JPH0545134B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a specimen preparation device for preparing blood specimens for testing, for example, leukemia, infectious diseases, red blood cell abnormalities, and the like.

(Prior art) Conventionally, this type of specimen preparation device collects blood from a single test tube containing blood as a specimen, and smears it by spotting it on a glass slide. What has been done is publicly known. After drying this smeared blood, a predetermined number of glass slides are grouped together in a so-called batch style.
Blood specimens were prepared by manually transporting the blood to a staining process in a staining tank.

(Problems to be Solved by the Invention) As described above, the conventional apparatus has poor workability because the work up to smearing blood onto a glass slide is performed in units of test tubes. In particular, specimen preparation is a heavy burden in hospital laboratories and the like that prepare a large number of specimens.

In addition, because blood is stained in batches, the drying time of the blood before staining differs for each specimen, so it is important to make the drying time uniform in order to create high-quality specimens and improve test accuracy. It was wanted.

Furthermore, with the specimen preparation method described above, there is a risk that workers may become infected with serum hepatitis due to direct contact with blood.

The present invention has been made in view of the above-mentioned conventional circumstances, and it is an object of the present invention to provide a specimen preparation device that can speed up specimen preparation and make preparation conditions uniform.

(Means for Solving the Problems) In order to solve the above problems, the present invention receives a specimen rack that holds a plurality of specimen containers containing specimens in an upright position at regular intervals, and The rack is equipped with a means for transporting specimens and a sampling rod capable of stirring and quantitatively collecting the specimens in the specimen containers. A sampling means for stirring and quantitatively collecting each sample from the sample rack transported to the above-mentioned predetermined position by a rod, and spotting each sample on a slide plate on a slide frame at a fixed position, and a slide frame that has accumulated a large number of samples. A slide frame automatic supply means for feeding the slide frames one by one, a slide frame conveyance means for conveying the supplied slide frames to the above-mentioned fixed position and once stopping them, and sending them out, a specimen smearing means for smearing a specimen uniformly and to a substantially equal thickness by sliding a block piece having a straight section at the lower part on a slide plate that has received a spot; and a slide sent out by the slide frame conveying means. The specimens on the frame are received in a vertically suspended state through appropriate transfer means while being dried in a breeze, and fed in fixed pitches, while appropriate types of staining tanks are installed from below this slide frame so that they can each be moved up and down independently. The slide frame was constructed of a continuous staining means for controlling the staining time by the length of the staining tank and the time interval of the above-mentioned vertical movement, and a carrying-out means for carrying out the slide frame after staining.

(Example) Next, an example of the present invention will be described with reference to the drawings.

FIG. 1 and subsequent diagrams show a blood specimen preparation apparatus according to the present invention, including a test tube rack transport means 1, a sampling means 2, an automatic slide frame supply means 3, a slide frame transport means 4, a blood smear means 5, and a continuous staining means 6. and an unloading means 7.

As shown in FIGS. 3 to 5, the test tube rack conveying means 1 includes a general-purpose test tube rack 11 (in this embodiment, as an example, 10 test tubes 12 are accommodated at a pitch of 20 mm, and a recess is provided on the bottom surface. 13), which has two belt conveyors 14 for conveying the conveyor belt, and a first movable stopper 1 and a second movable stopper 1 in the middle thereof.
5 and 16 are provided. Among these, the first movable stopper 15 has a vertical portion 17 and a test tube rack 1 on its upper surface.
A horizontal portion 18 whose width is slightly narrower than that of the bottom surface of 1.
The test tube rack 11 is shaped so that it can be raised and lowered to three positions: upper, middle, and lower, and the test tube rack 11 can be moved in the width direction while in the upper position.

