JPH0638843B2 - Antibacterial structure having infection prevention property - Google Patents

Description

TECHNICAL FIELD The present invention is used in contact with a human body, as represented by slippers used in hospitals, etc., and is reused after cleaning or sterilizing cleaning after use. It relates to the structure to be used for.

Conventional technology As part of infection control measures in the central operating room, intensive care unit (ICU), coronary unit (CCU), central material room, infectious disease ward, neonatal room, leukemia ward, artificial dialysis center, etc. of hospitals Measures are taken to prevent the contamination of slippers. That is, in such a clean area, it is common knowledge to perform careful washing and sterilization every time the slipper is used once, and a washing and sterilizing apparatus for that purpose has also been developed.

In addition, waiting rooms and consultation rooms at hospitals, libraries, public halls, inns,
In the auditorium and the like, unspecified number of people usually share shoes such as slippers. However, it is well known that sharing footwear may cause pathogenic bacterial infections,
Especially in hospitals, many harmful bacteria often cause nosocomial infections, which may cause social problems.

In such a place, it is best to use footwear such as slippers and then wash the footwear with a detergent or wash and disinfect the footwear with a germicidal detergent.

A simple method of preventing the growth of bacteria is to spray an antibacterial agent after using the footwear.

In addition, in order to suppress the growth of bacteria, it has been attempted to manufacture slippers using a resin containing an antibacterial agent as a raw material.

Problems to be Solved by the Invention However, even if the used footwear is washed with a detergent or disinfectant detergent, it cannot be completely sterilized because the detergent or disinfectant detergent cannot sufficiently enter the inside of the seam of the footwear. , As a result, although the number of bacteria is temporarily reduced to near zero immediately after washing, a few residual bacteria begin to grow soon and are released from there, so that the desired bactericidal effect is often not expected.

The method of spraying the antibacterial agent after use of the footwear merely reduces the bacteria temporarily, and complete sterilization cannot be expected at all.

The method of manufacturing slippers using a resin in which an antibacterial agent is kneaded is limited to the extent of suppressing the growth of bacteria. Also, after using this antibacterial agent kneading slipper, even if you wash it with a detergent or germicidal detergent, it will not reach the completion of sterilization,
It is not possible to adequately prevent the growth of residual bacteria.

The present invention has been made in view of such circumstances, and an object thereof is to provide a slipper or other structure capable of suppressing the growth of bacteria during use and exhibiting complete bactericidal properties during washing.

MEANS FOR SOLVING THE PROBLEMS The present invention relates to a structure which is used in a state of being in contact with a human body, and which is subjected to cleaning or sterilization cleaning after use and then reused, and at least a surface layer of the structure. But polymer (A)
An antibacterial structure having an infection preventive property, which is formed of a polymer composition obtained by mixing an antibacterial agent (B) and a surfactant (C). The present invention has achieved the above-mentioned object by finding such a specific structure.

The present invention will be described in detail below.

Structure The structure intended by the present invention is used in contact with the human body, and after use (for example, after one use or one day use), it is washed or sterilized and washed before reuse. The structure to be served. After washing or sterilization washing, it is possible to complete sterilization by irradiating with ultraviolet rays.

Such structures include footwear (slippers, heps,
Typical examples are sandals, insoles, etc.), knob covers (for toilets, etc.), and seats used in clean areas (seats used on operating tables, seats used on hospital beds, etc.). The surface materials for beds and elbow pads in operating rooms and examination rooms, and sofa surface materials for hospital waiting rooms are examples.

Polymer (A) As the polymer (A), various polymers that can be molded or formed into a layer are used, and thermoplastic polymers or rubber polymers are suitable. Examples of these polymers include vinyl chloride polymers, acrylic polymers, olefin polymers, vinylidene chloride polymers, styrene polymers, polyester polymers, urethane polymers, polyamide polymers, cellulose derivatives, polycarbonate polymers, Examples thereof include fluorine-based resins, silicone-based resins, vinyl alcohol-based polymers, vinyl ester-based polymers, synthetic rubbers and natural rubbers. Among these polymers, vinyl chloride polymers are especially important, and urethane resins are also important.

