JPH0370977B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (1) Industrial Field of Application The present invention relates to a balloon-equipped catheter for vascular occlusion that is used in combination with a subcutaneously implantable drug solution injection catheter.

(2) Conventional technology A drug solution injected into the vascular system of a patient with an unresectable advanced malignant tumor using an injection catheter is diluted by the blood flow through the blood vessel into which the catheter is inserted, resulting in extremely high concentrations in the affected area. The effectiveness of the medicinal solution may be reduced.

For things like this, traditionally, BOAI
(Balloon occlusion arterial infusion) is a method that uses a balloon catheter inserted into a blood vessel to block the blood flow in the blood vessel to prevent the drug solution from flowing into blood vessels that do not require the drug solution.
The concentration of the medicinal solution in the affected area was increased by allowing the medicinal solution to flow only into the blood vessels that needed it.

(3) Problems to be solved by the invention By the way, in the case of the above-mentioned method of inserting a balloon, which is a foreign substance to a living body, into a blood vessel to occlude it and cut off blood flow, a blood clot is likely to form at the balloon portion. . Furthermore, each time the blood flow is blocked, it is necessary to insert a balloon catheter into the blood vessel, which causes great pain to the patient and causes problems in that occlusion of the blood vessel is time-consuming and has poor workability.

Therefore, the present invention eliminates the problems of the conventional methods and makes it possible to minimize the formation of blood clots and quickly occlude blood vessels when increasing the concentration of the medicinal solution in the affected area. The technical challenge is to do so.

(4) Means for solving the problems In order to achieve the above technical problem, this invention has the following features:
A puncture part made of an elastic material having self-occluding properties is fitted into the upper part of the lumen of the main body having a lumen with an opening at the upper end, and the rear end opening of the catheter tube is connected to communicate with the lumen below the puncture part. A balloon is connected to the main body and is inflated by injecting a liquid such as saline through the catheter tube from an injector inserted into the puncture section at the distal end opening of the catheter tube. The distal end opening of the catheter tube is formed in a sealed interior formed by the support part and the balloon part. The device is characterized in that the support portion is open and fixed to the support portion.

(5) Action First, position the balloon of the catheter tube at the site of the blood vessel into which the drug injection catheter tube is inserted, and bend the support portion from the outside of the blood vessel with the balloon portion inside. Wrap a thread, etc. around the support part and secure it.
Next, an injector is inserted into the puncture part of the main body to inject a medical solution such as physiological saline, and the balloon is inflated to compress the blood vessel from the outside and occlude it, temporarily blocking blood flow. This increases the concentration of the medicinal solution flowing to the affected area, allowing more effective treatment. After use, the injected liquid, such as physiological saline, is extracted by inserting the injection tool into the puncture site again.

(6) Embodiment Figures 1 and 2 show a catheter with a balloon for occluding a blood vessel. A horizontal communication hole 4 that communicates with the lower part of 3 is formed to open on the side surface. Bore 3 of body 1
A needle receiving container 5 made of stainless steel is fixed to the main body 1 around the inner cavity 3 and is fitted in a manner that cannot be removed. A tactile section 6 is provided around the upper end opening of the inner cavity 3 into which the needle receiving container 5 is fitted. The tactile part 6 has a convex padding so that the upper end opening of the inner cavity 3 can be confirmed from above the skin when the main body 1 is implanted subcutaneously. The needle receiving container 5 is connected to a cylindrical portion 5a fitted in the lower part of the inner cavity 3, and the cylindrical part 5a is connected to the upper end of the cylindrical part so as to gradually increase in diameter upward from the upper end of the cylindrical part, and is fitted in the upper part of the inner cavity 3. A through hole 7 communicating with the communication hole 4 is bored in the side wall of the cylindrical part 5a, and an upper end opening of the inner cavity 3 is formed in the top wall of the expandable cylindrical part 5b. A communicating opening 8 is bored. A puncture part 10 made of silicone rubber is fitted into the expansion tube part 5b in a compressed state, and the outer peripheral surface of the upper end of the puncture part 10 has a flange 11 around the opening 8 of the expansion tube part 5b so that the puncture part 10 does not slip out. is being held down. Since the puncture part 10 is made of silicone rubber, it is possible to make multiple punctures with the injection needle.
In addition, when a pierced injection needle is removed, the needle closes the passage of the removed needle due to its own elasticity, and has good self-closing properties to prevent leakage of the drug solution.
The inside of the container 5 below the puncture part 10 is a reservoir 13 in which a medicinal solution can be temporarily stored, like the lower part of the lumen of a conventional catheter.

