JPH0423541B2 - - Google Patents

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a blood component separation bag device for separating and recovering necessary blood components from collected blood and returning the remaining blood to the blood collector. It is.

[Prior art] Conventionally, blood used for plasma preparations, etc. was generally separated from necessary components such as plasma components from the collected blood, and then the remaining blood was discarded. . In order to avoid such waste, recently, a system that separates and extracts only the necessary components from blood and then returns the remaining blood components to the blood collector has been attracting attention. As such devices, various devices have been developed that separate blood into plasma components and blood cell components using a filtration membrane and return the blood cell components to the blood collector, but these devices are large-scale and expensive. This can only be carried out in well-equipped hospitals. For this reason, plasmapheresis bags, which are a combination of conventional plastic blood bags, are also used.

FIG. 16 is a schematic diagram of a conventional plasma pheresis bag. As shown in the figure, this plasmapheresis bag 500 is a blood bag 501.
and a plasma separation bag 502, and a combination of two or three pairs of these is also used.

A blood collection tube 503 is connected to the upper end of the blood collection bag 501, and to this blood collection tube 503,
A branch blood collection tube 507 to which a blood collection needle 506 is attached and a blood cell return tube 505 to which a blood return port 504 is attached are connected via a Y-tube.

The upper end of the blood collection bag 501 further includes blood transfusion ports 508, 508 and protectors 509, 50.
A connecting tube 410 is provided which is connected to the plasma separation bag 502 via a connecting piece 9 and a communicating piece 410a.

These plasmapheresis bags 500
In the case where a pair of blood collection bag 501 and plasma separation bag 502 are provided, the system is used in the following manner.

First, the blood sampling needle 506 is penetrated into the blood vessel of the person collecting blood.
Blood is introduced into a blood collection bag 501 via blood collection tubes 507 and 503. After collecting a predetermined amount of blood, the blood collection needle 506 is covered with a needle cap 511, and the plasma pheresis bag 500 is centrifuged to separate the blood in the blood collection bag 501 into blood cell components and plasma components.

Next, the communicating piece 410a is folded, and only the plasma component of the supernatant is separated into the plasma separation bag 502 via the connecting tube 410, and the remaining blood cell components in the blood collection bag 501 are transferred to a blood transfusion set as shown in FIG. 520 was used to return the blood to the blood collector.

This blood transfusion set 520 includes a physiological saline bottle 521 containing physiological saline added with an anticoagulant;
Physiological saline introduction tube 522, introduction needle 52
3. Blood cell return tube 529, its tube 52
Blood return needle 524 attached to the tip of 9, drip barrel 525, and blood cell return tube 52 with an adapter 528 formed to fit with the blood cell return port 504 of the plasma pheresis bag 500.
6, and a clamp 527 installed in the middle of the blood cell return tube 526.

When in use, the blood cell return tube 526, physiological saline introduction tube 522, and drip tube 525 of the blood transfusion set 520 are filled with physiological saline in advance, and the adapter 528 of the transfusion set 520 is connected to the plasma pheresis bag 500. After connecting to the blood cell return port 504, the blood return needle 506 is inserted into the blood donor's blood vessel, and the blood return needle 524 is inserted into the blood transfusion port 99 of the blood collection bag 501.
The blood cell components therein were led to a drip tube 525 through a blood cell return tube 529, diluted with physiological saline inside the drip tube 525, and returned to the blood collector.

[Problems to be Solved by the Invention] However, in the plasma pheresis bag described above, when blood cell components are returned to the blood collector after plasma separation, the blood transfusion set 520 is used to transfer blood cells from the plasma pheresis bag 500. Return tube 50
5 or connect the blood return needle 524 to the blood collection bag 50.
The introduction needle 523 must be inserted into the blood transfusion port 508 of No. 1 and the physiological saline bottle 521, which is not only a clumsy operation, but also involves the blood return needle 524, the introduction needle 523, and the connector 528. There were concerns about contamination due to contact with unsterilized materials or the atmosphere.

In addition, in such a bag system, blood collection
Each operation of plasma separation processing and blood return must be performed independently in sequence, and especially when multiple pairs of blood collection bags and plasma separation bags are provided, the operations are time-consuming and time-consuming, and the blood collector The problem is that it places a psychological burden on people.

