JPH0420145B2 - - Google Patents
Info
- Publication number
- JPH0420145B2 JPH0420145B2 JP13242384A JP13242384A JPH0420145B2 JP H0420145 B2 JPH0420145 B2 JP H0420145B2 JP 13242384 A JP13242384 A JP 13242384A JP 13242384 A JP13242384 A JP 13242384A JP H0420145 B2 JPH0420145 B2 JP H0420145B2
- Authority
- JP
- Japan
- Prior art keywords
- disk
- transfer path
- measurement
- transferred
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000005259 measurement Methods 0.000 claims description 37
- 230000003287 optical effect Effects 0.000 claims description 20
- 210000004369 blood Anatomy 0.000 claims description 12
- 239000008280 blood Substances 0.000 claims description 12
- 210000002966 serum Anatomy 0.000 description 18
- 238000004458 analytical method Methods 0.000 description 9
- 238000004140 cleaning Methods 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 238000004159 blood analysis Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000036760 body temperature Effects 0.000 description 2
- 210000000078 claw Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000012742 biochemical analysis Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000004506 ultrasonic cleaning Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
【発明の詳細な説明】
〔発明の技術分野〕
この発明は、多項目の血液分析（生化学的分析
や免疫的分析）を行う、所謂スーパーマルチチヤ
ンネル方式の自動分析方法及びその装置に係り、
特に装置を大幅に小型化することができる血液の
自動分析装置に関する。[Detailed Description of the Invention] [Technical Field of the Invention] The present invention relates to a so-called super multi-channel automatic analysis method and apparatus for performing multi-item blood analysis (biochemical analysis and immunological analysis).
In particular, the present invention relates to an automatic blood analyzer that can be significantly miniaturized.
従来の所謂スーパーマルチチヤンネル方式の自
動分析装置は種々提案されているが、そのほとん
どのものは、血液移送装置、血液分注装置、光学
測定装置とから構成された血液分析ユニツトを複
数ユニツト組合せてこれらを同時に駆動すること
で、例えば32項目（８項目×４ユニツトの場合）
の血液分析を行うようにしたものがある。
Various conventional so-called super multi-channel automatic analyzers have been proposed, but most of them combine multiple blood analysis units consisting of a blood transfer device, a blood dispensing device, and an optical measurement device. For example, 32 items (in the case of 8 items x 4 units) can be
There is a method that allows blood analysis to be performed.
しかしながら、これら従来の所謂スーパーマル
チチヤンネル方式の自動分析装置にあつては、そ
の全てが、同じ構成、作用を奏する血液分析ユニ
ツトを単に平面状に並置し、これらを一つの制御
装置で同期駆動するよう制御することで多項目測
定を行うように構成していることから、装置が非
常に大型化するばかりでなく、同じ構成、作用の
上記ユニツトを数ユニツト必要とすることから、
部品点数が非常に多く、組立作業が極めて煩雑で
あるとともに、これらの各パーツの駆動制御を全
て同期させる必要があるので、これらの制御プロ
グラムが困難を極め、操作及び管理作業が煩雑で
実用性に乏しいという問題を有していた。 However, in all of these conventional so-called super multi-channel automatic analyzers, blood analysis units that have the same configuration and function are simply arranged side by side in a plane, and they are driven synchronously by a single control device. Since the device is configured to perform multi-item measurements through control, it not only becomes very large, but also requires several of the above units with the same configuration and function.
The number of parts is extremely large, and the assembly work is extremely complicated.In addition, the drive control of each part must be synchronized, making the control program extremely difficult, making operation and management work complicated, and impractical. The problem was that there was a lack of
この発明は、かかる現状に鑑み創案されたもの
であつて、その目的とするところは、この種の所
謂スーパーマルチチヤンネル方式の血液の自動分
析を、簡易な方法と構成で行うことができ、以つ
てこの種の装置を大幅に小型化することができる
とともに、その取扱いも極めて簡易に行うことが
できる高精度にして分析データに対する信頼生も
高い血液の自動分析装置を提供しようとするもの
である。
The present invention was devised in view of the current situation, and its purpose is to be able to perform this type of so-called super multi-channel automatic blood analysis using a simple method and configuration; It is an object of the present invention to provide an automatic blood analyzer that can significantly reduce the size of this type of device, is extremely easy to handle, has high precision, and has high reliability for analysis data.