Here, the vinyl chloride-based polymer is a homopolymer of vinyl chloride (particularly, a polymer having a molecular weight of about 800 to 2000), and vinyl chloride and other copolymerizable monomers such as ethylene, vinyl acetate, vinylidene chloride, and ethylenic Includes copolymers with unsaturated carboxylic acids and the like, as well as blends with other polymers.

Polymers other than vinyl chloride-based polymers also include copolymers and blends with other polymers.

Antibacterial agent (B) The antibacterial agent (B) is a general term for a bactericide, an antifungal agent, a disinfectant, etc. For the purpose of the present invention, it shows a strong antibacterial activity even in a small amount, has a wide antibacterial spectrum and low toxicity And, those with low volatility and odor are used.

Examples of the antibacterial agent (B) include organic phosphorus compounds, organic sulfur compounds (monomethyldithiocarbamate compounds, dimethyldithiocarbamate compounds, ethylenebisdithiocarbamate compounds, thiuram, etc.), antibiotic compounds, quinone compounds, phenol compounds, dinitrobenzene compounds, Known antibacterial agents such as cyan, phthalimide, quinoline, and organic arsenic are used. Specific examples of preferable antibacterial agents include 2,4,4'-trichloro-2'-hydroxydiphenyl ether and 2- (4-thiazolyl). ) Benzimidazole (generic name: thiabendazole), chlorhexidine, 3-allyloxy-1,2
-Benzisothiazole-1,1-dioxide (generic name: probenazole), 5-butyl-2-dimethylamino-6-methylpyrimidin-4-ol (generic name: dimethylylimole), N- (parafluorophenyl) di Chlormaleimide (generic name: fluorimide), 3- (3,5
-Dichlorophenyl) -N-isopropyl-2,4-dioxoimidazolidine (generic name: lobral, 1,2-
Bis- (2,2,2-trichloro-1-formamidoethyl) piperazine (generic name: triphorine), methyl-1
-(Butylcarbamoyl) -2-benzimidazole carbamate (generic name: benlate), 5-methyl-1,
2,4-triazolo (3,4-b) benzothiazole (generic name: tricyclazole), 3'-isopropoxy-2-methylbenzanilide (generic name: mepronil),
Examples include tribromsaran, isopropylmethylphenol, benzalkonium chloride, alkylisoquinolium bromide, trichlorocarbanilide, halocarbane, thiuram and the like.

Among these, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 2- (4-thiazolyl)
It is desirable to use at least one antibacterial agent selected from the group consisting of benzimidazole and chlorhexidine, in particular at least one selected from the group consisting of 2,4,4'-trichloro-2'-hydroxydiphenyl ether and chlorhexidine. It is particularly desirable to use both one type and 2- (4-thiazolyl) benzimidazole in combination.

2,4,4'-Trichloro-2'-hydroxydiphenyl ether has a broad antibacterial spectrum,
Acts on both Gram-negative bacteria and fungi. Its mechanism of action is believed to clot or denature proteins and inhibit cell function. It is hardly absorbed by the body and has low toxicity. Acute toxicity LD ₅₀ (rat oral) is 47
It is 00 mg / kg.

Chlorhexidine has a broad antibacterial spectrum and shows a rapid bactericidal action even at low concentrations, especially against Gram-positive bacteria such as grape-like bacteria, and it also acts at relatively low concentrations on Gram-negative bacteria such as Escherichia coli, and many fungi. Also works. Its mechanism of action is thought to bind to lipoproteins, inhibit the function of the membrane, and cover the cells. It is hardly absorbed by the body and has low toxicity. Acute toxicity LD
₅₀ (oral rat) is 2270 mg / kg.

2- (4-thiazolyl) benzimidazole is commonly referred to as thiabendazole. Shows excellent growth-inhibiting effect against a wide range of molds. It has very low toxicity and is approved as a food additive for citrus and banana.
The acute toxicity LD ₅₀ (oral for mice) is 3600 mg / kg.

Surfactant (C) As the surfactant (C), an anionic surfactant or a nonionic surfactant as described below is used. Depending on the case, an amphoteric surfactant or a cationic surfactant may be used.

