JPH0641418B2 - Cholesterol-lowering substances - Google Patents

Description

TECHNICAL FIELD The present invention relates to a blood cholesterol lowering substance.

[Conventional technology and its problems]

Blood lipids include cholesterol, neutral fats, phospholipids, and free fatty acids. Because of their hydrophobicity, these lipids generally exist in association with proteins, and the conjugate is called lipoprotein. Abnormal lipid metabolism is generally understood as a qualitative and quantitative abnormality of lipoprotein. It has long been known that cholesterol among lipids is particularly closely related to arteriosclerosis, and various drugs have been developed in order to lower the blood cholesterol concentration.

On the other hand, recently, dietary leaf eye bar (or dietary fiber, hereinafter referred to as DF) has been attracting attention for its physiological action. And there are various actions as its physiological action,
There are colorectal cancer preventive action, blood glucose lowering action, toxicity lowering action of toxic substances in food, prevention and treatment of constipation, prevention and treatment of obesity and the like. And wheat bran has been highlighted as an important source of DF. Its physiological activities include prevention of colon cancer and prevention and treatment of constipation, but its cholesterol lowering effect is said to be weak. 〔A
mJClin.Nutr., 32 , 2430-2434 (1979)].

DF is a naturally synthesized cholesterol-lowering substance, whereas it is a naturally-occurring drug. Therefore, DF is an excellent cholesterol-lowering drug in terms of the side effects often seen in synthetic substances. If an action is found in wheat bran, its utility is extremely great.

[Means for solving problems]

As a result of pursuing the cholesterol lowering action of wheat bran, the present inventors have found that the objective can be achieved by an extremely simple means.

That is, the present invention relates to a cholesterol lowering substance comprising wheat bran having a particle size of 60 mesh or less.

In the production of the cholesterol-lowering substance of the present invention, wheat bran is washed with water, air-dried, then pulverized and classified to collect a section having a particle size of 60 mesh or less.

According to the animal test, the cholesterol-lowering substance of the present invention markedly exhibits a blood cholesterol-lowering action, and further, does not impair any physiological actions such as the above-mentioned prevention of constipation. Further, since the substance of the present invention includes wheat bran, it does not show any harmful side effects to humans or animals and is extremely safe.

The cholesterol-lowering substance of the present invention is administered orally. Generally, any dosage form for oral administration can be used, but a solid solid form is preferable. For example, powders, granules, tablets, fine granules, capsules and the like may be used, but they may be used as they are, but conventionally used additives such as excipients, binders, disintegrants, fillers, lubricants, It is also formulated with a coloring agent and the like. Or, although this is one of the features of the present invention, even if it is not made into such a dosage form, it is conventionally used for food, such as bread, cakes, kutsky, biscuit, macaroni, spaghetti, buckwheat, udon, etc. Foods such as muffins, mashed potatoes, snack foods, steamed buns, pizza pies, rice cakes, chewy rice, okonomiyaki, shiyumai, kamaboko, hamburg, tofu, ham, sausage, beverages, sauces, ketchup, salad dressing, jiyam, jelly , Ice cream, etc. can be used.

The higher the intake amount of the substance of the present invention, the more effective it is, and no inconvenience occurs. For example, 1 to several times a day, 5 to 60 g, preferably 10 to 30 g are used.

〔Example〕

 Next, examples will be shown.

Example 1 Wheat bran was washed with water, air-dried, and then crushed by a crusher. The crushed product was applied to an air classifier [Turbo Classif Ear TC-15N (manufactured by Nisshin Engineering)] for classification. First, the crushed material was designated as F-1, and this was designated as the F-2 portion (77.5
%) And the F-5 part (22.5%), and the F-2 part is further F-
It was divided into 4 parts (34.2%) and F-5 parts (43.3%). The particle size distribution of each part is shown in Table 1.

The section that passed 60 mesh was filled in a hard capsule according to a conventional method.

〔effect〕

The cholesterol lowering effect of the substance of the present invention is shown by the following tests.

Six kinds of feeds shown in Table 2 below were prepared by a conventional method.

That is, feed A is a normal feed, feed B is a control, feeds C and D are those containing unclassified wheat bran, and feeds E and F are those containing 60 mesh or less wheat bran.

6 male rat rats in 1 ward (weight approximately 100
g) was used and fed for 2 weeks with the above-mentioned feed as free feeding. The results are shown in Table 3.

As can be seen from the results shown in Table 3, the diet containing the substance of the present invention significantly lowers blood cholesterol and blood triglyceride.

Since the substance of the present invention is obtained from nature, it does not exhibit any harmful side effects which are often observed in synthetic pharmaceuticals, and even if it is used in a large amount and over a long period of time, there is almost no inconvenience. It has an excellent advantage that it rarely occurs. Further, as described above, it can be used by adding it to food.

Claims (1)

[Claims] 1. A cholesterol-lowering substance comprising wheat bran having a particle size of 60 mesh or less.