. Conventionally, female hormones such as etradiol, estrone, and diethylstilbestrol, which act on endocrine glands, and corticoids, such as cortisone, hydrocortisone, and brednisolone, have been used to enhance the function of the adrenal cortex to treat and prevent alopecia. However, there are concerns about the systemic effects of these hormones, and they have not been able to exert sufficient effects. On the other hand, from a nutritional standpoint, vitamins such as vitamin E and biotin, amino acids such as leucine, threonine, and methionine, peripheral vasodilators such as nicotinic acid derivatives and acetylcholine derivatives, and keratin substances such as salicylic acid and resorcinol. solubilizer,
Skin function-enhancing agents such as cephalanthine, photosensitive pigments, capsicum and candalus tincture, and disinfectants such as trichlorocarbanilide and alkylisoquinolium bromide have often been used as additives to external liquids or hair cosmetics. However, sufficient effects could not be obtained. Therefore, the present inventor has conducted intensive research in order to obtain hair-nourishing substances from herbal medicine extracts, which have more hair-growth and growth effects than ever before, and which have almost no risk of side effects, compared to processed products. As a result of repeated research, we discovered that millet extract fully met our expectations, and that products containing wheat germ oil, calcium pantothenate, L-cysteine, etc. synergistically enhanced the hair-nourishing effect, and thus completed the present invention. It is something. Therefore, an object of the present invention is to provide a health food mainly containing millet extract, which promotes hair growth and growth, prevents hair loss, and maintains hair health. Another object of the present invention is to provide a health food based on millet extract that does not have side effects such as systemic hormone effects. Another object of the present invention is to provide a health food mainly containing millet extract, which can be easily formulated into capsules for oral use. The health food according to the present invention uses four types of millet extract, wheat germ extract, calcium pantothenate, and L-cystine. These extracts are made by first extracting lipids with an organic solvent such as hexane or petroleum ether, and then extracting water-soluble components with water or aqueous ethanol.
It is obtained by combining the extracts from which the solvent has been distilled off. For example, in the production of a fat-soluble extract of millet, millet seeds are ground into powder and extracted with hexane by a filtration method. The hexane extract is then distilled at normal pressure to remove hexane. Add sodium sulfate to the extract from which hexane has been removed, dry it, filter it to remove the desiccant,
Obtain the desired oily substance. For storage, a closed container is used, and the air in the container is replaced and filled with nitrogen gas to prevent oxidation. In addition, regarding the production method of water-soluble millet extract,
The hexane extraction residue of millet is used as a raw material and extracted with sugar water using filtration means. Water is evaporated from the aqueous extract solution under reduced pressure to form a viscous substance. This viscous material is further dried in a vacuum dryer to obtain the desired product. In order to have suitable properties when using this solid material,
In order to improve its fluidity, it is preferable to add high-purity soft silicic anhydride (Aerosil), mix it, grind it and sieve it into a dry powder material of a suitable particle size. The millet extract obtained in this way is rich in lipids mainly consisting of linoleic acid, oleic acid, stearic acid, palmitic acid, etc., and sterols including α, β, and γ-sitosterol. I'm here. In addition, the aqueous extract contains VB ₁ , VB ₂ , vitamins such as nicotinamide, inorganic substances such as Mg, Ca, Fe, P, and several amino acids, among which the content of leucine is high, as well as myriacin and lignoceric acid. It also contains erucic acid and lysolecithin. Furthermore, commercially available wheat germ oil can be used as is as a fat-soluble extract of wheat germ. In the case of manufacturing, 1 to 5 parts by weight of water, 0.001 to 0.01 parts by weight of protease, per 1 part by weight of wheat germ powder.
An enzyme such as amylase is added, and the tissue is fermented at 60 to 70°C for 1 to 2 days to disrupt the tissue.Then, the mixture is heated to 100°C to inactivate the enzyme, and then extracted with about the same volume of hexane. Hexane is distilled off from the extract to obtain an oily substance. Separately, as a method for producing a water-soluble extract, a heat-treated defatted germ-containing aqueous solution is filtered, the resulting extracted aqueous solution is evaporated to dryness, and crushed.
Sort the particles. At that time, an anti-caking agent such as silicic anhydride may be added and the treatment may be carried out in a conventional manner. Or, after concentrating the aqueous extract solution to about 20%, add lactose to the solution at 10%
It is also possible to add about % and powder it by a spray drying method. On the other hand, the enzymatic treatment of wheat germ can be omitted; in this case, the extraction efficiency will be lower, but the operation will be much simpler. In addition, wheat germ is gum arabic,
Edible emulsifiers such as gum tragacanth and gelatin and 2~
After adding 4 times the amount of water and stirring and kneading, water-soluble components and fat-soluble components can be recovered at the same time by collecting a liquid layer by means such as filtration, squeezing, or centrifugation. Wheat germ extract is rich in fat-soluble components such as vitamin E and other tocopherols, carotenoids, triglycerides whose main component is the essential fatty acid linoleic acid, and oryzanol, which is said to be effective for autonomic imbalance, and is water-soluble. Approximately 70 ingredients
In addition to carbohydrates accounting for 20% and crude protein accounting for 20%, minerals such as K, Ma, Na, Ca, Fe, and P, VB ₁ ,
Contains VB ₂ , VB ₆ , nicotinic acid, pantothenic acid, etc. In general, incomplete removal of organic solvents during the extraction of fat-soluble components may cause harm to the human body.
Conventionally known compression methods, polymer distillation methods, etc. can also be used. In addition, millet extract is 30-50% by weight from the raw material,
Wheat germ extract can be obtained at 15-35% by weight. The main fat-soluble component of millet extract is fatty acid glyceride, and this fatty acid glyceride is VE in the body.
A deficiency in fat tends to result in oxidatively degraded fat, which is said to accelerate cell aging, so it is preferable to remove this from the standpoint of advanced utilization as a health food. It has been found that the product of the present invention can be made into a more effective health food by containing L-cystine and calcium pantothenate in addition to the above ingredients. Calcium pantothenate, also known as vitamin _B5 , is already used medically, and its deficiency is known to cause abnormal lipid metabolism, keratinization of the skin, and hair loss, and it is also used as a hair tonic. However, although it may be somewhat effective against alopecia caused by calcium pantothenate deficiency, it has not been sufficiently effective against alopecia of unknown cause. L-cystine is the most abundant amino acid component in hair, and although it is not recognized as a general protein component, it is abundant in hair and keratin, and approximately 14 g of cystine is contained in 100 g of keratin material in human hair. As an industrial method for producing cystine, a method in which cystine is obtained by hydrolysis using hair as a raw material has also been adopted. By the way, millet extract and wheat germ oil are rich in nutritional value, and contain various minerals, vitamins, and amino acids that are essential for hair formation. However, it is well known that, apart from the extremely rare hair loss and graying caused by malnutrition, it has not been as effective as expected for general hair growth abnormalities. In addition, pantothenic acid is a component of coenzyme A, which is a precursor of acetyl coenzyme A, which is essential for carbohydrate and fat metabolism, and its deficiency is said to cause hair loss. Since it is produced by bacteria, many researchers question whether it is possible for deficiency diseases to occur, and there are also reports that it has been used to treat various symptoms that are thought to be deficiency diseases, but this effect has been denied. There are also reports that. In addition, L-cystine is said to undergo mutual redox exchange with L-cysteine and play an important role in metabolism as a component of glutathione in the body, but it is synthesized in the body more than methionine. Therefore, it is not an essential amino acid. Since this L-cystine is a constituent core of the keratin synthesis process essential for hair formation, attempts have been made to use it as a hair nourishing agent, but no satisfactory effects have been obtained. From the above, we believe that hair growth and hair growth mechanisms that cannot be explained by mere nutritional supplementation or administration of metabolic improvers, etc.
It is surprising that the health food according to the present invention exhibits excellent hair nourishing and hair growth effects. In the present invention, in order to obtain a high-density nutritional composition, it is preferable to use a form in which excipients are not used as much as possible, and since the present composition contains wheat germ oil, soft capsules, preferably millet extract, are ~
100mg, wheat germ oil 100~200mg, calcium pantothenate 1~10mg and L-cystine 0.5~
Preferably, it is in the form of a soft capsule containing 20 mg. Examples are shown below. Example 1 35 parts by weight of fat-soluble extract of millet, 35 parts by weight of water-soluble extract of millet, 150 parts by weight of wheat germ oil, 1 part by weight of L-cystine, and 5 parts by weight of calcium pantothenate were mixed and stirred to form an oily suspension. Obtain a cloudy liquid. On the other hand, 22 parts by weight of glycerin, 28 parts by weight of purified water, and 0.0003 parts by weight of methylparaben were added to 40 parts by weight of gelatin granules, kneaded, and allowed to swell overnight. Then,
Soft capsules containing 0.25 ml of content were obtained from the above oily solution and the gelatin composition heated and melted by a conventional method using a rotary continuous soft capsule automatic filling machine. Example 2 10 parts by weight of gelatin, 100 parts by weight of purified water, and 50 parts by weight of wheat germ oil are mixed and stirred to disperse and emulsify. On the other hand, 40 parts by weight of Avicel, 20 parts by weight of unsaponifiables of fat-soluble millet extract, 50 parts by weight of water-soluble millet extract, 100 parts by weight of wheat germ water-soluble extract, 3 parts by weight of L-cystine, pantothenic acid. 3 parts by weight of calcium is mixed, the above wheat germ oil emulsion is added and kneaded, and the kneaded mixture is crushed and granulated using a granulator (screen: herringbone opening 3 m/m and rotation speed 3000 rpm).
The product is granulated, dried, and sized to obtain 20 to 150 mesh granules. After adding and mixing 1 part by weight of magnesium stearate to 70 parts by weight of this granulated material,
The mixture was compressed and shaped using a yuxcentric tablet machine to obtain tablets each weighing 300 mg. Examples 3 to 5 Soft capsules were prepared in the same manner as in Example 1, except that each component was mixed so that the weight composition ratio of the contents in the soft capsule was as shown in Table 1 below to obtain an oily suspension. Obtained.