The present invention was proposed in order to solve these problems, and it enables the operations of blood collection, component separation, and blood return to be carried out simultaneously in parallel, and moreover, the operations are carried out in a sterile and hygienic manner. It is an object of the present invention to provide a blood component separation bag device that can be used in various ways. These objectives are achieved by the means described below.

[Means for Solving the Problems] As shown in FIG. 1, the present invention provides a bag for fractionating collected blood to separate, for example, plasma components, and then returning the remaining blood cell components to the blood collector. An apparatus comprising a blood collection bag 1 and a plasma separation bag 2,
The blood collection bag 1 and plasma separation bag 2 are connected by a connecting tube 4, and the blood collection bag 1 is connected to a blood collection tube 5a and a blood return tube 6a.
Further, a diluent introduction tube 7 is connected to the diluent storage bag 3, and a drip tube 1 is connected to this introduction tube.
A blood guiding tube 20 is connected via 6.
This guide tube 20 is provided with a blood guide needle 9. Further, a blood return tube 6 is connected to the diluent introduction tube 7, and a blood collection tube 5 is connected to the guide tube 20. Furthermore, a connector 8 is provided in the middle of the blood return tube 6a. In FIG. 1, two pairs of blood collection bags and plasma separation bags are provided, and correspondingly, a connecting tube 4a, a blood collection tube 5b, a blood return tube 6b, and a connector 8a are provided on the blood return tube.

The connectors 8, 8a are composed of a male member and a female member, and these are shown in FIGS. 2 and 3, for example.
As shown in the figure, it is preferable to provide a matching means that allows a plurality of key rings to be combined and only the same male and female members to be joined.

[Operation] After puncturing the blood collection needle 9 into the blood donor's blood vessel and collecting a predetermined amount of blood into the blood collection bag 1 through the blood collection tubes 5 and 5a, the male and female members of the connector 8 are separated, and the blood collection tube 5a is fused and the blood collection bag 1 is removed. The blood in the tube is centrifuged, and the supernatant blood components are separated into a separation bag 2 through a connecting tube 4. Note that while this centrifugation process is being performed, blood is being collected in the other blood collection bag 1a.

Next, the connector 8 is connected, and the blood components remaining in the blood collection bag 1 are passed through the blood return tubes 6a, 6.
Blood is returned to the person collecting blood from the blood guide needle 9 through the diluent introduction tube 7, the drip tube 16, and the blood guide tube 20 together with the diluent from the diluent storage bag 3.

While the blood collecting bag 1 is being returned, the blood collecting bag 1a is centrifuged, and after the blood collecting bag 1 is being returned, the blood collecting bag 1a is being returned.

[Example] FIG. 1 is a schematic diagram showing an example of the present invention. In the figure, 1 and 1a are blood collection bags, and 2 and 2a are plasma separation bags, and these are connected by connection tubes 4 and 4a, respectively, and connection ports on the blood collection bags 1 and 1a side of these connection tubes 4 and 4a. The communicating pieces 10, 10a are provided in the section.

Further, 5 is a blood collection tube, and 6 is a blood return tube. The blood collection tube 5 is branched into blood collection tubes 5a and 5b at a Y-tube 11, and the blood collection tube 5a is connected to the blood collection bag 1, and the blood collection tube 5b is connected to the blood collection tube 5b.
is connected to the other blood collection bag 1a. Similarly, the blood return tube 6 also branches into blood return tubes 6a and 6b at the Y-tube 12, the blood return tube 6a is connected to the blood collection bag 1, and the blood return tube 6b is connected to the blood collection bag 1. It is connected to the blood collection bag 1a.

Communication pieces 13, 13a are connected to the blood collection bags 1, 1a of these blood return tubes 6a, 6b.
Connectors 8, 8 each consisting of a male member and a female member are provided in the middle of each blood return tube.
A is provided.

Reference numeral 20 denotes a blood guiding tube, at the tip of which a blood guiding needle 9 is attached, and a Y-shaped tube 1.
4, the blood collection tube 5 and diluent introduction tube 7 are branched and connected. A diluent storage bag 3 is connected to the diluent introduction tube 7, and a communication piece 15 is provided at its connection port. This diluent storage bag 3 and introduction tube 7
The connection may be made via the introduction needle 7.