〔発明の構成〕
かかる目的を達成するため、この発明にあつて
は、被測定血液が分注される反応管を所要本数保
持する平均略Ｃ字状のデイスクと、該デイスクを
垂直方向へ移送する縦型筒状の恒温移送路と、該
移送路に隣設され上記デイスクを垂直方向へと順
次移送する縦型筒状の測定移送路と、該測定移送
路の中途に介装されてなる光学測定装置と、該測
定装置の配設部位に到来した上記デイスクを少な
くとも一回転回動制御する回転駆動装置とからな
り、上記回転駆動装置は、デイスクに配設された
磁力と測定移送路に配設された磁力との磁力作用
を利用することで同デイスクを測定移送路内の所
要位置で少なくとも一回転回動制御するよう構成
したものである。[Structure of the Invention] In order to achieve the above object, the present invention includes a disk having an average approximately C-shape that holds a required number of reaction tubes into which blood to be measured is dispensed, and a disk that is vertically conveyed. a vertical cylindrical constant-temperature transfer path for transporting the disks, a vertical cylindrical measurement transfer path that is adjacent to the transfer path and sequentially transfers the disks in the vertical direction, and an intervening midway of the measurement transfer path. It consists of an optical measurement device and a rotational drive device that rotates the disk at least once when it has arrived at the location where the measurement device is installed, and the rotational drive device is configured to act on the magnetic force provided on the disk and the measurement transfer path. The disk is configured to be rotated by at least one rotation at a desired position within the measurement transfer path by utilizing the magnetic force effect with the disposed magnetic force.
次に図面に示す一実施例にもとづき、この発明
を詳細に説明する。
Next, the present invention will be explained in detail based on an embodiment shown in the drawings.
第１図中１０は、平面略Ｃ字状に形成されたデ
イスクを示し、同デイスク１０には所要間隔毎に
所要数の小孔１１が開設されており、同各孔１１
には第２図に示すように反応管１２が対応本数保
持されている。また、同デイスク１０の上記各小
孔１１には、同各孔１１の軸方向と直交する方向
に光軸孔１３がデイスク１０を貫通して開設され
ている。つまり各光軸孔１３は、後述するよう
に、デイスク１０の中心部位に配設される光源Ｋ
からの測定光が同光軸孔１３を経て反応管１２内
の血清内を透過した後、再び光軸孔１３を経てデ
イスク１０の外方へ導かれるように構成されてい
る。 Reference numeral 10 in FIG. 1 indicates a disk formed in a substantially C-shape in plan, and the disk 10 is provided with a required number of small holes 11 at required intervals.
As shown in FIG. 2, a corresponding number of reaction tubes 12 are held. Further, in each of the small holes 11 of the disk 10, an optical axis hole 13 is formed passing through the disk 10 in a direction perpendicular to the axial direction of each hole 11. In other words, each optical axis hole 13 is connected to a light source K disposed at the center of the disk 10, as will be described later.
After the measurement light from the disk passes through the optical axis hole 13 and passes through the serum in the reaction tube 12, it is guided to the outside of the disk 10 through the optical axis hole 13 again.
尚、上記デイスク１０は、好ましくは、その上
面及び下面より反応管１２が突出しない状態で保
持するのが望ましい。 The disk 10 is preferably held in such a manner that the reaction tube 12 does not protrude from its upper and lower surfaces.
