JPH0613046B2 - Oral bandage - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to the prevention of the outflow of a drug that is applied to the mucous membrane of the oral cavity and the tooth surface and is administered to the mucous membrane of the oral cavity, and the coating of the damaged portion of the mucous membrane of the oral cavity. The present invention relates to an oral bandage for protection and the like.

[Conventional technology]

Conventionally, various drugs have been administered as ointments and liquids for oral diseases such as alveolar pyorrhea and inflammation.
In addition to these local therapeutic agents, focusing on the fact that the mucosal surface absorbs the drug relatively well compared to the outer skin,
It has been attempted to administer systemic drugs such as hormones, which are difficult to be absorbed by oral administration, through the oral mucosa. The biggest obstacle to the administration of a drug through the oral mucosa is that the drug is washed away in a short time due to the secretion of saliva and the eating and drinking, and it is difficult to exert a sufficient drug effect. is there.

Further, it has been hardly performed to cover and protect the damaged part in the oral cavity because there is no effective oral bandage, but saliva is always secreted in the oral cavity as described above, and food and drink are also Therefore, there is a major obstacle to realizing the coating protection.

Recently, various oral bandages have been proposed for overcoming these obstacles and effectively administering a drug for diseases in the oral cavity, or for covering and protecting a damaged portion in the oral cavity. For example, Japanese Patent Publication No. 56-27491 and Japanese Patent Publication No. 56-25
211, Japanese Patent Publication No. 58-7605, Japanese Patent Publication No. 4
JP-A-4-16676 and JP-A-59-186913 disclose intraoral mucoadhesive preparations of various dosage forms using a water-soluble polymer as an adhesive component.

[Problems to be solved by the invention]

However, these oral mucosa-adhesive preparations do not have long-term adhesion persistence and have the drawback that they do not adhere to the mucous membrane for a sufficient time for administration of the drug, and thus do not have sufficient performance. . Recently, an oral band having enhanced adhesion to mucous membranes has been disclosed by dispersing a water-absorbing polymer in an adhesive layer (Jitsuko Sho6).
No. 0-13462, Jitsuko 60-13463). This intraoral band is intended to prevent the adhesive layer from being dissolved and dispersed by absorbing saliva with a water-absorbing polymer substance, and to exhibit adhesiveness over a long period of time. In the case of bleeding from the skin, the adhesive force to the damaged part is insufficient, and there is a drawback that the damaged part cannot be sufficiently covered and protected. Further, the saliva secretion amount varies from person to person, and even when the saliva secretion amount is large, sufficient adhesive force cannot be obtained and there is a problem in long-term adhesion persistence.

The present invention has been made in view of such circumstances, and even when the bleeding from the damaged site in the oral cavity is continued, and even when the saliva secretion is large, long-term adhesion is maintained. The purpose is to provide an oral bandage capable of exerting power.

[Means for solving problems]

In order to achieve the above-mentioned object, the oral bandage of the present invention is an oral bandage consisting of a film-like adherent alone or an integrated product of a film-like adherent and a flexible film-like support, wherein the film-like adherent is Is a flexible film in which at least one of a polycarboxylic acid and a polycarboxylic acid anhydride and a vinyl acetate polymer are in a compatible state, and the water-absorbing polymer substance is dispersed and contained at a ratio of less than 20% by weight. It is configured to be composed of what is being done.

That is, the present inventors, when the adherend is composed of a film composed of a compatible solution of at least one of a polycarboxylic acid and a polycarboxylic acid anhydride and a vinyl acetate polymer, the obtained oral cavity bandage is on the oral mucosa for a long time. It has been found that it adheres and the therapeutic effect on the affected area can be sustained, and a patent application has already been filed (Japanese Patent Application No. 60-91580,
Japanese Patent Application No. 60-91581). As a result of further research, when the water-absorbing polymer substance is contained in the film constituting the above-mentioned adherent in a specific amount in a dispersed manner, the adherence to the oral mucosa is further improved and bleeding occurs from the damaged site in the oral cavity. It has been found that the present invention can be applied to a case where a large amount of saliva is secreted and a good coating protection effect can be obtained, and the present invention has been reached.

