JPH0352045B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION <Industrial Field> The present invention relates to the cleaning of hard and soft contact lenses.

BACKGROUND OF THE INVENTION As is well known, contact lenses accumulate deposits in the form of proteins and lipids that must be removed from the lenses to provide clear vision and adequate cleanliness. Various products have been proposed for this purpose, some of which are based on the action of enzymes or surfactants.

Another type of product, disclosed in US Pat. No. 4,394,179, consists of small, insoluble particles that are rubbed against the lens surface to dislodge organic deposits. Such products run the risk of damaging the lens surfaces with repeated use and must be carefully cleaned to ensure that all particles have been removed from the lens before reinserting the lens into the eye. Must be thoroughly cleaned. Otherwise, it can cause inflammation and tissue damage to the eye.

Therefore, there is a need for a product for removing deposits from hard and soft contact lenses without damaging the lenses and reducing the risk of introducing undesirable irritating particles into the eye. Although (facial) cleaners containing soluble abrasives have been disclosed in U.S. Pat. was.

<Structure of the Invention> The present invention is a sterile abrasive cleaner for cleaning contact lenses by rubbing it onto the lens surface, comprising a water-soluble, non-toxic, physiologically acceptable inorganic abrasive component and an interface. A contact lens containing an amount of liquid less than that required to dissolve the total amount of the activator and the abrasive component at 25°C, and the abrasive component consists of boric acid, a borate, or a mixture thereof. It is an abrasive cleaner.

Preferably the composition further contains an amount of liquid less than that required to dissolve the entire amount of the inorganic acid or salt at room temperature.

In a second aspect, the invention is a composition containing the ingredients as defined above and further containing one or more surfactants.

DETAILED DESCRIPTION OF THE EMBODIMENTS As described above, the present invention provides compositions that effectively clean hard and soft contact lenses and are safe for the lenses and the eyes of contact lens wearers. do. Other features will become apparent from the description below.

The lens cleaning and sterilization method according to the present invention is effective for both hard and soft contact lenses. Hard lenses are made from poly(methyl methacrylate) as well as various monomer-based materials in which substituted silicones (e.g. tris(trimethylsiloxy)silyl) are bonded to acrylic or methacrylic moieties via alkylene bridges. This includes well-known lenses. Soft lenses useful in the present invention include any of a wide variety of hydrophilic homopolymers and copolymers based on hydroxyethyl methacrylate alone or copolymerized with, for example, vinyl pyrrolidone, methacrylic acid, methyl methacrylate, diacetone acrylamide, and the like. . Examples of other suitable hydrophilic lens polymers are numerous in the literature and will be apparent to those skilled in the art. Soft lenses to which the present invention is effective also include soft, non-hydrophilic lenses made by various modifications of silicone rubber.

The abrasive component is preferably slightly soluble in water and typically
About 30wt% less at 40℃, and at 20℃
It dissolves in water in an amount less than about 10wt%. The abrasive component should have a solubility in water at 20°C of at least 0.5 wt%, and usually at least about 1 wt%, and preferably at least about 3 wt%. Abrasive ingredients need to be non-toxic and non-irritating to the eyes.

The abrasive component must have a particle size that will not damage the lens when rubbed on the palm of the hand with normal finger pressure. When the abrasive component consists of particles of an inorganic acid solid at room temperature, such particles have a particle size of about 40 microns, and especially about 10 microns, in each case about 0.01 of the particle size. wt%
No more than the above particle size is exceeded, but preferably all particles are below the above particle size.
In either case (i.e., if the solid inorganic acid particles at room temperature are about 40 microns or about 10 microns), smaller particles may be present, but in the first case about 40
consisting of micron particles, and in other cases approx.
Particles consisting of 10 micron particles constitute about 98% to about 99% of the particles in each case. Of course, the abrasive component can be a mixture of particles having different particle sizes. Particle sizes of about 210 microns or less (US Standard Sieve No. 70), preferably about 105 microns or less, and more preferably about 74 microns or less are generally acceptable when the abrasive component is an inorganic salt. In a more preferred embodiment, at least
It is preferred for such inorganic salts that 99% is less than or equal to about 210 microns, and preferably at least 98% is less than or equal to about 149 microns (and more preferably at least 98% is less than or equal to about 105 microns).