The opening of the communication hole 4 is connected to the rear end opening of a catheter tube 15 of a predetermined length made of silicone rubber. The distal end opening of the catheter tube 15 is made of silicone rubber, which is made up of a bendable outer support section 16 made by cutting the tube, and a thin sheet-like inner balloon section 17 whose peripheral edge is adhered to the inner peripheral surface of the support section. It is fixed to the support part 16 of the manufactured balloon 18 so as to communicate with the inside of the balloon 18. Balloon part 1 of balloon 18
When a liquid such as physiological saline is injected into the balloon 18 from the catheter tube 15, the balloon 7 expands by pushing the support portion 16 apart from the bent state shown in FIG. 1 as shown in FIG. 3. 20
are protrusions provided on the outer circumferential surface of both ends of the support section 16, and are used to prevent the thread wound around the support section 17 from slipping off when the balloon 18 is fixed to the blood vessel. Reference numeral 21 indicates a suture hole drilled in the lower periphery of the main body 1 for sewing and fixing the main body 1 to the fascia of the subcutaneous tissue. Reference numeral 22 indicates a reinforcing hole attached to the bottom of the main body 1 including the suture hole 21. It is polyester mesh.

FIG. 4 shows another embodiment in which a catheter with a balloon for occluding a blood vessel is integrated with a catheter for injecting a drug solution. That is, both catheters are fixed at their main bodies 1 and 1' with an adhesive or the like for ease of use. The drug solution injection catheter is constructed as shown in Fig. 5, and the main body 1' is designed to prevent blood from flowing back from the catheter tube 15' to the reservoir 13' side, compared to the main body 1' of the catheter with a balloon for vascular occlusion. The structure is substantially the same except that a check valve 25 for preventing the problem is fitted into the communication hole 4'. Therefore, similar parts are given the same reference numerals and a dash, and their explanation will be omitted. A rear end opening of a catheter tube 26 of a predetermined length made of silicone rubber is connected to the distal end opening of the catheter tube 15' via a connector 27 so as to be communicable. An annular protrusion 28 is provided near the tip opening (outlet) of the catheter tube 26 for fixing to the tip. In this embodiment, a marking part 30 is attached to the surface of the touch finger part 6 of the main body 1 in order to identify the integrated main body 1 and the main body 1'.

Next, the operation of the above embodiment will be explained based on the embodiment shown in FIG.

To implant the catheter subcutaneously, step 6
As shown in the figure, the catheter tube 26 is inserted into the blood vessel from the distal end of the hepatic artery 41 of the liver 40, for example, and the distal opening is advanced to the affected area to be treated and fixed, and the balloon 18 of the catheter tube 15 is inserted into the blood vessel. It is positioned in the intended hepatic artery 41, and the string 42 is wound and fixed with the balloon part 17 facing inside as shown in FIG.

On the other hand, the main bodies 1 and 1' are also sewn and fixed to the fascia of the subcutaneous tissue through the suture holes 21 and 21'.

