JPH0432049B2 - - Google Patents

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention prevents gingivitis and alveolar pyorrhea by preventing the formation of tartar, and at the same time prevents bad breath by adsorbing and removing substances that cause bad breath. The present invention relates to an oral composition.

[Conventional technology and its problems]

It is known that gingivitis and alveolar pyorrhea are directly caused by dental plaque and tartar. Dental plaque is a sticky substance formed by various oral bacteria adsorbing and multiplying, and dental tartar is the plaque that is further calcified by calcium and phosphoric acid in saliva.
Plaque can be easily removed with a toothbrush, but tartar cannot be removed unless it is scraped off by scaling.
Therefore, brushing your teeth using a toothpaste that prevents the formation of tartar is thought to be effective in preventing gingivitis and alveolar pyorrhea, and various oral drugs and their compositions that promote the prevention of tartar have been developed. is proposed. Zeolite itself is already incorporated into toothpastes, etc.
Its effectiveness in preventing tartar has also been demonstrated, and a patent application has been filed for particularly fine zeolite for tooth brushing as being effective in preventing tartar (Public Patent Publication, 1982-24112).

[Problem that the invention seeks to solve]

On the other hand, patients with gingivitis and alveolar pyorrhea often have strong bad breath, which is said to be mainly due to the presence of volatile sulfides such as methyl mercaptan and hydrogen sulfide produced in the oral cavity in their breath. If zeolite adsorbs and removes these substances that cause bad breath, it is thought to be effective in preventing bad breath in addition to preventing tartar, but zeolite shows excellent adsorption effects on hydrogen sulfide and ammonia in dry systems. However, in systems where a large amount of water coexists, such as in the oral cavity,
Because it adsorbs water with the highest priority, there was a problem that it was difficult to see any effects [Akio Oyamada; On the deodorizing and deodorizing effects of zeolite, "Fragrance Journal" No. 72 (1985) P79-82].

[Means for solving problems]

Under these circumstances, the present inventor conducted intensive research and found that acid-treated zeolite has an excellent adsorption effect on substances that cause bad breath even in the coexistence of water, and completed the present invention.

That is, the present invention provides an oral composition containing an acid-treated zeolite, which is obtained by treating the zeolite with an acid so that the pH thereof is lower than the pH value.

In the present invention, both synthetic zeolite and natural zeolite can be used as the zeolite. Zeolite has a particle size of 1 to 1 in terms of its anti-tartar effect.
Preferably, the fine particles are about 10 μm. Natural zeolite requires sophisticated pulverization technology to produce such fine particles, but synthetic zeolite is advantageous because the particle size can be adjusted during the synthesis process. Preferred synthetic zeolites include, for example, A
Examples include zeolite, 4A type, X type, and Y type zeolite and mordenite.

Such acid treatment of zeolite is carried out by bringing the zeolite into contact with an acid. Examples of acids include mineral acids such as sulfuric acid, hydrochloric acid, and nitric acid; organic acids such as citric acid, succinic acid, malic acid, and tartaric acid. Some zeolites, such as A-type zeolite, have their structures destroyed by acid, so the acid is generally made into a solution of around 1M, and this is gradually added to the slurry of zeolite while stirring. is preferred.

Although the untreated zeolite has a pH of 10 or higher, the acid treatment is performed until the pH of the acid-treated zeolite becomes 9 or lower. In particular, since it is applied to the oral cavity, PH8
It is preferable to process it so that it becomes 6. The pH of zeolite is determined by sampling over time.
A water suspension with a solid content of approximately 5% by weight is prepared, and its PH is measured using a PH meter. When the predetermined PH is reached, the treatment is terminated and thoroughly washed.

The acid-treated zeolite thus obtained may be blended into the oral composition as a slurry, or may be blended in a dried form. The amount of acid-treated zeolite added varies from 1 to 99% of the total composition depending on the type of composition.
Can be selected from a wide range of weight percentages.

