JPH0366928B2 - - Google Patents
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- Publication number
- JPH0366928B2 JPH0366928B2 JP59098163A JP9816384A JPH0366928B2 JP H0366928 B2 JPH0366928 B2 JP H0366928B2 JP 59098163 A JP59098163 A JP 59098163A JP 9816384 A JP9816384 A JP 9816384A JP H0366928 B2 JPH0366928 B2 JP H0366928B2
- Authority
- JP
- Japan
- Prior art keywords
- stock solution
- concentration
- liquid
- amount
- value
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Control Of Non-Electrical Variables (AREA)
Description
【発明の詳細な説明】
（技術分野）
本発明は、原液を稀釈水で所定濃度に稀釈して
連続供給する装置にし、特に人工透析装置の透析
液供給装置として最適な液供給装置に関する。DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a liquid supply apparatus that continuously supplies a diluted solution to a predetermined concentration with dilution water, and is particularly suitable as a dialysate supply apparatus for an artificial dialysis machine.
（従来技術）
例えば、従来より第１図に示すような人工透析
装置が知られている。第１図において、１はダイ
アライザ、２は血液回路、３は透析液回路、４は
透析液供給装置である。該透析液供給装置４は、
稀釈水の流量を一定にする定流量弁５と、稀釈水
の温度を一定にするヒータ６と、アセテート液等
の原液を供給する流量可変ポンプ７と、稀釈水と
原液を混合する混合器８と、混合器８の出口の液
濃度を検出する導電率計９と、導電率計９からの
信号を測定値として設定部１０からの信号を設定
値（目標値）として、比例、微分、積分等の制御
演算を行い制御信号を出力する制御部１１と、制
御部１１からの制御信号に基づき流量可変ポンプ
７を駆動する駆動部１２とで構成される。(Prior Art) For example, an artificial dialysis apparatus as shown in FIG. 1 has been conventionally known. In FIG. 1, 1 is a dialyzer, 2 is a blood circuit, 3 is a dialysate circuit, and 4 is a dialysate supply device. The dialysate supply device 4 includes:
A constant flow valve 5 that keeps the flow rate of the dilution water constant, a heater 6 that keeps the temperature of the dilution water constant, a variable flow rate pump 7 that supplies a stock solution such as acetate solution, and a mixer 8 that mixes the dilution water and the stock solution. and a conductivity meter 9 that detects the liquid concentration at the outlet of the mixer 8, with the signal from the conductivity meter 9 as the measured value and the signal from the setting unit 10 as the set value (target value), proportional, differential, and integral The control unit 11 includes a control unit 11 that performs control calculations such as the above and outputs a control signal, and a drive unit 12 that drives the variable flow rate pump 7 based on the control signal from the control unit 11.
この透析液供給装置４によれば、透析液は、混
合器８において、定流量弁５及びヒータ６によつ
て一定流量、所定温度になつて流入する稀釈水
と、制御部１１を中心とする制御系によつて所定
流量となつて流入する原液とが十分混合され、所
定濃度、所定温度となつてダイアライザに供給さ
れる。しかしながら、従来の透析液供給装置にあ
つては、制御部１１が比例、微分、積分等の制御
演算によるフイードバツク制御で原液の注入量を
操作していたため、供給開始時や設定値変更時の
応答性が悪い（所定濃度に達するのに時間がかか
る）という問題があつた。 According to this dialysate supply device 4, the dialysate is supplied to the mixer 8 through the dilution water which flows in at a constant flow rate and at a predetermined temperature by the constant flow valve 5 and the heater 6, and the control unit 11. The control system thoroughly mixes the stock solution flowing in at a predetermined flow rate, and supplies it to the dialyzer at a predetermined concentration and temperature. However, in the case of conventional dialysate supply devices, the control unit 11 manipulates the injection amount of stock solution through feedback control using control calculations such as proportional, differential, and integral control, so the response when starting supply or changing set values is There was a problem that the properties were poor (it took a long time to reach a predetermined concentration).