Then, the test tube rack 11 conveyed by the belt conveyor 14 is temporarily stopped at the vertical portion 17 of the first movable stopper 15 in the middle position while the belt conveyor 14 is kept in operation (FIG. 3).
After being raised to the upper stage position by the horizontal section 18, the test tube 12 is shifted laterally by 5 pitches, that is, a distance of 20 mm x 5, and then lowered to the middle stage position for positioning. Then test tube rack 1 again.
1 and move it laterally to the pre-shift position (Fig. 4), and lower the first movable stopper 15 to the lower stage.
At the same time, the first movable stopper 15 is raised to the middle position and the same operation as described above is repeated for the subsequent test tube racks 11. Furthermore, when sending out this test tube rack 11, even if test tube racks 11 are successively following, the first movable stopper 15 is lowered to the lower position and at the same time the second
The movable stopper 16 is raised and fitted into the recess 13 to temporarily stop the subsequent test tube racks 11, and then feed out the previous test tube racks 11 one by one. figure).

As shown in FIGS. 6 to 8, the sampling means 2 includes a sampling arm 19 that is movable in forward and reverse directions and up and down, and a plurality of sampling rods 20, for example, five in this embodiment, which are attached at variable intervals. (indicated by a circle in Figure 6), each sampling rod consists of 20
A collection end 22 is provided at the tip of the test tube 12 and has a diameter slightly smaller than the inner diameter of the test tube 12 and a spherical recess 21 at the bottom. It has been done.

That is, the arms 19 are located at blood sampling positions that are angularly spaced from each other by 90 degrees (indicated by solid lines in FIG. 6);
Cleaning position (same, broken line), dotting position (same, two-dot chain line)
It is formed so that it can be rotated forward and backward to each position, and can be raised and lowered at each position.

In addition, the other four of the five sampling rods 20 except for the central one are attached to each of four rotatably supported pulleys 23 of the same diameter, and the circular center of each pulley 23 and the center of rotation are The centers of rotation of each pulley 23 and the center of the center sampling rod 20 (each indicated by a + mark in FIG. 6) are arranged at equal intervals, that is, at intervals A. and,
For example, in the example of FIG. 6, at the sampling position (solid line), the first, second, third, fourth, and fifth sampling rods 20 from the left in the figure are placed in order from the left with respect to the rotation center of the pulley 23. 2B to the right, B to the right,
It is installed eccentrically by B on the left and 2B on the left. Furthermore, a fixed pulley 24 having the same diameter as the pulley 23 is provided at the center of rotation of the arm 19,
A belt 25 is installed between the pulley 23 and the fixed pulley 24.
is wound around the belt 25, pulley 23, and fixed pulley 24 using a tension pulley (not shown).
It is formed so that they are in close contact with each other.

Therefore, even if the arm 19 rotates, the fixed pulley 24 rotates in the opposite direction by the same angle as the rotation angle of the arm 19 relative to the frame 26.
Each pulley 23 stops rotating, and each sampling rod 20 (○ mark) with respect to the rotation center (+ mark) of each pulley 23
The eccentric direction of is always constant. However, as the arm 19 rotates 180°, the arrangement order of the sampling rods 20 is reversed left and right, so the influence of the eccentricity B or 2B on the spacing between the sampling rods 20 is reversed before and after the 180° rotation. become. Therefore, as shown in the figure, the interval that was "A-B" at the sampling position is "A+" at the spotting position rotated 180 degrees from here.
It becomes “B”.

In addition to the sampling position and the spotting position, the arm 19 also rotates to an intermediate cleaning position, where a cleaning tank 2 is installed to clean the tip of the sampling rod 20.
7 is provided.

Incidentally, in order to explain the method of changing the interval, FIG. 7 is a simplified illustration with a part of the structure of FIG. 6 omitted.

Next, the operation of this sampling means 2 will be explained.