Anionic surfactant: fatty acid salt, alkylbenzenesulfonate, alkylnaphthalenesulfonate, alkylsulfonate, α-olefinsulfonate, dialkylsulfosuccinate, α-sulfonated fatty acid salt, N-methyl-N-oleyl Taurine, petroleum sulfonate, alkyl sulfate, sulfated oil, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkylphenol ether sulfate, polyoxyethylene styrenated phenyl ether sulfate, alkyl phosphate, polyoxyethylene alkyl Phenyl ether phosphate, naphthalene sulfonate formaldehyde condensate, etc.

Nonionic surfactant: polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether,
Polyoxyethylene polystyryl phenyl ether, polyoxyethylene polyoxypropylene block or random copolymer, polyoxyethylene polyoxypropylene alkyl ether, polyhydric alcohol fatty acid partial ester, polyoxyethylene polyhydric alcohol fatty acid partial ester, polyoxyethylene fatty acid ester , Polyglycerin fatty acid ester, polyoxyethylenated castor oil, fatty acid diethanolamide, polyoxyethylene alkylamine, triethanolamine fatty acid partial ester, trialkylamine oxide and the like.

Among these, polyhydric alcohol fatty acid partial ester, polyoxyethylene polyhydric alcohol fatty acid partial ester, and polyglycerin fatty acid ester in the nonionic surfactant are particularly preferable. Polyhydric alcohol means sorbitan, sorbitol, mannitol, pentaerythritol, glycerin, glycol,
Examples of the sucrose include fatty acids such as stearic acid, oleic acid, linoleic acid, ricinolenic acid, lauric acid, and palmitic acid.

The surfactant may be used alone or in combination of two or more. Particularly, from the viewpoint of sustainability, it is desirable to use two or more kinds of surfactants having different transferability to the surface in combination.

Blending ratio of each component The blending amount of the antibacterial agent (B) in the polymer composition is selected from the range of 0.01 to 15 parts by weight, preferably 0.02 to 10 parts by weight, based on 100 parts by weight of the polymer (A). If the blending ratio of the antibacterial agent (B) is less than this range, the antibacterial activity is lowered and the intended purpose cannot be sufficiently achieved. On the other hand, if the blending ratio of the antibacterial agent (B) exceeds the range, Even so, the antibacterial property does not rise above a certain limit, and there is a cost disadvantage.

The blending amount of the surfactant (C) is selected from the range of 0.05 to 15 parts by weight, preferably 0.1 to 10 parts by weight, based on 100 parts by weight of the polymer (A). When the blending ratio of the surfactant (C) is less than this range, the antibacterial action of the antimicrobial agent (B) is not sufficiently exerted, while when the blending ratio is more than this range, the amount transferred to the structure surface is large. Is too much, the feeling becomes bad, and the durability of the antibacterial activity of the antibacterial agent (B) is lowered, so that the desired antibacterial effect cannot be obtained by washing several times.

Other components In addition to the above-mentioned polymer (A), antibacterial agent (B) and surfactant (C), the polymer composition may include a plasticizer, a lubricant, a stabilizer, an ultraviolet absorber, an anti-adhesion agent if necessary. Additives such as agents, fillers, colorants, antistatic agents and foaming agents may be included.

Here, as the plasticizer, phthalic acid esters, adipic acid esters, sebacic acid esters, citric acid esters, phosphoric acid esters, trimellitic acid esters,
Examples thereof include epoxy compounds, chlorinated compounds and polyesters.

Particularly when the polymer (A) is a vinyl chloride polymer, it is desirable to add, for example, 20 to 120 parts by weight of a plasticizer to 100 parts by weight of the vinyl chloride polymer. This is because the compounding of the plasticizer is not only necessary for the physical properties of the molded product, but also helps the migration of the surfactant (C) to the surface and serves to increase the antibacterial effect of the antibacterial agent (B).
Then, it is usual to add an appropriate amount of a lubricant, a stabilizer and an ultraviolet absorber together with the plasticizer.

Molding method In molding the polymer composition, usually a calendering method, an extrusion molding method, an injection molding method, a melt coating method, a compression molding method, a molding method, a solution coating method, a dispersion coating method and the like. Any of these molding means can be adopted.

Structure of Molded Product In the structure of the present invention, at least the surface layer is formed of the above polymer composition. That is, the polymer composition may form the structure by itself, or may be formed as a surface layer on another substrate.

