JPH0569092B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Application Field] The present invention relates to an anti-rotavirus agent for mammals containing sodium polyacrylate. [Prior Art] Rotavirus proliferates in the intestinal epithelium of human infants and young domestic animals such as cows, pigs, and sheep, and often causes severe non-bacterial diarrhea.Vaccines are used as a treatment and prevention method for this. A method of administering milk components from a dairy animal immunized with rotavirus (Japanese Unexamined Patent Publication No. 154513/1983) is known. [Problems to be solved by the invention] However, these treatment and prevention methods have not yet been put into practical use, and as a countermeasure, oral or parenteral infusions are implemented as symptomatic treatment for dehydration symptoms caused by diarrhea. There are no other options, and no fundamental treatment has been established. [Means for Solving the Problems] The present inventors conducted various studies on anti-rotavirus agents for mammals and found that sodium polyacrylate has an anti-rotavirus effect. The present invention has been completed based on the above findings. The sodium polyacrylate used in the present invention preferably has an average molecular weight of 10,000 or more, preferably 100,000 to 10,000,000. Subjects to which the anti-rotavirus agent of the present invention is administered include humans and livestock such as cows, pigs, and sheep. The dosage is preferably 0.02 to 0.2 g per 1 kg of body weight, and preferably administered orally. The administration period is usually the period of rotavirus disease, but it may also be administered throughout the period when rotavirus disease is likely to occur, for example, during infancy or early childhood. The anti-rotavirus agent for mammals of the present invention contains sodium polyacrylate as it is or mixed with a physiologically harmless solid or liquid carrier such that the sodium polyacrylate content is 1% or more, preferably 10% or more in the preparation. These preparations can be administered as they are in the form of solid preparations such as tablets, capsules, granules, powders, and syrups, or in the form of liquid preparations. Alternatively, it may be administered by adding it to feed. Examples of solid carriers used here include lactose, cornstarch, calcium carbonate, calcium lactate, cellulose, defatted rice bran, soybean meal, bran, corn flour, and corn starch, and examples of liquid carriers include water and physiological saline. Examples include water and syrup. In addition, auxiliary agents or additives such as emulsifiers, dispersants, suspending agents, wetting agents, stabilizers, and sweeteners may be used as necessary. Note that there is no problem in adding other drugs to the anti-rotavirus agent for homeothermic animals of the present invention. Example 1 An example of manufacturing a powder will be explained as follows. 1 part by weight of sodium polyacrylate and 4 parts by weight of corn starch were placed in a V-type mixer and mixed with sufficient stirring to obtain a powder. Example 2 1 part by weight of sodium polyacrylic powder and 7 parts by weight of lactose were uniformly mixed, water was added and the mixture was kneaded and then granulated using an extrusion granulator to obtain granules. [Effect] The excellent effects of the anti-rotavirus agent for mammals of the present invention will be explained below using experimental examples. Experimental example (1) Experimental method The anti-rotavirus effect against rotavirus was investigated using a cultured cell system. The virus used was human rotavirus (MO strain), and this virus was derived from monkey fetal kidney.
After infecting MA104 cells at an moi of 0.5, they were cultured in serum-free MEM medium supplemented with sodium polyacrylate for 20 hours while changing the medium every 5 hours. The amount of virus released into the medium was then determined using a fluorescence focus assay method. (2) Experimental results The results are shown in Table 1.

[Table] From this table, sodium polyacrylate is
It can be seen that virus proliferation is significantly inhibited at concentrations of 200 ppm or higher. Therefore, the preparation of the present invention is expected to be used as an anti-rotavirus agent for mammals.

Claims (1)

[Claims] 1. Anti-rotavirus agent for mammals containing sodium polyacrylate.