また、同デイスク１０の外周面部には、後記す
る光学測定位置で同デイスク１０を少なくとも一
回転させるのに必要な回転手段として異なる磁力
Ｎ極とＳ極とが周方向に沿つて交互に配列されて
いる。 Further, on the outer peripheral surface of the disk 10, different magnetic north poles and south poles are arranged alternately along the circumferential direction as rotation means necessary to rotate the disk 10 at least once at an optical measurement position to be described later. ing.
このように構成されたデイスク１０は、縦断面
〓状のデイスクホルダ１５に嵌装保持され、同ホ
ルダ１５はモータ等の回転手段１６で回転制御さ
れる。この制御は制御装置CPUを介して行なわ
れる。 The disk 10 configured in this manner is fitted and held in a disk holder 15 having a round-shaped longitudinal section, and the rotation of the holder 15 is controlled by a rotating means 16 such as a motor. This control is performed via the control device CPU.
このようにデイスクホルダ１５に保持されてな
るデイスク１０の反応管１２には、デイスクホル
ダ１５に隣設されたサンプラ２０のサンプルカツ
プ２１内に収容されてなる血清がピペツト装置Ｐ
を介して所要量づつ分注される。このピペツド装
置Ｐは、サンプルカツプ２１の開口径に対応して
所要本数のピペツドP1、P2…Pnより構成され、
該各ピペツトP1、P2…Pnはサンプルカツプ２１
の上部、つまり血清吸引位置では近接して集合さ
れた状態（束ねられたような状態）で昇降案内さ
れてサンプルカツプ２１内の血清を所要量づつ吸
引し、血清分注位置では、所要間隔毎に展開さ
れ、各ピペツトP1、P2…Pnがデイスク１０の対
応反応管１２位置で停止した後下降して血清を所
要量づつ同対応反応管１２に分注する。この時、
同各ピペツトP1，P2…Pnからは、分析項目に対
応する第１試薬又は希釈液R1が所要量づつ対応
反応管１２内に分注される。 The serum contained in the sample cup 21 of the sampler 20 adjacent to the disk holder 15 is transferred to the reaction tube 12 of the disk 10 held in the disk holder 15 by the pipetting device P.
The required amount is dispensed via the . This pipette device P is composed of a required number of pipettes P 1 , P 2 . . . Pn corresponding to the opening diameter of the sample cup 21,
Each pipette P 1 , P 2 ...Pn is a sample cup 21
At the upper part of the sample cup 21, that is, at the serum suction position, the serum in the sample cup 21 is guided up and down in a closely gathered state (bundled state) to aspirate the required amount of serum in the sample cup 21, and at the serum dispensing position, the serum is collected at required intervals. Each pipette P 1 , P 2 . . . Pn stops at the corresponding reaction tube 12 position of the disk 10 and then descends to dispense the required amount of serum into the corresponding reaction tube 12. At this time,
From each pipette P 1 , P 2 . . . Pn, a required amount of the first reagent or diluent R 1 corresponding to the analysis item is dispensed into the corresponding reaction tube 12 .
