JPH0554995B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a vacuum blood sampling device for collecting blood into a blood container.

[Prior Art] Conventionally, a vacuum blood sampling device as described in Japanese Patent Publication No. 51-3153 has been proposed. The vacuum blood collection device is equipped with a vacuum blood collection chamber in which the pressure is reduced by a vacuum pump and a blood container is set, and blood is collected into the blood container by the negative pressure generated in the vacuum blood collection chamber.

Here, the negative pressure generated in the vacuum blood collection chamber and applied to the blood container acts as a blood collection suction force on the donor's blood vessel via the blood collection needle connected to the blood container.

[Problems to be Solved by the Invention] By the way, in conventional vacuum blood sampling devices, after the start of blood sampling, a predetermined negative pressure determined in consideration of blood sampling workability is achieved in the vacuum blood sampling chamber as soon as possible. In order to achieve this, the negative pressure level is controlled by adjusting a pressure control valve provided in the vacuum piping.

However, when reducing the negative pressure level as quickly as possible toward the final target value as described above,
There is a risk that the blood sampling suction force exerted on the blood vessel changes too rapidly, putting an excessive burden on the donor, and the large suction force generated at the needle hole of the blood sampling needle may cause damage to the blood vessel wall (especially if the donor's blood vessel is smaller than standard). ), which may clog the needle hole, making blood collection difficult or impossible, and as a result, blood collection efficiency may be impaired.

The present invention aims to reduce the burden on blood donors as much as possible and improve blood collection efficiency as much as possible when blood is collected into a blood container using negative pressure generated in a vacuum blood collection chamber. .

[Means for Solving the Problem] The present invention as set forth in claim 1 includes a vacuum blood collection chamber in which the pressure is reduced by a vacuum pump and a blood container is set, and blood is collected by negative pressure generated in the vacuum blood collection chamber. A vacuum blood sampling device for collecting blood into a container, comprising a blood sampling amount measuring means for measuring the amount of blood drawn into the blood container, and a control means for controlling an increase rate of the measurement result of the blood sampling amount measuring means during the blood sampling process. It was made so that it would become so.

The present invention according to claim 2 is characterized in that the control means comprises:
The negative pressure level of the vacuum blood collection chamber is continuously controlled to be reduced until the measurement increase rate exceeds a predetermined set increase rate.

The present invention according to claim 3 is characterized in that the control means comprises:
The negative pressure level is controlled to maintain the negative pressure level in the vacuum blood collection chamber when the measured increase rate reaches the set increase rate.

The present invention according to claim 4 is characterized in that the control means comprises:
The negative pressure level of the vacuum blood collection chamber is controlled so that the measured increase rate maintains the set increase rate.

The present invention according to claim 5 is characterized in that the control means comprises:
The negative pressure level in the vacuum blood collection chamber is kept under reduced pressure control until the measured increase rate reaches a saturated increase rate that no longer changes.

The present invention according to claim 6 is characterized in that the control means comprises:
The negative pressure level is controlled to maintain the negative pressure level of the vacuum blood collection chamber when the measured increase rate reaches the saturation increase rate.

The present invention according to claim 7 is characterized in that the control means comprises:
The negative pressure level of the vacuum blood collection chamber is controlled so that the measured increase rate maintains the saturation increase rate.

The present invention according to claim 8 provides that the control means:
The negative pressure level of the vacuum blood collection chamber is controlled so that the measured increase rate changes in a predetermined specific increase rate pattern with the passage of blood collection time.

The present invention according to claim 9 is characterized in that the control means comprises:
The negative pressure level of the vacuum blood collection chamber is controlled to be reduced in stages as the blood collection time passes, and the measurement increase rate is extracted every time the negative pressure level reaches each stage.

