JPH0582365B2 - - Google Patents

Description

[Detailed description of the invention]

INDUSTRIAL APPLICATION FIELD The present invention relates to a skin preparation for external use, and more specifically, it is a safe and effective skin preparation that not only prevents and improves rough skin, but also prevents skin sagging and loss of luster, thereby preventing aging. Regarding expensive skin external preparations. Conventional technology Various medicinal agents are blended into external skin preparations such as cosmetics, and the development of medicinal agents that have the effect of preventing or improving skin roughness is long awaited, but to date there are no medicinal agents that have such effects. It has not been discovered yet. Conventionally, pyridoxine (ie, vitamin B ₆ ) or its derivatives have been used to improve rough skin, but the effects have not yet been sufficient. Problems to be Solved by the Invention In view of the current situation, the present inventors conducted intensive research to develop a skin preparation for external use that has the effect of preventing and improving skin roughness. It has been discovered that by blending with the above ingredients, it is possible to obtain a skin preparation that is excellent in preventing and improving skin roughness, as well as in preventing aging by preventing skin sagging and loss of luster, and has developed the present invention. It was completed. Means for Solving the Problems That is, the present invention provides an external skin preparation comprising pyridoxine or a derivative thereof and iris or an extract thereof. The iris contained in the skin external preparation according to the present invention is the root of the iris of the Iridaceae family, such as odor iris, purple iris, and iris iris,
Contains irisine, fatty acids, and tannins. These iris roots may be powdered and blended into external skin preparations, or may be blended as an extract extracted with an appropriate solvent. An iris extract can be obtained by heating iris roots in a suitable solvent such as water, a lower alcohol such as methanol or ethanol, or a water-containing lower alcohol, followed by filtration. Concentrate the liquid before use. After the solvent is distilled off, the iris extract obtained by such a method is further dissolved in a solvent such as 1,3-butylene glycol, or the obtained liquid is appropriately concentrated to make a concentrate. It can also be used for inventions. Alternatively, the extract obtained by extracting the iris root with the above-mentioned suitable extraction solvent, or the extract obtained by extracting the iris root with hot water, can be subjected to adsorption chromatography such as silica gel chromatography. It is also possible to use an extract obtained by fractionation using E. The derivatives of pyridoxine, that is, vitamin B ₆ derivatives used in the present invention include vitamin B ₆ hydrochloride, vitamin B ₆ dioctanoate, vitamin B ₆
tripalmitate, vitamin _B6 dipalmitate,
Examples include vitamin _B6 dilaurate, pyridoxal phosphate, and pyridoxine glycyrrhetinate. In the present invention, pyridoxine and its derivatives can be used alone or in any mixture. The amount of pyridoxine or its derivative in the present invention is not particularly limited, but preferably 0.005 to 2% by weight in the total amount of the skin external preparation, more preferably,
It is blended in an amount of 0.01 to 1% by weight. On the other hand, there is no particular limitation on the amount of iris blended in the present invention, but in general, when the dried root is used, it is 0.001 to 5% by weight of the total amount of the skin external preparation, and when the root extract is used, it is 0.001 to 5% by weight of the total amount of the skin external preparation. Total volume of skin external preparations
It is preferable to use 0.001 to 10% by weight (more preferably 0.01 to 5% by weight). If the amount used is too small, the intended effects of the present invention may not be fully exhibited. In addition to the above-mentioned essential ingredients, the external skin preparation of the present invention may optionally contain various ingredients commonly used in cosmetics, pharmaceuticals, etc., such as aqueous ingredients, powder ingredients, etc., as long as they do not impair the effects of the present invention. extract, surfactant, humectant, thickener, preservative, antioxidant,
