JPH0529003B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Application Field] The present invention relates to a bath agent, and more particularly to a novel bath agent containing a cyclodextrin or a cyclodextrin derivative on which carbon dioxide gas has been adsorbed. [Prior Art] Hot springs are widely popular among the people because they are effective against various diseases depending on the ingredients they contain, and are also used as a means of medical treatment. Salts such as table salt, mirabilite, and baking soda are well known as active ingredients in hot springs, but gas components such as carbon dioxide and hydrogen sulfide also play an important role. However, since these hot spring effective gas components are gases, the effective gas components often volatilize from the hot spring water, making it impossible to obtain sufficient effects. Therefore, various efforts have been made to obtain the therapeutic effects of hot spring effective gas components even during bathing at home. In the case of carbon dioxide gas (carbonated springs), the most common reaction is between acid and carbonate,
The idea is to generate carbon dioxide gas in bath water to efficiently dissolve it. [Problems to be solved by the invention] However, in these conventional methods, if bath additives are continuously added every time the bath water is reheated, the concentration of salts other than carbon dioxide gas in the bath water increases. There were various problems such as the skin feeling sticky and the hot water tasting bad. [Means for Solving the Problems] Under these circumstances, the inventor of the present invention has made extensive studies to make it possible to comfortably obtain the conventional hot water treatment effect of carbon dioxide gas while taking a bath at home. By bringing carbon dioxide gas into contact with cyclodextrin under high pressure, cyclodextrin containing adsorbed carbon dioxide gas can be stably obtained, and this has the property of releasing the adsorbed carbon dioxide gas when it comes into contact with water. The present invention has been based on the discovery that a bath agent having excellent bathing effects can be obtained without increasing the salt concentration by incorporating carbon dioxide adsorbed into a cyclodextrin or cyclodextrin derivative into a bath agent. completed. That is, the present invention provides a bath agent characterized by containing cyclodextrin or a cyclodextrin derivative to which carbon dioxide gas has been adsorbed. Examples of the cyclodextrin used in the present invention include α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin. In addition, as cyclodextrin derivatives, branched cyclodextrin such as glucosyl-α-cyclodextrin, crucosyl-β-cyclodextrin, glucosyl-γ-cyclodextrin, maltosyl-α-cyclodextrin, maltotriosyl-α-cyclodextrin, etc. ;o-ji-
Methylated cyclodextrin such as methyl-β-cyclodextrin and o-tri-methyl-β-cyclodextrin; cyclodextrin polymers such as low polymerization polymers obtained by crosslinking cyclodextrin with epichlorohydrin; acylated cyclodextrin; alkylated cyclodextrin; Examples include aminated cyclodextrin. Among these, α-cyclodextrin seems to have a strong ability to adsorb carbon dioxide gas. Moreover, these cyclodextrins or cyclodextrin derivatives preferably contain substantially no water. Carbon dioxide gas can be adsorbed on cyclodextrin or cyclodextrin derivatives by, for example, bringing carbon dioxide gas into contact with cyclodextrin or cyclodextrin derivatives under a pressure of 1 kg/cm ² or more, preferably 5 to 15 kg/cm ² . . The temperature in the adsorption step is preferably 30°C or lower, particularly 20°C or lower. The amount of carbon dioxide gas adsorbed is preferably 2 g or more per 100 g of cyclodextrin or cyclodextrin derivative. The bath additive of the present invention has a weakly acidic liquid property when added to the bath water, and more specifically, the bath additive has a weak acidity.
It is preferable that the pH of the 0.01% by weight aqueous solution is 4 to 7, particularly 6 to 6.7. When the pH is lower than 4, the irritation to the skin becomes strong, and when it exceeds 7, the effect of the present invention tends to decrease. This means that the effect of the present invention is that when the pH is acidic, carbon dioxide gas is
Exists as CO ₂ molecules and exhibits a blood flow promoting effect,
When the pH is alkaline, carbon dioxide gas is mostly CO ₂ ^2-
This is because it is based on the principle that since it exists as an ion or HCO ₃ ^- ion, the effect cannot be expected much. In order to meet such conditions, organic acids such as succinic acid and fumaric acid, or salts thereof; or phosphoric acid or salts thereof, etc. are added to the bath agent of the present invention so that the pH of the 0.01% aqueous solution is 4 to 7. It is preferable to blend an appropriate amount of an acidic substance. The bath agent of the present invention may optionally contain sodium chloride, sodium hydrogen carbonate, sodium carbonate, borax, alum, sodium sulfate, potassium sulfide, sodium sesquicarbonate, sodium thiosulfate, sodium phosphate, calcium oxide, potassium nitrate, In addition to inorganic salts such as sodium nitrate, potassium chloride, potassium carbonate, heavy magnesium carbonate, ammonium chloride, and sulfur, organic salts, organic acids, monohydric alcohols, polyhydric alcohols, oils and fats, minerals, herbal medicines, and humectants. Ingredients commonly used in bath preparations, such as dyes, fragrances, etc., can be added. The bath additive of the present invention can act as a tablet, granule, or other conventional bath additive formulation, but it can be wrapped in a fiber aggregate such as a water-permeable cloth or nonwoven fabric, such as a bag. It can also be put to use. [Effects of the Present Invention] The bath additive of the present invention has excellent hot water treatment effects due to the carbon dioxide gas released when added to bath water, ie, blood circulation promoting effect, skin moisturizing feeling, etc. In addition, the bath preparation of the present invention does not require the use of salt, so even if it is added every time hot water is reheated, the salt concentration does not increase as with conventional products, and it is also excellent in terms of feeling of use. . Furthermore, since the cyclodextrin and its derivatives used in the present invention are water-soluble, it is an excellent bathing agent that does not cause the water to become cloudy or to form precipitates. Next, the bath effect of the bath agent of the present invention was evaluated by the following method. The results are shown in Table 1. Evaluation method: One bath additive shown in Examples 1 and 2 and Comparative Example 1 described later was added to bath water every day, and 20 panelists were asked to use it according to the usual method for 5 days, and after 5 days, one was added. Overall evaluation as a bath additive (overall feeling of use),
The feeling of warmth, refreshing feeling after bathing, and refreshing feeling were investigated.

