JPH0534331B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a dentifrice composition that has an excellent effect of removing bad breath by incorporating N-alkyloyl sarcosinate and chlorhexidine salts into the dentifrice composition containing a silica-based abrasive. Toothpaste compositions are used to clean and clean the oral cavity and keep the oral cavity hygienic.
In this case, it is desired that the dentifrice composition has the function of removing bad breath that makes people feel uncomfortable. Conventionally, chlorhexidine salts have been incorporated into dentifrice compositions as an active ingredient for preventing bad breath, but the effect may not be sufficient in some cases. In this case, in order to improve the effect of preventing halitosis, a large amount of fragrance or the like is added or a strong fragrance is used to suppress the appearance of bad breath, but this does not necessarily result in a sufficient effect. The present inventors have conducted extensive research on toothpaste compositions that have excellent breath odor removal effects, and have unexpectedly found that they use silica-based abrasives as the abrasives and N
- It has been found that when an alkyl sarcosinate and a chlorhexidine salt are used in combination, the halitosis suppressing effect is significantly exhibited and bad breath can be reliably removed, and the present invention has been completed. The present invention will be explained in more detail below. The dentifrice composition according to the present invention contains a silica-based abrasive.
Contains 10-40% by weight and N as an active ingredient
- It is a mixture of alkyloyl sarcosinate and chlorhexidine salts. In this case, as the silica-based abrasive, for example, JP-A-49-91994, JP-A-49-94712,
JP-A-50-64198, JP-A-50-65497, JP-A-51-928695, JP-A-51-136841
Those described in Japanese Patent Publication No. 54-4919 and the like are used. To give a more specific example,
Sold under the Zeodent, Zeo, and Sident trademarks, the primary particles are 500 mμ or less and the secondary particles are 1 to 1.
Precipitated silica, silica xerogel, silica aerogel, etc. with a thickness of 30μ can be used. In this case, precipitated silica is particularly preferably used, with a SiO ₂ content of 70%
above, preferably 90% or more, alkali/alkaline earth metal oxide content 0 to 5%, bond amount of metal oxides such as aluminum, magnesium, calcium, etc. to SiO ₂ 0 to 10%, preferably 0 to 5
%, adhering moisture content (loss on drying) of 1 to 10%, average particle size of 0.5 to 30μ, more preferably 1 to 15μ,
Those having properties of a specific surface area per gram (BET method) of 500 m ² or less, more preferably 300 m ² or less, a refractive index of 1.44 to 1.47, and a liquid absorption amount of 0.6 to 1.3 cc/g are preferably used. Specifically, Zeo49 from Huber in the United States,
Zeodent113, Syloid AL− from WRGrace, USA
1, 63, 74, 404, UK J.Crossfield & Sons
Neosyl ET from Degussa, Germany, Sident3 from Degussa,
20 etc. are mentioned. In the present invention, the silica-based abrasive may be used alone or in combination of two or more types, and the amount of the silica-based abrasive is not particularly limited. %, hereinafter the same), preferably 10 to 30%. In addition, as N-alkyloyl sarcosinate, N-lauroyl, N-myristoyl or N-
Sodium, potassium or ethanolamine salts of palmitoyl sarcosine are used. In this case, the amount of N-alkyloyl sarcosinate blended is preferably 0.05 to 0.5%, more preferably 0.1 to 0.5% of the total composition. N-
If the amount of alkyl sarcosinate blended is less than 0.05%, the blending effect may not be sufficiently achieved. Further, as the chlorhexidine salts used in the present invention, chlorhexidine hydrochloride, chlorhexidine gluconate, etc. can be used. The amount of chlorhexidine salts contained in the entire composition is 1 to 1.
It is preferably 1000 ppm, particularly 10 to 100 ppm. In the present invention, in addition to the silica-based abrasive, other abrasives may be used as necessary, such as dibasic calcium phosphate dihydrate and anhydride, monobasic calcium phosphate, tertiary calcium phosphate, calcium carbonate,
One type of calcium pyrophosphate, calcium sulfate, titanium oxide, alumina, hydrated alumina, aluminum silicate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, bentonite, zirconium silicate, synthetic resin, etc. Or two or more types may be blended. In this case, the amount of these abrasives to be blended is selected as appropriate, but when producing transparent toothpaste, the amount used is preferably 10% or less based on the weight of the silica-based abrasive. Further, in the present invention, in addition to the silica-based abrasive, a silica-based thickener may be added,
For example, Cab-O-Sil, a gelatable igneous ultrafine silica sold under the trademark Aerosil;