Flavors, colorants, drugs, etc. can be added. Among drugs, especially when vitamin B ₆ or its derivatives are combined, remarkable effects are exhibited. Further, the dosage form of the skin external preparation of the present invention is arbitrary,
For example, it can take the form of a solubilized system such as a lotion, an emulsified system such as a milky lotion or a cream, or a dosage form such as an ointment, a dispersion, or a powder product. Examples and Effects of the Invention Examples of the present invention will be described below, but it goes without saying that the scope of the present invention is not limited to these examples. Example 1: Lotion (prescription) Ingredients % Iris extract* 0.05 Glycerin 4.0 1,3-butylene glycol 4.0 Ethanol 7.0 Polyoxyethylene oleyl alcohol 0.5 Methylparaben 0.05 Citric acid 0.01 Sodium citrate 0.1 Vitamin B ₆ hydrochloride 0.1 Fragrance 0.05 Purified water 84.14 *: Wash iris roots thoroughly and cut them into approximately 5 mm pieces, add 40% ethanol 80 to 10 kg, and boil at 50℃.
Soaked for 2 days. This was filtered, the filtrate was stirred at 40°C for 5 hours, and the precipitate that had separated out was removed by filtration. This filtrate was distilled under reduced pressure at 50 mmHg and 40°C.
Kg. 8 kg of 1,3-butylene glycol was added to this solution, stirred for 1 hour, and left to stand for 3 days.
Obtained by filtration. (Production method) Citric acid, sodium citrate, glycerin, 1,3-butylene glycol, iris extract, and vitamin B ₆ hydrochloride were dissolved in purified water. Separately, ethanol and polyoxyethylene oleyl alcohol,
Fragrance and methylparaben were dissolved, added to the above-mentioned purified aqueous solution to solubilize, and filtered to obtain a lotion. Example 2: Cream (prescription) ingredients % Cetostearyl alcohol 3.5 Squalane 40.0 Beeswax 3.0 Reduced lanolin 5.0 Ethylparaben 5.0 Polyoxyethylene (20) Sorbitan monopalmitate 2.0 Stearic acid monoglyceride 2.0 Iris extract* 1.0 Fragrance 0.03 1,3 -Butylene glycol 5.0 Glycerin 5.0 Vitamin B _6- dioctanoate 0.1 Purified water 33.07 *: Wash the iris root thoroughly with water, cut it into approximately 5 mm pieces, add 70% ethanol 100 to 10 kg,
It was soaked at 50°C for 2 days. This was filtered, and the filtrate was distilled under reduced pressure at 50 mmHg and 40°C to weigh 40 kg. (Manufacturing method) The ingredients were melted by heating and kept at 75℃, then heated to 75℃,
,, with stirring. After treatment with a homomixer to make emulsified particles fine, the mixture was rapidly cooled while stirring to obtain cream. Example 3: Emulsion (formulation) ingredients % Iris extract * 0.001 Stearic acid 1.5 Cetyl alcohol 0.5 Beeswax 2.0 Polyoxyethylene (10) monooleate 1.0 Glycerin monostearate 1.0 Quince seed extract (5% aqueous solution) 20.0 Propylene glycol 5.0 Ethanol 3.0 Ethylparaben 0.3 Fragrance 0.03 Vitamin B ₆ hydrochloride 0.5 Purified water Remaining *: Wash the iris roots thoroughly and cut them into approximately 5 mm pieces. Add 10 kg of water to 5 kg and heat under reflux (10 hours). The resulting filtrate was left to stand for 3 days, and water was added to the filtrate to make a total volume of 10. (Manufacturing method) A fragrance was added and dissolved in ethanol (alcohol phase). Propylene glycol, iris extract, and vitamin B ₆ hydrochloride were added to purified water, dissolved by heating, and kept at 70°C (aqueous phase). Other ingredients except quince seed extract were mixed, heated and dissolved and kept at 70°C (oil phase). Next, the oil phase is added to the water phase for preliminary emulsification.
It was uniformly emulsified using a homomixer. The alcohol phase and quince seed extract were added to this while stirring, and then cooled to 30°C while stirring to obtain a milky lotion. Example 4: Pack (prescription) Ingredients % Iris extract * 0.1 Holivinyl alcohol 15.0 Polyethylene glycol 3.0 Propylene glycol 7.0 Ethanol 10.0 Methylparaben 0.05 Fragrance 0.05 Vitamin B _6- dioctanoate 0.3 Purified water 64.50 *: Wash the iris root thoroughly with water and prepare approximately Add 50% methanol to 10kg of 5mm pieces and heat at 50°C.
Soaked for 2 days. This was filtered and the filtrate was passed through a silica gel column. Further eluate 70