In the latter case, as the other substrate, a fiber entangled body (nonwoven fabric,
Woven cloth, artificial leather, paper, etc. and polymer molded products are preferred. Antibacterial agent (B) also on the side of these other base materials
Can be blended.

FIG. 1 is a perspective view showing an example of the structure of the present invention.
In this example, the polymer composition (1) alone forms a structure.

FIG. 2 is a perspective view showing another example of the structure of the present invention. In this example, the polymer composition (1) is integrally formed on another base material (2).

Action The structure (slippers, etc.) of the present invention is washed with a detergent or disinfectant detergent after one use or one day use. Most of the bacteria can be removed by this washing operation, but only a small portion is unavoidable to remain between the seams. This is because the detergent and germicidal detergent do not fully enter the inside of the seams.

However, in the structure of the present invention, since the surfactant (C) is added, it gradually leaches to the surface and wets the surface. The compounding of the plasticizer promotes the leachability of the surfactant (C) to the surface. Then, the antibacterial agent (B) is gradually exuded to the surface along with the leaching of the surfactant (C), and the surface is evenly wetted. Therefore, a strong bactericidal force is exerted on the entire surface, and the bactericidal force is exerted. It lasts for a long time.

That is, the bactericidal power is given only by the antibacterial agent (B), but the surfactant (C) has a role of gradually transferring the antibacterial agent (B) to the surface and the antibacterial agent (B) by uniformly wetting the surface. Plays the two roles of maximizing the action of. When used in combination with a plasticizer, the plasticizer plays a role of making the above two roles of the surfactant (C) more effective.

In addition, when only the antibacterial agent (B) is mixed with the polymer (A), the amount of the antibacterial agent (B) that leaches to the surface is limited and the wettability of the surface is poor, and the desired antibacterial activity is sufficient. Is not played by. Even when washing with warm water using a detergent or germicidal detergent,
Since repellency is generated on the surface, the antibacterial agent (B) is unevenly distributed, and there is a risk that the bacteria adhered to the portion where the antibacterial agent (B) is small will proliferate.

During the above-mentioned washing or sterilizing washing, the structure is in a state of being wet with water, and since washing is often performed with warm water, leaching of the surfactant (C) to the surface is promoted, The leaching of non-antibacterial agent (B) to the surface is also promoted. Moreover, the antibacterial agent (B) that has leached onto the surface is under the condition that it can exert its antibacterial activity most of all, including the presence of water and the high temperature, and it is even more effective for the bacteria remaining in the seams. I will kill you.

In addition, the concentration of antibacterial agent on the surface is increased even in the drying process after washing, and the antibacterial activity is increased.

Generally, under high-humidity and high-temperature conditions, bacterial growth is remarkable, but in the present invention, under high-humidity and high-temperature conditions, the leaching amount of the antibacterial agent increases, and since the surface becomes wet,
The more easily the bacteria can grow during storage or use of the structure of the present invention, the stronger the antibacterial action becomes, and the more effectively the growth of the bacteria is prevented.

EXAMPLES Next, the present invention will be further described with reference to examples. Hereinafter, "parts" and "%" are shown by weight.

Example 1 Preparation of antibacterial leather After mixing the following components, the mixture was supplied to a calender roll,
A sheet having a thickness of 400 μm was manufactured by rolling at a temperature of 160 ° C., and then a sheet having a thickness of 1.2 mm (artificial leather) was laminated. After heating this at 200 ℃ / 50sec with an embosser, 4kg / c
Embossing was performed at m ² to obtain antibacterial leather.

Formulation Polyvinyl chloride (A) with a molecular weight of 1500 100 parts Dioctyl phthalate (plasticizer) 80 parts Ba-Zn composite stabilizer 3 parts Heavy calcium carbonate 20 parts Titanium oxide 10 parts 2,4,4'-Trichloro-2 ′ -Hydroxydiphenyl ether (B1) 3 parts 2- (4-thiazolyl) benzimidazole (B2) 1.5 parts Equivalent mixture of sorbitan palmitate and sorbitan stearate (C1) 2.5 parts Polyglycerin oleic acid monoester ( C2) 0.5 parts Preparation of various structures The antibacterial leather obtained in this manner is cut to prepare the band part (3) of the slipper and the surface coating part (the part where the sole contacts) (4), Low foaming ethylene-
A slipper for an operating room as shown in a perspective view of FIG. 3 was manufactured using a vinyl acetate copolymer molded article as a base component (5).