（発明の目的）
本発明は、このような点に鑑みてなされたもの
で、その目的は、供給開始時や設定変更時の濃度
の応答性を高めた液供給装置を提供することにあ
る。(Objective of the Invention) The present invention has been made in view of the above-mentioned points, and an object thereof is to provide a liquid supply device with improved concentration responsiveness at the time of starting supply or changing settings.
（発明の構成）
この目的を達成する本発明は、稀釈水と原液を
混合する混合器の出口側における液濃度を検出す
る濃度検出手段と、原液供給ポンプを操作して原
液供給量を変え得る制御部を具備した液供給装置
において、前記制御部は、液供給開始に際し、前
記液濃度の設定値、稀釈水の流量値及び前記原液
の濃度値から前記原液供給ポンプの操作量を求
め、該操作量に基づき前記原液供給ポンプを駆動
すると共に、原液供給開始後、前記濃度検出手段
の出力から前記液濃度の偏差を求めこれが所定値
以上になると、その時点の前記液濃度に基づき、
前記原液供給量の必要変更量を算出し、該算出値
に対応して前記原液供給ポンプの操作を行うこと
を特徴とするものである。(Structure of the Invention) The present invention that achieves this object includes a concentration detection means for detecting the liquid concentration at the outlet side of a mixer for mixing dilution water and a stock solution, and a stock solution supply pump that can be operated to change the stock solution supply amount. In the liquid supply device equipped with a control unit, the control unit determines the operation amount of the stock solution supply pump from the set value of the solution concentration, the flow rate value of the dilution water, and the concentration value of the stock solution when starting the liquid supply, and Drive the stock solution supply pump based on the operation amount, and after starting supply of the stock solution, calculate the deviation of the solution concentration from the output of the concentration detection means, and when the deviation exceeds a predetermined value, based on the solution concentration at that time,
The method is characterized in that a necessary change in the amount of stock solution supplied is calculated, and the stock solution supply pump is operated in accordance with the calculated value.
（実施例）
以下、図面を参照し本発明の実施例を詳細に説
明する。(Embodiments) Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
第２図は本発明の一実施例を示す構成図であ
る。第２図において、第１図と同一部分には同一
符号を付して示し、その説明は省略する。図中、
２１はマイクロプロセツサ、ROM，RAM，
Ｉ／Ｏ等から成る制御部、２２は導電率計９の出
力信号をデイイジタル信号に変換し制御部２１に
出力するアナログデイジタル変換器、２３は制御
目標値（混合器８の出口の液濃度の目標値）、原
液の濃度、稀釈水の流量等の各設定値（この実施
例ではデイジタル信号）を制御部２１に出力する
設定部、２４は制御部２１からの信号に基づき発
振回路２５からのパルス信号を分周して出力する
分周回路、２６は分周回路２４からのパルス信号
でパルスモータを駆動する駆動回路、２７はパル
スモータを備えた流量可変形の原液供給ポンプで
ある。制御部２１内のROMには、透析液供給開
始時、設定部２３からの各設定値を読み込み、所
定の演算をして原液供給ポンプ２７の回転数（原
液の流入量）を求め、この回転数を保持させるよ
うな動作を行わせるプログラムと、制御系の偏差
が所定値以上になると、その時点の透析液濃度
（導電率計９からの測定値）に基づき、偏差を零
にするに必要な原液供給量の変更量に対応する原
液供給ポンプ２７の回転数の変更量を求めてこの
変更を行うためのプログラムとが格納されてい
る。更に、制御部２１のROMには、導電率計９
の出力信号の中で、瞬間的に変化する信号（所謂
ヒゲ信号；気泡によつて発生する）を無視する処
理プログラムも格納されている。 FIG. 2 is a configuration diagram showing an embodiment of the present invention. In FIG. 2, the same parts as in FIG. 1 are designated by the same reference numerals, and their explanation will be omitted. In the figure,
21 is a microprocessor, ROM, RAM,
22 is an analog-to-digital converter that converts the output signal of the conductivity meter 9 into a digital signal and outputs it to the control unit 21; A setting section 24 outputs set values (digital signals in this embodiment) such as target value), concentration of stock solution, flow rate of dilution water, etc. to the control section 21; A frequency dividing circuit 26 divides and outputs a pulse signal, a drive circuit 26 drives a pulse motor using a pulse signal from the frequency dividing circuit 24, and a variable flow rate raw solution supply pump 27 includes a pulse motor. When starting dialysate supply, the ROM in the control unit 21 reads each set value from the setting unit 23, performs a predetermined calculation, calculates the number of revolutions (inflow amount of stock solution) of the stock solution supply pump 27, When the deviation of the control system exceeds a predetermined value, the program performs an operation that maintains the number, and when the deviation of the control system exceeds a predetermined value, it is necessary to reduce the deviation to zero based on the dialysate concentration at that time (measured value from the conductivity meter 9). A program for determining the amount of change in the rotational speed of the stock solution supply pump 27 corresponding to the amount of change in the amount of stock solution supply and making this change is stored. Furthermore, the ROM of the control unit 21 includes a conductivity meter 9.