この場合、ピペツトP1、P2…Pnの本数がデイ
スク１０に保持された反応管１２の数より少ない
場合、例えばピペツトの本数が８本で反応管１２
の数が32本である場合には、前記デイスクホルダ
１５は、８本のピペツトによ血清の吸引・分注作
業が終了する毎に所要角度づつ４回回動するよう
制御装置CPUで駆動制御されるので、32本の反
応管１２の全てに同一血清が分注される。もつと
も、この分注作業時間を短縮する場合には、上記
ピペツト装置Ｐを複数基配設し、これらを同時に
駆動制御することで可能である。例えば第３図に
示すように、ピペツト装置Ｐが４基PA、PB、PC、
PD配設されており、各ピペツト装置Ｐに設けら
れたピペツトが夫々８本、デイスク１０に保持さ
れた反応管１２が32本である場合、血清ａはピペ
ツト装置PAを介して第３図θ1の範囲にある８本の
反応管１２に、血清ｂはピペツト装置PBを介し
て第３図θ2の範囲にある８本の反応管１２に、血
清ｃはピペツト装置Pcを介して第３図θ3の範囲
にある８本の反応管１２に、血清ｄはピペツト装
置PDを介して第３図θ4の範囲にある８本の反応管
１２に、各ピペツトが展開して対応反応管１２に
各血清を分注する。これらの作業を４個のデイス
ク１０に行うことで所望の分析項目数に対応する
血清分注を行うことができる。 In this case, if the number of pipettes P 1 , P 2 ...Pn is smaller than the number of reaction tubes 12 held on the disk 10, for example, if the number of pipettes is 8,
When the number of pipettes is 32, the disk holder 15 is driven and controlled by the control device CPU so that it rotates four times by the required angle each time the eight pipettes finish aspirating and dispensing serum. Therefore, the same serum is dispensed into all 32 reaction tubes 12. However, in order to shorten the dispensing operation time, it is possible to provide a plurality of the pipetting apparatuses P and drive and control them at the same time. For example, as shown in FIG. 3, there are four pipetting devices P, P A , P B , P C ,
When the number of pipettes provided in each pipetting device P is 8 and the number of reaction tubes 12 held in the disk 10 is 32, the serum a is passed through the pipetting device P Serum b is transferred to the eight reaction tubes 12 in the range of θ 1 in Figure 3 through a pipette P B , and serum c is transferred to the eight reaction tubes 12 in the range of θ 2 in Figure 3 via the pipette Pc. Each pipette spreads the serum d into the eight reaction tubes 12 in the range of θ 3 in FIG. 3 through the pipette device PD . and dispense each serum into the corresponding reaction tube 12. By performing these operations on four disks 10, it is possible to dispense serum corresponding to the desired number of analysis items.
尚、各分注作業が終了したピペツトP1、P2…
Pnは、勿論図示しないピペツト洗浄装置で洗浄
される。 In addition, pipettes P 1 , P 2 after each dispensing work have been completed...
Of course, Pn is washed with a pipette washing device (not shown).
このようにして血清等が分注された反応管１２
を保持してなるデイスク１０は恒温移送路３０へ
と移送される。この差し換え作業手段としては、
手作業又は公知の機械手段、例えば所要タイミン
グで作動するベルトコンベアと把持装置との組合
せよりなる移送機構等種々の公知機構が適用され
得る。 Reaction tube 12 into which serum etc. were dispensed in this way
The disk 10 holding the is transferred to a constant temperature transfer path 30. As a means of this replacement work,
Various known mechanisms can be applied, such as manual or known mechanical means, for example a transfer mechanism consisting of a combination of a belt conveyor and a gripping device operating at the required timing.
恒温移送路３０は縦型筒状に形成され、同路３
０の内径は、デイスク１０の外径と略同一或いは
若干大径に形成され、前記血清及び試薬等の分注
が終了したデイスク１０は同路３０の最下部の側
部開口３２より同路３０に移送される。 The constant temperature transfer path 30 is formed in a vertical cylindrical shape.
The inner diameter of the disk 10 is approximately the same as or slightly larger than the outer diameter of the disk 10, and the disk 10 after dispensing the serum, reagents, etc. will be transferred to.
このように恒温移送路３０に移送されたデイス
ク１０は、同路３０内の底部付近に配設された押
し上げ機構３１を介して上方へ押し上げられる。
この押し上げ作用は、次のデイスク１０の同路３
０内への移送作業が妨げられない程度とタイミン
グ、つまりデイスク１０の高さ寸法分押し上げら
れる。このとき、上方へ押し上げられたデイスク
１０は同路３０の側部開口３０の上部位置に内設
され、デイスク１０の上昇は許容するが下降が阻
止するスプリング爪等の爪体３３により保持され
る。すなわち、上記移送路３０内に移送されたデ
イスク１０は同路上下方向に密に積層された状態
で順次押し上げ移送される。こうして順次押し上
げ移送される過程で各デイスク１０に保持された
血液等は生体温度に保温される。つまり恒温移送
路３０は電熱ヒータや温水循環等による加熱手段
３４によつて同路３０内及び移送されるデイスク
１０内の血液等は生体温度に加熱保持される。 The disk 10 thus transferred to the constant temperature transfer path 30 is pushed upward via a push-up mechanism 31 disposed near the bottom of the path 30.
