JPH0457642B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Field of Application] The present invention relates to a hair growth agent contained in an aerosol container. [Prior Art] The mainstream of currently commercially available hair nourishing agents is one in which a small amount of a hair nourishing base is dissolved in a large amount of a mixture of water and ethanol. The mixed liquid is usually water/
Ethanol with a weight ratio of 30/70 to 70/30 is used. The reason for this is that if the amount of water exceeds the above range, the solubility and drying properties of the hair nourishing base will deteriorate, resulting in a less refreshing feeling, and because the vaporization is not sufficient, some excess water may run off from the scalp. This is to do so. On the other hand, if the amount of ethanol exceeds the above range, the large amount of ethanol may cause flammability to become an issue during manufacturing or product distribution, or water in the hair may be extracted and damage the hair. It's hot,
Alternatively, if the lid is closed and rubbed after use, problems such as the composition of the hair tonic changing and separation may occur. In this way, the mixture of water and ethanol that makes up most of the hair growth products that are currently mainstream is
It mainly works to dissolve the hair nourishing base and give a refreshing feeling when used, but it is a formulation designed to reduce the problems mentioned above.
It is hard to say that it is the best prescription for a hair tonic. [Problems to be Solved by the Invention] The present invention solves problems in the currently mainstream hair nourishing agents that are flammable, do not have sufficient vaporization,
In addition to solving problems such as the composition of the hair nourishing agent changing and separating when the lid is closed and forgotten, the hair nourishing effect is not due to the chemical action of the hair nourishing base, but when the hair nourishing agent is used. By removing the heat necessary for evaporation from the scalp, it physically stimulates the scalp, improves blood circulation in the scalp, improves skin function, activates hair roots, and prevents hair loss. It was developed for the purpose of producing a hair nourishing agent. [Means for Solving the Problems] The present invention involves filling an aerosol container with 30 to 70 parts (by weight, the same applies hereinafter) of a low boiling point solvent and 70 to 30 parts of a liquefied gas so that the total amount becomes 100 parts. 25℃
A hair tonic in an aerosol container with a pressure of 2.0 to 5.0 Kg/cm ² G, wherein the aerosol container stimulates the scalp when applied to the scalp and has a button that activates a valve to spray the hair tonic. The present invention relates to a hair growth agent contained in an aerosol container, characterized in that the container is an aerosol container having an injection port that allows the hair growth agent to be applied directly to the scalp by mouth. [Example] When the low boiling point solvent used in the present invention is applied to the scalp, it cools the scalp and physically stimulates it, improves blood circulation in the scalp, improves skin function, and activates hair roots to improve hair removal. In addition to providing a cooling sensation when used, it dissolves the hair nourishing base used if necessary and creates a uniform solution. Non-flammable materials with less undesirable skin irritation are preferred. Specific examples include nonflammable trichloromonofluoromethane (bp23.8
℃), dichlorotetrafluoroethane (bp3.8℃),
Trichlorotrifluoroethane (bp47.6°C), etc., pentane and hexane, which are highly flammable and cannot be used in large quantities, and ethanol (which can only be used in small quantities because they are flammable and have a slightly high boiling point) bp78.3℃), but are not limited to these. Among these, trichloromonofluoromethane and dichlorotetrafluoroethane are particularly preferred because they have a boiling point suitable for physically stimulating the scalp and are nonflammable, and trichlorotrifluoroethane is also suitable. There is. The nonflammable low boiling point solvent may be used alone or in combination with two or more nonflammable low boiling point solvents or with a flammable low boiling point solvent, but trichloromonofluoromethane and (or ) If the main component is dichlorotetrafluoroethane, that is, if it is contained in a low boiling point solvent at 80% or more (by weight, the same applies hereinafter), it has a low boiling point and maintains the characteristics of being nonflammable. It is preferable because it is almost odorless and has almost no undesirable irritation to the skin. The liquefied gas used in the present invention primarily functions as a propellant. Specific examples thereof include nonflammable liquefied gases such as dichlorodifluoromethane and chlorodifluoromethane, and combustible liquefied gases such as dimethyl ether and liquefied petroleum gas. The nonflammable liquefied gas may be used alone, or may be mixed with other nonflammable liquefied gases or with flammable liquefied gas within a range that maintains nonflammability to semi-nonflammability. It is preferable to use it by mixing it with a nonflammable liquefied gas so as to make it nonflammable to semi-nonflammable. In particular, when it contains 50% or more of dichlorodifluoromethane as the main component, it is stable against any low boiling point solvent and is easy to handle, which is preferable. In the present invention, 30 to 70 parts of low boiling point solvent and 30 to 70 parts of liquefied gas are used so that the total amount is 100 parts.
It is filled into a specific aerosol container to produce a hair tonic. If the amount of low boiling point solvent used is less than 30 parts, the amount of liquefied gas will inevitably increase, and when applied or sprayed to the scalp, a large amount will be dispersed into the air, causing physical damage to the scalp. The effect of stimulating the body is reduced. Also, to prevent it from escaping into the air, using it too close to the scalp may cause frostbite. On the other hand, the amount of low boiling point solvent used is 70