The abrasive component has a hardness generally less than about 6 on the Mohs scale, and preferably falling in the range of about 1.5 to about 4. Both the hardness and size of the particles are characteristic of the particles' ability to remove protein and lipid materials from the lens surface without damaging the lens itself. The size of the particles is also related to how quickly the particles dissolve upon contact with additional amounts of water when rinsing the lens with a suitable solution and/or storing it in solution. However, as mentioned above, since the abrasive component is only slightly soluble in water, the lens cleaning composition of the present invention can be prepared for several hours without dissolving the abrasive component in the liquid present in the composition. , can be stored for days or weeks.

The most preferred room temperature solid inorganic acid abrasive component useful in the present invention comprises boric acid. The term “boric acid” as used herein includes boric acid of various qualities (e.g.
H ₃ BO ₃ ), for example, finely divided NF of boric acid available from standard commercial sources, as well as various boric acid compounds and compositions, such as salts with altered solubility in water (to reduce or increase solubility) and boric acid ( For example, mixtures of H ₃ BO ₃ ) are also included.
Such salts consist of alkali metal salts, including halogenated, alkali sulfates or borates. For example, the water solubility of sulfuric acid (H ₃ BO ₃ ) decreases with sodium chloride and lithium chloride and increases with sodium sulfate, potassium chloride, and potassium sulfate. Basic anions and other nucleophiles such as fluoride and borate increase the solubility of boric acid (H ₃ BO ₃ ). By adding salts such as boric acid, the solubility can be controlled and, as a result, the amount of particles in the boric acid solution can be controlled (ie, increased or decreased).
Boric acids suitable for the present invention (including mixtures with such salts) are described in Kirk-Othmer, Encyclopedia of Chemical Technology, 3rd edition;
Volumes 71-80, pages 108-110, all of which are hereby incorporated by reference.

A preferred inorganic salt component useful in the present invention is sodium borate, the term encompassing any salt of sodium borate (eg, boric acid or boric anhydride). The most preferred sodium borate is borax, which is sodium borate decahydrate. Satisfactory borax products useful in the practice of this invention include US Pat.
It is known as a powder or fine grade "NF grade" borax, which is commercially available from Borax Company.

The abrasive component must be present in undissolved form in the cleaning composition in an amount effective to perform the desired lens cleaning function. This amount is generally approximately
It is in the range of 50wt% or less. smaller amount i.e. 30%
Less than or even less than 20% can be used provided the amount of water and the amounts of other components present are adjusted so that the abrasive components do not dissolve upon standing.
Generally, the undissolved abrasive will represent at least 1 wt% of the composition, and preferably at least 5 wt%.

The composition of the invention preferably includes a surfactant component,
It also includes one or more surfactants. Although surfactants are not strictly necessary for the abrasive component to perform its function, surfactants assist in removing lens deposits. Furthermore, it has surprisingly been found that a combination of a surfactant component and an abrasive component produces a better effect than when each component is used alone. Surfactant components include lipid substances, mucin,
Preferably, it comprises one or more components capable of solubilizing one or more contaminants known as proteinaceous substances and facilitating the removal of such contaminants from the lens surface. . Preferably, the surfactant component has an HLB value of about 7 to about 18.