This pushing up action is caused by the same path 3 of the next disk 10.
The amount and timing are such that the transfer operation into the disk 10 is not hindered, that is, the disk 10 is pushed up by the height dimension. At this time, the disk 10 pushed upward is placed inside the upper part of the side opening 30 of the passage 30, and is held by a claw body 33 such as a spring claw that allows the disk 10 to rise but prevents it from descending. . That is, the disks 10 transferred into the transfer path 30 are sequentially pushed up and transferred in a densely stacked state in a downward direction on the same path. In this way, the blood and the like held in each disk 10 is kept at the body temperature in the process of being sequentially pushed up and transferred. That is, in the constant temperature transfer path 30, the blood, etc. in the constant temperature transfer path 30 and in the transferred disk 10 are heated and maintained at the body temperature by a heating means 34 such as an electric heater or hot water circulation.
このようにしてデイスク１０が恒温移送路３０
の最上部まで移送されると、同デイスク１０は恒
温移送路３０に隣設された、これも縦型筒状の測
定移送路４０に移しかえられる。この移しかえ作
業は、手作業若しくは公知の水平押し出し機構等
の機械機構で行うことができる。 In this way, the disk 10 is transferred to the constant temperature transfer path 30.
When the disk 10 is transferred to the top of the tube, it is transferred to a measurement transfer path 40, which is also vertical and cylindrical, and is adjacent to the constant temperature transfer path 30. This transfer operation can be performed manually or by a mechanical mechanism such as a known horizontal extrusion mechanism.
測定移送路４０に移しかえられたデイスク１０
は、同移送路４０に沿つて順次間歇的に下方へ所
要タイミングで一段階（つまりデイスク１０の高
さ寸法分）づつ移送される。この移送は、同所要
タイミングで上記移送路４０の最下部からデイス
ク１０が１個づつ抜き取られることで行なわれ
る。 Disk 10 transferred to measurement transfer path 40
are sequentially and intermittently transferred downward along the transfer path 40 one step at a time (that is, the height of the disk 10) at a required timing. This transfer is performed by pulling out the disks 10 one by one from the bottom of the transfer path 40 at the same required timing.
また上記デイスク１０は、測定移送路４０に移
しかえられる際に、デイスク１０の切欠部１０′
が上記移送路４０の最上部に設けられた突起４１
に嵌装されることで位置決めが行なわれた後下方
へ移送されるよう公知の例えば回転式姿勢修正装
置（図示省略）で姿勢制御される。 Further, when the disk 10 is transferred to the measurement transfer path 40, the notch 10' of the disk 10 is
is a protrusion 41 provided at the top of the transfer path 40.
After being positioned by being fitted into the body, the posture is controlled by a known rotary posture correction device (not shown), for example, so as to be transferred downward.
また、さらに上記デイスク１０の位置決め作業
が行なわれた後であつて、同デイスク１０が下方
へ移送されるまでの停止時には第５図に示すよう
に分析項目に対応して第２試薬又は第２希釈液
R2が、制御装置CPUにより駆動制御されるピペ
ツト装置P′を介して所要量づつ分注される。 Further, after the positioning work of the disk 10 is performed, and when the disk 10 is stopped before being transferred downward, a second reagent or a second reagent is added corresponding to the analysis item as shown in FIG. Diluted solution
R2 is dispensed in the required amount via a pipetting device P' which is driven and controlled by the control device CPU.
測定移送路４０の中途には光学測定部４１が所
要段数（図示の実施例では４段）配設されてい
る。 A required number of optical measuring units 41 (four stages in the illustrated embodiment) are arranged in the middle of the measurement transfer path 40 .