In addition, in the middle part of the diluent introduction tube 7,
A Y-tube 17 is provided to which the blood return tube 6 branches and is connected, and a filtered drip tube 16 is attached to the downstream portion of the Y-tube 17.

The plasma separation bags 2, 2a and the diluent storage bag 3 have infusion ports 19, 19a, 19b,
are provided for each. Additionally, in FIG. 1, 18a to 18f are clamps attached to each tube.

Each of the communication pieces has a structure in which the flow path is closed when not in use, and can be easily opened by folding it with a finger when in use. The structure is such that the thin wall part at the middle of the cylinder can be broken. Furthermore, each of the above-mentioned bags is formed by stacking two sheets of soft plastic such as polyvinyl chloride to form a bag shape, and each tube, Y-shaped tube, and drip tube are also made of plastic such as polyvinyl chloride.

In the embodiment shown in FIG. 1, two pairs of blood collection bags and plasma separation bags are provided, but the number may be one pair or two or more pairs. Alternatively, a blood collection bag, a plasma separation bag, and a child bag may be paired, and one or more pairs may be provided.

The connectors 8, 8a in the present invention may be of a type in which both male and female members are simply fitted together, but
It is preferable to provide a verification means in order to confirm the identity of both members when reconnecting them after being removed.

FIGS. 2 and 3 show an embodiment of the collation means.

In the figure, 70 is a male member, 71 is a female member,
The male member 70 includes a housing 72 and a large diameter key ring 73 that is inserted and fixed inside the housing 72.
The female member 71 also includes a housing 75, and a large-diameter keyring 76 and a small-diameter keyring 77 that are inserted and fixed into the housing. Also,
A seal packing 78 is inserted into either one of the small diameter key rings 74, 76.

A tube connection port 79 is protruded from the rear end of the male member 70, and a male connection tube 80 is provided at the center of the interior.
is installed protrudingly. Further, a pair of upper and lower hook portions 81 and 82 are formed on the outside of the casing 72. These hook parts 81 and 82 both have elastic force in the vertical direction, and one hook part 8
The width of the hook portion 1 is slightly wider than the width of the other hook portion 82.

In this way, as will be described later, when connecting the male member 70 and the female member 71, they will not be connected upside down.

Further, a tube connection port 83 is protruded from the rear end of the housing 75 of the female member 71, and a female connecting tube 90 (see FIG. 3) is protruded from the center of the interior. Further, hook portions 81 and 82 of the male member are provided on the outer peripheral edge of the opening side of the housing 75.
Insertion holes 84 and 85 are opened correspondingly. These insertion holes 84 and 85 are connected to the hook portion 8.
1,82, the width of one of the insertion holes 84 is
It is wider than the other insertion hole 85.

Each of the large-diameter key rings 73 and 76 has a cylindrical body with a half circumference cut out at its tip to form a concave portion 86a and a convex portion 86b. Similarly, the small-diameter key rings 74 and 77 have a half circumference cut out at the tip of the cylindrical body to form a recess 87a and a protrusion 87b.

The large-diameter key rings 73, 76 and the small-diameter key rings 74, 77 are inserted and fixed into each housing with the positions of the projections and depressions slightly shifted in the circumferential direction. When the concavo-convex portions of the large-diameter keyring and small-diameter keyring on the male member side and the female member side match, the hook portions 81 and 82 of the male member are inserted into the insertion hole 8 of the female member.
4,85. For example, if the angles of the large-diameter key ring and the small-diameter key ring are adjusted by 5 degrees, a total of 72 x 72 x 72 = 373,248 combinations can be obtained.

In the above embodiment, it consists of a large-diameter keyring and a small-diameter keyring, but if the combination of types is at least good, one may be omitted, and if more types are required, another keyring can be added. It's okay.

Note that polycarbonate, polypropylene, vinyl chloride, etc. are used as the material for the housing and key ring. Also, seal packing 78
Rubber, elastic synthetic resin, etc. are used.

FIG. 4 shows another embodiment of the collation means, in which 101 is a male member and 102 is a female member.