To explain this in more detail, water-soluble polymeric substances such as polycarboxylic acid and polycarboxylic acid anhydride have a shape-retaining property by themselves, and exhibit strong adhesiveness when a small amount of water is absorbed. However, it immediately becomes an excessively water-absorbed state, the viscosity is lowered, and it disintegrates to become a state of being substantially dissolved in water, and the adhesiveness is lost.

The present inventors make use of the strong adhesive force of water-soluble polymer substances such as polycarboxylic acid and polycarboxylic acid anhydride at the time of such water absorption, and effectively utilize this for oral cavity dressing, and A series of studies have been repeated with the aim of improving the loss of adhesion during a certain amount of excessive water absorption. As a result, the polycarboxylic acid and polycarboxylic acid anhydride are compatible with the vinyl acetate polymer, and when both are made compatible, the polycarboxylic acid and polycarboxylic acid anhydride are substantially insolubilized in water. It is realized in an enhanced state without impairing the strong adhesiveness at the time of absorbing water, and even if the compatibilized material of both is formed into a thin flexible film, it does not collapse by absorbing water in a wet state and has a strong adhesive force for a long time. I found that it started to express. As mentioned above, a patent application has already been made in this regard. And
Due to the continuation of subsequent research, a special film in which polycarboxylic acid and vinyl acetate polymer are in a compatible state,
Further, when the water-absorbing polymer substance is dispersed and contained in a proportion of less than 20% by weight, the effect of further improving the adhesive force to the oral mucosa can be obtained, and as a result, it seems that bleeding occurs from the site of oral cavity damage. The inventors have found that even in such cases, even when the saliva is secreted a lot, they adhere strongly, and it becomes possible to realize coating protection for a long period of time, and arrived at the present invention.

A flexible film made of a compatible material of at least one of the above polycarboxylic acid and polycarboxylic acid anhydride (hereinafter collectively referred to as “polycarboxylic acids”) and a vinyl acetate polymer has adhesiveness when dried. Although it has not, it has an epoch-making property that it exhibits strong adhesiveness when absorbing water and its state hardly changes even when immersed in water.

In the present invention, the above-mentioned film is a film-like adherend of an oral bandage. The epoch-making characteristics as described above are exhibited only when the polycarboxylic acid and the vinyl acetate polymer are in a compatible state, and do not appear when they are not in a compatible state.

The term "compatible state" as used herein means a state in which polycarboxylic acids and a vinyl acetate polymer or the like are uniformly dissolved without phase-separating to form independent small regions. When the polycarboxylic acids and the vinyl acetate polymer are in a compatible state, they exhibit properties that cannot be predicted from the properties of the mixture in the phase-separated state. That is, in the mixture of polycarboxylic acids and vinyl acetate polymer, the phase-separated film becomes cloudy and the compatible film becomes highly transparent. However, in some cases, the oral dressing of the present invention may contain salts for neutralizing the polycarboxylic acids, and in such a case, the polycarboxylic acids and the vinyl acetate polymer are However, if the salts are in a coarse mixed state, the film becomes cloudy. Therefore, it may not always be possible to determine the mixed state of the polycarboxylic acid and the vinyl acetate polymer by visual observation or observation with an optical microscope.

However, when the polycarboxylic acids and the vinyl acetate polymer are in a compatible state, the water solubility of the polycarboxylic acids, which should be water-soluble, is significantly limited, and even if the polycarboxylic acids are immersed in water for a considerably long time, they are homogeneous. It swells and does not collapse. This property is observed with and without the neutralizing salt. Utilizing this property, the compatibility of polycarboxylic acids and vinyl acetate polymer can be investigated. That is, in the present invention, the compatibility state of the polycarboxylic acid and the vinyl acetate polymer is to be investigated from the elution amount of the polycarboxylic acid, and the compatibility state in the present invention,
Specifically, it refers to a mixed state in which the dissolution rate determined by the following dissolution rate measurement method is 50% by weight (hereinafter abbreviated as "%") or less.

<Elution rate measurement method> A film (film-like adherent) composed of polycarboxylic acids, a vinyl acetate polymer and a salt having a neutralizing action is used at 0 ° C.
Grind and weigh as follows. This is placed in a mesh bag and immersed in purified water at 20 ° C., which is 300 times or more the weight of the adherent, in a stationary state for 1 hour, and then the adherent is taken out together with the bag. The amount of the polycarboxylic acids eluted in the purified water by this operation is determined by the weight reduction of the adherent due to immersion. The dissolution rate is calculated by dividing this by the blending amount of polycarboxylic acids in the film.

