JPH0376343B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an antibacterial latex composition, and its purpose is to mold latex for medical instruments, sanitary products, food manufacturing equipment, supplies, etc., which have sustained antibacterial activity. The purpose of this invention is to propose an antibacterial latex composition suitable for manufacturing products.

Conventionally, various sterilizing disinfectants have been used in the fields of medicine, hygiene, testing, and food to prevent contamination and infection from various types of bacteria, actinobacteria, fungi, slime molds, viruses, and the like. Among them, 6,9-diamino-2-ethoxyalklidine lactate (also called acrinol)
Acridine compounds are one of the most widely used antibacterial agents today, as they have strong bactericidal activity against a wide range of microorganisms and have low toxicity to the human body. It is. Currently, these are usually provided as an aqueous solution, and the desired purpose can be achieved by immersing medical instruments in the aqueous solution or spraying the aqueous solution on them before use.

However, when medical instruments are used for a long period of time, we often experience in our daily lives that the effectiveness of antibacterial agents gradually decreases or disappears if only the initial disinfection is carried out, and there is a strong desire to improve this situation. There is.

The most appropriate countermeasure would be a system in which a constant amount of antibacterial agent at a minimum (growth) inhibitory concentration or higher is slowly released from the device during the course of its use. In order to realize such a system, it is necessary to obtain latex in which antibacterial agents are uniformly and stably dispersed.
It is necessary to mold this material into, for example, a medical device, etc., but the latex in which the acridine compound is uniformly and stably dispersed can be
It has not been obtained so far.

First, polymer latex, which is made by dispersing hydrophobic natural rubber or synthetic polymer compounds in an aqueous medium, is
These latexes are used in a variety of useful applications today, and these latexes usually contain various surfactants, protective colloids, etc. to help stabilize the floating and dispersion of latex particles. For example, in natural rubber latex, protein, which is an ampholyte contained in its components, is adsorbed onto the surface of rubber particles, thereby acting as a kind of protective colloid and helping to stabilize the dispersion of latex particles. In addition, natural rubber latex tends to generate acid and coagulate due to the action of enzymes and bacteria contained in it, so to prevent this, 0.5 to 1.0% ammonia is usually added, and the benefit is to maintain alkalinity. There is. Therefore, since the rubber particles are basically negatively charged, they are stably suspended and dispersed without agglomerating due to the mutual electrostatic repulsion between the particles. In addition, anionic and/or nonionic surfactants are added to synthetic polymer latexes before or after polymerization, and in practice, cationic surfactants are used unless there are special circumstances. For example, very few. On the other hand, as can be seen from its chemical structure, acridine compounds as antibacterial agents belong to cationic fungicides that have a positive charge and a hydrophobic ring structure in one molecule, and therefore, for example, commercially available products such as 6, 9-diamino-2-
Adding an anionic surfactant such as soap to an aqueous solution of lactate, which is a readily water-soluble salt of ethoxyacridine, causes the elimination or replacement of lactic acid.
It has been considered contraindicated in the past because it forms poorly water-soluble salts, resulting in a decrease in bactericidal activity.

Under the above technical background, for example, when an aqueous acrinol solution is added to natural rubber latex, the negative charge of the latex particles is neutralized and destabilized, resulting in immediate irreversible gelation of the latex. Therefore, the addition of these acridine-based antibacterial agents to latex was considered to be nonsense, and no further serious consideration was given.

The present inventors have conducted intensive studies on antibacterial latex compositions suitable for manufacturing medical devices, sanitary products, food manufacturing equipment, etc. made of latex with sustained antibacterial activity, and have surprisingly found that The present invention has been achieved based on the discovery that a stable antibacterial latex composition can be obtained without causing gelation even if a poorly water-soluble and antibacterial acridine compound or its salt is added to the latex.

That is, the present invention is an antibacterial latex composition comprising natural rubber latex or synthetic polymer latex and a poorly water-soluble and antibacterial acridine compound or its salt.

The acridine compound in the present invention is a compound having the following acridine skeleton, and is a compound having the following acridine skeleton. Various derivatives are described on pages 286-326 (Asakura Shoten, 1960). Preferred specific examples of such acridine compounds include 9-aminoacridine, 3,
6-diaminoacridine, 6,9-diamino-2
-Ethoxyacridine and the like.

The salt of an acridine compound in the present invention refers to a salt formed from an acridine compound and an inorganic acid or an organic acid.

Poor water solubility in the present invention means 100%
The solubility in distilled water is 0.001 to 1.0 g, preferably 0.005 to 0.7 g. If the solubility in water is less than 0.001 g, the efficacy as a bactericidal agent will be reduced, while if it exceeds 1.0 g, the latex will irreversibly gel when added to the latex, which is undesirable.

The content of the poorly water-soluble and antibacterial acridine compound or its salt in the antibacterial latex composition of the present invention varies depending on the purpose, but is usually preferably 0.01 to 30 wt% based on the solid content of the latex. , more preferably 0.1~10wt
%. If the content exceeds 30wt%, the physical strength of the film of the molded product obtained from this latex composition tends to be poor, while if it is less than 0.01wt%, it becomes difficult to exert its effectiveness as an antibacterial agent. Undesirable.