Finely powdered gelling silica with secondary particles of several μm or less sold under the trademarks of Tokusil, Vitasil, and Nipsil may be blended. The dentifrice composition according to the present invention can be used as a toothpaste, a moist toothpaste, a powdered dentifrice, etc., but as other components of the dentifrice composition, any commonly used appropriate components can be used. Examples of binders include cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, and sodium carboxymethylhydroxyethylcellulose, alkali metal alginates such as sodium alginate, propylene glycol alginate, xanthan gum, gum tragacanth, gum karaya, and gum arabic. gums, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, synthetic binders such as polyvinylpyrrolidone, ve-gum,
One or more types of inorganic binders such as laponite may be blended (the blending amount is usually 0.5 to 5%). In addition, sorbit, glycerin,
ethylene glycol, propylene glycol,
One or more of 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xyrite, maltite, lactite, etc. may be blended (the blending amount is usually 10 to 75%). Also,
Water-soluble salts of higher alkyl sulfates whose alkyl group has 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate; water-soluble higher fatty acid monoglyceride monosulfates, such as sodium hydrogenated coconut oil fatty acid monoglyceride monosulfate; Alkylaryl sulfonates such as sodium dodecylbenzenesulfonate, higher alkyl sulfonates, higher fatty acid esters of 1,2-dihydroxypropanesulfonate, sucrose mono- and dilaurates with a fatty acid group having 12 to 18 carbon atoms. Certain sucrose fatty acid esters, lactose fatty acid esters,
Lactitol fatty acid ester, maltitose fatty acid ester, stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate,
Polyoxyethylene (10, 20, 40, 60, 80, 100
mol) nonionic activators such as hydrogenated castor oil, polymers of ethylene oxide and propylene oxide, and condensation products of polyethylene oxide with fatty acids, fatty alcohols, polyhydric alcohols, and polypropylene oxide, such as polyoxyethylene polyoxypropylene monolauryl ester; One or more surfactants such as betaine type, amino acid type, etc.
%, preferably 0.5 to 5%). The dentifrice composition of the present invention further contains saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartine, thaumatin, asparatylphenylalanine methyl ester, p-methoxycinnamic aldehyde, sucrose, lactose. , fructose, sweeteners such as sodium cyclamate (0 to 1%, preferably 0.01 to 0.5%), p-hydroxymethylbenzoitsquacid, p-hydroxyethylbenzoitsquacid, p-hydroxypropylbenzoitsquacid, p- It can contain preservatives such as hydroxybutylbenzoic acid, sodium benzoate, and lower fatty acid monoglycerides, whitening agents such as gelatin, peptone, arginine hydrochloride, albumin, casein, and titanium dioxide, silicone, pigments, and other ingredients. For example, in the case of toothpaste, it can be manufactured by kneading the above-mentioned desired ingredients with an appropriate amount of water. In addition, when preparing the toothpaste composition in a transparent form, a silica-based abrasive is used as the abrasive, and a transparent form in which Vihtal is mixed with the silica-based abrasive is adjusted to have substantially the same refractive index as the silica-based abrasive. The silica-based abrasive and this transparent vehicle are kneaded together. Furthermore, in the present invention, allantoins such as allantoin chlorhydroxyaluminum, epsilon aminocaproic acid, tranexamic acid, dextranase, amylase, protease, mutanase, lysozyme, phostase, lytic enzyme,
Enzymes such as Litetsuenzyme, alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate, sodium fluoride, ammonium fluoride, and difluoride fluoride.
Fluorides such as tin, dihydrocholesterol, glycyrrhetinic salts, glycyrrhetinic acid, glycerophosphate, EHDP, sodium copper chlorophyllin, herbal medicines such as hinokitiol, calopeptide, azulene, chamomile, water-soluble inorganic phosphoric acid compounds, vitamins, tartar prevention One or more types of active ingredients such as antibacterial agents, antibacterial agents, and plaque inhibitors may be included. According to the present invention, when chlorhexidine salts are blended alone in a dentifrice composition, the effect of preventing bad breath may not be sufficient, but when a silica-based abrasive is used as an abrasive and N-alkyloyl sarcosinate is used, By incorporating chlorhexidine and chlorhexidine salts, bad breath could be reliably removed. Next, experimental examples will be shown to specifically explain the effects of the present invention. [Experimental example] A toothpaste composition with the following formulation was prepared, and the durability of its halitosis prevention effect was evaluated in situ by a panel of 10 people with strong halitosis, a panel with normal halitosis, and a panel with weak halitosis.
It was evaluated using the evaluation method. The results are shown in Table 1.