この光学測定部４１の各段部に配設される光学
装置Ｋは、正面Ｌ字状の支持台４２と、この支持
台４１の垂直部分であつて各段部に対応する部位
に配設され、水平方向に測定光ｌを照射する光源
４３，４３…と、同光源４３，４３…から照射さ
れ、各段部に位置するデイスク１０の光軸孔１３
より反応管１２を透過した透過光を受光する素子
４４とから構成され、該素子４４で受光された測
定光ｌは受光レベルに対応して電圧変換されて制
御装置CPUに入力され、所定のデータ分析がな
されて記憶或いは必要に応じてデイスプレイに表
示され、若しくはプリントアウトされる。尚、各
段部に配設される光源光ｌを分析項目に対応させ
てその波長を異ならしめることで、各種測定をほ
とんど同時に行うことができる。 The optical devices K disposed at each step of the optical measuring section 41 are arranged on a support stand 42 having an L-shape in the front and at a vertical portion of the support stand 41 corresponding to each step. , light sources 43, 43... that emit measurement light l in the horizontal direction, and optical axis holes 13 of the disk 10 that are irradiated from the same light sources 43, 43... and are located at each step.
The measuring light l received by the element 44 is converted into a voltage corresponding to the received light level and inputted to the control device CPU, and is then inputted to the control device CPU to receive predetermined data. The analysis is performed and stored, displayed on a display, or printed out if necessary. In addition, by making the wavelengths of the light sources 1 disposed in each stage different depending on the analysis items, various measurements can be performed almost simultaneously.
また、測定移送路４０の上記光学測定部４１と
対面する部位には電磁石から形成された回転駆動
装置４５が光学測定段部に対応して所要数配設さ
れている。 Furthermore, a required number of rotational drive devices 45 formed from electromagnets are disposed at a portion of the measurement transfer path 40 facing the optical measurement section 41, corresponding to the optical measurement step sections.
この各回転駆動装置４５は、Ｓ極とＮ極とが測
定移送路４０の周方向に沿つて交互に形成される
よう構成されており、同回転駆動装置４５に通電
することで光学測定部４１に到来したデイスク１
０の各磁性体と対面する部位には同じ磁場が形成
され、この同じ磁力の反発力を利用することでデ
イスク１０は一定方向に回動され、一回転したと
ころでデイスク１０と回転駆動装置４５の相対面
する部位は異なる磁場（Ｓ極とＮ極）となるよう
回転駆動装置４５に通電されるので、デイスク１
０は正確に一回転してその回転は停止される。こ
の回転制御は各光学測定部４１で同様に行なわれ
る。 Each rotation drive device 45 is configured such that S poles and N poles are alternately formed along the circumferential direction of the measurement transfer path 40, and when the rotation drive device 45 is energized, the optical measurement unit 41 Disk 1 arrived in
The same magnetic field is formed in the portion facing each magnetic body of 0, and by using the repulsive force of this same magnetic force, the disk 10 is rotated in a certain direction, and after one rotation, the disk 10 and the rotation drive device 45 are rotated. Since the rotary drive device 45 is energized so that the parts facing each other have different magnetic fields (S pole and N pole), the disk 1
0 rotates exactly one revolution and its rotation is stopped. This rotation control is performed in the same way in each optical measurement section 41.
それ故、該デイスク１０に保持された各反応管
１２は、同デイスク１０の回転によつて順次光学
測定が行なわれる。 Therefore, each reaction tube 12 held on the disk 10 is sequentially subjected to optical measurement as the disk 10 rotates.