The male member 101 is connected to the housing 103 and 1
It consists of a pair of large and small key rings 104 and 105. The housing 103 has a connecting tube 106 formed in its center, and a seal ring 107 is attached to the tip of the connecting tube 106. Further, a hook portion 109 is formed on the outside of the housing 103 in an elastic manner in the vertical direction, and a tube 108 communicating with the connecting cylinder 106 is connected to the rear end portion. Further, in the key ring, a small diameter key ring 105 is inserted and fixed inside the large diameter key ring 104, and this small diameter key ring 105 is inserted and fixed on the outer periphery of the connecting cylinder 106 of the housing.

Further, like the male member 101, the female member 102 also includes a housing 101 and a pair of large and small key rings 111 and 112.

At the center of the housing 110 is a connecting tube 11 into which the tip of the male side connecting tube 116 can be inserted.
3 is formed on the outside of the housing 110, and at a position facing the hook part 109 of the male housing 101, an engaging part 114 into which the tip of the hook engages is formed. Further, a tube 115 communicating with the connecting cylinder 113 is connected to the rear end of the housing 110. Further, in the key ring, a small diameter key ring 111 is inserted into a large diameter key ring 112, and these are inserted and fixed into a communication tube 113 of the housing 110.

The configurations of the large-diameter keyrings 104, 112 and the small-diameter keyrings 105, 111 are the same as those shown in FIGS.
The hook portion 109 and the engaging portion 114 are adapted to engage with each other.

FIG. 5 shows a modification of the engaging portion of the housing in the embodiment shown in FIG. 4 above. That is, in this engagement part, the hook part 120 is attached to the outside of the male housing 103 using the support part 121 as a fulcrum.
is elastically movable up and down, and the tip of the hook portion 120 is adapted to engage with an annular groove 122 of the female housing 110. This hook portion 120 may be provided at the upper and lower portions.

FIG. 6 shows still another embodiment of the engaging portion of the housing, in which the hook portion 1 shown in FIG.
09 and the stopper part 114, the hook part 123 and the engaging part 1 are also installed in the lower part of the housing in the opposite direction.
24 are provided.

The key rings shown in the above embodiments can be mass-produced at low cost because the male and female sides may have the same shape.

In addition to the methods described above, methods for comparing the male member and female member include methods shown in FIGS. 7, 8, and 9.

In FIG. 7, 201 is a male member, 202 is a female member, and tubes 203, 203 are connected to the female member 201 and the male member 202.

The male member 201 has a cap shape as a whole, and a tapered connecting tube 204 is formed in the center, and the inside thereof communicates with the tube 203. Further, a notch 207 is formed at the end edge of the outer cylinder 206.

Further, the female member 202 also has a cap shape as a whole, and a connecting tube 205 is formed in the center, and the inside thereof communicates with the other tube 203. Then, the outer cylinder 208 of the female member 202
Also, a notch 209 is formed at a position corresponding to the edge protrusion of the outer cylinder 206.

On the surfaces of the outer cylinders 206 and 208 of the male member 201 and the female member 202, markers 210 and 210 for face matching are formed at opposing positions, respectively. The markers 210, 210 may be colored or engraved, or may be provided with identification numbers as shown in FIG. Furthermore, as shown in FIG. 9, it may be a combination of a fitting protrusion and a fitting groove.

In this embodiment, the markers 210, 210 are attached to each product while being aligned and shifted in the circumferential direction, or the markers 210, 210 are always placed at a constant position (for example, at the top end of the connector). The position of the notch can be adjusted in a timely manner.

FIGS. 10A and 10B show yet another embodiment of the collation means.

In these drawings, 302 is a male member, and a cap-shaped ring 306 serves as a housing.
, and large and small rings 304 and 305 that are housed and fixed within this ring 306.

Each ring 304, 305, 306 is formed with a fitting protrusion 308, 309 (the protrusion of the ring 304 is formed on the back surface of the connecting cylinder 311), and the ring 306 is provided with a liquid passage 31.
A connecting cylinder 311 having a diameter of 0 is provided in a protruding manner, and a tube 303 is connected to the rear end.