Among the various anionic surfactants useful in the present invention, special mention is made of the alkali (metal), ammonium, amine or aminoalcohol salts of the following compounds: alkyl sulfates, alkyl ether sulfates, alkyl ether sulfates, Amidosulfates and other sulfates, alkylaryl polyether sulfates, monoglyceride sulfates, alkyl sulfonates, alkylamido sulfonates, alkylaryl sulfonates, alpha olefin sulfonates, alkyl sulfosuccinates, alkyl ether sulfosuccinates, alkylamides sulfosuccinates The alkyl group of all these compounds is 12 to 18
A chain of carbon atoms.

Useful anionic surfactants have the formula ROSO ₃ M,
ROC(O)CH ₂ SO ₃ M or RO(C ₂ H ₄ O) _x SO ₃ M, where R is an alkyl or alkenyl of about 10 to about 20 carbon atoms, and x is 1 to 10. , M is a water-soluble cation such as ammonium, sodium, potassium or triethanolamine)
It can be shown as The alkyl ether sulfates useful in this invention include ethylene oxide and about 10
Condensation products of monohydric alcohols having from about 20 carbon atoms are included. Preferably R has 14 to 18 carbon atoms in the alkyl sulfate, alkyl ether sulfate and alkyl sulfoacetate. Alcohols can be derived from fats, such as coconut oil or tallow, or can be synthesized. Such alcohol is reacted with 1 to 10 moles of ethylene oxide, preferably 3 moles, and the resulting mixture of molecular species is neutralized to sulfate.

Other examples of anionic surfactants include the reaction products of fatty acids esterified with, for example, isethionic acid and neutralized with sodium hydroxide [fatty acids can be obtained, for example, from coconut oil or from sodium or potassium fatty acid amides of methyltauride]. salt (derived from fat, for example, from coconut oil). Still other anionic surfactants include those named succinamates. This group includes disodium N-octadecyl sulfosuccinamate; tetrasodium N-(1,2
-dicarboxyethyl)-N-octadecyl sulfosuccinamate; and surfactants such as dioctyl ester of sodium sulfosuccinate. Other suitable anionic surfactants include olefin sulfonates having about 12-24 carbon atoms.

Additionally, one or more nonionic surfactants may also be used. Useful nonionic surfactants have the formula: (Acyl)-(OAlk) _o OH [where (Acyl) is derived from a _C12 - _C20 fatty acid such as oleic, lauryl or palmitic acid;
(OAlk) means that each alkylene unit “Alk” has the formula C ₂ H ₄
or a polyoxyalkylene moiety having C ₃ H ₆ and n being 2 to 60].
Other satisfactory nonionic surfactants have the formula (Alk)-(AAlk) _o OH, where (Alk) is a saturated or monosaturated alkyl or alkylene moiety of 10 to 20 carbon atoms; ) and n is the same as above] are included. Further examples of satisfactory nonionic surfactants include mixtures of C ₁₂ -C ₂₀ fatty acid esters of sorbitol, commonly known as "polysorbates" and sorbitol anhydride condensed with 4-20 moles of ethylene oxide. What is defined is included.

One group of preferred surfactants are the nonionic surfactants known as hydroxyalkylated surfactants and polyoxyalkylated surfactants.
Extraordinarily effective at very low concentrations are N-hydroxy fatty acids having 10-18 carbon atoms, preferably 12-14 carbon atoms, and having 0 or 1 site of olefinic unsaturation. It is an alkylated carboxamide. They will usually have up to two hydroxyalkyl groups of 2-3 carbon atoms, which may be the same or different.

Polyoxyalkylated nonionic surfactants may consist of only a chain of 2 to 60 polyoxyalkylene groups of 2-3 carbon atoms each, or directly on an aliphatic chain of 10-10 carbon atoms. It may have such a polyalkylene chain bonded to or indirectly. The polyoxyalkylene chains can be homo-oligomers or cooligomers, the homo-oligomers usually being ethyleneoxy groups and the cooligomers being random or block oligomers of ethyleneoxy and propyleneoxy groups.