Examples of the water-absorbing polymer substance dispersedly contained in the film-like adherent composed of a flexible film in which the polycarboxylic acids and the vinyl acetate polymer are in a compatible state include starch acrylate graft polymer (starch-based polymer). ), Cross-linked carboxymethyl cellulose (cellulose type) and vinyl alcohol acrylate copolymer, polyacrylonitrile hydrolyzate, cross-linked polyacrylic acid salt, and synthetic polymer type such as modified polyvinyl alcohol. These may be used alone or in combination of two or more kinds without any problem. It is preferable that such a water-absorbing polymer substance is uniformly dispersed in the flexible film, and it is necessary to disperse the water-absorbing polymer substance in the film so as to be less than 20%. In particular, it is preferably in the range of 5 to 20%, and within this range, the extension of the adhesion time and the hemostatic effect are satisfactorily exhibited. Furthermore, 5 to 5 are suitable.
15%. Within this range, it does not peel off even after 5 hours from application and a good hemostatic effect is observed. However, when the dispersed content of the water-absorbent polymer substance is 20% or more, the adhesion time and the result of hemostasis are inferior to the case where the water-absorbent polymer substance is not dispersed and mixed. Therefore, it is necessary to set the dispersed content of the water-absorbing polymer substance to be less than 20%.

The oral bandage of the present invention, as described above, is a film-like adherent which is a flexible film that does not exhibit adhesiveness when dried and exhibits adhesiveness only when absorbing water, and the film-like adherent is dried. Since it does not have adhesiveness when it is in use, it can be stored as it is without any special storage mode, and when it is used, it simply presses against the mucous membrane in the oral cavity to absorb saliva on the mucous membrane and moisture in the mucous membrane and quickly develop adhesiveness. Strongly adheres to mucous membranes. Therefore, it strongly adheres to the intraoral disease site or damaged site where it is difficult to adhere due to the administered drug or bleeding, etc., and exerts a drug outflow and a wound covering protection effect. This adhered state lasts for a remarkably long time, which is a major feature of the present invention. In this case, it is conceivable that the polycarboxylic acids may stimulate the damaged part or the like in the initial stage of applying the oral bandage to the mucous membrane. In such a case, as described above, it is preferable to add a salt having a neutralizing action to polycarboxylic acids to the film-like adhered body composed of the above-mentioned flexible film. By doing so, the polycarboxylic acids are neutralized, so that irritation is not applied to the damaged site and no problem occurs even if the adhesion is continued for a long time. As described above, the long-term adhesion persistence of such an oral dressing is due to the fact that the polycarboxylic acid and the vinyl acetate polymer are in a compatible state in the film-like adherent, and there is a high water absorption property there. This is realized only when a predetermined amount of the molecular substance is dispersed and contained.

The generation mechanism of this adhesion persistence is not clear, but under compatible conditions, polycarboxylic acids provide adhesion to wet mucous membranes, vinyl acetate polymer imparts water resistance, and water-absorbing polymer substances It is considered that it exerts an appropriate water supply action for carboxylic acids, and these are well coordinated to develop long-term adhesion persistence. The mixed state of the salts having a neutralizing effect on the polycarboxylic acids does not affect the adhesiveness, but the properties of the salts slightly affect the adhesiveness and the like. For example, polyvalent metal salts such as zinc oxide and calcium oxide function to reduce adhesion and increase water resistance, but monovalent metal salts such as sodium acetate and sodium hydroxide and triethanolamine. The monovalent base acts to increase adhesion and reduce water resistance.