[Function] According to the present invention as set forth in claim 1, after the start of blood collection, the amount of blood collected into the blood container is measured, and the control means collects blood while controlling the increase rate α of the measured amount of blood collected during the blood collection process. to proceed. Therefore, blood can be collected at a blood increase rate α without putting a burden on the donor.
In addition, since the rate of increase α in the amount of blood collected is the control amount, an abnormal state occurs in which the rate of increase decreases from the normal level due to "the needle hole of the blood collection needle adhering to the blood vessel wall and becoming occluded". This can be avoided, and blood collection efficiency can be improved without causing difficulty or inability to collect blood even from blood donors with small blood vessels.

According to the present invention as set forth in claims 2, 3, and 4, by setting the blood increase rate α to an appropriately set increase rate α0 in advance, the burden on the blood donor is reduced and the blood collection efficiency is improved. Appropriate blood sampling conditions can be achieved.

According to the present invention described in claims 5, 6, and 7, by setting the final value of the blood increase rate α to the saturation increase rate αmax, the burden on the blood donor during the intermediate process of blood collection is reduced as much as possible. The blood sampling efficiency can be further improved.

According to the eighth aspect of the present invention, blood collection can be performed in accordance with a specific increase rate pattern determined in consideration of reducing the burden on blood donors and improving blood collection efficiency.
This means that, for example, by adopting an increasing rate pattern as shown in Figure 7, a gradual increasing pattern is adopted in the initial stage of blood collection up to the elapsed time tx, which reduces the burden on the blood donor and prevents hemolysis. At the final stage of blood sampling after time ty, the accuracy of the blood sampling amount can be improved by a gradual reduction pattern.

According to the present invention as set forth in claim 9, the actually occurring blood increase rate α does not change suddenly with the progress of blood collection, and the above-described control of the increase rate α can be stably executed.

[Example] Fig. 1 is a front view showing a blood sampling device according to an embodiment of the present invention, Fig. 2 is a side view showing a main part of Fig. 1 cut away, and Fig. 3 is a plan view of Fig. 1. Figure 4 is the first
FIG. 5 is a vacuum circuit diagram, FIG. 6 is a control block diagram, and FIG. 7 is a schematic diagram showing an example of a blood increase rate pattern.

The blood sampling device 10, as shown in FIGS. 1 to 4,
A display panel 12 is provided on the front of the housing 11,
A vacuum blood collection chamber 13 is formed inside the housing 11. 14 is the opening/closing lid of the blood collection chamber 13, 15 is the lid 1
Hinge 4 and 16 are sealing rubber for sealing the blood collection chamber 13. 14A is a handle of the lid 14.
Further, the blood sampling device 10 includes a vacuum pump 17 and a control device 18 in the lower part of the housing 11.

The vacuum blood collection chamber 13 of the blood collection device 10 is connected to an inlet port 17A of a vacuum pump 17 so as to be able to reduce the pressure, and is equipped with a bag tray 19 that supports a blood bag (blood container) 1 made of polyvinyl chloride or the like. There is. The blood sampling device 10 applies a predetermined negative pressure to the blood bag 1 supported by the bag receiving tray 19 to collect blood while reducing the pressure in the vacuum blood sampling chamber 13 . At this time, the blood collecting device 10 shakes the bag tray 19 to stir the blood and an anticoagulant such as heparin that has been loaded in the blood bag 1 in advance, and also measures the weight of the blood bag 1 to collect blood. measure quantity.

The structure for swinging the bag receiving tray 19 and the structure for measuring the weight of the blood bag 1 in the blood collecting device 10 are as follows.

First, a pedestal 20 is installed at the bottom of the vacuum blood collection chamber 13, and a swing frame 22 that is rotatable via a support shaft 21 is supported on the pedestal 20.
Further, a swing motor 23 is fixed to the pedestal 20,
and a driving shaft 24 driven by a swing motor 23
is supported. 25 and 26 are toothed pulleys,
27 is a toothed belt. A crank wheel 28 is fixed to one end of the driving shaft 24.
One end of the link 29 is connected to the rotation radius of the
The other end of the link 29 is connected to a connecting piece 30 that is integral with the swing frame 22.