[Table] In order to confirm the effectiveness of the product of the present invention, one group consisted of 6 mice weighing 20 g in the growing stage, and the administration group included:
The contents of one capsule of Example 1, which will be described later, and the shredded capsule shell were forcibly administered orally after feeding three times a day. The amount of feed fed during the test period was reduced to two-thirds of the normal amount for both the administration and control groups, and the average weight gain was measured one week later. As a result, an average weight gain of 6.2 g was observed in the group administered with the product of the present invention and 2.3 g in the control group. No changes in appearance or behavioral abnormalities were observed in either group. Next, the millet extract was mixed with regular feed and given to mice, and a test was conducted to determine its hair growth effect. (Test method) Five-week-old C3H mice were obtained and preliminarily fed with solid feed for 21 days. The backs of the mice were depilated (clippers/depilatory cream), and the animals were kept in different treatment groups for 21 days. The administration groups and feed content are [A] Control (N-Control) Oriental CMF [B] Positive control (P-Control) 5% wheat germ oil [C] Test substance 1% millet extract [D] Test Substances Millet extract 5% [E] Comparison control Wheat germ oil 96.2% Calcium pantothenate 3.2% L-cystine 0.6% 5% [F] Other company's reference product Kaminomoto 5% blend After the test (21 days of administration and rearing) (After), hair was removed from a certain area, and this was randomly collected on a slide glass and measured using a magnifying glass with a measurer. The results are shown in Table 2.

