JPH06104604B2 - Skin cosmetics - Google Patents

Description

TECHNICAL FIELD The present invention relates to skin cosmetics.

[Conventional technology]

Goat eyes (Gorgonacea) and sea turtles (Alcyonace)
The sembrane-type diterpene compounds extracted from coelenterates belonging to a) have recently been found to have antitumor activity, and are currently receiving attention. (For example, B.Tu
rsch) et al., Tetrahedron, Vol. 31, 129.
Page, 1975, UK and Weinheimer (AJWe
inheimer) et al., Tetrahedron
(See Letters), p. 2923, 1977, UK) In view of these circumstances, Hirayama et al. Conducted a diligent examination of the coelenterate bacterium (Sarcophyton glaucum), which belongs to the order Lepidoptera, and found that it has an anti-solid tumor action. We have found a new semblanc type diterpene compound. (See, for example, JP-A-56-61318) However, it has only been reported so far that the compound has an anti-solid tumor action, and no effect has been reported on dry skin.

[Problems to be solved by the invention]

The present inventors have been studying the carcinogenic effect of sarcophytol-A, which is one of the sembrane-type diterpene compounds, using mice, and found that the skin of the carcinogenic promoter (tereosidine) -administered group was red and swollen. Paying attention to the fact that the skin is extremely smooth and clean in the sarcophytol A-administered group, while it is rough and dry.
The healing effect on human dry skin was examined. As a result, it was confirmed that smooth and healthy skin was recovered by continuously applying the extract from the coelenterate C. elegans mushroom to dry skin due to a decrease in stratum corneum water content for several weeks.

These have not been suggested at all in the previous reports, and the present inventors have completed the present invention based on the above findings.

[Means for solving problems]

That is, the gist of the present invention resides in a skin cosmetic characterized in that it contains, as an active ingredient, an ingredient extracted from the soft coral Coriolus annuus (Sarcophyton glaucum).

Hereinafter, the present invention will be described in detail.

The extract component from C. communis used in the present invention can be obtained, for example, by the method described in JP-A-56-61317 and JP-A-56-61318.

It is known that the holly mushrooms usually inhabit the coral reefs of the Indian Ocean and the Pacific Ocean, for example, the holly mushrooms that inhabit the Red Sea include sarcophine and 16-deoxo sarcophine. [Bernstein (J.Be
rnstein) et al., Tetrahedron, Vol. 30, 2817, 1974,
See England and Y. Kashman et al., Tetrahedron, Vol. 30, page 3615, 1974, United Kingdom.) The components contained in the holly mushroom may differ depending on the time and place of collection. There is a need.

During extraction, it is preferable to dehydrate and shred so that the surface becomes less viscous.

Extraction solvents include, for example, alcohols such as methanol, ethanol, isopropanol; halogenated hydrocarbons such as chloroform; hydrocarbons such as benzene, hexane, heptane; ethers such as ethyl ether, isopropyl ether, dioxane; acetone, methyl ethyl ketone. And the like; organic solvents such as esters such as ethyl acetate, and mixed solvents thereof.

During the extraction operation, in order to avoid decomposition of the contained components, it is preferable to make the contact area with the air as small as possible or to make it under an inert gas atmosphere.

Extraction is possible at room temperature, but in order to speed up the extraction,
You may go under heating.

The solvent of the extract obtained by separating from the residue by a conventional method can be distilled off by a conventional method to obtain a crude extract.

The crude extract may be treated with activated carbon or by a conventional method (for example, Foucault (J.
Folch) -Forsyux et al., Journal of Biological Chemistry (J. Biol. Chem.) 226, 497.
Page, 1957, USA)].

The lipid fraction of the extract of C. mellifera thus obtained is a viscous brown oil.

For further purification, chromatography may be used.
Chromatography may be either column chromatography or preparative thin layer chromatography.

As a packing material for column chromatography, silica gel, alumina, cellulose powder, activated carbon or the like is used. The elution solvent may be appropriately selected and determined according to the filler, but when silica gel is used as the filler, hexane, hexane-ethyl acetate (volume ratio 0.95 to 0.
9: 0.05-0.1) and the like are preferable.

Further, the crude fraction obtained here can be further purified and isolated by column chromatography by changing the packing material and the elution solvent.

As the gel for preparative thin layer chromatography, silica gel, alumina, cellulose powder or the like is used.
As a developing solvent, chloroform or a hexane-ethyl acetate mixed solvent is suitable.

Among the compounds represented by the following general formula (I) thus obtained, those in which R is a hydrogen atom are designated as Sarcophytol-A.

When this sarcophytol-A is acylated by a conventional method, an acylated product such as sarcophytol-A acetate is obtained, and when this sarcophytol-A acylated product is esterified by a conventional method, sarcophytol-A is obtained.

Further, among the compounds represented by the following general formula (II) obtained in the same manner, those in which R is a hydrogen atom are designated as Sarcophyntol-B.