On the other hand, a pair of scale mounting blocks 31 are fixed to the upper surface of the swing frame 22, and both mounting blocks 31
A scale (collected amount measuring means) 33 is supported in a cantilever manner by a support plate 32 that spans over the end of the sample. The scale 33 is equipped with strain gauges 34 as weight sensors attached to two positions on the top surface and two positions on the bottom end to form a Wheatstone bridge circuit, and a weighing platform 35 and a receiving plate 36 are attached to the tip of the scale 33. The bag receiving tray 19 described above is fixed therebetween.
37 is a stopper that prevents the balance 33 from swinging from side to side;
38 is a weight sensor amplification unit.

That is, the blood sampling device 10 rotates the driving shaft 24 and the crank wheel 28 by the operation of the swing motor 23, thereby swinging the swing frame 22, and is supported by the swing frame 22 via the scale 33. This means that the bag receiving tray 19 that is in place will be rocked. In addition, the blood sampling device 10 has a bag tray 19 supported on a scale 33 that is cantilever-supported via a mounting block 31 and a support plate 32 on the swing frame 22.
The weight of the blood bag 1 is measured by this deflection and deformation of the scale 33, and thus the amount of blood to be collected is measured.

The blood sampling device 10 detects the rotational position of the detection cam 39 provided at the other end of the driving shaft 24 using an optical sensor 40.
Under the condition that the bag receiving tray 19 is temporarily stopped at the lowest point of descent (bottom dead center) and held under a constant posture condition, the swing motor 23 is driven and controlled thereby. The weight of the blood bag 1 is measured as described above.

As shown in FIG. 5, the blood collection device 10 connects the inlet port 17A of the vacuum pump 17 and the vacuum blood collection chamber 13 with a vacuum pipe 41, and connects the vacuum pipe 41 with a
The exhaust valve 43 is closed when the exhaust solenoid 42 is turned on and opened by gravity when the exhaust solenoid 42 is turned off. The blood sampling device 10 generates negative pressure (degree of vacuum) in the vacuum blood sampling chamber 13 by driving the vacuum pump 17, and when the blood sampling is finished, the exhaust valve 43 is opened.
By opening the vacuum blood collection chamber 3, the vacuum blood collection chamber 3 is released to the atmosphere.

The blood collection device 10 includes a tube holder 44 in the upper part of the front side of the housing 11 adjacent to the vacuum blood collection chamber 13, so that the blood collection tube 2 connected to the blood bag 1 housed in the vacuum blood collection chamber 13 can be pulled out. The tube holder 44 includes a tube clamp (blood collection stop means) 46 driven by a tube clamp solenoid 45, and the tube clamp 46 clamps and closes the blood collection tube 2 to stop the blood collection operation into the blood bag 1.
47 is a clamp release button for the tube clamp 46, and 48 is a clamp button for operating the tube clamp 46 in an emergency.

The display panel 12 of the blood sampling device 10 includes a blood sampling amount/vacuum degree switching indicator lamp 49, a blood sampling amount/vacuum degree switching switch 50, a 400ml/200ml switching indicator lamp 51,
400ml/200ml changeover switch 52, stop switch 5
3. Start switch 54, usage bug indicator lamp 5
5, a use bag changeover switch 56 and a blood sampling amount/vacuum degree display section 57 are provided. Note that the blood sampling device 10 is
A power switch 58 is located at the lower front of the housing 11.
A fuse holder 59 is provided, and a power connector 60 is provided at the lower rear of the housing 11.

Next, the control device 18 of the blood sampling device 10 will be explained. The control device 18 mainly includes a main control circuit 61, a drive circuit 62, and a display circuit 63, as shown in FIG. Note that 64 is a power supply unit.