A processing program for ignoring instantaneously changing signals (so-called whisker signals; generated by air bubbles) among the output signals is also stored.
このような構成の透析液供給装置においては、
設定部２３にて、原液濃度C1及び稀釈水流量V2
［ml／min］（これらは何れも既知の数値である）
が設定されると共に、ダイアライザ１に供給する
透析液濃度C2（目標値）が設定されると、制御部
２１は、ROMに格納されているプログラムに基
づき、原液供給量V1［ml／min］を後述の(1)式に
より算出し、これに対応する原液供給ポンプ２７
の回転数を求めて、分周回路２４の分周値を設定
する。 In a dialysate supply device with such a configuration,
In the setting section 23, the concentration of the stock solution C 1 and the flow rate of dilution water V 2
[ml/min] (These are all known values)
is set and the dialysate concentration C 2 (target value) supplied to the dialyzer 1 is set, the control unit 21 controls the stock solution supply amount V 1 [ml/min] based on the program stored in the ROM. ] is calculated using equation (1) below, and the stock solution supply pump 27 corresponding to this is calculated.
The frequency dividing value of the frequency dividing circuit 24 is set by determining the rotation speed of the frequency dividing circuit 24.
V1＝C2・V2／（C1−C2） …(1)
これにより、混合器８の出口側の液濃度（透析
液濃度）を、設定値（目標値）近傍まで急激にも
つてゆくことができる。 V 1 = C 2 · V 2 / (C 1 − C 2 ) …(1) As a result, the liquid concentration (dialysate concentration) on the outlet side of the mixer 8 is rapidly brought to the vicinity of the set value (target value). You can go there.
しかし、時間経過と共に原液供給ポンプ２７の
経時的な特性変化等により、前記分周値が同一値
であつても原液供給量V1が変化し、透析液濃度
がC2′になり、目標値C2に対して所定以上の偏差
が生じることになる。すると、この偏差が零にな
るように制御部２１はROMに格納されているプ
ログラムに基づき次のような処理を行う。ここ
で、濃度がC2′に変化しているときの(1)式と等価
的な関係を示す式は後述の(2)式となり（尚、(2)式
中のV1′は濃度C2′に対応する原液供給量）、V1′の
変量に対するC2′の変量を示す式は(3)式となる。 However, as time passes, due to changes in characteristics of the stock solution supply pump 27 over time, the stock solution supply amount V 1 changes even if the frequency division value is the same value, and the dialysate concentration becomes C 2 ', and the target value A deviation greater than a predetermined value will occur with respect to C 2 . Then, the control unit 21 performs the following processing based on the program stored in the ROM so that this deviation becomes zero. Here, when the concentration is changing to C 2 ′, the equation that shows the equivalent relationship to equation (1) is equation (2), which will be described later (note that V 1 ′ in equation (2) is the concentration C 2 ′), the equation showing the variable of C 2 ′ with respect to the variable of V 1 ′ is equation (3).