When the test tube rack 11 is transported to the first movable stopper 15, the arm 19, which is in the raised position at the collection position, is lowered to remove the first five test tubes 12 from one end of the test tube rack 11. Place the sampling end 22 into each of the . This sampling end 22
As described above, the inner diameter of the test tube 12 is slightly smaller than the inner diameter of the test tube 12, and there is a gap between the inner diameter of the test tube 12 and the inner diameter of the test tube 12. Therefore, the blood is stirred by moving the sampling end 22 up and down within the blood an appropriate number of times to uniformly mix blood clots and clots therein, and then the arm 19 is raised and the sampling end 22 is tested. Take it out from tube 12. Furthermore, since a spherical recess 21 is formed at the lower part of the sampling end 22, when the test tube 12 is taken out, a certain amount of blood adheres to the spherical recess 21 and its periphery. Quantitative sampling is now possible.

In addition, since the general-purpose test tube rack 11 has been used up to this point, the axes of the sampling rods 20 are set at a spacing of 20 mm.

Next, the arm 19 is rotated 180 degrees and then lowered, and a quantitative amount of blood is spotted on each of the five slide plates 38 attached to the slide frame 34 in a fixed position as described below. As soon as this is completed, the arm 19 is raised.

Note that since a general-purpose slide frame 34 is used here, the axial center spacing of each sampling rod 20 must match the pitch of the slide plate 38 during spotting. However, the pitch of this slide plate 38 is not necessarily the same as the pitch of the test tube 12. For example, considering a case where the pitch of the slide plate 38 is 25.6 mm, in this embodiment, the above-mentioned interval A is 22.8 mm, and the eccentric Assuming that the amount B is 2.8 mm, set the sampling rod 2 so that the interval at the sampling position is A-B = 20 mm, and the interval at the spotting position is A + B = 25.6 mm.
0 is installed so that the interval can be changed.

After spotting, the arm 19 is raised and rotated 90 degrees to bring it to the cleaning position. A cleaning tank 27 is provided here, and the sampling end 22 is cleaned by moving the rotary arm 19 up and down as appropriate, and after drying, the arm 19 is rotated 90 degrees and returned to the sampling position again.

On the other hand, after the first five test tubes 12 have been quantitatively sampled, until the arm 19 returns to the sampling position, the test tube rack 11 is moved horizontally into five pitches of the test tubes 12 as described above. The remaining five test tubes 12 are made to stand by at the blood sampling position.

Then, when the arm 19 returns to the collection position, a quantitative amount of blood is collected from the remaining five test tubes 12 in the same manner as the first five test tubes 12, and a new blood sample different from the above is collected. slide frame 34
After spotting the blood on the slide plate 38, the arm 19 is returned to the sampling position. After taking quantitative samples from the remaining five test tubes 12, the test tube rack 11 is shifted back to the initial position and sent out beyond the first movable stopper 15, while the subsequent test tube rack 11 is is sent to the first movable stopper 15.

After that, repeat the above operation.

Note that the present invention is not limited to the above-mentioned sampling rod 20, and other sampling rods 20a and 20b shown in FIGS. 9 to 11 may also be used. That is, FIG. 9 shows one row of protrusions 28 with a triangular cross section on the lower surface, and FIG. 10 shows two rows of protrusions 28 of the same shape, and the number of protrusions 28 is determined depending on the characteristics of the specimen. It may be increased as appropriate.

The slide frame automatic supply means 3 is a hopper 31
a vertical guide member 33 erected on the bottom surface 32 of the vertical guide member 33; an arcuate guide member 35 provided at a distance from the vertical guide member 33 that is approximately equal to the height of the general-purpose slide frame 34; The separating member 37 is rotatably fixed to a vertical shaft 36 which is rotated one rotation at a time by a driving means (not shown).

As mentioned above, the slide frame 34 is a general-purpose one with a fixed pitch (25.6 in this embodiment) on one side.
Five slide plates 38 made of glass are adhered to each other with a pitch of 5 mm (mm pitch), and the upper sides 39 are made to protrude on both sides. Further, a screw 40 is formed around the separating member 37, and the width of the screw groove is made approximately equal to the thickness of the upper side 39 of the slide frame 34.