As described above, the oral dressing of the present invention has a strong adhesive force to the oral mucosa, so that it prevents the washout of the administered drug to the oral disease site for a long time, and significantly enhances its absorption rate and cures it. It is possible to accelerate the recovery of the oral cavity, and to sufficiently protect the intraoral injury site, in particular, the site of the oral injury such as bleeding, and accelerate the recovery thereof. Further, the film-like adherent in the oral bandage of the present invention comprises a substantially water-insoluble flexible film in which polycarboxylic acids and a vinyl acetate polymer are in a compatible state, and is simply a water-soluble polymer substance. Since it is not used as it is, it exhibits long-term adhesion persistence in a very thin state. That is, when using the water-soluble polymer as it is,
If it is made too thin, it will be rapidly dissolved by saliva in a short time and the adhesiveness will be rapidly lost, so that it cannot be made thin and it will have a considerable thickness. However, in this case, the feeling of foreign matter during use is increased, and at the same time, the flexibility of the oral bandage is impaired. The film-like adherent of the oral bandage of the present invention exhibits a strong adhesive force over a long period of time in a very thin state, so that it is not necessary to make the thickness thick, and a feeling of foreign matter due to an excessive thickness is not felt. is there. The oral dressing of the present invention is thus flexible and thin as a whole because the film-like adherent is constituted by the thin and flexible film. Therefore, when it is used, it can be smoothly deformed along the mucous membrane in the oral cavity and easily attached by simply pressing it lightly, and it has an advantage that it does not give a foreign body sensation.

The oral dressing of the present invention, for example, polycarboxylic acids and vinyl acetate polymer, dissolved in a solvent common to both, further blended a predetermined amount of a water-absorbing polymeric substance, depending on the case, Further, it can be produced by adding a salt having a neutralizing action to the above polycarboxylic acids, rapidly casting and drying it to form a film-like adherent. The above-mentioned salt may be compounded by dissolving the salt in the solution or by dispersing a powdery one. This manufacturing method has an advantage that a very thin film-like body can be easily formed.

Representative examples of the above polycarboxylic acids include acrylic acid polymers, methacrylic acid polymers, and maleic anhydride polymers, which can be used alone or in combination. Specific examples of the acrylic acid polymer include acrylic acid homopolymers, acrylates such as butyl acrylate and 2-ethylhexyl acrylate, and
Examples thereof include copolymers with methacrylic acid esters such as methyl methacrylate and vinyl monomers such as vinyl acetate, and copolymers such as carboxyvinyl polymer. Further, specific examples of the methacrylic acid polymer include, in addition to the methacrylic acid homopolymer, the same copolymers as in the case of the acrylic acid polymer, and specific examples of the maleic anhydride polymer include methyl vinyl ether. Examples include copolymers such as N. It goes without saying that the compounds exemplified in the above specific examples can be used not only individually but also as a mixture. In these polycarboxylic acids, it is effective that the polycarboxylic acid contains 20% or more of —COOH groups and the polycarboxylic acid anhydride contains 16% or more of —CO—O—CO— groups. It is preferable above.

A typical example of the vinyl acetate polymer is a vinyl acetate homopolymer. In addition to this, a vinyl acetate homopolymer and a vinyl monomer copolymer such as an acrylic ester and a vinyl acetate homopolymer are partially saponified. Partially saponified compounds are also included. These can be used alone or in combination. Moreover, it is preferable that these have an average molecular weight (viscosity average molecular weight) of 60,000 or more. If the average molecular weight is less than 60,000, the water resistance of the above film-like adherent is lowered, and it is difficult to obtain the desired effect.

Salts having a neutralizing effect on polycarboxylic acids,
Not only salts but also bases are included, and typical examples thereof include salts of metals and weak acids, metal oxides, metal hydroxides, amines, and mixtures thereof. Specific examples of salts of metals and weak acids include sodium, potassium,
Examples thereof include salts of calcium, magnesium and the like with carboxylic acids such as acetic acid, lactic acid and citric acid, and specific examples of metal oxides include zinc oxide, calcium oxide and magnesium oxide. Specific examples of metal hydroxides include sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide and the like, and specific examples of amines include triethanolamine, diisopropanolamine and the like. To be The compounds specifically exemplified above can be used alone or in combination. The preferable blending amount of such salts greatly varies depending on the type of salt or base. When a polyvalent metal salt is used, the amount of the polycarboxylic acid in the film-like adherent is 0.2 to
It is preferable to add 0.8 equivalent, and if the amount is less than 0.2 equivalent, the effect of reducing irritation to the damaged site (damaged mucous membrane) will be insufficient, and if it exceeds 0.8 equivalent, sufficient adhesion persistence will be achieved. Is difficult to obtain. When a monovalent metal salt or a monovalent base is used, it is preferable to add 0.03 to 0.2 equivalent to the polycarboxylic acid in the film-like adherent, and the amount is 0. If it is less than 0.03 equivalent, the effect of reducing irritation to the damaged site becomes insufficient, and if it exceeds 0.2 equivalent, the water resistance of the film-like adherent is lowered and it becomes difficult to obtain sufficient adhesive force.

