JPH0642886B2 - Dialysis probe - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention mainly relates to the structure of a dialysis probe for animal experiments.

[0002]

BACKGROUND ART [0002] Conventionally, dialysis probes have been used for various purposes such as treatment and examination. However, dialysis probes intended by the inventor have been used in animal experiments in living tissue extracellular (liver, adrenal gland, heart, etc.). (Inside organs, etc.), components derived from the living body or drugs administered from the outside are continuously collected outside under anesthesia or non-anesthesia. The concentrations of the components and drugs derived from the living body are measured by an analyzer, and their continuous concentration changes outside the living tissue cells are traced.

[0003]

A dialysis probe is used for the recovery of the above-mentioned components or drugs derived from a living body, which is not damaged by a tensile force when it is inserted into a living body, and after the insertion, It is necessary that the tissue of the indwelling part is not destroyed by the friction between the living tissue and the dialysis probe that is active during the indwelling of the probe in the inspected part of the living body. That is, when the biological tissue is gradually destroyed, not only the extracellular components and drugs are recovered, but also the intracellular components are leached and mixed in, and the purpose cannot be achieved. In addition, when the probe conduit is pulled out from the subcutaneous part of the animal body under no anesthesia and in an unrestrained state, it is necessary to perform the pulling-out operation in a state where there are as few obstacles as possible.

The present invention seeks to provide a dialysis probe which can be effectively inserted into an animal body and which does not damage living tissues.

[0005]

[Means for Solving the Problems] In order to achieve the above object, the present invention inserts one rigid reinforcing tube at each end of a hollow fiber dialysis membrane having a platinum core wire, The platinum which is connected and fixed to a pair of flexible conduits having surface smoothness and flexibility that does not damage living tissue and which is projected from both ends of the dialysis membrane including the reinforcing tube insertion part. The dialysis probe is characterized in that the core wire is locked in the material of the conduit, and a stainless steel hollow needle is connected and fixed to the other end of each conduit.

[0006]

According to the above construction, when the dialysis probe is inserted into the living tissue, the dialysis membrane is reinforced by the platinum core wire even if a tensile force is applied, so that the dialysis membrane is not broken and the dialysis probe is not broken. Since the flexible conduit forming the main body has sufficient surface smoothness and flexibility, it can be easily pulled out after insertion from the needle tip.

Further, after being placed in a living tissue, the biological activity (physical movement) of the tissue is well absorbed by the flexible conduit of the probe having surface smoothness and flexibility, and scratches and the like are less likely to occur.

[0008]

1 is a vertical sectional view showing an embodiment of the present invention. In FIG. 1, the hollow fiber dialysis membrane 2 located at the center of the probe 1 is made of, for example, a semipermeable membrane material such as cellulose, and in this case has a platinum wire 3 with a diameter of 0.075 mm as a core wire, which itself is Diameter about 0.2-0.5mm, length number
It has a size of mm to several tens of mm. A quartz tube 4 having, for example, a polyimide coating is inserted as a rigidity reinforcing member at both ends of the dialysis membrane 2, and the platinum wire 3 further projects from the quartz tube 4 projecting from the dialysis membrane 2. Both ends of the dialysis membrane 2 including the insertion structure of the quartz tube 4 are further inserted into the pair of flexible conduits 5a and 5b and fixed and connected by the epoxy adhesive layer A. This flexible conduit is made of, for example, polyimide, polyethylene or Teflon, and is finished so as to have surface smoothness and flexibility that does not damage living tissue.
The above-mentioned protrusion of the platinum wire 3 is bent and locked in this conduit material. At the front end of the distal-side conduit 5a, a tip a
A stainless hollow needle 6 having a
The injection needle rear part 7 is inserted at the rear end of b.

The dialysis probe of the embodiment is constructed as described above, and is inserted into the body of an experimental animal such as a rat from the hollow needle 6 at the front end, and the front end of the dialysis membrane 2 is located at the exposed portion of the dialysis membrane. If the part is pulled out of the body, the Ringer's solution supplied to the test part through the conduit 5b passes through the dialysis membrane 2 and is recovered again from the conduit 5a. The drug and the drug enter the dialysis membrane 2 by diffusion and are collected together with the Ringer's solution through the conduit 5a.

[0010]

EFFECTS OF THE INVENTION Since the dialysis probe of the present invention has the above-mentioned structure, the platinum core wire sufficiently opposes the tensile force when it is inserted into the tissue, and at the time of insertion and the part to be examined. Even after indwelling in the tissue, it exerts an extremely effective dialysis and component recovery function without damaging the subject tissue.

[Brief description of drawings]

FIG. 1 is a partially cutaway / longitudinal sectional view of an embodiment.

[Explanation of symbols]

 1 Probe 2 Hollow Fiber Dialysis Membrane 3 Platinum Wire 4 Quartz Tube 5a Tip Flexible Tube 5b Rear Flexible Tube 6 Stainless Steel Hollow Needle 6a Hollow Needle Tip 7 Hollow Needle Rear A Adhesive

Claims (1)

[Claims] 1. A hollow fiber-shaped dialysis membrane having a platinum core wire, and one rigid reinforcing tube is attached to each end of the hollow fiber dialysis membrane, and the both ends including the attachment structure have a smooth surface that does not damage living tissue. And a flexible pipe having flexibility and flexibility, the part of the platinum core wire protruding from both ends of the dialysis membrane including the reinforcing tube insertion part is locked in the material of the conduit. A dialysis probe, further comprising a stainless steel hollow needle connected and fixed to the other end of each of the conduits.