If the amount exceeds 50%, even when used in an appropriate amount, it will not evaporate completely within the desired time due to the heat from the scalp, and will tend to flow on the scalp, causing discomfort. In addition, there may be cases where the injection performance is insufficient. The pressure at 25°C when each component used in the production of the hair tonic of the present invention is filled into an aerosol container is
It is 2.0 to 5.0 Kg/cm ² G. If the pressure is less than 2.0 Kg/cm ² G, the spraying force is small, so the active ingredients are difficult to diffuse during use, and are difficult to spray as fine droplets.
Alternatively, there may be less liquefied gas, which may slow down its diffusion, making it easier for it to flow over the scalp and cause discomfort. On the other hand, the pressure
If it exceeds 5.0 Kg/cm ² G, a large amount is likely to be applied or sprayed locally on the scalp, and the area where it is applied or sprayed will be rapidly cooled, causing damage to the scalp and hair. The aerosol container used in the present invention has an injection port that allows the hair tonic to be applied directly to the scalp, and it is more effective not to attach the hair tonic to the hair. As shown in Figure 1, when button 1 is pressed onto the scalp, button 1 moves along guide 2, as shown in Figure 1. However, it is preferable that the aerosol product 6 has an injection port that can actuate the valve 3 and spray the hair tonic content directly onto the scalp, which is the application surface, and directly give physical stimulation to the scalp. . When using an aerosol product 6 having a spray nozzle as shown in Figure 1, most of the hair tonic contained therein generates heat on the application surface, the scalp, which tends to cause physical irritation to the scalp. It improves blood circulation, improves skin function, activates hair roots, and has a greater effect on preventing hair loss. The hair nourishing agent of the present invention may contain, if necessary, a hair nourishing base of 0.01 to 15 parts per 100 parts of the total amount of the low boiling point solvent and liquefied gas, and a fragrance, a polypeptide, or an oil or fat such as castor oil in the above total amount. for 100 copies
It may be added in an amount of 10 parts or less. If the amount of hair growth base used is less than 0.01 part, the effect of using it cannot be obtained, and if it is more than 15 parts, it tends to flow easily on the scalp and cause discomfort. Similar problems tend to occur when the amount of polypeptide or castor oil in the fragrance exceeds 10 parts. Specific examples of the hair growth base include hormones (follicular hormone, adrenal cortical hormone), vitamins (vitamin E, B ₂ , B ₆ , biotin, inosit, pantothenic acid and pantothenyl alcohol, niconic acid amide, para-aminobenzoic acid, etc.), amino acids, herbal medicine extracts (Squateria japonica extract, etc.), anti-inflammatory agents (diphenhydramine hydrochloride,
glycyrrhizin, glycyrrhetinic acid, etc.), photosensor No. 301, hinokitiol, keratolytic agents (lactic acid,
resorcinol, salicylic acid, etc.), scalp irritants (benzyl nicotinate, capsicum tincture, nonylic acid vanilamide, cantharis tincture, etc.), disinfectants (isopropylmethylphenol, alkyldiaminoethylglycine hydrochloride solution, parachloromethaxylenol, quaternary ammonium) salt, etc.), cooling agents ((DL)-menthol, etc.), humectants (glycerin, propylene glycol, sorbitol, DL-sodium pyrrolidonecarboxylate solution, etc.), etc., which are generally used as hair growth bases. It can be used without particular limitation. These hair nourishing bases may be used alone or in combination of two or more. Next, the hair growth agent of the present invention will be explained based on Examples. Example 1 0.3 parts of salicylic acid, 0.5 parts of glycerin, and an appropriate amount of fragrance are dissolved in 3 parts of castor oil, and this is filled into a pressure container, a valve is attached, and 55 parts of dichlorodifluoromethane and trichlorofluoromethane are added.
After filling 41.2 parts of the mixture, a button as shown in FIG. 1 was attached to produce a hair growth agent in an aerosol container at 5° C. and an internal pressure of 3.5 kg/cm ² G. The convenience of use, revitalizing sensation on the scalp, flow on the scalp, and flammability of the resulting hair tonic were evaluated. The results are shown in Table 1. Convenience of use, activation sensation on the scalp, and flow on the scalp were evaluated by a monitor test. If 10 or more out of 20 people felt it was favorable, it was ○, and if less than 10 people felt it was favorable, it was ×. It was evaluated as In addition, flammability was evaluated by applying 5g on a glass surface and bringing a torch close to it. Those that did not catch fire were evaluated as ○, and those that did catch fire were evaluated as ×. Example 2 0.0003 parts of ethinyl estradiol, dl-acetic acid
α-tocopherol 0.05 parts, -menthol 0.1
Dissolve 30.6 parts of tetrafluorodichloroethane and 45.9 parts of dichlorodifluoromethane in a pressure-resistant container and attach a valve.
After separately filling 13.5 parts of liquefied petroleum gas,
Attach the button shown in Figure 1 and internal pressure 4.0 at 25℃.
A hair tonic in an aerosol container weighing Kg/cm ² G was produced. The properties of the obtained hair tonic were evaluated in the same manner as in Example 1. The results are shown in Table 1. Comparative example 1 3 parts castor oil, 0.3 parts salicylic acid, glycerin
0.5 part, appropriate amount of fragrance, 70 parts of ethanol and water
A hair growth agent was prepared by uniformly dissolving 26.2 parts of the mixture and placing it in a bottle. The properties of the obtained bottled hair tonic were evaluated in the same manner as in Example 1. The results are shown in Table 1. Comparative example 2 60 parts of ethanol, ethinyl estradiol
0.0003 parts, dl-α-tocopherol acetate 0.05 parts,
- A hair nourishing agent was prepared by uniformly dissolving 0.1 part of menthol and water to a total amount of 100 parts, and the product was placed in a bottle. The properties of the obtained bottled hair tonic were evaluated in the same manner as in Example 1. The results are shown in Table 1. Comparative Example 3 In the aerosol type hair nourishing agent obtained in Example 1,
An aerosol-type hair tonic was produced and evaluated in the same manner, except that a conventional aerosol button that sprayed into a mist was used instead of a button that was applied to the scalp. The results are shown in Table 1.