A large number of slide frames 34 are accumulated between the vertical guide member 33 and the arcuate guide member 35, and the slide frame 34 of the lowest layer
The upper side 39 of the slide frame 34 is engaged with the screw 40 of the separating member 37, and each time the separating member 37 rotates once, the slide frame 34 is separated one by one and successively positioned between the screw grooves. send it downward,
supply.

The slide frame conveyance means 4 includes a chain conveyor 41 for horizontal conveyance equipped with an attachment 42 for hooking both overhanging portions 39a of the upper side 39 of the slide frame 34, and a plate that supports the main body of the slide frame 34 between the chain conveyor 41. It consists of 43. Then, the slide frames 34 supplied by the automatic slide frame supply means 3 are conveyed one by one to a predetermined position for the next blood smear, and when the work here is completed, they are conveyed to the end of the conveyor and sent out.
The chain conveyor 41 is reversed, the attachment 42 is returned below the slide frame automatic supply means 3, and the above operation is repeated thereafter.

The blood smearing means 5 is connected to the chain conveyor 41.
It has a smearing arm 44 which extends upwardly and is movable horizontally and linearly along a horizontal guide member (not shown) and whose speed can be controlled.
Further, on the lower surface of this arm 44, five holders 45 are suspended by pin members at a pitch of 25.6 mm, similar to the slide plate 38, and a rectangular parallelepiped block piece 46 is held at the lower end of each holder 45. . This block piece 46 is made of glass, ceramic,
It is made of metal or plastic material.

Further, a roller 47 is rotatably attached to the side surface of each holder 45, and a direct-acting cam 48 is fixed to the frame side of the blood smearing means 5, so that the holder 45 is lowered by its own weight, and the direct-acting cam 48 is A roller 47 is positioned at the holder 47, and the roller 47 is configured to roll as the arm 44 moves, thereby moving the block piece 46 at the lower end of the holder 45 up and down as appropriate. That is, a cleaning tank 49 is provided above the chain conveyor 41 at an appropriate interval, and the block pieces 4 are cleaned every time the arm 44 makes one reciprocation.
6 is designed to be cleaned here.

Then, as described above, blood is spotted on each slide plate 38 of the slide frame 34 that has been transported to a fixed position by the slide frame transport means 3, and the sampling arm 19 is released to the cleaning tank 27 side. Until then, the arm 44 is kept on standby at an intermediate position indicated by the arm 44a indicated by a two-dot chain line in FIG. When the sampling arm 19 moves toward the washing tank 27, the arm 44 is moved to the left in FIG. Slide on the plate 38.

Next, by sliding the block piece 46 on the slide plate 38, the spotted blood is smeared onto the slide plate 38. At this time, it is preferable to operate the arm 44 and therefore the block piece 46 as shown in FIG. 15 in order to smear the blood uniformly and uniformly on the slide plate 38 over a long range in the sliding direction. That is, after the block piece 46 is temporarily stopped at the smearing start position (Fig. 16), it moves very slightly to the left in Fig. 14 (Fig. 17, blood spreads on the block piece 46), and then it is stopped once and then moved to the left in Fig. 14 (Fig. 17). Operate in the order of slight movement to the right in Figure 14 and then stop once. Subsequently, blood is smeared onto the slide plate 38 by sliding the block piece 46, which has returned to its substantially original position, to the right in FIG. 14 while gradually increasing the speed (FIG. 18).

Furthermore, the arm 44 is continuously moved in the same direction, and the roller 47 rolling on the linear drive cam 48
The block piece 46 is moved to the right and raised once, then lowered and immersed in the cleaning tank 49 for cleaning.Then, the arm 44 is returned to the above-mentioned standby position and the block piece 46 is taken out of the cleaning tank 49. and dry.

The subsequent operation of the arm 44 is repeated as described above.

On the other hand, when the smearing is completed, the chain conveyor 41
is activated again to convey the smeared slide frame 34 to its tip, transfer it to the following conveyance means, and send it out. Then, the chain conveyor 41 is reversed and the attachment 42 is moved to the source below the slide frame automatic supply means 3. Return to position. Then, by returning this attachment 42,
The separation member 37 is rotated once to provide only one slide frame 34 on the chain conveyor 41, and the slide frame 34 is further conveyed to a predetermined position for smearing as described above. The following operations are the same as above.