The main control circuit 61 includes a CPU (central processing unit) 65 [including a memory in which a control program for a series of operations of the device 10 is written], a memory (storage means) 66, an input/output control unit 67, an LED ( It has a light emitting diode) drive circuit 68, a buzzer 69, and a failsafe circuit 70. The input/output control unit 67 is configured to transfer detection signals from the aforementioned optical sensor 40 that detects the swinging position of the bag receiving tray 19 and the blood leakage sensor 71 that detects blood leakage from the blood bag 1. It's summery.

The memory 66 is composed of a nonvolatile memory such as EA-ROM or EEP-ROM, and can read and rewrite stored data, and can hold stored data even without application of a power supply voltage. The data stored in the memory 66 includes the negative pressure generated in the vacuum blood collection chamber 13, the set amount of blood to be collected into the blood bag 1, the extended period of swinging of the bag tray 19 after blood collection is completed, and the set blood increase rate.

The buzzer 69 indicates the completion of blood collection, vacuum blood collection chamber 1
Error of negative pressure formed in 3, swing motor 2
3, the detection of blood leakage by the blood leakage sensor 71, etc., the sounds are made in different ways.

The failsafe circuit 70 monitors the occurrence of runaway in the CPU 65 and safely stops the device when the runaway occurs.

The drive circuit 62 is connected to the main control circuit 61 and includes an A/D conversion circuit 72. The A/D conversion circuit 72 includes the aforementioned weight sensor amplification unit 38.
At the same time, a pressure sensor 73 provided in the vacuum piping 41 and detecting the negative pressure of the vacuum blood collection chamber 13 is connected via a pressure sensor amplification circuit 74.

The drive circuit 62 also includes a solenoid drive circuit 75 that controls the tube clamp solenoid 45, a solenoid drive circuit 76 that controls the exhaust solenoid 42, a pump drive circuit 78 that turns on/off the power supply switch 77 of the vacuum pump 17, and a swing motor. A motor drive circuit 80 is provided to turn on/off the power supply switch 79 of 23.

The drive circuit 62 also operates a mode changeover switch 81.
The operating mode of the CPU 65 can be changed as appropriate. The modes set by the mode changeover switch 81 include first blood collection mode, second blood collection mode, blood collection amount setting mode, degree of vacuum setting mode, specific gravity setting mode, rocking extension time setting mode, weight detection calibration mode, There are pressure detection calibration mode, blood increase rate setting mode, etc.

In the first blood sampling mode, a pre-registered value previously stored in the memory 66 as the empty weight of the blood bag 1 to be used this time is called up, and the amount of blood to be collected is measured using this pre-registered value. The empty weight of the blood bag 1 to be used this time is measured this time, and the amount of blood to be collected is measured using this measured value this time.

In addition, the blood collection amount setting mode is for changing the set blood collection amount, the vacuum level setting mode is for changing the set vacuum level (negative pressure), the specific gravity setting mode is for changing the set blood specific gravity, and the rocking extension. The time setting mode is for changing the set rocking extension time, and the blood increase rate setting mode is for changing the set blood increase rate. These settings can be changed by
After turning on the mode changeover switch 81, the current set values are displayed on the display section 57, turning on the stop switch 53 to decrease the set values, turning on the start switch 54 to increase the set values, and turning on the changeover switch 50. By turning on, the changed data is written into the memory 66, and the completion of writing can be confirmed by the sound of the buzzer 69.

Further, the weight detection calibration mode is for calibrating the detection result of the scale 33, and the pressure detection calibration mode is for calibrating the detection result of the pressure sensor 73.

The display circuit 63 is connected to the main control circuit 61 and includes various indicators such as the display lamp 49 provided on the display pulse 12 and the changeover switch 50 as described above.
It is configured with various switches such as.

Next, a blood sampling operation procedure using the blood sampling apparatus 10 will be described.

Turn on the power switch 58.

Select the blood collection mode. The mode changeover switch 81 selects either the first blood collection mode or the second blood collection mode described above.

