JPH0610680B2 - Automatic chemical analyzer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Object of the Invention] (Industrial field of application) The present invention detects the concentration of a specific component in a reaction solution obtained by reacting a sample with a desired reagent and measures the desired item. The present invention relates to an automatic chemical analyzer for performing.

(Prior art) Various items can be obtained by using human serum as a sample and using it as a sample (sample) to cause a chemical reaction to detect the concentration of a specific component in the reaction solution. For example, total protein (TP), uric acid (UA), neutral fat (T
2. Description of the Related Art An automatic chemical analysis device is known in which items such as G) are measured and used for diagnosis. FIG. 6 shows an example of the configuration of such an analyzer. A plurality of reaction cells 2 (2a, 2b, 2c, ...) Are housed in a cell cassette 3 in an annular thermostatic chamber 1. The cell cassettes 3 are sequentially moved in the arrow Z direction by a driving source (not shown). The cell cassette 3 can move each reaction cell in sequence for each cycle by performing a moving movement at a constant cycle time through the stop period.

The P ₁ position of the outer circumference of the annular thermostatic chamber 1 is a sample pipetting mechanism 4 is disposed, by this the mechanism 4 are accommodated desired sample tubes, the nozzle 5 as necessary to move back and forth A sample is dispensed to the reaction cell 2 at the opposite position. A reagent dispensing mechanism 6 is arranged at the P ₂ position, and a desired reagent tube is accommodated in this mechanism 6, and a plurality of nozzles 7 (7a, 7b, 7c, ...) Correspond to the nozzles as necessary. A desired reagent is dispensed into the reaction cell 2. The stirring mechanism 8 is arranged at the P ₃ position, and the stirring bar 9 stirs the reaction cell 2 at the facing position. Both of these dispensing and stirring operations are performed during the suspension period of the cell cassette 3.

Further, a photometric system 10 for detecting the concentration of a specific component in the reaction liquid of the sample and the reagent in the reaction cell is arranged at an intermediate position of the constant temperature bath 1, and the photometric system 10 is arranged in the constant temperature bath 1. , A lamp provided on the inner peripheral side, a detector provided on the outer peripheral side, and the like. At the moment when each reaction cell crosses the optical path from the lamp to the detector during the rotational movement, the absorbance in the reaction cell is measured by the detector to obtain photometric data.

By the way, when various items are measured by such an analyzer, the measurement item is specified according to each sample (sample), but usually a plurality of single measurement items are prepared in advance corresponding to the determination of the target pathological condition. In many cases, (hereinafter simply referred to as “item”) are combined as a set item, and the set item is designated according to the pathological condition of the sample. The following table is an example showing the relationship between a single item and a set item combined in this way.

As an example, the above table shows five types of set items (each corresponding to five types of pathological conditions) by arbitrarily combining the seven types of single items A to G. When the measurement is performed by designating the set items in this way, it may be sufficient to designate one set item, but in some cases, two or more set items may be designated. In addition, an optional single item may be additionally specified. Designation of such a required set item or a single item is performed by inputting necessary information by operating a desired key switch on the console section of the analyzer.

As an example, if set items 1 and 2 and a single item G are specified for a certain sample, this sample is combined with F of A, B, C, D, E, and G as is clear from the previous table. Measurements will be made for 6 types of items except for.

(Problems to be Solved by the Invention) By the way, in the conventional analyzer, when the contents including many items are designated as the item selection information of one specimen by superimposing a plurality of set items, However, other set items may be measured, but there is a problem that the contents cannot be confirmed after the input operation. For example, in the case of a certain sample mentioned in the above example, A, B, C, and
When six kinds of items D, E and G are measured, set item 3 substantially consisting of items D and G and set item 4 consisting of items B, E and G are also measured as apparent from the above table. It has been done. When the number of set items is small as in the example of the above table, there is not so much influence, but when actually analyzing a sample, the set items may be combined from several tens to 100 or more, so it is considerably large. It can be easily inferred that the set items that are not planned or duplicated have been measured. As a result, the efficiency of measurement is reduced.

Further, when a plurality of set items are simply designated, in order to confirm the set items, a storage means for storing the type of the input set item is required. Further, even when simply confirming the specified set item, a storage means is required according to the type of the set item, and a large-scale storage capacity is required as the number of set items increases. In many cases, there are restrictions on storage capacity. Therefore, it is difficult to confirm easily.

The present invention has been made in response to the above circumstances,
It is an object of the present invention to provide an automatic chemical analyzer capable of easily confirming a set item that has actually been selected after a selection operation and capable of supporting a wide range of pathological condition tests.