Moreover, after cutting the antibacterial leather obtained above, a string was attached and a knob cover for a toilet was manufactured.

Similarly, the periphery of the antibacterial leather obtained above was folded back to a narrow width and “sewn” to prepare a bed sheet for a sick person.

Comparative Example 1 Components (B1), (B2), (C1) and (C2) in the compounding recipe of Example 1
Leather was manufactured in the same manner as in Example 1 except that the compounding was omitted, and then slippers for an operating room, a knob cover for a door of a toilet, and a bed sheet for a patient room were manufactured.

Comparative Example 2 A leather was manufactured in the same manner as in Example 1 except that the components (C1) and (C2) were omitted from the formulation of Example 1, and then slippers for an operating room, a knob cover, and a bed sheet were produced. did.

Comparative Example 3 An antibacterial leather was manufactured in the same manner as in Example 1 except that the components (B1) and (B2) were omitted from the formulation of Example 1, and then slippers for an operating room, a knob cover, and a bed sheet. Was produced.

Antibacterial test (a) Contamination of slippers The number of bacteria was measured for the slippers after one use with bare feet. (Step 1) The slippers after one-time use were washed with warm water with a sterilizing detergent and then dried, and the number of bacteria was measured again. (Step 2) The slipper after one-time use was washed with warm water with a sterilizing detergent and then dried, and allowed to stand for 3 days in an environment of a temperature of 40 ° C. and a humidity of 80% RH, and then the number of bacteria was measured. (Step 3) The above measurement is performed for each of 7 slippers (on one leg),
The maximum value and the minimum value were excluded, and the average value of the remaining 5 was determined and used as the measured value.

The bacteria count was measured according to the stamp agar method by cutting off the surface-covered portion of the slipper (the portion where the sole contacts) to obtain a sample.

The results are shown in Table 1.

From Table 1, it can be seen that in Example 1, the adherence of bacteria was suppressed even after 1 day of use as compared with each Comparative Example, and most of the bacteria were removed by sterilizing and washing after use. It can be seen that, when this is left under high temperature and high humidity conditions, in Example 1, bacterial growth is remarkably suppressed as compared with each comparative example.

(B) Antibacterial spectrum The antibacterial spectrum was investigated by the following method.

1. Chips of 5 mm square are cut out from the bed sheets produced in Example 1 and Comparative Examples 1 to 3.

2. Sterilize each chip for 2 hours with a germicidal lamp.

3. 10 ⁶ CFU / m of each culture cultivated in Sensitive Mueller-Hinton's medium and BTB Dolgalski's modified medium for 24 hours
After inoculating 0.1 ml of the solution to a concentration of 1, apply 15 glass beads having a diameter of 5 mm.

4. The chip prepared in 1 above is placed in each medium.

After standing in a refrigerator at 5.4 ° C for 2 hours, incubate at 37 ° C for 24 hours.

6. Measure the size of each stop band.

The results are shown in Table 2.

(C) Wash resistance of knob cover The knob cover prepared in Example 1 and Comparative Examples 1 to 3 is set on the knob of the door of the toilet, the number of bacteria is measured once a day, and then washed with hot water with a sterilizing detergent and dried. Then I set it on the door knob. This work was repeated for 2 months to examine the washing resistance.

The above measurement was carried out for each of the five knob covers, and the maximum value and the minimum value were excluded each time, and the average value of the remaining three pieces was determined as the measured value.

The number of bacteria was measured according to the stamp agar method.

The results are shown in Table 3.

It can be seen from Table 3 that the knob cover of Example 1 has the largest antibacterial activity as compared with the comparative examples, and that the antibacterial activity is hardly reduced even after washing for 60 times for 2 months.