Further, the female member 312 corresponds to the male member 302, and a cap-shaped ring 31 serving as a housing.
6, and large and small rings 314 and 315 that are housed and fixed within this ring 306.
And each ring 314, 315, 31
6 includes a fitting protrusion 30 of the male member 302;
A fitting groove 317 that can be fitted with 7, 308, 309,
318 and 319 are formed. The ring 316 also has a liquid passage 320, and the male member 3
A connecting cylinder 321 that can be fitted with the connecting cylinder 311 of 02 is provided in a protruding manner, and a tube 313 is connected to the rear end.

In the above-mentioned connector, as shown in FIG. 11, both members 302 and 312 are separated and each is hermetically housed in a protector 352 made of soft plastic, and when connecting both members 302 and 312, The protector 352 may be torn off.

Further, in the present invention, as shown in FIG. 12, a verification sticker 354 may be attached to the joint portion of the male member and the female member to ensure verification of the male member 302 and the female member 312. This seal 354 is
A wavy perforation 355 is formed in the center, and characters 356 for verification are marked symmetrically with this perforation 355. Further, this seal 354 is pasted with the perforation 355 aligned with the joining line 357 between the male member 302 and the female member 312.

By applying such stickers 354 to each connector at different positions in the outer circumferential direction, if the female member and male member are of different types, the characters 356
Since the perforations 355 and 355 do not match, it is easy to determine the identity of the connectors from their appearance.

13A and 13B show a modification of the embodiment shown in FIGS. 10A and 10B.

In the figure, 362 is a male member, and the male member 302
Similarly, it has a three-layer structure made by stacking three types of rings with different diameters.

Fitting protrusions 367, 368, 369 are formed on the rings 364, 365, 366, and a communication cylinder 380 is formed on the ring 366 serving as a housing.
is installed. A thin broken part 382 is formed in the middle of the communicating tube 380, and a tube 363 is connected to the rear end of the communicating tube 380.

In this embodiment, the communicating tube 380 may be omitted, the tube 363 may be extended inside the ring 366, and a broken portion may be formed inside the tip of the tube.

Further, 372 is a female member, which, like the female member 312, has a three-layer structure formed by stacking three types of rings.

The rings 374, 375, 376 have fitting protrusions 367, 368, 369 of the male member 362.
Fitting grooves 378 and 379 (in FIG. 14A, the fitting groove of the ring 374 is formed on the back surface of the needle member 384) are formed into which the ring 374 can be fitted. A needle member 388 is attached to the rear end of the ring 376, which serves as a housing. This needle member 388
The needle base 3 has a flange 383 formed in the middle part.
85 and a needle tube 384 connected to the distal end of the needle base 385, and a tube 373 is connected to the rear end of the needle base 385.

The male member 362 and the female member 372 cover the communicating tube 380 and the needle member 388, and further cover the entirety of each member separately.
Cover it with the protector shown in Figure 1 so that it does not come into direct contact with the atmosphere. In use, after removing the cover, cap, or protector, align the fitting protrusions 367, 368, 369 of the male member 362 with the fitting grooves 377, 378, 379 of the female member 372, so that they fit together. Only when possible, the needle 384 of the female member 372 connects to the communication tube 38 attached to the male member 362.
Both members 362, 3 pass through the broken part 382 of
The tube connected to 72 will be in communication.

14A and 14B show still another embodiment of the collation means, in which 402 is a male member and 411 is a female member.

The male member 402 has a tube 403 at the rear end.
A fitting part 410 in which a liquid passage is formed is formed in the center of the base end part 404. Further, a protrusion 405 for positioning is formed at the peripheral end of the base end 404, and protrusions 406, 407, 40 for collation having different lengths are formed on the front surface.
8 is formed.

The female member 411 has a tube 412 at the rear end.
is formed, and a fitting groove 417 is formed in the center corresponding to the male member 402. In addition, an engagement groove 41 for positioning is provided on the inner peripheral surface.
3, and pores 414, 4 for verification with different depths.
15,416 are formed. Then, the collation protrusions 406, 407, 408 of the male member and the corresponding pores 414, 41 of the female member 411
5 and 416 are formed to have the same length and depth, so if the male and female members are different, they cannot be connected. Therefore, the identity of the connector can be confirmed by checking whether this connection is possible or not.