C2′＝C1・V1′／（V1′＋V2） …(2)
dC2＜／dV1′＝C1／（V1′＋V2）＋C1
・V1′／（V1′＋V2）2 …(3)
そこで、制御部２１は、偏差C2′−C2を零にす
るのに必要な原液供給量の変更量を算出し、その
算出値に対応する原液供給ポンプ２７の回転数の
増減を求て分周回路２４の分周値を増減する。こ
れにより、再び混合液８の出口側での液濃度が設
定値に急激に近づく。以下、偏差が大きくなる毎
に上記動作が繰り返される。 C 2 ′=C 1・V 1 ′/(V 1 ′+V 2 ) …(2) dC 2 ＜/dV 1 ′=C 1 /(V 1 ′+V 2 )+C 1・V 1 ′/(V 1 ′+V 2 ) 2 (3) Therefore, the control unit 21 calculates the amount of change in the stock solution supply amount necessary to make the deviation C 2 ′−C 2 zero, and adjusts the stock solution supply pump corresponding to the calculated value. The frequency dividing value of the frequency dividing circuit 24 is increased or decreased based on the increase or decrease in the number of rotations of the frequency dividing circuit 27. As a result, the liquid concentration at the outlet side of the mixed liquid 8 rapidly approaches the set value again. Thereafter, the above operation is repeated each time the deviation increases.
上記の各動作で透析液濃度を設定値に早くもつ
てゆくことができると共に、その近傍に保持でき
る。 With each of the above operations, the dialysate concentration can quickly reach the set value and can be maintained near the set value.
又、上記動作中、混合器８からの透析液に気泡
が混入し導電率計９の出力信号が瞬間的に下がつ
たとしても、制御部２１が瞬間的な変化信号を測
定値としないため、制御系への外乱とはならな
い。 Furthermore, even if air bubbles are mixed into the dialysate from the mixer 8 and the output signal of the conductivity meter 9 momentarily drops during the above operation, the control unit 21 does not take the instantaneous change signal as a measured value. , it does not cause disturbance to the control system.
尚、上記実施例は、一液希釈の透析液供給装置
について説明したが、本発明は二液希釈の場合で
あつてもよい。又、希釈水の流量、原液濃度を予
め設定する構成となつているが、本発明はこれに
限定するものでもない。これらが変動する場合、
それぞれセンサを設けて制御部に入力するように
すればよい。更に、制御部をマイクロプロセツサ
等で構成し、ソフト的に制御する場合を示した
が、これに限る必要はない。又、本発明を透析液
供給装置に限定する必要もない。 In the above embodiment, a dialysate supply device for one-liquid dilution has been described, but the present invention may also apply to a two-liquid dilution. Further, although the configuration is such that the flow rate of the dilution water and the concentration of the stock solution are set in advance, the present invention is not limited to this. If these vary,
What is necessary is to provide a sensor for each and input the information to the control section. Further, although the case where the control section is configured with a microprocessor or the like and controlled by software is shown, it is not necessary to be limited to this. Also, there is no need to limit the invention to dialysate supply devices.
（発明の効果）
以上説明したように、本発明によれば、設定値
（目標値）に達するのに必要な原液供給量を算出
し、この算出値に対応する原液供給ポンプの操作
量を求めて該ポンプを操作するようにしたため、
混合器の出口側の液濃度の応答性を高めることが
できる。(Effects of the Invention) As explained above, according to the present invention, the amount of stock solution supplied necessary to reach a set value (target value) is calculated, and the operating amount of the stock solution supply pump corresponding to this calculated value is determined. Since the pump was operated by
The responsiveness of the liquid concentration on the outlet side of the mixer can be improved.