Examples of the oral composition of the present invention include dentifrice, chewing gum, troche tablets, and toothpaste tablets, and as components other than acid-treated zeolite, those normally used in these preparations can be used. For example, as an abrasive for toothpaste, calcium hydrogen phosphate, calcium carbonate, aluminum hydroxide, alumina, hydrated silicic acid, anhydrous silicic acid, zirconium silicate, insoluble sodium metaphosphate, calcium pyrophosphate, etc.; as a foaming agent, lauryl Sodium sulfate, sodium myristyl sulfate, sucrose long chain fatty acid ester, various amino acid long chain fatty acid amides, long chain fatty acid ethanolamide, polyoxyethylene alkyl ether, polyoxyethylene polypropylene copolymer, polyoxyethylene long chain fatty acid ester, sorbitol long chain Fatty acid esters, polyoxyethylene sorbitol long chain fatty acid esters, long chain fatty acid salts, saponins, etc.; as humectants, glycerin,
Sorbiturate liquid, propylene glycol, pyrrolidone carboxylic acid salts, etc.; binders include sodium carboxymethyl cellulose, sodium polyacrylate, carrageenan, xanthan gum, guar gum, gum gum, gum arabic, sodium alginate, gelatin, etc.; sweeteners Examples include saccharin sodium, dipotassium glycyrrhizinate, licorice extract, palatinose, aspartame, stevioside, etc.; active ingredients that prevent tooth decay and alveolar pyorrhea include ascorbic acid and its esters, azulene, dextranase, and mutanase. , amylase, protease,
Lipase, lytic enzyme, allantoin and its salts, ε-aminocaproic acid, tranexamic acid, Irgasan DP-300, dihydrocholesterol, epdihydrocholesterol, cetylpyridinium chloride, dequalinium chloride, sodium chloride, benzalkonium chloride, benzethonium chloride, lysozyme chloride , pyridoxine chloride, chlorhexidine salts, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, nicotinic acid alkyl ester, sodium copper chlorophyllin, trichlorocarbanilide, halocarban, hinokitiol, stannous fluoride, futu Sodium chloride, polyethylene glycol, sodium monofluorophosphate, propolis, Rohobo, Kawayumi, Toki, Safflower, etc.; natural chicle and vinyl acetate as the gum base for chewing gum; troche tablets, chewable tablets Excipients include lactose, crystalline cellulose, white sugar, and the like. In addition, an appropriate flavoring agent such as peppermint, spearmint, or anethole may be added to improve the feeling of use.

[Function and Effect] Next, an experimental example will be shown to prove that acid-treated zeolite has an excellent adsorption effect on substances that cause bad breath even in the presence of water. In this experiment, we used methyl mercaptan, a major substance that causes bad breath, and 4A type zeolite, a type of synthetic zeolite, with an average particle size of 3.63μ. i.e. 10 in a 10 ml glass stoppered test tube.
Precisely weigh ~100 mg of zeolite sample,
Add 3 ml of 1 ppm methyl mercaptan aqueous solution, stopper, shake well, and let stand at 20°C for 15 minutes.
Free methyl mercaptan was determined by the DBC-Conway method. The DBC-Conway method uses BDC-OH (4,
4-bis-dimethylaminodiphenylcarbonylcarbinol) is acidic and exhibits a strong blue color based on carbonium immonium ions;
This method takes advantage of the fact that this blue color disappears quickly when an SH compound is reacted. in particular,
BDC solution (0.1% BDC-OH acetone solution 50μ, 50mM Tris-Maleate of PH6.5) was placed in one reservoir of Conwaydish (a micrometer tester manufactured by Shibata), which is a sealed container with two reservoirs separated inside.
Add 2 ml of Buffer (10 ml of 10% sodium lauryl sulfate aqueous solution) and 3 ml of the sample to the other reservoir, then seal.
Incubate at 37°C for 2 hours. Thereafter, the absorbance of the BDC solution at 610 nm was measured after cooling to room temperature. Separately, a calibration curve was prepared in the same manner, and the amount of free methyl mercaptan was calculated. Figure 1 shows the results. The vertical axis shows the amount of free methyl mercaptan that remained without being adsorbed to the zeolite.
The horizontal axis shows the amount of zeolite added. This figure shows that 10 mg of acid-treated zeolite has the same effect as 50 mg of untreated zeolite, that is, acid-treated zeolite is superior to untreated zeolite in adsorbing substances that cause bad breath.