Another satisfactory nonionic surfactant is polyalkyleneoxy-modified silicone, which is a silicone modified with polyalkyleneoxy groups in which each alkylene group has 2 or 3 carbon atoms. Exemplary compositions include U.S. Pat.
Described in No. 3505377. The composition for use in the invention is about 900-1600 cSt, more preferably about
It has a 25℃ viscosity of 100-1500cSt. The specific gravity at 25°C is about 20-22, more commonly 21 dynes/cm. 1
The surface tension of % aqueous solutions at 25°C is generally 25-28, more usually about 26-27 dynes/cm. The cloud point of a 1 wt% aqueous solution is below 50°C, usually below about 40°C, and usually above about 30°C. Silicone polymers are usually block copolymers with polyalkyleneoxy polymers.

The siloxy units are preferably dimethylsiloxy units and the alkyleneoxy units are preferably ethyleneoxy or 1,2-propyleneoxy units. The ratio of the number of ethyleneoxy units to other units (dimethylsiloxy and propyleneoxy) is at least 0.5:1 and generally does not exceed 5:1 and usually about 2:1. The molecular weight of the copolymer generally ranges from about 4,000 to 10,000, preferably from about 5,000 to 10,000.
It is 7000. The end groups of polymers are usually C ₁ on one side.
-C ₃ alkylsiloxy group, and the other is an alkoxy group of 1 to 6 carbon atoms.

A preferred siloxane-polyoxyalkylene copolymer for use in the present invention has the formula: TSi(O(SiMe ₂ O) _x (C _o H _2o O) _y Y ₃ where each of the chains is the same or The values given for x and y are averages over the entire composition, with x being a number ranging from 3 to 10, usually 4 to 8; y being a number ranging from 20 to 50, usually 25 to 8. is a number in the range of 40; n is an integer from 2 to 3; T
is alkyl of 1 to 3 carbon atoms, usually methyl; and Y is alkyl of 1 to 6 carbon atoms, usually 3 to 4 carbon atoms.

More preferably, the siloxane-polyalkylene block copolymer has the formula: TSi(O(SiMe ₂ O) _x (C ₂ H ₄ O) _a (C ₃ H ₆ O) _b Y) ₃ where the chain may be the same or different, and the values shown for x, a, and b are averages over all compositions, where x is a number ranging from 4 to 8, usually 5 to 7; a is 15 30 to 30, usually 15 to 25
b is a number in the range of 10 to 20, usually 12 to 20;
16; and other symbols are the same as defined above.

Other satisfactory surfactants are fatty acid amides of amines or their nitrogen analogues, substituted at least twice by two to three aliphatic groups, two of the groups being oxygen-containing substituents such as oxy or carbonyl. ,
In particular, it has a non-oxocarbonyl. In most cases, the aliphatic amide used in the invention has the following formula: However, R is 9 to 18, preferably 9 to 13
a saturated or monosaturated, preferably saturated, alkyl or alkylene group of 2, usually 11 carbon atoms; X is oxygen or nitrogen; m is 0 when X is oxygen and is 0 when X is nitrogen; is 1 (provided that the nitrogen to which Y and Z are bonded is positive); Y is 2 to 4 carbon atoms and 1 to 3 oxygen atoms as the only heteroatom; An aliphatic saturated group in which the oxygen atom is present as hydroxy or other where at least two carbon atoms are present between the heteroatoms, or carboxy, and when oxygen is present as carboxy, carbonyl The group may be present as an acid or a physiologically acceptable salt thereof, such as sodium; and Z has 2 to 3, usually 2 carbon atoms and 1 to 2 oxygen atoms as the only heteroatoms. saturated aliphatic radicals in which the oxygen atom is present as hydroxy, ether or carbonyl, and the carbonyl group may be present as an acid or a physiologically acceptable salt.

The fatty acid amide of the above formula when m is 0 almost always has the following formula: However, R' falls under the definition of R; Y' and Z' are the same or different and are hydroxyalkyl of 2 to 3 carbon atoms, and oxygen and nitrogen are hydroxyalkyl of at least 2 carbon atoms. Being separated.