The common solvent for the polycarboxylic acids and the vinyl acetate polymer is a lower alcohol such as methanol or ethanol, and a mixture thereof with an organic solvent such as soluble acetone or ethyl acetate, the lower alcohol being the main component. Examples thereof include those described above, or the above mixture or a mixture obtained by further adding water to a lower alcohol. Regarding the above-mentioned solvent, it is preferable to limit the content of the organic solvent such as acetone and ethyl acetate to 30% or less. This is because if it exceeds 30%, it becomes difficult to dissolve the polycarboxylic acids. With regard to the above solvents, it is preferable to limit the content of water to 30% or less. This is because if the water content exceeds 30%, it tends to be difficult to dissolve the vinyl acetate polymer.

In the case of manufacturing an oral bandage as described above,
The mixing ratio of the polycarboxylic acid and the vinyl acetate polymer is
It is preferable to regulate so that the A value obtained by the following equation is within the range of 15 to 55.

As the A value increases, the adhesive force of the film-like adherent to the mucous membrane increases, but the sticking durability tends to decrease. Conversely, the smaller the A value, the lower the adhesive force,
The adhesion persistence tends to increase. When the A value is less than 15, it becomes difficult to obtain sufficient adhesive force, and when it exceeds 55, it becomes difficult to obtain sufficient adhesion durability. Therefore, it is preferable to regulate the mixing ratio of the polycarboxylic acid and the vinyl acetate polymer so that the A value is within the range of 15 to 55. The case where polyacrylic acid is used as the polycarboxylic acid will be described as an example. The ratio of the polyacrylic acid in the film-like adherent is 24 to 24%.
When it is in the range of 88%, the A value falls within the above range, and a preferable result can be obtained.

Further, when the above-mentioned polycarboxylic acids and vinyl acetate polymer are dissolved in a common solvent, it is necessary to take care so that both are sufficiently dissolved. In this case, the concentration of the polymer substance such as polycarboxylic acid and vinyl acetate polymer is not limited, but if the concentration of the polymer substance becomes too high,
It is preferable to take care so that the concentration of the polymer substance does not exceed 40% because the solution viscosity becomes large and it tends to become difficult when cast into a cast film.

A solution of a polycarboxylic acid and a vinyl acetate polymer is dissolved and a water-absorbing polymer is added to the solution as described above, and if necessary, salts for neutralization are added. After casting the above solution on an appropriate film such as polyethylene-laminated paper that has been subjected to release treatment,
It can be carried out by rapidly drying and forming into a film by using a hot air bath such as a dryer or a drying tower. The appropriate drying time or drying temperature varies depending on the composition of the common solvent, the solid content concentration in the solution, the casting thickness, etc., but generally the drying is performed at a temperature of 60 ° C to 120 ° C for about 1 to 20 minutes. Is preferred.

In this way a very thin film-like deposit is obtained. This film-like adherent can be used as it is in the oral cavity bandage of the present invention. In this case, the thickness of the film-like adherent can be adjusted by controlling the casting amount and the like, and is preferably regulated within the range of 10 to 100 μm. This is because if the thickness is less than 10 μm, it becomes difficult to develop sufficient adhesive properties, and if it exceeds 100 μm, a feeling of foreign matter in the mouth is likely to be given during use, and the flexibility of the film-like adhered body tends to be impaired.

As described above, the oral dressing according to the present invention can be formed by only the film-like adherent, but it can also be formed by combining it with a flexible film-like support.