【table】

【table】

[Table] The "in situ" evaluation method is as follows. Evaluation method: Rinse the mouth with a small amount of water, add methionine to this discharged liquid, keep it warm under anaerobic conditions, and measure the produced methyl mercaptan (CH ₃ SH) by gas chromatography. This operation was performed before and after tooth brushing to evaluate the halitosis suppressing effect. Bad breath suppression rate = CH ₃ SH amount before tooth brushing - CH ₃ SH amount after tooth brushing / CH ₃ SH amount before tooth brushing x 100 As is clear from the results in the table, silica-based abrasive was used as the abrasive, and It has been found that by using N-lauroyl sarcosine sodium and chlorhexidine hydrochloride in combination, a toothpaste with good halitosis suppression rate can be obtained. Examples are shown below. Example 1 Precipitated silica 30% 70% sorbitol 50 Polyethylene glycol 400 5 Sodium carboxymethyl cellulose 1 Sodium lauryl sulfate 1.8 Fatty acid diethanolamide 0.5 Sodium saccharin 0.1 Flavor 1 Chlorhexidine gluconate 0.003 Sodium N-lauroyl sarcosine 0.1 Purified water Remaining Total 100% Example 2 Precipitated silica 28% 95% glycerin 30 70% sorbitol 20 Polyethylene glycol 400 5 Sodium carboxymethyl cellulose 1.1 Sodium α-olefin sulfonate 1.7 Fatty acid diethanolamide 0.5 Sodium saccharin 0.1 Flavor 1 Chlorhexidine gluconate 0.005 N-lauroyl sarcosine sodium 0.2 Purified water Balance 100% Example 3 Precipitated silica 25 Pyrogenic silica 2 95% glycerin 31 70% sorbitol 31 Polyethylene glycol 400 4 Sodium carboxymethyl cellulose 0.5 Carbopol/neutralizing agent 0.5/0.2 Sodium lauryl sulfate 1 Sucrose fatty acid ester 1 Fatty acid diethanolamide 0.5 Sodium saccharin 0.1 Flavor 1.1 Chlorhexidine gluconate 0.01 Sodium N-lauroyl sarcosine 0.1 Purified water Balance 100% Example 4 Precipitated silica 20 Pigneous silica 2.5 95% glycerin 39 70% sorbitol 31 Sodium carboxymethyl cellulose 0.4 Carrageenan 0.6 Sodium lauryl sulfate 1.5 Fatty acid diethanolamide 0.5 Sodium saccharin 0.1 Flavor 1 Chlorhexidine hydrochloride 0.001 Sodium N-lauroyl sarcosine 0.5 Purified water Balance 100% Example 5 Sedimentation Silica 28% 95% Glycerin 25 70% Sorbit 30 Propylene glycol 4 Sodium carboxymethylcellulose 0.3 Carrageenan 0.4 Xanthan gum 0.3 Sodium lauryl sulfate 1.7 Fatty acid diethanolamide 1 Sodium saccharin 0.1 Flavoring 1 Chlorhexidine hydrochloride 0.003 Sodium N-lauroyl sarcosine 0 .3 Purification Water Balance 100% Example 6 Precipitated silica 18% Igneous silica 3 95% Glycerin 20 70% Sorbit 39 Polyethylene glycol 400 3 Sodium carboxymethyl cellulose 0.6 Carbopol/neutralizing agent 0.5/0.2 Sodium lauryl sulfate 1.7 Fatty acid diethanolamide 0.8 Sodium satucalin 0.1 Flavoring 1.1 Chlorhexidine hydrochloride 0.008 Sodium N-lauroyl sarcosine 0.4 Purified water Balance 100% Example 7 Precipitated silica 20% 95% glycerin 19 70% sorbitol 41 Polyethylene glycol 400 5 Sodium carboxymethylcellulose 0.5 Carrageenan 0.6 Sodium lauryl sulfate 1 Sucrose fatty acid ester 1 Fatty acid diethanolamide 1 Sodium saccharin 0.1 Flavor 1.1 Chlorhexidine hydrochloride 0.01 Sodium N-lauroyl sarcosine 0.05 Purified water Balance 100% Example 8 Precipitated silica 10% Pigneous silica 4 95% glycerin 50 Propylene glycol 3 Sodium carboxymethyl cellulose 0.6 Xanthan gum 0.3 Sodium α-olefin sulfonate 1.5 Fatty acid diethanolamide 1 Sodium saccharin 0.1 Flavoring 1 Chlorhexidine gluconate 0.03 Sodium N-lauroyl sarcosine 0.2 Purified water Balance 100% Example 9 Precipitated silica 15% Pyrogenic silica 3 95% glycerin 45 Propylene glycol 3 Sodium carboxymethyl cellulose 1.1 Sodium α-olefin sulfonate 1.7 Fatty acid diethanolamide 0.5 Sodium saccharin 0.1 Flavor 1 Chlorhexidine hydrochloride 0.05 N-lauroyl salt Cocin sodium 0.5 Purified water Balance 100% Example 10 Precipitated silica 35% 95% glycerin 25 70% sorbitol 25 Polyethylene glycol 400 5 Sodium carboxymethyl cellulose 0.3 Carrageenan 0.8 Sodium α-olefin sulfonate 1.7 Fatty acid diethanolamide 0.5 Satucalin sodium 0.1 Fragrance 1.1 Chlorhexidine gluconate 0.5 N-lauroyl sarcosine sodium 0.1 Purified water Balance 100% All of the toothpastes of Examples 1 to 10 have enhanced halitosis preventive effects and have good sustainability.

Claims (1)

[Scope of Claims] 1. A dentifrice composition characterized in that N-alkyloyl sarcosinate and chlorhexidine salts are blended into a dentifrice composition containing 10 to 40% by weight of a silica-based abrasive. 2. The dentifrice composition according to claim 1, wherein the amount of the N-alkyloyl sarcosinate is 0.05 to 0.5% by weight of the total amount. 3 The amount of chlorhexidine salts is 1 to 1 of the total.
The dentifrice composition according to claim 1 or 2, which has a content of 1000 ppm. 4. The dentifrice composition according to any one of claims 1 to 3, wherein the chlorhexidine salt is chlorhexidine hydrochloride or chlorhexidine gluconate.