The fatty acid amide of the above formula when m is 1 preferably has the following formula: However, R'' corresponds to the definition of R; Y is 0 to 1
an aliphatic saturated carboxylic acid group of 2 to 4 carbon atoms with 2 etheric oxygens and no other heterofunctionality;
aliphatic saturated carboxylic acid groups of from to 3 carbon atoms; the acid and quaternary ammonium groups are physiologically acceptable cations, e.g. zwitterions,
It has a proton or an alkali metal (preferably sodium).

Of particular interest are compounds of the formula: provided that R is 9-13 carbon atoms, usually 11 carbon atoms.

Imidazoline compounds can be prepared according to the teachings of US Pat. No. 2,586,496.

Of particular interest are diethanolamine and 2-
Undecyl-3-carboxymethyl-3-(2'-
lauramide of carboxymethoxy)-ethyl)-1-imidazoline.

In particular, organic salts of diethanolamine or its analogs in combination with diethanolamine or its analogs in small amounts, in particular 16 to 18 fatty acids with 0 to 1 ethylenic unsaturation sites, such as oleates or (where the alkyl group is directly Alkylbenzene sulfonate salts (chain or branched, usually 6 to 18, more usually 8 to 14 carbon atoms) can be used. When present, salts are generally used in a salt to amide molar ratio of 1:2-4, more usually 1:3. It has about 20-33%, usually 25%, of the amide being substituted with salt.

Satisfactory surfactants have various trade names such as "Pluronic", "Steol", "Miranol",
Available on the market as “Tween”, “Igepal”, “Brij” and “Myrj”. These surfactants include those having the following general formula.

“Pluronic”: Formula; HO(CH ₂ CH ₂ O) _x (CH(CH ₃ ) CH ₂ O) _y (CH ₂ CH ₂ O) _z H where the sum of (x+y+z) is 2-60. Oxyalkylene compound.

“Steol”: an alkali (e.g. sodium or ammonium) salt of the sulfate ester of the polyethylene glycol ether of lauryl alcohol, the ester has the formula: CH ₃ (CH ₂ ) ₁₀ CH ₂ (OCH ₂ CH ₂ ) _1-12 OSO ₃ “Miranol”: Formula; RC(O)NHCH ₂ CH ₂ N(R ₁ ) _1-2 (CH ₂ ) _1-2 COOH However, RC(O) is coconut, laurin, stearin, capric, or acyl of stearic acid. group; R ₁ is −CH ₂ CH ₂ OH, −
An amphoteric surfactant having _{-CH2CH2OCH2CH2COOH} , an alkali salt _thereof , or _{-CH2COOH or an} alkali salt thereof.

“Tween”： However, (a+w+x+y) is 4-20;
(Acyl) is a saturated or monosaturated acyl group having 10-20 carbon atoms.

"Igepal": _An ethoxylated alkylphenol having the general formula: _C9H19C6H4 ( _{OCH2CH2 ) oOH} , where _{n is} 4-50.

“Brij”: Polyethylene glycol of stearyl, oleyl, cetyl or lauryl alcohol, with the general formula: R-(OCH ₂ CH ₂ ) _o OH where n is 2-30 and R is the dehydroxylated residue of the alcohol. have, have.

"Myrj": A polyethylene glycol ester of stearic acid, having the general formula: R-(OCH ₂ CH ₂ ) _o OH, where n is 2-60 and R is a stearoyl acyl group.

The surfactant component can also consist of an amphoteric surfactant, which typically has an aliphatic carbon chain attached to the nitrogen of about 10-18 carbon atoms, preferably about 10-14 carbon atoms. Probably betaine.

The surfactant component is generally present in an effective amount to aid in the removal of protein and/or lipid materials (preferably both) from the contact lens surface. Amounts of about 0.1 to about 70 wt%, preferably about 1 to about 60 wt%, more preferably about 10 to about 50 wt% of the composition are sufficient.