Explaining the production method of this combination, this combination produces a film-like adherent as described above, and the film-like adherent is prepared by a conventional method such as thermocompression bonding or using an adhesive. It can be produced by laminating to a flexible film-like support, and the composition used for producing the film-like adherent is cast onto a flexible film-like support to produce the film-like adherent and sticking to the flexible film-like support. It can also be manufactured by performing the matching at the same time. In the latter case, there is an advantage that the thermocompression bonding and the bonding work become unnecessary and the manufacturing can be simplified.

It is preferable to use a water-impermeable material as the flexible film-shaped support. Typical examples are polyethylene, vinyl acetate resin, ethylene-vinyl acetate copolymer, polyvinyl chloride, polyurethane and other plastic films, aluminum foil, tin foil and other metal foils, cloth and paper and plastic films. Laminated film and the like. Of these, from the viewpoint of safety and usability, it is preferable to use a plastic film such as polyethylene, vinyl acetate resin, ethylene-vinyl acetate copolymer. It is preferable to use such a flexible film-shaped support having a thickness of 10 to 100 μm from the viewpoints of handling and not giving a feeling of foreign matter during use. The integrated product with and is preferably regulated in thickness within the range of 30 to 150 μm. That is, when the thickness is less than 30 μm, the handling and operability are deteriorated, and when the thickness exceeds 150 μm, a feeling of foreign matter tends to be given during use.

The oral bandage obtained by integrating the film-like adherent and the flexible film-like support as described above is strongly adhered to the oral mucus by the action of the film-like adherent,
It develops long-term adhesion sustainability, but by integrating the flexible film-like support mentioned above, the strength of the oral bandage increases and it becomes easy to use, and at the same time, the action of the film-like support makes it possible to apply it to the back surface. The effect of preventing foreign matter such as food from adhering is further obtained. Further, by using a water-impermeable material as the flexible film-like material, it is possible to further obtain the effect of preventing the intrusion of water from the back surface and extending the attachment duration time.

It should be noted that it is free to add a coloring agent, a flavoring agent, a softening agent or the like to the film-like adherent or the film-like support of the oral bandage of the present invention within a range that does not hinder the adherence. For example, in the case where both the adherent and the support are colorless, blending a coloring agent into one of the adherents and the support provides an advantage that the front and back of the bandage are clear and easy to use.

As described above, the oral dressing of the present invention is made of a compatible material containing a polycarboxylic acid and a vinyl acetate polymer, in which the water-absorbing polymer is dispersed and contained in a proportion of less than 20%. Since it is formed into a thin film and is used as a film-like adherent, both the film-like adherent and the flexible film-like support are both highly flexible. Is out,
When applied to the oral cavity, it absorbs moisture in the oral cavity and further softens. Therefore, it easily fits to any part of the oral cavity and exhibits a strong adhesive force and a long-lasting adhesive force. In particular, the oral dressing of the present invention contains the water-absorbing polymer substance dispersedly contained in the above-mentioned compatible material, so that the adhesive force to the oral mucosa is remarkably improved, and bleeding occurs at the site of oral damage. It also adheres well to areas where it is present and can realize long-term film protection. In addition, it can be applied even when the amount of saliva secretion is large, and long-term film protection can be realized.

〔The invention's effect〕

The oral bandage of the present invention, which is configured as described above, has significantly improved adhesion to the mucous membrane of the oral cavity, adheres well to a damaged site in a bleeding state, and protects the coating for a long time. In addition, it can be adhered even when the amount of saliva secretion is large, and long-term coating protection can be realized. As a result, it is possible to prevent the injured site from being stimulated and to achieve early recovery of the injured site, and at the same time, to obtain a remarkable anti-drainage effect of the administered drug on the intraoral disease site. Moreover, the above-mentioned oral cavity dressing is flexible and deforms and adheres along the oral mucosa by simply pressing it during use, and it is extremely practical because it can be attached to any part of the oral mucosa.

Next, examples will be described together with comparative examples.

Example 1 A carboxyvinyl polymer was used as the polycarboxylic acid, and 4.7 parts by weight of this (hereinafter abbreviated as “part”) and 4.7 parts of vinyl acetate resin (1500) were used as a common solvent for both methanol. 90 parts, and then 0.6 parts of diisopropanolamine were added and mixed and dissolved to form a uniform solution. Next, 0.53 parts of a water-absorbing polymer of vinyl alcohol acrylate copolymer system was added to this solution,
Dispersed as evenly as possible. The solution is then cast onto release-treated polyethylene laminated paper,
It was dried in a dryer at 0 ° C. for 8 minutes to form a film-like adherent having a thickness of 40 μm. Then, the above-mentioned film-like adherent was thermocompression-bonded to a film of vinyl acetate resin (2000) having a thickness of 40 μm at 100 ° C. to obtain an oral bandage.