〔Example〕

Next, the present invention will be explained in more detail by showing Examples, but the present invention is not limited to these Examples.

Example 1 The following components were degassed and mixed to form a paste toothpaste.

Acid-treated zeolite ^*1 (4A type, average particle size 2.0μ)
5.0W% Calcium hydrogen phosphate for toothpaste 35.0 Anhydrous silicic acid 2.0 Sodium carboxymethyl cellulose 2.0 Sodium lauryl sulfate 1.7 Sodium saccharin 0.2 Glycerin 10.0 70% sorbitol solution 15.0 Methylparaben 0.1 Fragrance 0.9 Purified water Balance meter 100.0W% *1 1M sulfuric acid aqueous solution processed to a pH of 7.0.

Example 2 Toothpaste The following components were degassed and mixed to form a toothpaste with a translucent appearance.

Acid-treated zeolite ^*2 (4A type, average particle size 2.0μ)
5.0W% Silicic anhydride 25.0 Sodium carboxymethyl cellulose 1.5 Sodium lauryl sulfate 1.5 Sodium saccharin 0.2 Glycerin 20.0 70% sorbitol 35.0 Butylparaben 0.1 Fragrance 0.9 Coloring agent Micro- purified water Balance meter 100.0W% *2 Treated with 1M aqueous hydrochloric acid solution , with a pH of 8.0.

Example 3 The following components were mixed to form a powdered dentifrice.

Acid-treated zeolite ^*3 (X type, average particle size 6.5μ)
25.0W% Precipitated calcium carbonate 70.0 Sodium lauroyl glutamate 0.5 Sucrose fatty acid ester 2.5 Sodium saccharin 0.1 Flavor Trace amount of glycerin Balance meter 100.0W% *3 Treated with 1M sulfuric acid aqueous solution to pH 7.5.

Example 4 The following components were mixed and a small amount of purified water was added to form a paste, which was then molded into a disk shape and dried to obtain a lozenge.

Acid-treated zeolite ^*4 (Y type, average particle size 4.6μ)
2.0W% Citric acid 0.1 Stevioside 0.05 Dextrin 10.0 Gum arabic 4.0 Flavor Trace lactose Balance meter 100.0W% *4 Treated with 1M tartaric acid aqueous solution and adjusted to PH8.0.

Example 5 The following components were mixed and dry compressed to obtain crushed tablets.

Acid-treated zeolite ^*5 (mordenite, average particle size
8.3μ) 10.0W% Dry aluminum hydroxide gel 45.0 Magnesium stearate 1.0 Aspartame 0.1 Fragrance Trace amount of magnesium aluminate metasilicate Balance meter 100.0W% *5 Treated with 1M succinic acid aqueous solution to pH 7.2.

Example 6 The following ingredients were heated and kneaded and molded into chewing gum.

Acid-treated zeolite ^*6 (4A type, average particle size 2.0μ)
5.0W% Gum base 20.0 Corn syrup 20.0 Flavoring Trace amount of powdered sucrose Balance meter 100.0W% *6 Treated with 1M malic acid aqueous solution and adjusted to PH6.5.

[Brief explanation of drawings]

Figure 1 shows the adsorption and removal effect of methyl mercaptan by zeolite in a water coexisting system.

Claims (1)

[Scope of Claims] 1. An oral composition characterized by containing acid-treated zeolite, which is obtained by treating zeolite with an acid to have a pH of 9 or less. 2. The oral composition according to claim 1, wherein the acid-treated zeolite content is 1 to 99% by weight of the total composition. 3. The oral composition according to claim 1, wherein the zeolite is selected from the group consisting of type A zeolite, type 4A zeolite, type X zeolite, type Y zeolite, and mordenite. 4. The oral composition according to claim 1 or 2, wherein the acid-treated zeolite has an average particle size of 1 to 10 μm.