Individual surfactants or combinations thereof can be used at total concentrations within the ranges mentioned above. The above description is illustrative and not restrictive; other examples of satisfactory surfactants meeting the subject matter of the present invention will be apparent to those skilled in the art and are within the scope of the present invention. shall be taken as a thing.

Preferably, the compositions of the present invention also contain a small amount of liquid to assist in spreading the composition onto the lens surface during the cleaning operation. About 3 wt% or more of the composition,
More usually it will be present in an amount of at least about 5 wt%. It should be noted that water is the preferred liquid, but when the surfactant component is a liquid (even a viscous liquid), water is not necessary to spread over the lens surface. The liquid also makes up about 50wt% of the composition.
It can account for less than or 75wt%. As specifically noted in the specification, the amount of water and/or other liquids present should be less than the amount of liquid present to completely dissolve the abrasive content of the composition. depends on the amount of In other words, sufficient abrasive component must be present relative to the liquid content so that the composition is supersaturated as an abrasive.

Compositions useful in this invention can range in consistency from slurries having a nearly water consistency to creams or pastes. To adjust the viscosity to the desired concentration, the relative proportions of liquid (eg, water), surfactant, and abrasive components can be adjusted accordingly. Alternatively, one or more additives may be added to the composition in an amount effective to control viscosity so that the composition is applied smoothly onto the lens and comes into contact with the lens during the wiping operation rather than just running off. You can also do it. Thickeners that satisfy this purpose include polyoxyethylene, guar gum, methyl cellulose, methyl hydroxypropyl cellulose, polypropylene hydroxyethyl cellulose, harlequin bean gum, hydroxypropyl gar gum, hydroxyethyl cellulose, hydroxypropyl cellulose and starch derivatives such as hydroxyethyl amylose. There are polymers like this. The amount of thickener will depend on the concentration of the final product according to the purposes described herein, but will generally range from about 0.1 to 20 wt%.

Although borax is not essential to the composition when it is an abrasive component, an ophthalmologically acceptable buffering agent may be added to achieve a pH generally in the range of 5-10, preferably about 7-10. good. Exemplary buffers include borates, phosphates, citrates, carbonates and lactates; other ophthalmically acceptable buffers may also be used. Buffer concentration is generally about 0.05 to 0.5wt%, usually about 0.1wt%
It is.

Compositions useful in the present invention can be easily prepared by mixing the ingredients listed above with stirring. The additive is preferably added in small portions while keeping the abrasive component in excess to avoid undesirable dissolution of the abrasive component. After preparation, the best method is to sterilize the composition so that contaminants introduced into the formulation do not grow microbially in the composition. After preparation,
Pour the composition into a suitable plastic bottle for approximately 2.5
Sterilize with megarad gamma irradiation. With ingredients that are sterilized prior to inclusion in the final product,
It will be appreciated that the compositions of the present invention can also be prepared aseptically by dispensing under aseptic conditions.

In another embodiment of the present invention, the composition may be heated for about 10-60 minutes in a sealed chamber at a temperature on the order of 100-130°C and a pressure of from atmospheric pressure to about 20 psi without losing the desired particle size distribution. It can also be sterilized in an autoclave without dissolving the substance. In particular, the composition is continuously stirred during sterilization, during and after cooling to ambient temperature for at least 5 hours. Additionally, the composition is cooled under controlled, gradual cooling conditions that allow reprecipitation of a large number of nuclei from the sterilization temperature to ambient temperature. For example, if the composition is slowly cooled from 121° C. to 25° C. over a period of 30 minutes or more with continuous stirring as described above, the desired small particle size distribution described above can be maintained. This condition allows sterilization of the composition under autoclave conditions without compromising in any way the desired particle size characteristics of the composition.