% ethanol and passed through a silica gel column to obtain an eluate. (Manufacturing method) Polyethylene glycol, propylene glycol, iris extract, and methylparaben were added to purified water and dissolved with stirring. Next, polyvinyl alcohol was added and stirred with heating, and ethanol in which vitamin B ₆ dioctanoate and fragrance were dissolved was added and dissolved with stirring to obtain a pack. Example 5: Scalp cosmetics (scalp treatment) (Formulation) Ingredients % Iris extract* 0.5 1,3-butylene glycol 6.5 Polyethylene glycol 1500 5.0 Ethanol 5.5 Caustic potash 0.05 Purified water 46.95 2-hexyldecyl palmitate 10.0 Squalane 5.0 Butyl Parabens 0.2 Vitamin C 0.15 Fragrance 0.05 Purified water 18.9 Carboxyvinyl polymer 0.2 Vitamin B ₆ hydrochloride 1.0 *: Iris root thoroughly washed with water and cut into approximately 5 mm pieces, 10 kg of 1,3-butylene glycol
50 was added and immersed at 50°C for 2 days. This was filtered, the filtrate was stirred at room temperature for 5 hours, and the precipitate deposited was removed by filtration. The filtrate is 1,3
- Butylene glycol was added to make the total amount 50. (Manufacturing method) Components, , , and are dissolved at 75℃ and added to the components , , , and kept at 75℃ with stirring, and then the components , , and dissolved at room temperature are added and stirred. While cooling, a scalp treatment was obtained. Example 6: Ointment (prescription) Ingredients % Iris extract * 5.0 Stearyl alcohol 18.0 Japanese wax 20.0 Polyoxyethylene (10) monooleate 0.25 Glycerin monostearate 0.25 Vaseline 40.0 Vitamin B _6- dioctanoate 0.2 Purified water 16.3 *: Iris The roots were extracted with hot water, the extract was adsorbed on a silica gel column, and the fraction eluted with methanol was dissolved in ethanol after the methanol was distilled off. (Manufacturing method) Purified water is kept at 70℃ (water phase), and other ingredients are kept at 70℃.
The mixture was mixed and dissolved. (oil phase). Next, the oil phase was added to the water phase, uniformly emulsified using a homomixer, and then cooled to obtain an ointment. Example 7: Aqueous essence (prescription) component % (A) Water Total amount 100 1,3-butylene glycol 5.0 DPG 5.0 Carboxy vinyl polymer 0.2 Vitamin B ₆ hydrochloride 0.2 Iris extract* 2.0 (B) Ethanol 10 POE (60) Hydrogenated castor oil 1.0 Fragrance 0.1 Methylparaben 0.2 (C) Potassium hydroxide 0.1 *: Wash the iris root thoroughly with water, cut it into pieces of about 5 mm, and then crush 5 kg of it. First, pass the resulting crushed product through a 100-mesh sieve. Sprinkle on top and then
Approximately 2 kg of powder with an average particle size of approximately 40 microns was obtained by passing through a 325 mesh sieve. (Production method) After uniformly dissolving the aqueous phase part of (A) and the alcohol phase part of (B) at room temperature, the alcohol phase (B) is added to the aqueous phase (A), mixed uniformly, and then solubilized. Component (C) potassium hydroxide was added to neutralize and increase the viscosity to obtain an aqueous essence. Example 8: Powder product (formulation) ingredient % (A) Talc 85.3 Titanium dioxide 2.0 Kaolin 2.0 Iris crushed 5.0 Vitamin B ₆ tripalmitate 0.5 Methylparaben 0.1 (B) Squalane 5.0 Fragrance 0.1 (Production method) Dissolve the fragrance in squalane, (A) was sprayed onto the mixture, further mixed and pulverized to obtain a powder product. Effect on improving rough skin: The lotion obtained in Example 1 and the formulation of Example 1 without iris extract (replaced with purified water) and without the combination of lotion and vitamin B ₆ (replaced with purified water)
Using the lotion, we conducted a test on skin improvement effects using human body panels. That is, the skin surface morphology of a healthy female subject (facial) was observed under a microscope (17x magnification) by taking a skin replica using the replica method using Millisne resin. Thirty people (skin roughness panel) who judged their rough skin to be rated 1 or 2 based on the condition of skin marks and peeling of the stratum corneum based on the criteria shown in Table 1, were given the results obtained in Example 1 on the left and right half of their faces. A lotion without iris extract or a lotion without vitamin _B6 was applied once a day for two weeks. Two weeks later, the skin condition was observed again using the replica method described above and evaluated according to the criteria in Table 1. The results were as shown in Table 2.

【table】

[Table] From the results in Table 2, it can be seen that the facial area using the lotion containing iris extract and vitamin B ₆ has a remarkable effect on improving rough skin compared to the facial area using other lotions. it is obvious.

Claims (1)

[Claims] 1. A skin preparation for external use, characterized by containing pyridoxine or a derivative thereof and iris or an extract thereof.