【table】

[Table] [Effects of the Invention] Since the hair tonic of the present invention is packaged in a specific aerosol container, the active ingredient can be applied directly and efficiently to the scalp. Moreover, since there is no need to open the lid during use, it is possible to use a solvent with a lower boiling point than conventionally used solvents, which reduces discomfort caused by running on the scalp. In addition, the physical stimulation of the skin caused by cooling with low-boiling point solvents and liquefied gases temporarily impedes blood circulation to the scalp, but the reaction causes blood vessels to expand and improves blood circulation. . This means that when a hair growth base is used in combination, it enhances skin function as well as its chemical stimulating effect, activates hair roots, and prevents hair loss. Furthermore, the physical stimulation is temporary, and it is also very good in that it does not cause allergies or the like. Furthermore, since nonflammable low boiling point solvents and liquefied gases can be used, there is no risk of fire.

[Brief explanation of the drawing]

FIG. 1 is an explanatory view of an embodiment of the injection port of an aerosol container filled with the hair growth agent of the present invention. (Main symbols in the drawing), 1: Button, 3: Valve.

[Claims]

1. A composition consisting of a solution of a water-soluble or water-dispersible carrier material inert to a chemical substance in a first solvent is frozen, and the first solvent is sublimed from the frozen composition to dissolve the carrier material. A product with a network structure,
of a solid molded article carrying a predetermined unit amount of a chemical substance, comprising adding a solution or suspension of a second non-aqueous solvent containing a predetermined amount of the chemical substance to the product, and then evaporating the second solvent. Production method. 2. The method of item 1 above, wherein the composition is frozen in a mold corresponding to the size and shape of the desired molded article, and the first solvent is sublimed while the frozen composition is in the mold. Method. 3. The method of item 2 above, wherein a second solvent containing a chemical substance is added to the sublimated product while the sublimated product is in the mold. 4. The method of item 3 above, wherein the mold is a recess existing in a sheet of film material. 5 After the chemicals are added to the sublimated product, the covering sheet is adhered to the film material to form the molded article.