The continuous staining means 6 has a chain conveyor 52 for vertical conveyance equipped with an attachment 51 that hooks both overhangs 39a of the upper side 39 of the slide frame 34, and both overhangs of the slide frame 34 conveyed to the tip of the chain conveyor 41. The section 39a is hooked from below by the attachment 51, the slide frame 34 is lifted up until it is in a vertical position, and the slide frame 34 is removed from the chain conveyor 41, and then lowered in this state.

Furthermore, at this lowered position, a hanger conveyor 55 is located close to the lower part of the chain conveyor 52, and is configured to operate a chain conveyor in tact at a constant pitch, which is equipped with a cap-shaped attachment 54 having a notch 53 on the side edge. They are installed continuously and horizontally.

Furthermore, the notch 53 of the attachment 54 faces sideways when it is in a state of horizontal movement on the upper or lower surface of the chain conveyor (in the example of FIG. 21, it faces to the right when it is on the upper surface and to the left when it is on the lower surface). , facing upward in the state closest to the chain conveyor 52 in the middle of the movement from the upper side to the lower side,
Further, when the attachment 52 is in the raised position, the attachment 54 waits at the closest position. In addition, attachment 54
is constantly connected to the hanger conveyor 5 by a spring (not shown).
5 so as to expand outwardly, while restricting the expansion from both sides by guide members 56 (see FIG. 23), so that the spacing between the attachments 54 on both sides is approximately equal to both projecting portions 39a of the slide frame 34.
The width is set equal to the width between the two. Then, as described above, the slide frame 3 is moved by the chain conveyor 52.
4 is lowered in a vertical position, both of its overhanging parts 39a fit into the attachment 54 from the upward notch 53, and by suspending the slide frame 34, it remains vertical on the hanger conveyor 55. It's becoming easier to transfer.

Thereafter, with the attachment 51 pulled away below the slide frame 34, the hanger conveyor 55 is operated by one pitch, and the chain conveyor 52 is operated to raise the attachment 51.

Further, below the hanger conveyor 55, there is a fan 57 and an appropriate number of dyeing tanks, for example, 5 in this embodiment.
Two dyeing tanks 58a, 58b, 58c, 58d, 5
8e is provided and contains various solutions for dyeing.

Among these, the fan 57 is for drying the smeared blood on the slide plate 38 with a breeze, and in order to prevent the wind from flowing toward the blood smearing means 5 side, the slide frame from this part is A hood 59 is attached above the conveyance means 4,
Air from the fan 57 is guided to the cleaning tank 27 side.

Next, the dyeing tanks 58a to 58e are arranged so that they can be raised and lowered individually, and each slide plate 38 is entirely immersed in the liquid in the tank when raised, and the width of each tank is
The number of tact operations corresponding to the maximum time required for processing in each tank, that is, the number of times × attachment 5
It is set equal to the length of 4 pitches. Further, in the case of this embodiment, the timing of the descent of each tank is determined separately, and the timing of the rise of each tank is made the same, so that various types of staining can be performed.

Fig. 22 shows time charts for three types of dyeing processes, and the numbers a to e in the top row indicate the dyeing tanks 58a to 58e, and the numbers in the second row correspond to the dyeing tanks 58a to 58e. The stop positions of the attachment 54 during operation, and therefore the slide frame 34, are shown in order from the left.The hatched part of the time chart shows the state in which the corresponding staining tank has risen and the slide plate 38 is immersed in the liquid. It shows.