[Structure of the Invention] (Means for Solving the Problems) In order to achieve the above object, the present invention relates to an automatic chemical analyzer for measuring selected items of a sample, in which a plurality of types of measurement are performed according to the pathological condition. Set item information storage means for storing in advance information of a plurality of set items configured by combining items, selection means for selecting the set item or a single item, a measurement item group selected by this selection means, and It is characterized in that it has a determination means for comparing a set item stored in the set item information storage means and determining a set item included in the measurement item group, and a display means for displaying the determination result of this determination means. It is a thing.

(Operation) According to the invention of the above-mentioned configuration, when a plurality of set items are selected by the selection means or a set item and a single item are selected, the determination means determines whether the selected measurement item group and the set item information storage means are present. The stored items are compared to determine the set items included in the measurement item group. The display means displays the determination result. This makes it possible to easily confirm the set item that has actually been selected.

(Embodiment) FIG. 1 is a block diagram showing an embodiment of an automatic chemical analyzer according to the present invention, in which an input section 11 is composed of a keyboard or the like provided in a console section and required information is operated by operating a desired key switch. Is entered. The control unit 12 is composed of a microprocessor or the like and performs a control operation such that necessary information signals are input and output between predetermined departments according to a preset program. The display unit 13 is composed of a CRT display or the like, and is controlled by the control unit 12 so that desired characters,
Display figures etc.

The set item information storage unit 14 is made up of various well-known memories, and stores information about a plurality of set items configured in advance by combining a plurality of types of measurement items according to the needs of the user. As an example, it is assumed that the storage unit 14 stores information about set items configured by combining individual items in the relationship shown in the above table. That is, set item 1 (corresponding to pathological condition 1) consisting of a single combination of items A, B and C, set item 2 (corresponding to pathological condition 1) consisting of a combination of items A, D and E, Set item 3 consisting of a combination of items D and G (corresponding to pathology 3), set item 4 consisting of a combination of items B, E and G
A total of five types of set item information (corresponding to pathological condition 4) and set item 5 (corresponding to pathological condition 5) including a combination of items A, C, and F are stored. The number and combination contents of the set items are determined by the needs of users such as hospitals and are usually fixed unless the routine work changes, but additions and changes can be freely made as necessary. As described above, the number of set items may actually be several tens to 100 or more. Information on such necessary set items is preset in the initial state of the apparatus and stored in the storage unit 14.

The item selection information storage unit 15 is composed of various well-known memories,
When a set item or a single item to be measured is selected according to the sample to be measured, the number of item types (item selection information) of the selected items (measurement item group) is stored in the storage unit 14, In the case of a single item, the item itself is sequentially added and stored. That is, when the set item 1 is first selected in the table, the individual items A, B, and C constituting the set item 1 are stored in the storage unit 14 as item selection information.
Are stored in the storage unit 15. Next, if the set item 2 is selected, the individual items A, D, and E constituting the set item 2 are added to the item as item selection information and stored in the storage unit 15. However, item A
Need not be added because they overlap, so at this point A,
Five types of items B, C, D and E are stored as item selection information. That is, each item added for each measurement may be OR-logically processed, and such processing can be easily performed by the control unit 12. Set item 3
The same addition process is performed when the subsequent items are selected. However, the types of set items actually selected are random, and not all are selected. In principle, the content of the item selection information storage unit 15 is reset to 0 in the initial state. In order to store necessary information in the storage units 14 and 15, an input operation is performed from the input unit 11 via the control unit 12 each time.

The information judging section 16 is made up of a combination of well-known various logic gates, and whenever the item selecting information is always inputted from the memory section 15 and the set item is selected, a specifying means for judging is provided separately for each judgment. When the set item information is input from the storage unit 14, both pieces of information are compared to determine whether each set item information is included in the item selection information at this time. The determination result is displayed on the display unit 13 via the control unit 12, and the display timing can be arbitrarily set in relation to the performance of the display unit 13.

FIG. 2 is a block diagram showing a specific configuration of the information judging section 16, and according to the above table, five kinds of seven items A to G are used.
An example in which the set items 1 to 5 of types are combined is shown. Item selection information corresponding to seven items from the storage unit 15 is always input to the seven input terminals 17A to 17G,
Further, set item information corresponding to seven items from the storage unit 14 is selectively input to the input terminals 18A to 18G each time. Seven AND gates 19A to 19
Input terminals 17A to 17G and 18A are provided on the G input side.
To 18G are sequentially connected, and AND gates 19A to 1A
The output side of 9G has 7 EXCLUSAVE OR (EO
R) One of the input sides of the gates 20A to 20G is connected. Similarly, input terminals 18A to 18G are connected to the other input side of the E-OR gates 20A to 20G.
Further, the output sides of the E-OR gates 20A to 20G are connected to the input side of the common OR gate 21, and the OR gate 2
The output side of 1 is connected to the control unit 12.

With such a logic gate, a logical operation as shown by the following equation is performed, and a target determination operation is performed.