When sarcophytol-B is acylated by a conventional method, an acylated product such as sarcophytol-B diacetate is obtained, and when sarcophytol-B diacetate is esterified by a conventional method, sarcophytol-B is obtained. To be

The cembran-type diterpene compound obtained by the above method, or an extract or partially refined extract of C. mellifera containing the compound is added to the dermatological preparation as an active ingredient. The blending amount is optional depending on the formulation, but it is preferable to blend in the range of 0.00001 to 10% by weight as the above-mentioned sembrane type diterpene compound in the total amount of the formulation, which is excellent for dry skin due to the decrease in stratum corneum water content. It has a good recovery effect and is suitable.

In the skin cosmetic of the present invention, in addition to the above-mentioned sembran type diterpene compound or a mixture containing the same, an extract, or a partially purified product, beeswax, liquid paraffin depending on the type of the cosmetic, as a cosmetic base, A base such as stearic acid and water or a mixture thereof may be blended, and if necessary, a surfactant such as sol-evitan monofatty acid ester or an emulsifier such as KOH, a moisturizer such as glycerin,
Emulsifying aids such as cetanol, lower alcohols such as ethanol (solubilizers, cooling agents), thickeners, fragrances, antioxidants, chelating agents, dyes, methyl paraoxybenzoate, ethyl ethyl, propyl paraoxybenzoic acid, etc. Conventional ingredients used in cosmetics such as preservatives and antifungal agents such as esters and mixtures thereof can be blended, and the blending amount may be in a range usually used.

The dosage form of the cosmetic of the present invention is arbitrary, and any dosage form such as solution system, solubilization system, emulsion system, powder dispersion system, water-oil two-layer system, water-oil-powder three-layer system, etc. good.

Further, the application of the cosmetics of the present invention is also arbitrary, not only facial cosmetics such as lotion, milky lotion, cream and pack, and hair cosmetics such as hair tonic, hair cream, shampoo and hair rinse, and further Shion,
It can also be used for makeup makeup cosmetics such as lipsticks and eyeshadows, body cosmetics, aromatic cosmetics and the like. Furthermore, in the cosmetic of the present invention, in addition to the mixture, extract or partially purified product containing the above-mentioned sembran type diterpene compound, the existing skin keratinization inhibitor, anti-inflammatory agent, etc. are added to the effect of the above-mentioned semplan type diterpene compound. It can also be used in combination as long as it does not impair.

〔Example〕

Next, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples unless it exceeds the gist.

Preparation Example 1 17 kg of Japanese alga mushroom collected in Ishigaki Island, Okinawa is roughly dehydrated, and finely chopped 10 methanol is extracted 3 times at room temperature. The solvent is distilled off under reduced pressure. The dry weight of the extraction residue was about 5.5 kg.

Next, it was dissolved in n-hexane 15 and treated with activated carbon to obtain a yellow oily substance. This is the extract of C. serrata. To obtain a partially purified product, if necessary, a fraction eluted with n-hexane-acetic acid ethyl ester (95: 5) in a column of 30 kg of silica gel with respect to the extraction residue of 3 kg is used as the partially purified product.
Further, to obtain a purified product, the purified product can be obtained by eluting with a solvent of n-hexane-ethyl acetate (95: 5) in a silica gel column of 40 kg for 2 kg of the partially purified product.

Example 1 Skin care cream <Manufacturing method> Add ingredients to the above ingredients and keep at 75 ° (water phase part). Separately, mix ,,, and and heat and melt 75
° (oil phase part). The water phase is added to this oil phase, and the mixture is uniformly emulsified with a homomixer and then cooled.

Test Example 1 The above-mentioned Example 1 was applied to the roughened skin surface due to a decrease in water content in the stratum corneum.
As a result of continuous application of the cream obtained in 1. above for 3 weeks, recovery to normal skin was observed.

Example 2 Skin care milk <Production method> Add and to the above ingredients and keep at 75 ° (water phase part).
Separately ,,,, and are mixed and heated to dissolve to 75 ° (oil phase portion). A water phase is added to this oil phase, and the mixture is uniformly emulsified with a homomixer and then cooled.

Comparative Example 1 Skin Care Cream (Comparative Example) A cream (Comparative Example) was obtained in the same manner as in Example 1, except that the extract of C. oleracea Mushroom as the component in Example 1 was omitted.

Test Example 2 The creams of Example 1 and Comparative Example 1 were continuously applied to a skin surface roughened due to a decrease in water content of the stratum corneum for two weeks, and then the changes in the skin surface were compared. The degree of improvement of the cream application site of No. 2 was superior to that of the cream application site of Comparative Example 1 which did not contain the extract of C. oleracea Mushroom.

〔The invention's effect〕

The skin cosmetic of the present invention is a cosmetic suitable for dry skin due to a decrease in stratum corneum water content.

Claims (1)

[Claims] 1. A soft-body coral, Sarcophyto
skin cosmetics, characterized in that it contains as an active ingredient the components extracted from (g glaucum).