JPH0617317B2 - Free-flowing powder composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to a composition which is a granular material which has excellent hygroscopicity and has excellent fluidity and is easy to handle even under high relative humidity in pharmaceuticals, cosmetics or foods. .

(Prior art) Conventionally, highly hygroscopic pharmaceuticals and foods, for example, powdered youth, powdered milk, amino acid-based seasonings, meat extracts, herbal medicine extracts, ethambutol, choline chloride, theophylline,
Vitamin U, methionine, etc. have strong hygroscopicity, and if the powder is left in the air, it will absorb moisture and block,
It was difficult to handle due to deliquescence. For the purpose of improving this, it has been performed that these substances are adsorbed on and supported by light anhydrous silicic acid, crystalline cellulose and the like to remove the blocking property and become a free-flowing powder. However, when light anhydrous silicic acid is used, it cannot be used in foods, it has poor tableting moldability as a drug, and other excipients must be added. However, there are drawbacks such as the decomposition of pharmaceutical products. When crystalline cellulose is used, its adsorption ability is not so large, so it is necessary to add a large amount to the hygroscopic substance. Moreover, when it is applied to food, it has a rough texture and a bad mouth feel. For crystalline cellulose that uses hydrochloric acid, etc. in the manufacturing process,
There were drawbacks such as showing a bad taste such as astringent taste.

(Object of the Invention) The present invention provides a free-flowing powdery or granular material composition containing a hygroscopic substance in which these drawbacks are improved. This composition consists of highly hygroscopic substances and microfibrous cellulose (hereinafter MF
It is called C).

(Structure of the Invention) As a result of intensive studies conducted by the present inventors on a method of efficiently converting the substance having high hygroscopicity into a free-flowing powdery granule, MFC has been widely used in the past. Despite being a substance similar to crystalline cellulose, MFC has a granular material in which a hygroscopic substance is adsorbed to this, but is a granular substance in which a hygroscopic substance is adsorbed to crystalline cellulose that has been widely used in the past. In comparison, the present inventors have found that the moisture resistance stability is remarkably good, and that when it is used as a food, it does not have an unpleasant taste and has a pleasant mouthfeel, and the present invention has been completed.

The gist of the present invention is "a free-flowing powdery or granular material composition obtained by adding and dispersing fine fibrous cellulose to a drug, cosmetics or food having high hygroscopicity".

In addition, the microfiber cellulose (manufactured and sold by Daicel Chemical Industries under the name of MFC) according to the present invention is prepared by suspending pulp in water and beating it under a high shearing force to physically divide the cellulose fiber into a diameter. It is obtained by forming microfibrils of about 1 μm or less, which is distinctly different from the above-mentioned crystalline cellulose which has been widely used conventionally. Microcrystalline cellulose is commercially available under the name "Avicel" (registered trademark).
Crystalline cellulose is obtained by hydrolyzing high-purity natural cellulose with a mineral acid, removing the non-crystalline portion, extracting the crystalline portion, purifying and drying. The microfibrous cellulose according to the composition of the present invention is conventionally marketed as a suspension in water of about 2% by weight and used as a thickener in the food industry and the like.

The present inventors obtain a free-flowing powdery or granular material composition of the present invention by treating a hygroscopic substance using the MFC as a suspension in water or dehydrated powder thereof. Was successful.

The highly hygroscopic food or drug used in the present invention, powdered diuse, powdered milk, seasonings, meat extract powder, seafood extract powder, food products such as yeast extract powder, ethambutol, choline chloride, Drugs such as vitamin U, methionine, lithium chloride, powdered crude drug, etc. are exemplified, and the attribute of high hygroscopicity is specifically that the powder of the substance in a dry state is at room temperature and 50% relative humidity for 7 days. Means to block within. It should be noted that the drug or food used as the raw material of the present invention is not limited to the powder form, but may include the solution form or the dispersion form. For example, the free-flowing powdery or granular material composition of the present invention can be obtained by adding and dispersing the microfibrous cellulose to the diuse liquid itself instead of the powder diuse, and spray-drying this liquid.

Although partially overlapping with the above description, in order to obtain the composition of the present invention, the powder of the hygroscopic substance may be mixed with the powder of MFC at an appropriate ratio, and the hygroscopic substance may be added to the suspension in MFC in water. In the case of being dissolved or in the case of an extract or the like, a mixed solution obtained by adding a raw material extract in a liquid state to a suspension of MFC in water may be dried and powdered by an appropriate means such as spray drying or freeze drying.

The composition of the present invention does not cause blocking even in an environment of high humidity and retains fluidity, as compared with a powdered product of crystalline cellulose that has been widely used in the past. The composition of the present invention has great utility mainly as a raw material for foods, pharmaceuticals and cosmetics. Further, since the composition of the present invention is easily mixed with other substances, it is used as a raw material for foods, pharmaceuticals and the like.

Next, a method for producing the composition of the present invention, an example and tests for comparing the fluidity of the example of the present invention with those of the comparative example are shown to specifically explain the composition of the present invention and to clarify the effect thereof. To do. However, the present invention is not limited to the description of these examples.