Example 2 A mold for preparing an elbow pad for measuring blood pressure was prepared, and a commercially available polyol composition for preparing polyurethane foam was prepared with 1.5.
% 2,4,4'-trichloro-2'-hydroxydiphenyl ether (B1), 1.5% 2- (4-thiazolyl) benzimidazole (B2), 1.5% chlorhexidine gluconate (B1)
3), 1.5% sorbitan stearate (C1), 1.0
% Polyoxyethylene (20) sorbitan oleic acid monoester (C2) and 0.5% glycerin ricinolenic acid monoester (C3) blended, using a commercially available diisocyanate composition for polyurethane foam production,
The elbow pads made of semi-rigid polyurethane foam were manufactured by pouring into the above mold by the one-shot method and foaming.

The number of bacteria after using this elbow pad for 1 day is 120 pieces / 10cm ²
Met.

When this elbow pad was used for one day, it was wiped with a cloth soaked in a detergent solution, and left in the room for 2 days, the number of bacteria was 3/10 cm ² .

Comparative Example 4 An elbow pad was produced in the same manner as in Example 2 except that the components (B1), (B2), (B3), (C1), (C2) and (C3) were omitted, and the same bacteria were prepared. When a number measurement test was performed, the number of bacteria after 1 day of use was 160 cells / 10 cm ² , and the number of bacteria after wiping with an aqueous detergent solution for 2 days was 80 cells / 10 cm ² .

Comparative Example 5 An elbow pad was manufactured in the same manner as in Example 2 except that only the components (C1), (C2) and (C3) were omitted, and the same bacterial count test was conducted. The number of bacteria after
Pieces / 10 cm ^2, the number of bacteria when left for 2 days after wiped with the detergent solution is 38/10 cm ^2, inferior results are compared to Example 2 were obtained.

EFFECTS OF THE INVENTION The antibacterial structure of the present invention has excellent antibacterial properties, increases antibacterial activity correspondingly under high temperature and high humidity conditions in which bacteria easily grow, and is washed many times. Also, the antibacterial action continues, and in terms of slippers, the antibacterial activity does not decrease so much even if the cleaning is performed for the number of times of its life (for example, about 100 times).

Therefore, when the structure of the present invention is used in a clean area or used by an unspecified number of people, infection can be effectively prevented, and it is extremely useful from the viewpoint of hygiene.

[Brief description of drawings]

FIG. 1 is a perspective view showing an example of the structure of the present invention, FIG. 2 is a perspective view showing another example of the structure of the present invention, and FIG. 3 is a slipper for an operating room of the structure of the present invention. It is a perspective view when it is. (1) ... Polymer composition, (2) ... Other base material, (3) ... Band portion, (4) ... Surface coating portion, (5) ... Base component material

Claims (12)

[Claims] 1. A structure which is used in contact with a human body, and which is used after being washed or sterilized after use and reused, wherein at least the surface layer of the structure is a polymer (A).
An antibacterial structure having an infection preventive property, which is formed of a polymer composition obtained by mixing an antibacterial agent (B) and a surfactant (C). 2. A polymer composition comprising 100 parts by weight of a polymer (A) and 0.01 to 15 parts by weight of an antibacterial agent (B) and 0.05 to 15 parts by weight of a surfactant (C). The structure according to claim 1, wherein 3. The structure according to claim 1, wherein the polymer (A) is a thermoplastic polymer or a rubber polymer. 4. The structure according to claim 3, wherein the polymer (A) is a vinyl chloride resin or a urethane resin. 5. The antibacterial agent (B) is 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 2- (4-
The structure according to claim 1, which is at least one antibacterial agent selected from the group consisting of thiazolyl) benzimidazole and chlorhexidine. 6. The antibacterial agent (B) contained in the polymer composition is at least one selected from the group consisting of 2,4,4'-trichloro-2'-hydroxydiphenyl ether and chlorhexidine, A structure according to claim 1 which is both 2- (4-thiazolyl) benzimidazole. 7. The surfactant (C) is at least one surfactant selected from the group consisting of polyhydric alcohol fatty acid partial esters, polyoxyethylene polyhydric alcohol fatty acid partial esters and polyglycerin fatty acid esters. The structure according to claim 1. 8. The structure according to claim 1, which is formed of the polymer composition alone. 9. The structure according to claim 1, wherein the polymer composition is formed as a surface layer on another substrate. 10. The structure according to claim 1, which is footwear. 11. The structure according to claim 1, which is a knob cover. 12. The structure according to claim 1, which is a sheet used in a clean area.