The amount of blood to be collected is set using the 400ml/200ml changeover switch 52. This selection result is shown in the switching display lamp 5.
1 is displayed.

The bag to be used is selected by the bag to be used switch 56. This selection result is displayed on the display lamp 55.
will be displayed. The types of bags used include single S, which has only a parent bag, double D, triple T, and quadruple Q, which also have one or more small bags.

Procedures for the first blood collection mode A blood collection needle provided at the end of the blood collection tube 2 is inserted into the blood donor, and a certain amount of blood is collected.

Blood bag 1 is placed in vacuum blood collection chamber 13 and placed on bag receiving tray 19, and blood collection tube 2 is set in tube holder 44.

Turn on the start switch 54. CPU65
controls the vacuum pump 17 and the swing motor 23 to collect blood by reducing the pressure in the vacuum blood collection chamber 13,
The bag tray 19 is swung. Also,
The CPU 65 obtains the output of the weight sensor amplification unit 38 at the timing when the bag tray 19 temporarily stops at the lowest point, and detects the measured amount of blood collected from the blood bag 1.
Using the set blood collection volume, blood specific gravity, and pre-registered weight of blood bag 1 written in , the remaining blood collection volume (capacity) is calculated using the following equation (1).

Remaining blood collection volume (ml) = [Setting blood collection volume (g) + Pre-registered weight (g) -
Measured blood collection amount (g)]/Specific gravity (g/ml)... (1) The CPU 65 closes the blood collection tube 2 with the tube clamp 46 on the condition that the remaining blood collection amount, which is the result of the above calculation, has reached zero. Blood sampling operation into blood bag 1 is stopped. At this time, the CPU 65 stops the vacuum pump 17,
And open the exhaust valve 43 to open the vacuum blood collection chamber 13.
released to the atmosphere.

After the blood collection is completed, the CPU 65 continues to drive the swing motor 23 for a certain period of time,
Swing the bag tray 19. Thereafter, the buzzer 69 notifies the end of blood collection.

The clamp release button 47 is turned on, the blood collection tube 2 is removed from the tube holder 44, and the blood bag 1 is taken out from the vacuum blood collection chamber 13.

Procedure for second blood collection mode Blood bag 1 is placed in vacuum blood collection chamber 13 and placed on bag receiving tray 19, and blood collection tube 2 is set in tube holder 44.

A blood collection needle provided at the end of the blood collection tube 2 is inserted into the blood donor.

Turn on the start switch 54. CPU65
obtains the output of the weight sensor amplification unit 38, measures the empty weight of the blood bag 1, and writes this to the memory 66 (or the internal memory of the CPU 65).

Turn on the start switch 54 again. As a result, the CPU 65 drives and controls the vacuum pump 17 and the swing motor 23 to collect blood by reducing the pressure in the vacuum blood collection chamber 13 and swing the bag tray 19. The CPU 65 obtains the output of the weight sensor amplification unit 38 at the timing when the bag tray 19 temporarily stops at the lowest point, detects the measured blood collection amount of the blood bag 1, and detects the blood collection settings written in the memory 66. Using the amount, blood specific gravity, and currently measured weight of blood bag 1, the remaining blood collection amount (volume) is calculated using the following equation (2).

Remaining blood collection volume (ml) = [Set blood collection volume (g) + current measured weight (g)
- Measured blood collection amount (g)]/Specific gravity (g/ml)... (2) Same as above.

Same as above.

Same as above.

In both cases, the amount of blood to be collected and the degree of vacuum during blood collection can be displayed on the display section 57 to monitor the progress of the measurement. The display amount is selected by the changeover switch 50.

Accordingly, in the blood sampling apparatus 10, the rate of increase α of the sampled blood into the blood bag 1 is controlled as follows during the above-mentioned blood sampling operation process.