Output = [(item selection information) AND (set item information)] E-OR (set item information) That is, the terminals 17A to 17 are connected by the logic gate in FIG.
With the item selection information always input to G,
When the set item information is input every time the set item is selected in 8A to 18G and the output of the OR gate 21 finally becomes 0 (LOW) level, the item selection information at the present time is It is determined that the input set item information is included.

Next, the operation of this embodiment will be described.

Set item information storage unit 14 or item selection information storage unit 15
When a certain item is stored in, the information of this item is 1 (H
In the initial state of the apparatus, it is assumed that the information of the five types of set items in the above table is stored and the content of the storage unit 15 is reset to 0 at the (IGH) level.

In this state, if set items 1 and 2 and a single item G are designated by an input operation for a certain sample (sample) X and measurement is performed, this sample X is collectively A,
This means that the measurement was performed on the six types of items B, C, D, E, and G. Therefore, at this point in time, the item selection information storage unit 15 stores the six types of items at one level. When six types of items are measured in this way, it is necessary to confirm whether or not the five types of set items prepared in advance include items other than the designated set items 1 and 2. It will be done in order of 5. However, since the set items 1 and 2 are designated in advance, they are excluded here.

By operating the input unit 11, the information of the set item 3 is first input from the storage unit 14 to the information determination unit 16. As shown in FIG. 3, the information of the items D and G constituting the set item 3 is input to the terminals 18D and 18G as one level, while the items A, B, C, D, E and G are stored in the storage unit 15. Information of each terminal 17A, 17B, 17C, 17D, 17E, 17
It is input to G as 11 levels. As a result, only one level is output from the AND gates 19D and 19G, but E-OR
All the gates including 20D and 20G become 0 level, and the output of the OR gate 21 becomes 0 level. Therefore, the information of the set item 3 that has just been input by the principle of the logic gate is the item selection information (A, B, C, D, E,
It is determined that it is included in G).

Next, when the information of the set item 4 is input to the information judging section 16 in the same manner, a logical result as shown in FIG. 4 is obtained. In this case as well, the output of the OR gate 21 becomes 0, so that the information of the set item 4 is also included in the item selection information at the present time.

Next, when the information of the set item 5 is similarly input to the information judging section 16, a logical result as shown in FIG. 5 is obtained. In this case, since the output of the E-OR gate 20F becomes 1 level and the output of the OR gate 21 does not become 0 level, the information of the set item 5 is not included in the item selection information at the current time.

As described above, according to the present embodiment, when the set items 1 and 2 and the single item G are designated for measurement, it can be easily confirmed that the other set items 3 and 4 are also measured. become. Such a result can be displayed on the display unit 13 via the control unit 12 at an arbitrary timing, and can also be displayed in real time.

Although an example in which five types of set items are prepared has been described in the embodiment, more set items are actually prepared. Therefore, according to the present embodiment, by confirming the set item information included in the item selection information up to that point in advance, it is possible to recognize in advance the designation of an unplanned or duplicate set item, thereby improving the measurement efficiency. be able to. Moreover, since the configuration is simple, it can be realized without using a large-capacity storage means. Therefore, it is possible to deal with a wide range of pathological examinations. Further, it becomes possible to know a new set item that is not specified, and the applicable range can be expanded.

The specific configuration of the information determination unit 16 shown in the text is an example, and can be arbitrarily changed.

[Configuration of Invention] As described above, according to the present invention, it is possible to easily confirm the set item that has been actually selected by the display unit, and thus it is possible to avoid unnecessary selection of the set item in advance.
In addition, it is possible to easily know set items that have not been selected, and it is possible to deal with a wide range of pathological examinations.

[Brief description of drawings]

FIG. 1 is a block diagram showing an embodiment of the automatic chemical analyzer of the present invention, FIG. 2 is a logic gate diagram showing the constitution of the main part of the apparatus of this embodiment, and FIGS. 3 to 5 are drawings of this embodiment. FIG. 6 is a plan view showing the structure of the automatic chemical analyzer, which is a logic gate diagram for explaining the operation. 11 ... Input unit, 13 ... Control unit, 14 ... Set item information storage unit, 15 ... Item selection information storage unit, 16 ... Information determination unit, 17A to 17G ... Item selection information input terminal, 18A To 18G ... Set item information input terminal, 19A to 19G ... AND gate, 20A to 20G ... E-OR gate, 21 ... OR gate.

Claims (1)

[Claims] 1. An automatic chemical analyzer for measuring selected items of a sample, wherein set item information storage stores in advance information of a plurality of set items configured by combining a plurality of types of measurement items corresponding to a pathological condition. Means, selecting means for selecting the set item or a single item, and comparing the measurement item group selected by the selecting means with the set item stored in the set item information storage means, to obtain the measurement item group. An automatic chemical analysis device, comprising: a determination means for determining a set item included therein, and a display means for displaying a determination result of the determination means.