The guide member 56 is gradually opened on both sides at the point where the hanger conveyor 55 passes the five dyeing tanks 58a to 58e, and the slide frame 3 is placed below the guide member 56.
A frame 61 is provided in which two bars are horizontally arranged side by side at an interval substantially equal to the interval between the two overhanging portions 39a of the frame 61. After the slide frame 34 is sent into each of the tanks, the attachment 54 that has reached this wide part is expanded to both sides by itself by the spring force.
The slide frame 34 is detached from the projecting portion 39a, and the slide frame 34 is supported by the frame 61 at the projecting portion 39a.

The carry-out means 7 includes a specimen storage container 62 which is replaceably provided adjacent to the pedestal 61, and a specimen container 62 with a hook at the tip, which slides the slide frame 34 on the pedestal 61 and sequentially takes it into the specimen storage container 62 by moving forward and backward. It consists of a shaped transfer member 63. When the specimen storage container 62 becomes full, it can be replaced with a new container through a specimen storage container outlet 64 provided on the side of the main body of the apparatus.

In addition, 65 in FIG. 1 is a dyeing tank inspection port.

Although the above embodiment describes the case of a blood image test, the present invention is not limited to this, but is also applicable to applications in which a liquid specimen is smeared onto a slide glass and stained to prepare a specimen, such as a cancer group. This includes cytodiagnosis (uterine cancer, lung cancer) in testing.

Further, the interval changing mechanism of the sampling rod 20 is not limited to the above embodiment using a cam, and other mechanisms such as those shown in FIGS. 24 to 26 may also be used.

That is, among the five sampling rods 20 supported by the frame 26 of the arm 19, the other four, excluding the central one, move along the long holes 70a, 70b, 70c, and 70d formed in the upper and lower surfaces of the frame 26. It is supported freely and is prevented from moving up and down.

On the other hand, a rotatable pulley 23 and a fixed pulley 24 that do not rotate are provided in the frame 26 as described above, and a belt 25 is wound around both pulleys.
Also, the belts 2 on both sides of the central sampling rod 20 are
Attachments 71 are attached to the inside of the belt 25, and the attachment surfaces are set to be different inside each of the opposing belts 25, and as the belt 25 moves, both attachments 71 become symmetrical with respect to the center sampling rod 20. It is designed to move.

Furthermore, set the left and right attachments 71 to two on each side.
First and second engaging portions 72 and 73 are formed on the attachment 71 so as to engage with the book collecting rod 20. Of these, the first engaging portion 72 is formed to operate integrally with the sampling rod 20 at both ends in the left and right directions in the figure. It has a shape. On the other hand, the second engaging part 73 is formed longer than the first engaging part 72 by the distance change (the difference in the distance before and after the change), and as described above, in this embodiment, the distance between the second engaging part 73 and the sampling rod 20 is longer than the first engaging part 72. The groove is shaped like a notch that creates a gap having a maximum dimension y (see FIG. 26).

In addition, the long holes 70b and 70c have a length that allows the sampling rod 20 to move by the distance change, and the long holes 70a and 70d
is formed to have a length that allows the sampling rod 20 to move twice as much as the interval change.

As shown in FIG. 24, in the state before the change, each attachment 71 is at the position closest to the center sampling rod 20, and the elongated holes 70a ,7
0b, 70c, and 70d are placed closer to the end faces. On the other hand, in the state after the change, each attachment 71 is at the farthest position from the center sampling rod 20, as shown in FIGS. Hole 70a,
It is in a state where it is brought closer to the end face side of 70b, 70c, and 70d.

This switching between before and after the change is the same as when using the above-mentioned cam, and when the arm 19 rotates, the fixed pulley 2 is moved relative to the frame 26.
This is done by rotating 4.

In this example, x, y, z in Fig. 26 are
An example is given in which the spacing for 11.2, 5.6, and 5.6 (mm) was 20 mm before the change, but becomes 25.6 mm after the change.

(Effects of the Invention) As is clear from the above description, according to the present invention, the sample rack transport means, sampling means, automatic slide frame supply means, slide frame transport means, specimen smearing means, continuous staining means, and It consists of a carrying out means. Therefore, it is possible to continuously prepare a large number of specimen samples. As a result, it becomes possible to speed up specimen preparation and save labor. Furthermore, since a large number of specimens are prepared under the same conditions, it is possible to obtain highly reliable test results using good specimens.