That is, the CPU 65 of the control device 18
The increase rate α of the measured blood collection amount according to 3 is controlled during the blood collection process. Note that the rate of increase in the amount of blood sampled is the rate of increase in the amount of blood sampled with respect to the passage of measurement time, and in this example, as described above, the rate of increase in the amount of blood sampled is the rate of increase in the amount of blood sampled over the course of the measurement time. It is calculated as the percentage increase in the amount of blood collected from the previous measurement.

Therefore, according to the blood sampling device 10, after the start of blood sampling, the amount of blood collected into the blood bag 1 is measured by the scale 33, and the CPU 65 calculates the increase rate α of the measured blood sampling amount.
Blood collection proceeds while controlling the blood collection process. Therefore, blood can be collected at a blood increase rate α that does not burden the donor. In addition, since the rate of increase α in the amount of blood collected is used as the control amount, the rate of increase is reduced from the normal level due to "the needle hole of the blood collection needle adhering to the blood vessel wall and becoming occluded". Blood collection efficiency can be improved without causing difficulty or inability to collect blood even from blood donors with small blood vessels.

In the implementation of the present invention, the control method for the blood increase rate α can be, for example, any one of the following (A), (B), and (C).

(A) A control method in which the CPU 65 continues to reduce the negative pressure level in the vacuum blood collection chamber 13 until the measurement increase rate α reaches a predetermined set increase rate α0 or more. According to this, by setting the measurement increase rate α to an appropriate setting increase rate α0 in advance, the burden on blood donors is reduced and blood collection efficiency is improved.
Appropriate blood sampling conditions can be achieved. Specifically, for example, according to any of the following.

The negative pressure level of the vacuum blood collection chamber 13 is controlled so as to maintain the negative pressure level P0 of the vacuum blood collection chamber 13 when the measurement increase rate α reaches the set increase rate α0.

The negative pressure level Px of the vacuum blood collection chamber 13 is controlled so that the measured increase rate α maintains the set increase rate α0.

Note that in (A) above, the set increase rate α0 is stored in the memory 66 as described above. Furthermore, α0 is
It can be stored in the internal memory of the CPU 65.

(B) A control method in which the CPU 65 continues to reduce the negative pressure level in the vacuum blood collection chamber 13 until the measured increase rate α reaches the saturation increase rate αmax where it no longer changes. According to this, by setting the final value of the blood increase rate α to the saturation increase rate αmax, the blood collection efficiency can be better improved while the burden on the donor during the blood collection intermediate process is reduced as much as possible. Specifically, for example, according to any of the following.

The negative pressure level of the vacuum blood collection chamber 13 is controlled so as to maintain the negative pressure level P0 of the vacuum blood collection chamber 13 when the measurement increase rate α reaches the saturation increase rate αmax.

The negative pressure level Px of the vacuum blood collection chamber 13 is controlled so that the measurement increase rate α maintains the saturation increase rate αmax.

(C) The negative pressure level of the vacuum blood collection chamber 13 is controlled by the CPU 65 so that the measured increase rate α changes in a predetermined specific increase rate pattern as the blood collection time t passes. According to this, blood collection can be performed according to a specific increase rate pattern determined in consideration of reducing the burden on blood donors and improving blood collection efficiency. For example, by adopting an increasing rate pattern as shown in Fig. 7, a gradual increasing pattern is adopted in the initial stage of blood collection up to the elapsed time tx, thereby reducing the burden on blood donors and preventing the occurrence of hemolysis. In the final stage of blood sampling after the elapsed time ty, the accuracy of the blood sampling amount can be improved by a gradual reduction pattern.

In addition, in (A), (B), and (C) above, vacuum blood collection chamber 1
The operation of reducing the negative pressure level in step 3 can be performed stepwise or continuously over the blood collection time. In addition, when considering it in stages, the CPU 65 is
The measured increase rate α is extracted every time the negative pressure level reaches each stage.

