JPH0412425B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Industrial Application Field The present invention relates to a flow injection type analyzer used in biochemical analysis and the like.

(b) Prior Art Figure 1 shows a typical conventional flow injection type analyzer. a is a reagent supply section, b is a pump, c is a sample injection section, (d) is a reaction coil, and e is a detector. In the case of this one,
The disadvantage is that there is a lot of wasted reagent because the reagent is constantly flowing. Figures 2 and 3 show other types, and the one shown in Figure 2 (merging zone method) has a sample injection part c and a reagent injection part f arranged in parallel flow paths, and the sample and reagent are respectively The components are conveyed by a carrier from a separate carrier supply section g and mixed together. In this configuration, only the required amount of reagent is flowed, so there is no waste, but two pumps b are required, and if two pumps b are used, there is a problem that data is disturbed due to the difference in pulsation period. In the method shown in FIG. 3 (Sand-Deutsch method), the sample is injected into the channel so as to be positioned between the reagents, but mixing in the channel direction is required within the channel.

(C) Purpose of the Invention The present invention aims to provide a flow-in injection type analyzer that solves the problems of the conventional products mentioned above, and allows for smooth and precise analysis since no reagents are wasted. The purpose of this project is to provide a flow-injection type analyzer that can perform this type of analysis.

(d) Structure of the Invention The structure of the present invention is such that the carrier supply section, the pump, the reaction coil, and the detector are sequentially connected by a flow path, and at least three flow paths are connected in parallel between the pump and the reaction coil. is incorporated,
One channel is provided with a sample injection section, the other channel is dedicated to the carrier, and the remaining channel is provided with a reagent injection section, and the other channel is dedicated to the carrier. This is a flow injection type analyzer characterized in that a carrier flow rate control means is attached to the flow path.

In this configuration, the carrier flow rate control means means something that has the function of stopping or reducing the flow of the carrier in a channel dedicated to the carrier, such as a channel switching valve or a resistance pipe.

(e) Examples Examples of the present invention will be described in detail below with reference to the drawings, but the invention is not limited to the following examples.

FIG. 4 shows the overall configuration of a flow injection type analyzer according to the present invention.

1 is a carrier supply section, 2 is a pump, 3 is a reaction coil, and 4 is a detector, which are connected in sequence through a flow path 5, and the pump 2 and the reaction coil 3
Three channels 5a, 5b, and 5c are arranged in parallel between them. A flow path 5 from the pump 2 reaches a switching valve (carrier flow rate control means) 6a, where it branches into three flow paths 5a, 5b, and 5c. The flow path 5a and the flow path 5b are joined by a three-way joint 7, and the merged flow path 5d and flow path 5c reach a switching valve (carrier flow rate control means) 6b. The flow path 5a includes a resistance tube 8a and a sample injection part 9.
A resistance tube 8b and a reagent injection part 10 are provided in the flow path 5b. Both the sample injection section 9 and the reagent injection section 10 are injection sections of a channel switching mechanism, and when the reagent and sample are sent to the injection sections, the channels 5a and 5b are in a closed state.

The analysis process in the analyzer of the above embodiment will be explained below.

First, switch the switching valves 6a and 6b.
A and 6b are communicated through a flow path 5c, and the carrier is caused to flow by operating the pump 2. In this state, on the one hand, a sample and a reagent are supplied to the sample injection section 9 and the reagent injection section 10, respectively. When the supply of the sample and reagent is completed, the switching valves 6a, 6b are switched, and the carrier is flowed into the channels 5a, 5b. The sample and reagent are then sent to the carrier, where they are mixed together at the three-way joint 7, and further passed through the switching valve 6b to the reaction coil 3, where the reactant is transferred to the detector 4.
Detected in The resistance tubes 8a and 8b are connected to both flow paths 5
a, 5b so that the liquid is stably distributed, this determines the flow rate in both flow paths 5a, 5b, and the sample and reagent are combined in a timely manner at the three-way joint 7. It is structured as follows.

Another embodiment will be explained with reference to FIG.

In this analyzer, a resistance pipe 11 is used in the flow path 5c as a means for controlling the flow rate of the carrier, so that when the carrier flows in the flow paths 5a and 5b, some carrier also flows in the flow path 5c. ing. Further, the flow paths 5a, 5b, 5c are configured to branch and merge by four-way joints 12a, 12b.

FIG. 6 shows yet another embodiment, which is a modification of the one shown in FIG.

This analyzer is provided with three channels 5b each having a reagent injection section 10, and is configured to perform analysis using three types of reagents.

(f) Effects of the invention Since this invention is configured as described above,
According to this device, the amount of reagents used can be reduced compared to conventional general flow-injection type analyzers. In addition, only one pump is required for carrier feeding, and the accompanying problem of data disturbance is also eliminated. Furthermore, since the sample and reagent are mixed by merging, there is no need to provide a separate mixing function.

[Brief explanation of drawings]

Figure 1 is a block diagram of a conventional general flow-injection type analyzer, Figure 2 is a block diagram of a conventional flow-injection type analyzer using the merging zone method, and Figure 3 is also a Sand-Deutsch method. FIG. 4 is a block diagram of an embodiment of a flow-injection type analyzer according to the present invention;
FIGS. 5 and 6 are configuration diagrams of other embodiments. DESCRIPTION OF SYMBOLS 1...Carrier supply part, 2...Pump, 3...Reaction coil, 4...Detector, 5, 5a, 5b, 5c
...Flow path, 6a, 6b...Switching valve (carrier flow rate control means), 9...Sample injection part, 10...Reagent injection part.

Claims (1)

[Claims] 1. A supply section of a carrier, a pump, a reaction coil, and a detector are sequentially connected by a flow path,
In addition, at least three channels are installed in parallel between the pump and the reaction coil, one of which is provided with a sample injection section, and the other channel is dedicated to the carrier. A flow injection type analyzer characterized in that the remaining flow path is provided with a reagent injection part, and the flow path dedicated to the carrier is further provided with carrier flow rate control means. 2. The flow injector according to claim 1, wherein the carrier flow rate control means is a flow path switching valve located at a branching part and a merging part of the flow path at the front end and the rear end of the flow path dedicated to the carrier. Excision type analyzer. 3. The flow injection type analyzer according to claim 1, wherein the carrier flow rate control means is a resistance tube.