Note that the number of the verification protrusions and pores can be changed as desired.

15A and 15B show still another embodiment of the collation means, in which 422 is a male member, 430
is a female member.

A liquid passage 42 is provided in the center of the male member 422.
8 is formed, a fitting protrusion 429 is formed at the distal end, and a tube 423 is connected to the rear end. Further, a wavy joint portion 425 is formed on the front edge of the ring portion formed at the rear end portion, and a marker 426 for positioning is marked on the peripheral surface of the cap portion 421.

A fitting groove 434 is formed inside the female member 430 to correspond to the fitting protrusion of the male member, and a tube 431 is connected to the rear end. In addition, a cap portion 421 of a male member is provided at the tip.
A ring portion 438 made of curable resin corresponds to the shape of
is connected, and the ring portion 438 is formed with a wavy joint portion 439 that matches the male joint portion 425. In addition, 433 is a ring part 438
The hook portion 440 supporting the is a positioning marker marked in correspondence with the marker on the male member.

As shown in FIG. 15B, the hardening resin ring 438 is made by attaching a mold 436 to the outside with the male member and the female member joined, and forming a mold between the cap portion 421 of the male member and the tip end of the female member. The injection hole 437 of the mold 436 is inserted into the cavity 435 formed in the mold 436.
It is molded by pouring a curable resin into the mold.

Next, an example of use of the blood component separation bag device shown in FIG. 1 will be explained.

First, close the clamps 18b and 18e, and
At the same time, the communication piece 13 is folded and the blood collection bags 1 and 2 are placed at a position lower than the arm of the person collecting blood. When the blood guide needle 9 is penetrated into the blood collector's blood vessel, the blood is introduced into the blood collection bag 1 via the blood guide tube 20 and the blood collection tubes 5 and 5a due to the effects of blood pressure and power.

After introducing the prescribed amount of blood, the clamp 18f is closed, the blood collection tube 5a is welded and cut with a welder, the connector 8 is divided into a male member and a female member, and a cap or the like is placed on the connector 8 to prevent it from coming into contact with the atmosphere. .

The blood collection bag 1 into which blood has been introduced is centrifuged together with the plasma separation bag 2 (empty bag). The supernatant plasma component in the blood collection bag 1 opens the communication bead 10 and is transferred to the plasma separation bag 2 through the connecting tube 4, after which the connecting tube 4 is melted by a welder. As a result, blood cell components remain in the blood collection bag 1. Blood collection bag 1
During the centrifugation process, the clamp 18c is opened, the communication piece 13a is opened, and blood is introduced from the blood collection tube 5b into the blood collection bag 1a. After introducing a predetermined amount, the blood collection tube 5b is fused in the same manner as described above, the connector 8a is divided and centrifuged, and the plasma is separated into the plasma separation bag 2a.

When the blood cell components remaining in the blood collection bag 1 are to be returned to the blood collector, the male and female members of the connector 8 are joined. In this case, by the verification method mentioned above,
Confirm the identity of both male and female parts. For example, in the verification means shown in FIGS. 2 and 3, large and small key rings 73, 7 for both male and female members are used.
Since the unevenness of 6, 74, and 77 are shifted circumferentially and fixed for each connector or product, both members 70 and 71 can be connected only when the unevenness of the male and female key rings match, and the hook 8
1 and 82 can be inserted into the insertion holes 84 and 85. Therefore, the identity of both male and female members can be confirmed by checking whether or not they can be joined, and mistakes such as returning someone else's blood can be prevented.

After connecting the connector 8 as described above, the clamp 18d is opened, the communication piece 13 is opened, and the blood cell components in the blood collection bag 1 are transferred to the blood return tubes 6a, 6.
and joins the diluent introduction tube 7.

Physiological saline added with an anticoagulant is sealed in the diluent storage bag 3. When returning blood cell components, the communication piece 15 is opened, the flow rate is adjusted with the clamp 18a, and the diluent is introduced into the tube. The liquid is allowed to flow down into the drip tube 16 through the tube. After the blood cell components and diluent from the blood return tube 6 are sufficiently mixed in the drip tube 16, the blood is returned to the person collecting blood via the guide tube 13 and the guide needle 9 while the flow rate is adjusted by the clamp 18b.