In addition, in (A), (B), and (C) above, the operation to control the negative pressure level of the vacuum blood collection chamber 13 is performed by on/off control of the vacuum pump 17 or by a control provided in the vacuum piping 41. This is carried out by on/off control or analog control of the pressure control valve.
That is, in the above, the CPU 65 is
The power supply switch 77 of the pump 17 is controlled on/off so that the pressure detected by the pressure sensor 73 matches the target pressure stored in the memory 66, for example.
Or perform on/off control or analog control of the above-mentioned pressure control valve.

In addition, the present invention relates to a measuring method of a blood sampling amount measuring means,
The pressure adjustment method of the vacuum blood collection chamber can be widely applied to any blood collection device.

[Effects of the Invention] As described above, according to the present invention, when blood is collected into a blood container using the negative pressure generated in the vacuum blood collection chamber, the burden on the blood donor can be reduced as much as possible, and the blood collection efficiency can be improved. It can be improved as much as possible.

[Brief explanation of drawings]

FIG. 1 is a front view showing a blood sampling device according to an embodiment of the present invention, FIG. 2 is a side view showing a main part of FIG. 1 broken away, FIG. The figure is the first
FIG. 5 is a vacuum circuit diagram, FIG. 6 is a control block diagram, and FIG. 7 is a schematic diagram showing an example of a blood increase rate pattern. 1...Blood bag (blood container), 10...Blood collection device, 13...Vacuum blood collection chamber, 17...Vacuum pump, 33...Weigher (blood sampling amount measuring means), 65...
CPU (control means).

Claims (1)

[Scope of Claims] 1. A vacuum blood collection device that is equipped with a vacuum blood collection chamber that is depressurized by a vacuum pump and in which a blood container is set, and that collects blood into the blood container using negative pressure generated in the vacuum blood collection chamber. An increase rate of collected blood characterized by comprising: a blood collection amount measuring means for measuring the amount of blood collected into a container; and a control means for controlling the increase rate of the measurement result of the blood collection amount measuring means during the blood collection process. Controllable vacuum blood sampling device. 2. The vacuum blood sampling device capable of controlling the rate of increase in collected blood according to claim 1, wherein the control means continues to reduce the negative pressure level of the vacuum blood collection chamber until the measured rate of increase reaches a predetermined set rate of increase or more. . 3. The increase rate of collected blood according to claim 2, wherein the control means controls the negative pressure level to maintain the negative pressure level of the vacuum blood collection chamber when the measured increase rate reaches the set increase rate. Controllable vacuum blood sampling device. 4. The vacuum blood collection device capable of controlling the rate of increase in collected blood according to claim 2, wherein the control means controls the negative pressure level of the vacuum blood collection chamber so that the measured rate of increase maintains the set rate of increase. 5. The vacuum blood sampling device capable of controlling the rate of increase in collected blood according to claim 1, wherein the control means continues to reduce the negative pressure level of the vacuum blood collection chamber until the measured rate of increase reaches a saturated rate of increase at which it no longer changes. 6. The increase rate of collected blood according to claim 5, wherein the control means controls the negative pressure level to maintain the negative pressure level of the vacuum blood collection chamber when the measured increase rate reaches the saturated increase rate. Controllable vacuum blood sampling device. 7. The vacuum blood collection device capable of controlling the rate of increase in collected blood according to claim 5, wherein the control means controls the negative pressure level of the vacuum blood collection chamber so that the measured rate of increase maintains the saturated rate of increase. 8. The method of collecting blood according to claim 1, wherein the control means controls the negative pressure level of the vacuum blood collection chamber so that the measured increase rate changes in a predetermined specific increase rate pattern with respect to the passage of blood collection time. Vacuum blood sampling device that can control the rate of increase. 9. Claims 1 to 8, wherein the control means controls the negative pressure level of the vacuum blood collection chamber to be reduced in stages with respect to the passage of blood collection time, and extracts the measurement increase rate each time the negative pressure level reaches each stage. A vacuum blood sampling device capable of controlling an increase rate of collected blood according to any one of the above.