〔Example〕

Next, the present invention will be explained with reference to Examples. Example 1 α-Cyclodextrin (Nihon Shokuhin Kako) 1Kg
was taken and carbon dioxide gas was adsorbed by applying a pressure of 8 kg/cm ² . The amount of carbon dioxide gas adsorbed was 40.4 g. 10 parts of sodium sulfate, 5 parts of sodium succinate, a trace amount of dye, 0.5 part of fragrance, and 4.5 parts of dextrin were added to 80 parts of α-cyclodextrin on which carbon dioxide gas had been adsorbed, and each tablet weighing 50 g was prepared. The tablets were packaged in an aluminum pillow and used as a bath preparation. Example 2 α-Cyclodextrin (Nihon Shokuhin Kako) 1Kg
was taken and carbon dioxide gas was adsorbed by applying a pressure of 10 kg/cm ² . The amount of carbon dioxide adsorbed was 42.0g. To 98 parts of α-cyclodextrin on which carbon dioxide gas had been adsorbed, 2 parts of sodium chloride, a trace amount of a coloring matter, and a trace amount of a fragrance were added to prepare a bath agent weighing 50 g per tablet. Comparative example 1 In Example 1, α that does not adsorb carbon dioxide gas
- Bath preparations were prepared using cyclodextrin and the same formulation.

[Claims]

1. An external pharmaceutical member comprising a drug-containing base layer containing a transdermal absorbable drug and having pressure-sensitive adhesive properties at room temperature, and a carrier containing a drug that evaporates and evaporates with body temperature.