The invention can be used by simply dropping a small amount (0.1-3 ml) onto the lens surface to be cleaned and rubbing the lens between the fingers or on the palm of the hand for an effective period of time, e.g. 10-30 seconds. The abrasive component particles aid in the removal of lens contaminants from the lens surface through a scrubbing action. The lens is then preferably a commercially available (physiological)
Rinse thoroughly with saline. The rinsing step causes rapid dissolution of the abrasive component particles and washes the composition from the lens surface as specified in the specification, especially when boric acid (H ₃ BO ₃ ) is the abrasive component. The effect is significant if ophthalmologically acceptable additives such as potassium chloride or nucleophiles (borates and fluorides) are included, which increase the solubility of the drug components. Such additives are described in detail in Kirk Othmer's book, cited above. The lens can be immediately reinserted into the eye without the risk of residual undissolved particles irritating or damaging the ocular tissue.

Alternatively, the cleaning steps described herein may be performed at the end of the day and the lenses then placed in a suitable storage solution overnight. The user can be confident that the residual abrasive particles will dissolve in the storage solution and will not cause discomfort when the lens is reinserted into the eye the next day.

A preferred embodiment using borax has the advantage that the borate anion produced by dissolution in the storage solution is completely compatible with the other components of the solution. The use of borax (although an optional additive) means that there is no need to add preservatives to the composition. In addition, the borate anions produced by the borax help keep the PH on the lens surface on the alkaline side during use, thus aiding in the removal of proteinaceous materials from the lens surface.

The invention is further illustrated in the following examples.

Example 1 A composition suitable for cleaning hard and soft contact lenses was prepared by thoroughly mixing predetermined amounts of the following ingredients. Ingredient amount (wt.%) Pure water 45.8 Steol 4N (28%) (sodium lauryl ether sulfate surfactant) 20.0 Organosilicone L-720 (nonionic surfactant,
Union Carbide) 1.0 Cab-O-Sperse 143 (colloidal, fumed silica 17%) 10.0 Sodium chloride, USP 6.0 Boric acid Fine NF 15.0 Arlacel 165 (glycerol and polyoxyethylene glycol stearate) 2.2 The resulting composition is When shaken, it became an effective contact lens cleaner.

Example 2 A composition suitable for cleaning hard and soft contact lenses was prepared by thoroughly mixing predetermined amounts of the following ingredients. Ingredient amount (wt.%) Organosilicone L-720) (nonionic surfactant,
Union Carbide) 1.0 MYRJ 52 (Nonionic Surfactant) 1.0 Steol 4N (Sodium Lauryl Ether Sulfate Surfactant) 9.0 Hydroxyethyl Cellulose (Viscosity Builder)
0.4 Borax Fine NF 33.0 Pure Water 55.6 The resulting composition was a suspension and, when shaken, became an effective contact lens cleaner.

Claims (1)

[Scope of Claims] 1. A sterile abrasive cleaner for cleaning contact lenses by rubbing it onto the lens surface, comprising a water-soluble, non-toxic, physiologically acceptable inorganic abrasive component and a surfactant. Contact lens polishing comprising an amount of liquid less than that required to dissolve the entire amount of the polishing agent and the polishing component at 25°C, and the polishing component comprises boric acid, a borate, or a mixture thereof. agent cleaner. 2. The cleaner according to claim 1, wherein the liquid is water. 3. The cleaner according to claim 1 or 2, wherein the abrasive component accounts for 1 to 50 wt% of the composition. 4. The cleaner of claim 1, wherein said surfactant accounts for 0.1 to 70 wt% of said composition. 5. A cleaner according to any one of claims 1 to 4, wherein the boric acid has a particle size of about 10 microns or about 40 microns, with less than 0.01 wt% exceeding the predetermined particle size. 6 The sodium borate has a particle size of 149 microns or less and at least 98% of the particles are 105
The cleaner according to any one of claims 1 to 4, which has a size of less than a micron.