In order to inject the anticancer drug as a medicinal solution into the affected area in the catheter implanted subcutaneously as described above, lightly place a finger on the tactile part 6' of the main body 1' identified by the marking part 30 to confirm the opening at the upper end of the lumen 3'. Moreover,
As shown in FIG. 8, the injection needle 43 is inserted into the puncture portion 10' of the main body 1', and the anticancer agent in the syringe is injected into the reservoir 13' from the needle tip. reservoir 1
The anticancer agent injected into the catheter tube 3' passes through the through hole 7' and the check valve 20' in the communicating hole 4', and flows through the catheter tube 15', 26 from the distal opening of the tube 26 to the affected area.

In this way, the anticancer drug flows into the affected area.

However, with this method, the anticancer drug becomes considerably diluted in the blood flowing from the hepatic artery 41 to the liver 40, making it impossible to expect effective treatment. Therefore, in order to increase the concentration of the anticancer drug, another injection needle (not shown) is inserted into the puncture part 10 of the main body 1, and a liquid such as physiological saline is injected into the reservoir 13, and the liquid is introduced into the balloon 18 through the catheter tube 15. The balloon portion 17 is inflated to compress the hepatic artery 41 from the outside to occlude it and temporarily cut off blood flow. This increases the concentration of the anticancer drug flowing to the affected area, making it possible to provide more effective treatment. Compared to the conventional method of blocking blood flow using a balloon catheter, such a method does not cause thrombi to form in the hepatic artery, and is extremely effective.

After the inflowing liquid such as physiological saline is used, the injection needle is inserted into the puncture part 10 again and extracted.

(7) Effects of the Invention This invention is as described above, and is used in combination with a drug solution injection catheter, and when injecting a drug solution, a liquid such as physiological saline is injected into a blood vessel into which the injection catheter is inserted. By compressing the blood vessel from the outside with an inflated balloon and occluding the blood vessel, the concentration of the drug flowing to the affected area can be increased. Therefore, the balloon is performed by bending the support part with the balloon part inside and fixing the balloon to the blood vessel by wrapping a thread, etc. around the bent support part, so it is more likely to form a thrombus than conventional methods that are performed inside the blood vessel. can be reduced. Furthermore, when a blood vessel is occluded due to compression of the balloon, it can be done simply by fixing the balloon to the blood vessel and then injecting a liquid such as physiological saline into the balloon from an injection tool inserted into the puncture part of the main body. In addition to being quick and efficient, the catheter tube does not need to be inserted into the blood vessel during occlusion, so there is no pain to the patient caused by insertion as in the case of conventional methods.

[Brief explanation of drawings]

Fig. 1 is a longitudinal sectional front view of a catheter showing one embodiment of the present invention, Fig. 2 is a plan view of the same, Fig. 3 is a partial perspective view of the balloon section of the same, and Fig. 4 shows another embodiment. A plan view of the catheter, FIG. 5 is a longitudinal sectional front view of the catheter for drug injection, FIG. 6 is an explanatory view of the operation, FIG. FIG. 3 is a perspective view showing a state in which a medical solution is being injected with a syringe. DESCRIPTION OF SYMBOLS 1...Main body, 3...Inner cavity, 4...Communication hole, 5...Needle receiving container, 6...Touch part, 7...Through hole, 8...Opening part, 10
...Puncture part, 15...Catheter tube, 16...Support part, 17...Balloon part, 18...Balloon,
30...Indication section.

Claims (1)

[Claims] 1 A puncture part made of a self-occluding elastic material is fitted into the upper part of the lumen of the main body having a lumen with an upper end opening, and the rear end of the catheter tube is connected to the lumen below the puncture part. An opening is connected to the main body, and a balloon inflated by injecting a liquid such as saline from an injection tool inserted into the punctured part through the catheter tube is provided at the tip opening of the catheter tube. It consists of a bendable support part and a thin sheet-like balloon part whose peripheral edge is adhered to the bending side surface of the support part, and the tip of the catheter tube is placed inside the sealed interior formed by the support part and the balloon part. A catheter with a balloon for vascular occlusion, characterized in that the opening is open and the catheter is fixed to the support part.