[Example 2] The amount of the water-absorbent polymer of the vinyl alcohol acrylate copolymer system was changed to 1.76 parts. Otherwise, Example 1
An oral bandage was obtained in the same manner as in.

[Example 3] The amount of the water-absorbent polymer of the vinyl alcohol acrylate copolymer system was changed to 2.5 parts. An oral bandage was obtained in the same manner as in Example 1 except for the above.

[Comparative Example 1] The amount of the water-absorbent polymer of the vinyl alcohol acrylate copolymer system was changed to 3.3 parts. An oral bandage was obtained in the same manner as in Example 1 except for the above.

[Comparative Example 2] The amount of the water-absorbent polymer of the vinyl alcohol acrylate copolymer system was changed to 5 parts. An oral bandage was obtained in the same manner as in Example 1 except for the above.

[Comparative Example 3] The amount of the water-absorbent polymer of the vinyl alcohol acrylate copolymer system was changed to 10 parts. An oral bandage was obtained in the same manner as in Example 1 except for the above.

[Comparative Example 4] The use of the water-absorbent polymer was discontinued. Otherwise, Example 1
An oral bandage was obtained in the same manner as in.

[Comparative Example 5] The following raw materials were prepared in the proportions shown below.

Carboxymethyl cellulose: 5% Hydroxypropyl cellulose: 85% Polyvinyl alcohol: 5% Vinyl alcohol acrylate Copolymer water-absorbing polymer: 5% Total: 100% The above ingredients are mixed and 10 parts of the purified water are mixed. In addition to the parts, the mixture was mixed uniformly, and air was blown into it to quickly spread it into a film on a smooth horizontal surface, freeze-dry it, and sponge-like adherent with a thickness of about 0.7 mm. Was formed, and this adhered body was used as an oral bandage.

[Comparative Example 6] The following raw materials were mixed in the following proportions.

Carboxymethyl cellulose: 5% Hydroxypropyl cellulose: 50% Polyvinyl alcohol: 5% Vinyl alcohol acrylate Copolymer system water-absorbing polymer: 40% Total: 100% The above component raw materials were mixed and treated in the same manner as in Comparative Example 5. An oral bandage consisting of a sponge-like adherent was obtained.

Next, a performance test was conducted on the oral bandages obtained in the above Examples and Comparative Examples. The results are shown in the table below.

As is clear from the above table, all of the example products are superior in the results of the water immersion test and the practical test to the comparative example product, and further, the hemostatic effect is remarkably excellent.

 ─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Yuji Ohgishi 3-1, Asahi-cho, Takatsuki-shi, Osaka Sunstar Co., Ltd. (72) Inventor Yuichi Inoue 1-2-1, Shimohozumi, Ibaraki-shi, Osaka Nitto Within the Electric Industry Co., Ltd. (72) Inventor Tetsuo Horiuchi 1-2 1-2 Shimohozumi, Ibaraki City, Osaka Prefecture Within the Nitto Electric Industry Co., Ltd. (56) Bibliographic references Sho 59-37253 (JP, Y2)

Claims (4)

[Claims] 1. An oral cavity dressing comprising a film-like adherent alone or an integrated product of a film-like adherent and a flexible film-like support, wherein the film-like adherent is at least a polycarboxylic acid and a polycarboxylic anhydride. One is composed of a flexible film-like material in which one of them and the vinyl acetate polymer are in a compatible state, and in which the water-absorbing polymer substance is dispersed and contained in a proportion of less than 20% by weight. An oral bandage characterized by: 2. The oral bandage according to claim 1, wherein the film-like adherent contains a salt having a neutralizing effect on polycarboxylic acid or polycarboxylic anhydride. 3. The oral dressing according to claim 2, wherein the salt is at least one of salt and base. 4. An oral bandage according to claim 1 or 2, wherein the flexible film support is a plastic film.