第１図は従来例を示す構成図、第２図は発明の
一実施例を示す構成図である。
１…ダイアライザ、４…透析液供給装置、５…
定流量弁、６…ヒータ、８…混合器、９…導電率
計、２１…制御部、２２…アナログデイジタル変
換器、２３…設定部、２４…分周回路、２５…発
振回路、２６…駆動回路、２７…原液供給ポン
プ。
FIG. 1 is a block diagram showing a conventional example, and FIG. 2 is a block diagram showing an embodiment of the invention. 1... dialyzer, 4... dialysate supply device, 5...
Constant flow valve, 6... Heater, 8... Mixer, 9... Conductivity meter, 21... Control section, 22... Analog-digital converter, 23... Setting section, 24... Frequency dividing circuit, 25... Oscillation circuit, 26... Drive Circuit, 27... Raw solution supply pump.
Claims (1)
ける液嚢度を検出する手段と、原液供給ポンプを
操作して原液供給量を変え得る制御部を具備した
液体供給措置において、前記制御部は、液供給開
始に際し、前記液濃度の設定値、稀釈水の流量値
及び前記原液の濃度差から前記原液供給ポンプの
操作量を求め、該操作量に基づき前記原液供給ポ
ンプを駆動すると共に、原液の供給を開始して一
定時間経過後、前記濃度検出手段の出力から前記
液濃度の偏差を求めこれが所定値以上になると、
その時点の前記液濃度に基づき、前記原液供給量
の必要変更量を算出し、該算出値に対応して前記
原液供給ポンプの操作を行うことを特徴とする液
供給装置。1. In a liquid supply device equipped with means for detecting the degree of liquid sac on the outlet side of a mixer for mixing dilution water and stock solution, and a control section that can operate a stock solution supply pump to change the supply amount of stock solution, the control section When starting the liquid supply, the operation amount of the stock solution supply pump is determined from the set value of the solution concentration, the flow rate value of the dilution water, and the concentration difference of the stock solution, and the operation amount of the stock solution supply pump is driven based on the operation amount. After a certain period of time has elapsed since the start of supply of the liquid, the deviation of the liquid concentration is determined from the output of the concentration detection means, and when the deviation exceeds a predetermined value,
A liquid supply device characterized in that a necessary change amount of the stock solution supply amount is calculated based on the liquid concentration at that time, and the stock solution supply pump is operated in accordance with the calculated value.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59098163A JPS60241907A (en) | 1984-05-16 | 1984-05-16 | Liquid supply device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59098163A JPS60241907A (en) | 1984-05-16 | 1984-05-16 | Liquid supply device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60241907A JPS60241907A (en) | 1985-11-30 |
| JPH0366928B2 true JPH0366928B2 (en) | 1991-10-21 |
Family
ID=14212422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59098163A Granted JPS60241907A (en) | 1984-05-16 | 1984-05-16 | Liquid supply device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60241907A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63164959A (en) * | 1986-10-30 | 1988-07-08 | コーブ・ラボラトリーズ・インコーポレーテッド | Dialytic liquid preparing apparatus |
| JPH0745219Y2 (en) * | 1988-12-12 | 1995-10-18 | 株式会社三陽電機製作所 | Dialysate preparation equipment |
| JP5150065B2 (en) * | 2006-06-09 | 2013-02-20 | 株式会社タクミナ | Metering pump and chemical injection system using the same |
| JP7307633B2 (en) * | 2019-08-30 | 2023-07-12 | 日機装株式会社 | mixer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS48103979A (en) * | 1972-04-12 | 1973-12-26 | ||
| JPS5160879A (en) * | 1974-11-25 | 1976-05-27 | Hitachi Ltd | |
| JPS5270287A (en) * | 1975-12-09 | 1977-06-11 | Fuji Electric Co Ltd | Automatic casting system of control meter in batch process |
| JPS542356A (en) * | 1977-06-07 | 1979-01-09 | Kanda Seiyouken Kk | Bread and production thereof |
| JPS5410871A (en) * | 1977-06-28 | 1979-01-26 | Toshiba Corp | Thickener control device |
-
1984
- 1984-05-16 JP JP59098163A patent/JPS60241907A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60241907A (en) | 1985-11-30 |
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