[Table] From the results in Table 2, the length of hair grown was the longest in group D, and also in groups C and E, which was significant compared to the positive control. Therefore, it can be inferred that a higher hair growth effect can be obtained by using millet extract together with calcium pantothenate and L-cystine. In addition, five men between the ages of 33 and 48 complained of physical complaints such as chronic loss of appetite, weak constitution, and general malaise.
When asked about their subjective symptoms after taking the capsules of Example 1 three times a day for two weeks, two people felt that they were clearly healthier than before. Two people said they thought it would not change, and one person said they thought it would remain unchanged. All of them said they had no side effects. In addition, in order to investigate whether the product of the present invention changes the blood flow in peripheral skin blood vessels, which is thought to be related to abnormal hair growth, a fluvography test was conducted to measure the effect of increasing blood flow in peripheral skin blood vessels. . (Method) The test articles were the capsules obtained in Example 1 above and a placebo, and the subjects were 18 volunteers. On the day of the test, participants were asked to avoid food and drink containing alcohol, caffeine, etc., and to avoid mental agitation prior to the measurement, they were given a demonstration of fixing the device's probe to the measurement site. The measurement site was the bald head, thigh, or forehead, or at two different locations at the same time.The probe was applied to the invisible part of the hairless vein, and the subject was made to lie down on the test floor.
The blood flow is brought to a normal level, and two capsules of the test substance are administered several minutes after the initiation of fulvography, and a fulvograph curve is obtained before and after administration (probe movement speed: 1 cm/min). The results are shown in Table 3.

[Table] From the results in Table 3, a total of 33 fulvograph curves were obtained, including simultaneous measurements at two locations, reproducibility tests several days later, and a placebo check. 62%), which lasted until the end of the test (25 to 85 minutes) except for one case. Therefore, the health food according to the present invention has excellent hair nourishing and hair growth effects, is safe with no side effects such as systemic effects of hormones, and is easy to prepare for oral use. It has advantages. In other words, in terms of safety, millet extract and wheat germ oil are derived from natural foods, so there is no problem, and the other ingredient, calcium pantothenate, is safe for humans up to 10g/day when taken orally. However, a very small amount (1/16 to 1/200 of the above-mentioned safe amount) is sufficient for this health food, and pantothenic acid is widely present in the animal and plant world. Furthermore, L-cystine can be considered a food, as it is added when skim milk is converted into breast milk. Moreover, only a small amount is used here. Therefore, this health food is safe and has no side effects. In addition, regarding the ease of formulation for oral use, conventional hair tonics are difficult to prepare due to the side effects of oral administration.
It can be included in hair nourishing cosmetics such as hair lotions and hair tonics, creams, ointments, liquids, etc.
Most of the products, such as emulsions, had to be used externally and had to contain keratolytic agents to be effective, but this health food has highly safe ingredients. There is no need for this, and oral preparations such as tablets, capsules, and powders can be used, which do not cause skin irritation, are convenient to carry, and are easy to take in a fixed amount. Conventionally known formulation methods can be used to produce these oral preparations.

Claims (1)

[Scope of Claims] 1. A health food mainly containing millet extract, which contains at least wheat germ extract, calcium pantothenate, and L-cystine in addition to millet extract. 2 Food form: millet extract 50-100mg, wheat germ oil 100-200mg, calcium pantothenate 1-100mg
10 mg of L-cystine and 0.5 to 20 mg of L-cystine, which is a soft capsule type health food mainly containing millet extract according to claim 1.