Furthermore, the worker does not come into direct contact with the specimen during specimen preparation, which has the effect of eliminating the risk of infection with serum hepatitis or the like.

[Brief explanation of drawings]

FIG. 1 is a perspective view of a specimen preparation device according to the present invention, FIG. 2 is a process diagram showing the order of specimen preparation, and FIG.
The figure is a schematic equipment configuration diagram of the test tube rack conveying means, Figures 4 and 5 are partial state diagrams for explanation showing the operating sequence of Figure 3, and Figure 6 shows the inside of the sampling arm portion of the sampling means. 7 is a schematic perspective view for explaining the interval changing mechanism in FIG. 6, FIG. 8 is a process diagram showing the order of blood sampling and spotting work, and FIGS. 9 and 10 are drawings. FIG. 11 is a side view of the slide frame automatic supply means, FIG. 12 is a perspective view of the slide frame conveyance means, FIG. 13 is a side view of the blood smearing means, and FIG. 14 is a perspective view showing another embodiment of the rod. Figure 15 shows the relationship between the speed of the block piece and time during smearing.
Fig. 17 is a perspective view showing the state during smearing, Fig. 18 is a schematic perspective view showing the feeding mechanism of the tip portion of the slide frame conveying means, Fig. 19 is a schematic equipment configuration diagram of the continuous staining means, and Fig. 20 is Fig. 19 is a schematic perspective view showing the transfer mechanism between the chain conveyor and the hanger conveyor, Fig. 21 is a time chart showing the operation of the dyeing tank, Fig. 22 is a schematic plan view showing the portion of the conveying means from the continuous dyeing means, and Fig. 23 Figure, 2nd
FIG. 4 is a vertical sectional view showing the inside of the sampling arm portion of another embodiment of the present invention, of which the 23rd embodiment
The figure shows the state before the interval is changed, FIG. 24 shows the state after the interval is changed, and FIG. 25 is a sectional view taken along the line -- in FIG. 24. DESCRIPTION OF SYMBOLS 1... Test tube rack conveyance means, 2... Sampling means, 3... Slide frame automatic supply means, 4... Slide frame conveyance means, 5... Blood smear means, 6... Continuous staining smear means, 7... Carrying out means, 11... test tube rack, 12... test tube, 20, 20a, 20b, 20c... sampling rod,
34...Slide frame, 38...Slide plate, 46...Block piece, 58a, 58b, 58
c, 58d, 58e... staining tank.

Claims (1)

[Claims] 1. After receiving a specimen rack that holds multiple specimen containers containing specimens at regular intervals, transporting it to a predetermined position, and performing the necessary operations to collect specimens from each specimen container. , equipped with a means for transporting sample racks to be sent out, and a sampling rod capable of stirring and quantitatively collecting the specimens in the sample container, and each sample in the sample rack transported to the above-mentioned predetermined position is stirred and quantitatively collected using the sampling rod, and a sampling means for spotting each specimen on a slide plate on a slide frame at a fixed position; an automatic slide frame supply means for supplying a large number of accumulated slide frames one by one; The block piece having a straight portion at the lower part is slid onto the slide plate which is stopped once at this fixed position and has received the above-mentioned spotting. A specimen smearing means for uniformly smearing the specimen to a substantially equal thickness; and a specimen smearing means for smearing the specimen uniformly to a substantially equal thickness, and a specimen on the slide frame sent out by the slide frame transporting means, while drying it with a breeze, and receiving it in a vertically suspended state via an appropriate transfer means. Continuous staining means in which, while feeding at a fixed pitch, appropriate types of staining tanks are independently movable up and down from below this slide frame, and the staining time is controlled by the length of the staining tank and the time interval of the above-mentioned up and down movements. and a carrying-out means for carrying out the slide frame after staining.