Examples and Tests (1) 50% Yeast Extract Extract Powder Adsorbing MFC Powder 100 g of yeast extract powder having a very high hygroscopic property was dissolved in 150 g of a water: ethanol (4: 1) mixed solution, and 100 g of the solution was mixed in a beaker. Stir-mixed with the MFC powder of 1. and dried to obtain a mixed powder. This powder is 50% concentrated yeast extract powder adsorbed MFC powder. In the same manner, crystalline cellulose and light anhydrous silicic acid were used instead of MFC powder to obtain 50% concentrated yeast extract extract powder-adsorbed crystalline cellulose powder and 50% concentrated yeast extract powder adsorbed light anhydrous silicic acid powder, respectively.

(2) The three kinds of powders obtained in (1) were allowed to stand for 24 hours under the conditions of 25 ° C and 75% RH (RH is the same as the relative humidity below), and the following comparative tests and The results are shown in Table I.

Angle of repose measurement: According to the fieldwork and Sugihara formula.

Adhesion test 200, 100, 60 mesh screens were stacked in order from the bottom, and 2 g of the sample powder was gently placed on the top 60 mesh screen, then the three screens were simultaneously vibrated for 120 seconds. After stopping the vibration, the weight of the powder left on the coarse screen is measured and the degree of adhesion is expressed in% to 2 g. However, if all 60 mesh passes and remains above 100 mesh, measure this amount to 2 g.
% Is calculated and the value of 3/5 of this is taken as the tackiness. 10
If all 0 meshes are passed and 200 meshes are left, multiply by 1/5 to obtain the tackiness. If all 2 g pass through 200 mesh, the tack is 0.

(3) 70% Yeast Extract Extract Powder Adsorbed MFC Powder Using 140 g of yeast extract powder and 60 g of MFC powder
By the same operation method as in (1), 70% concentration yeast extract extract powder-adsorbed MFC powder was obtained. Similarly, a 70% concentration yeast extract powder adsorbed crystalline cellulose powder and a 70% yeast extract powder adsorbed light anhydrous silicic acid powder were obtained.

(4) Using the powder obtained in (3), the angle of repose and the tackiness were tested for fluidity under the same conditions as in (2), and the results are shown in Table 1.

(5) Adsorption M of 70% concentrated yeast extract powder by fluidized bed
FC powder 700 g of yeast extract powder having a very high hygroscopic property is dissolved in a mixed solution of water and ethanol (4: 1, 1,250 g) to prepare a spray liquid. This liquid was mixed with MFC powder 30 using a fluidized bed of Flow Coater Mini (manufactured by Freund Corporation).
It was sprayed and adsorbed on 0 g. 70% of the powder thus obtained
Adsorbed MFC powder in a fluidized bed of concentrated yeast extract powder. Similarly, crystalline cellulose and light anhydrous silicic acid were used to obtain crystalline cellulose powder adsorbed by a fluidized bed of 70% concentrated yeast extract powder and adsorbed light anhydrous silicic acid powder by a fluidized bed of 70% yeast extract powder.

(6) With respect to each of the powders obtained in (5), a comparative test was conducted on the fluidity under the same conditions as in (2) regarding the angle of repose and the degree of adhesion. The results are shown in Table I.

(7) 50% concentration Kakkonto powder adsorbed MFC powder 100 g of Kakkonto powder having a very high hygroscopicity was dissolved in 150 g of water, and 100 g of MFC powder was stirred and mixed, followed by spray drying to obtain a powder. This is 50% concentration Kakkonto powder adsorption M
FC powder. The same procedure was performed for light anhydrous silicic acid to obtain a 50% concentrated Kakkonto powder adsorbed light anhydrous silicic acid powder.

(8) Using the powder obtained in (7), the angle of repose and the tackiness relating to fluidity were tested under the same conditions as in (2), and the results are shown in Table I.

(9) 70% concentration Kakkonto powder adsorbed MF by the same operation method as (7)
C powder and 70% concentrated Kakkonto powder adsorbed light anhydrous silicic acid powder were obtained.

(10) Using the powder obtained in (9), the angle of repose and the tackiness relating to fluidity were tested under the same conditions as in (2), and the results are shown in Table I.

(11) 70% concentration Kakkonto powder MFC powder using a fluidized bed
Dissolve in and use this as the spray liquid. This spray solution is spray-adsorbed on 300 g of MFC powder using a fluidized bed. The powder thus obtained is used as 70% Kakkonto adsorption fluidized bed MFC powder. Similarly, light anhydrous silicic acid was also used to obtain 70% Kakkonto adsorption fluidized bed light anhydrous silicic acid powder.

(12) Table I shows the results obtained by subjecting the powder obtained in (11) to the repose angle and the tackiness relating to the fluidity under the same conditions as in (2).

(13) 0.5% to each powder obtained in (7), (9) and (11) above
(W / W) Magnesium stearate was added and a single-shot tableting machine Kimura KT-II type was used.
Tableting was carried out on 50 mg, and a comparative test of tableting property was carried out for each tableting. The results are shown in Table II.

From Table I, it can be seen that a difference appears between MFC and crystalline cellulose powder at a concentration of 50%. This difference clearly appears at the 70% concentration. A difference between MFC and crystalline cellulose is clearly recognized in the concentration range that can be handled as powder.
There is no difference in handling as powder between MFC powder and light anhydrous silicic acid powder.

From Table II, it can be seen that regardless of the concentration, when light anhydrous silicic acid is used, the formability is significantly inferior to that of MFC.

Claims (1)

[Claims] 1. A free-flowing powdery or granular material composition obtained by adding and dispersing microfibrous cellulose to a drug, cosmetics or food having high hygroscopicity.