このようにして光学測定が終了し測定移送路４
０の最下部に到来したデイスク１０は公知の押し
出し装置５０を介して同移送路４０内より洗浄装
置Ｗ位置へと移送される。この時、デイスク１０
の中心部位には支持台４２が立設されているが、
同支持台４２の胴部直径ｆはデイスク１０の切欠
部１０′の開口寸法Ｆより少径に形成されている
ので、該デイスク１０が支持台４２に引掛かつて
抜けなくなることはなくスムーズに洗浄位置まで
移送される。 In this way, the optical measurement is completed and the measurement transfer path 4
The disk 10 that has reached the bottom of the cleaning device 0 is transferred from the transfer path 40 to the cleaning device W position via a known pushing device 50. At this time, disk 10
A support stand 42 is erected at the center of the
Since the diameter f of the body of the support stand 42 is smaller than the opening dimension F of the notch 10' of the disk 10, the disk 10 will not get caught on the support stand 42 and become unable to come out, and can be smoothly moved to the cleaning position. be transported to.
洗浄位置では、デイスク１０の各反応管１２内
に収容されていた血液等は全て捨てられ、同反応
管１２は超音波洗浄装置等の公知の洗浄装置Ｗを
介してきれいに洗浄され、再びデイスクホルダ１
５に移送装置され再使用に供与される。尚、洗浄
精度を高めようとする場合には、洗浄装置Ｗを第
７図に示すように複数台配設することにより可能
である。 At the cleaning position, all the blood contained in each reaction tube 12 of the disk 10 is discarded, and the reaction tube 12 is thoroughly cleaned using a known cleaning device W such as an ultrasonic cleaning device, and then returned to the disk holder. 1
5 is transferred to a transfer device and provided for reuse. In addition, if it is desired to improve the cleaning accuracy, it is possible to do so by arranging a plurality of cleaning apparatuses W as shown in FIG.
尚、上記実施例では、回転駆動装置４５を電磁
石方式にした場合を例にとり説明したが、この発
明にあつては永久磁石を利用してもよく、この永
久磁石を回転することでデイスク１０を回転させ
るよう構成してもよいこと勿論である。 In the above embodiment, the rotary drive device 45 is of an electromagnetic type. However, in the present invention, a permanent magnet may be used, and the disk 10 can be moved by rotating this permanent magnet. Of course, it may be configured to rotate.
この発明は以上説明したように、所要量づつ分
注された血液等が収容されてなる反応管を所要本
保持されてなるデイスクが、縦型筒状の恒温移送
路と測定移送路とを移送される過程で生体温度ま
で加温され、かつ比色測定を行うように構成した
ので、多項目分析を一つの移送過程で行うことが
でき、以つて、装置全体が水平方向に拡大するこ
となく大幅に小型化でき、しかも装置の構成が簡
易となるのでその取扱いが至便で故障も少なくメ
ンテナンスも容易となる他、各部の制御も容易で
あるので上記各効果と相俟つて測定精度に対する
信頼性も高く維持向上できるとともに光学測定部
におけるデイスクの回転を磁力作用により行うよ
う構成されているので機械的精度ロスが生ずるこ
ともなく生産精度管理が容易で、しかも回転ロス
を大幅に減ずることができる。 As explained above, in this invention, a disk holding a required number of reaction tubes each containing a required amount of blood, etc. is transferred between a vertical cylindrical constant-temperature transfer path and a measurement transfer path. Since the device is configured to be heated to the biological temperature during the transfer process and perform colorimetric measurements, multi-item analysis can be performed in one transfer process, without the need for the entire device to expand horizontally. It can be significantly miniaturized, and the configuration of the device is simple, making it easy to handle, less likely to break down, and easy to maintain.In addition, each part is easy to control, which, combined with the above effects, increases reliability in measurement accuracy. In addition, since the disk in the optical measuring section is rotated by magnetic force, there is no loss of mechanical accuracy, making production accuracy control easy, and rotation loss can be significantly reduced. .