Blood cell components from which plasma components are separated are themselves
It is viscous and tends to clog or destroy blood cells when passing through the guide needle 9. For this reason, a diluent is added to the blood cell components to improve fluidity.

While the blood cell components in the blood collection bag 1 are being returned, the blood in the blood collection bag 1a is centrifuged as described above. After the blood return operation of the blood collection bag 1 is completed, the blood cell components remaining in the blood collection bag 1a are returned by the same method.

When blood is collected using the method described above, the blood is collected and returned in two steps, so there is less burden on the person collecting the blood. In the case of a confident blood collector, it is also possible to simultaneously collect blood into blood collection bags 1 and 1a, and perform centrifugal separation of blood components and return processing of blood cell components at the same time.

[Effects] According to the present invention described above, the series of operations of blood collection, blood component separation, and blood return can be performed in a closed system equipped with a blood collection bag, a blood component separation bag, and a diluent storage bag. Extremely hygienic. In addition, when blood cell components are returned after blood components have been separated, the diluent in the diluent storage bag can be immediately mixed with the blood cell components, eliminating the need to connect a diluent infusion set to a conventional container. The operation time per person is shortened, and the mental burden on blood collectors is also reduced. Furthermore, by providing a verification means on the male and female parts of the connector installed in the middle of the blood return tube, it is possible to confirm the identity of the person collecting blood and the blood components to be returned, thereby preventing the person from returning another person's blood by mistake. Since mistakes can be prevented, effects such as safety can be obtained.

[Brief explanation of drawings]

FIG. 1 is an overall schematic diagram showing an embodiment of the present invention;
FIG. 2 is an exploded view of the verification means in the present invention;
3 is a half-sectional view of the verification means in FIG. 2, FIGS. 4 to 15 all show other embodiments of the verification means in the present invention, and FIG. 4 is a half-sectional view of the verification means in the present invention. 5 is a half sectional view, FIGS. 6 and 7 are perspective views, and FIGS. 8 and 9 are perspective views showing modifications of FIG. 7. , FIG. 10A is a perspective view showing another embodiment of the verification means, FIG. 10B is a sectional view of FIG. 10A,
Figure 11 is a schematic diagram of the male member and female member sealed with a protector, Figure 12 is a schematic diagram of the male member and female member with a verification sticker affixed to the joint, and Figure 13A. 13B is a sectional view of FIG. 13A, FIG. 14A is a sectional view of yet another embodiment of the verification means, and FIG. 14B is a cross-sectional view of FIG. 14A. A side view of the male member in the means, FIG. 15A is a sectional view showing an embodiment of the verification means of the present invention,
Fig. 15B is a sectional view for explaining the assembly method of Fig. 15A, Fig. 16 is a schematic diagram of a conventional plasma pheresis bag, and Fig. 17 is connected to the plasma pheresis bag of Fig. 16. FIG. 2 is a schematic diagram of a blood transfusion set. In the figure, 1 and 1a are blood collection bags, 2 and 2a are plasma separation bags, 3 is a diluent storage bag, 4 and 4a are connection tubes, 5, 5a, and 5b are blood collection tubes,
6, 6a, 6b are blood return tubes, 7 is a diluent introduction bag, 8, 8a are connectors, 9 is a blood guide needle, 70 is a male member, 71 is a female member, 73, 7
6 is a large diameter key ring, 74 and 77 are small diameter key rings, 81 and 82 are hook portions, and 84 and 85 are insertion holes.

Claims (1)

[Scope of Claims] 1. A blood component separation bag device that fractionates collected blood, separates necessary blood components, and then returns the remaining blood components to the blood collector, comprising: a blood collection bag; A component separation bag and a diluent storage bag are provided, the blood collection bag and blood component separation bag are connected by a connecting tube, the blood collection tube and the blood return tube are respectively connected to the blood collection bag, and the diluent storage bag is connected to the blood collection bag and the blood component separation bag. connects a circulation tube that communicates with the blood guiding needle, connects the blood collection tube and the blood return tube to this circulation tube, and provides a connector equipped with a verification means in the middle of the blood return tube to connect the blood return tube. A blood component separation bag device characterized in that it can be attached and detached midway.