The natural rubber latex used in the present invention is
The dispersion medium is an aqueous solution containing various organic and inorganic substances that flows out when the bark of a rubber plant is cut, and the rubber component is used as the dispersoid. This refers to products that contain softeners, fillers, anti-aging agents, colorants, etc. Also,
Examples of synthetic polymer latexes include homopolymers of vinyl monomers such as ethylene, styrene, vinyl acetate, vinyl chloride, vinylidene chloride, acrylonitrile, (meth)acrylic acid esters, vinyl pyridine, and methyl vinyl ether, or copolymers thereof. , homopolymers of diene monomers such as butadiene, isoprene, 1,3-pentaethyl, 1,5-hexadiene, 1,6-heptadiene, chloroprene, etc., or copolymers thereof, copolymers of the above vinyl monomers and diene monomers. Copolymers, etc. of vinyl monomers having other functional groups such as epoxide groups, amino groups, carboxyl groups, acid anhydride groups, hydroxyl groups, amide groups, N-methylolamide groups, isocyanate groups, and the above various monomers. Examples include those containing a surfactant, a crosslinking agent, a filler, a softening agent, etc. as the main ingredient.

The method for preparing the antibacterial latex composition of the present invention is not particularly limited as long as each component is mixed uniformly, and various known methods can be used. Preferably, a method is employed in which a homogeneous paste-like aqueous dispersion is obtained by grinding with a grinder, and natural rubber latex or synthetic polymer latex is added thereto and mixed by stirring.

The antibacterial latex composition of the present invention can be suitably used for molding medical instruments, sanitary instruments, food manufacturing equipment or fixtures, etc., which have sustained antibacterial properties even during long-term use. Examples of specific molded products include various catheters including urinary catheters, bags such as urine storage bags, fluid supply and drainage tubes, sponges, rubberized cloth, paper sizing agents,
Examples include non-woven fabric binders, paints, adhesives, etc. These are molded by a conventionally known dipping method, casting method, electrodeposition method, or the like. To give a more specific application example, the antibacterial latex composition of the present invention can be used for urinary catheters, which frequently cause urethritis, cystitis, pyelitis, etc. due to bacteria that enter through the catheter when left in the body for a long period of time. The molded urinary catheter and urine storage bag have the ability to release antibacterial agents in a sustained manner, and during the process of use, the antibacterial agents are continuously released in urine or body fluids, so they can be used to protect the urinary tract from various bacteria. Extremely effective in preventing infection.

The present invention will be described in detail with reference to specific examples below.

Note that "parts" in the examples mean "parts by weight."

Example 1 0.3 parts of zinc dimethyldithiocarbaminsate, 1.5 parts of sulfur, 3 parts of zinc white, and 1.2 parts of stearic acid were added to 100 parts of a natural rubber latex solution (PH10.7) with a solid content concentration of approximately 50 wt%, and uniformly dispersed. A compounded latex containing natural rubber as the main component was obtained. When 10 parts of 6,9-diamino-2-ethoxyacridine hydrochloride as an antibacterial agent was uniformly dispersed into a paste in 12 parts of distilled water to this mixed latex while stirring, the latex coagulated. It was possible to obtain a latex composition in which the antibacterial agent was uniformly dispersed without having to do so.

A film can be formed from the obtained composition, and about this film, Bacillus subtilis
When an antibacterial activity test was conducted using ATCC6633 (medium NUTRIENT AGAR) as a test bacterium by the cylindrical plate method (disk method), an inhibition circle was produced, and the composition was confirmed to have antibacterial properties.

Comparative Example 1 When a 1.5 wt% aqueous solution of 6,9-diamino-2-ethoxyacridine lactate was added little by little to 100 parts of the same compounded latex used in Example 1 while stirring, the latex gradually increased in viscosity. ,
After approximately 5 ml was added, the mixture completely gelled.

Example 2 To 100 parts of the same mixed latex used in Example 1, 10 parts of 9-aminoacridine hydrochloride was dispersed in paste form in 12 parts of distilled water, and this was added with stirring, and the latex agglomerated. It was evenly dispersed without any smudging.

When the obtained composition was subjected to the same test as in Example 1, the film showed antibacterial properties.

Example 3 To 100 parts of the same mixed latex used in Example 1, 10 parts of 3,6-diaminoacridine sulfate was uniformly dispersed in a paste form in 12 parts of distilled water, and this was added with stirring. However, the latex was uniformly dispersed without agglomeration.

When the obtained composition was subjected to the same test as in Example 1, the film showed antibacterial properties.

Example 4 Anionic styrene with a solid content concentration of approximately 50 wt%
When 10 parts of 6,9-diamino-2-ethoxyacridine hydrochloride was uniformly dispersed in 12 parts of distilled water and added to 100 parts of butadiene copolymer latex (PH=9.5) while stirring, the latex was uniformly dispersed without agglomeration.

When the obtained composition was subjected to the same test as in Example 1, the film showed antibacterial properties.

Example 5 Anionic vinyl chloride-vinylidene chloride copolymer latex with a solid content concentration of approximately 45 wt% (PH = 9.0)
100 parts of 3,6-diaminoacridine sulfate
When 10 parts of the latex solution was uniformly dispersed in 12 parts of distilled water, the latex solution was uniformly dispersed without agglomeration.

When the resulting composition was tested in the same manner as in Example 1, the film showed antibacterial properties.

Claims (1)

[Scope of Claims] 1. An antibacterial latex composition comprising natural rubber latex or synthetic polymer latex and a sparingly water-soluble and antibacterial acridine compound or its salt. 2. The antibacterial latex composition according to claim 1, wherein the acridine compound is 9-aminoacridine. 3. The antibacterial latex composition according to claim 1, wherein the acridine compound is 3,6-diaminoacridine. 4 The acridine compound is 6,9-diamino-2-
The antibacterial latex composition according to claim 1, which is ethoxyacridine.