図面はこの発明の一実施例を示し、第１図はデ
イスクの平面図、第２図は同デイスクとサンプラ
ーとの構成を示す概略的に示す断面説明図、第３
図はサンプルカツプ内の血液をデイスクの反応管
に分注する際の分配態様の一例を示す平面説明
図、第４図は自動分析装置の全体機構を示す概略
説明図、第５図は測定移送路及び回転駆動装置の
構成説明図、第６図は第５図−線断面図、第
７図は装置全体の平面からみた配置説明図であ
る。
１０……デイスク、１２……反応管、１５……
デイスクホルダ、２０……サンプラ、３０……恒
温移送路、３１……押し上げ機構、４０……測定
移送路、４３……光源、４４……受光素子、４５
……回転駆動装置、CPU……制御装置、Ｋ……
光学測定装置。
The drawings show an embodiment of the present invention, and FIG. 1 is a plan view of a disk, FIG. 2 is a schematic cross-sectional view showing the structure of the disk and a sampler, and FIG.
The figure is an explanatory plan view showing an example of the distribution mode when blood in the sample cup is dispensed into the reaction tube of the disk, Figure 4 is a schematic explanatory diagram showing the overall mechanism of the automatic analyzer, and Figure 5 is the measurement transfer. FIG. 6 is a sectional view taken along the line of FIG. 5, and FIG. 7 is an explanatory diagram of the arrangement of the entire device as seen from a plane. 10... disk, 12... reaction tube, 15...
Disk holder, 20... Sampler, 30... Constant temperature transfer path, 31... Pushing mechanism, 40... Measurement transfer path, 43... Light source, 44... Light receiving element, 45
...Rotary drive device, CPU...Control device, K...
Optical measurement equipment.
Claims (1)
持する平面略Ｃ字状のデイスクと、該デイスクを
垂直方向へ移送する縦型筒状の恒温移送路と、該
移送路に隣設され上記デイスクを垂直方向へと順
次移送する縦型筒状の測定移送路と、該測定移送
路の中途に介装されてなる光学測定装置と、該測
定装置の配設部位に到来した上記デイスクを少な
くとも一回転回動制御する回転駆動装置とからな
り、 上記回転駆動装置は、デイスクに配設された磁
力と測定移送路に配設された磁力との磁力作用を
利用することで同デイスクを測定移送路内の所要
位置で少なくとも一回転回動制御するよう構成さ
れていることを特徴とする血液の自動分析装置。[Scope of Claims] 1. A planar approximately C-shaped disk that holds a required number of reaction tubes into which blood to be measured is dispensed, a vertical cylindrical constant-temperature transfer path that vertically transfers the disk, and a A vertical cylindrical measurement transfer path that is adjacent to the transfer path and sequentially transfers the disks in the vertical direction; an optical measurement device that is interposed in the middle of the measurement transfer path; and a location where the measurement device is installed. and a rotational drive device that rotates the disk at least once when the disk has arrived, and the rotational drive device utilizes the magnetic force between the magnetic force disposed on the disk and the magnetic force disposed on the measurement transfer path. 1. An automatic blood analyzer characterized in that said disk is configured to be rotated at least one rotation at a desired position within a measurement transfer path.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13242384A JPS6134468A (en) | 1984-06-27 | 1984-06-27 | Automatic analyzer of blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13242384A JPS6134468A (en) | 1984-06-27 | 1984-06-27 | Automatic analyzer of blood |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6134468A JPS6134468A (en) | 1986-02-18 |
| JPH0420145B2 true JPH0420145B2 (en) | 1992-03-31 |
Family
ID=15081026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13242384A Granted JPS6134468A (en) | 1984-06-27 | 1984-06-27 | Automatic analyzer of blood |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6134468A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007205904A (en) * | 2006-02-02 | 2007-08-16 | Gs Yuasa Corporation:Kk | Electrochemical oxygen sensor |
| JP6326828B2 (en) * | 2014-01-27 | 2018-05-23 | セイコーエプソン株式会社 | Sensor unit complex, Raman spectroscopic device, and electronic device |
-
1984
- 1984-06-27 JP JP13242384A patent/JPS6134468A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6134468A (en) | 1986-02-18 |
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