JPH0643281B2 - Acaricide - Google Patents

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to an acaricide.

[0002]

[Background of the Invention] Problems to be Solved by the Invention Mites occurring in tatami or carpets can cause allergic diseases such as rhinitis, bronchial asthma or dermatitis. The number of patients with the above-mentioned diseases is increasing because the hermeticity of buildings is improved and the living environment where heat and moisture are easily stored is a favorable condition for the reproduction of mites.

Organic phosphorus agents, carbamate agents, pyrethroids and the like are known as agents capable of controlling such mite damage.

However, the above-mentioned medicines are not only very expensive, but their safety has recently been regarded as a problem because they cause fatal accidents of infants and clouding of consciousness.

By the way, recently, it has been reported that a mixed solution containing menthol known as an aromatic agent and a cooling agent and alcohol known as an antiseptic agent has an acaricidal effect (special feature: See Kaihei 2-104503).

As a result of repeated studies to obtain an inexpensive and highly safe acaricide, the present inventors have found that the mixed solution contains glutaraldehyde, which is known as a germicidal disinfectant, and pH 7.
The present invention has been found out that the acaricidal effect exhibited by the above mixed solution is improved by mixing with a buffer solution capable of holding 5 to 8.5.

[0007]

That is, the acaricide according to claim 1 of the first invention is (A) menthol, (B) alcohol, (C) glutaraldehyde, and (D) pH7. It contains a buffer solution capable of holding 0.5 to 8.5, and has an alcohol concentration of 60 to 80% by volume.

According to a second aspect of the present invention, the acaricide according to claim 2 is the acaricide according to claim 1, wherein the glutaraldehyde concentration is 2 to 4% by volume.

Used in the first and second inventions (A)
Menthol as an ingredient is not only natural menthol,
It is also possible to use synthetic menthol. Further, 1-menthol or dl-menthol may be used. The natural menthol is Mentha arvensis
L. var. piperacens MALIN
V. Alternatively, it can be obtained from the above-ground whole plants or leaves of its variety or variety.

Synthetic menthol is l-menthone or d
-Citronellal or the like can be obtained as a raw material.

It is preferable to use such menthol dissolved in an organic solvent in advance, but it is not limited to this. As the organic solvent, any solvent can be used as long as it can dissolve menthol, and methyl alcohol, ethyl alcohol, isopropyl alcohol and the like are preferable in terms of easy availability and easy handling. In addition to the above menthol, camphor, eucalyptus oil, eugenol, peppermint oil and the like can be mixed in the menthol-containing liquid.

The alcohol which is the component (B) is not particularly limited, but examples thereof include relatively volatile alcohols such as ethyl alcohol, methyl alcohol and isopropyl alcohol. Among them, it is preferable to use isopropyl alcohol which is inexpensive and has low toxicity.
In addition, denatured alcohol obtained by modifying the above alcohol may be used. For example, so-called methyl alcohol-modified alcohol in which 6.3 liters of 95% concentration of methyl alcohol are mixed with 200 liters of 95% concentration of ethyl alcohol can be used. in any case,
Alcohol concentration in the finally obtained acaricide is 60 ~
Any alcohol and any concentration may be used as the component (B) as long as it is within the range of 80% by volume.

The blending ratio of the component (A) to the component (B) is not particularly limited, but the acaricide finally obtained should contain menthol in an amount of 0.3 to 4.0% by weight. It is preferable to mix it, and it is more preferable to mix it so as to contain 0.6 to 3.0% by weight. If it is less than 0.3% by weight, a sufficient acaricidal effect cannot be obtained, and if it exceeds 4.0% by weight, the aroma of menthol is too strong, which is not preferable. In addition, menthol may be directly mixed into the component (B) as it is as a crystal.

The amount of glutaraldehyde used as the component (C) is not particularly limited, and it is preferable that the amount of glutaraldehyde in the finally obtained acaricide is 2 to 4% by volume. This glutaraldehyde is
It is intended to improve the acaricidal effect obtained by the combination of the component (A) and the component (B). If the blending ratio of glutaraldehyde is less than 2% by volume, the acaricidal effect of menthol cannot be improved, and if it exceeds 4% by volume, the pungent odor of glutaraldehyde tends to be strong.

The above-mentioned glutaraldehyde does not exert its sufficient effect when the pH of the solution containing the glutaraldehyde deviates from the range of 8.5 to 7.5.
It is necessary to maintain the H value. The mixing ratio of the buffer solution is preferably 3 to 7% by volume, but not limited to this. As the buffer solution, it is preferable to use an aqueous solution of diethanolamine having a concentration of 1 to 2% or an aqueous solution of sodium hydrogencarbonate from the viewpoint of easy handling and safety. In this way, the effect of the acaricide can be maintained for about 10 days by mixing the buffer solution.

The method for applying the acaricide of the present invention to an object is not particularly limited, and a cloth impregnated with the acaricide can be used to wipe the object, for example, a tatami mat, but high pressure gas Using the pressure of the acaricide, ultrafine particles (15 ~ 3
0 μm) and spraying is preferable.

As the high-pressure gas, it is preferable to use a liquefied inert gas such as liquefied carbon dioxide gas or liquefied nitrogen gas, but it is not particularly limited. In this case, the acaricide must be sprayed at a mixing ratio far below the dust explosion limit of alcohol with respect to the amount of inert gas. That is, since the lower flammability limit of alcohol in air is around 4% by volume, it is suitable to set it to 0.01% by volume or less, preferably 0.001% by volume.

Further, the vaporized gas pressure of the liquefied inert gas at this time is adjusted to about 3 to 6 kg / cm ^{2 in} gauge pressure and then injected.

By spraying in this way, the above-mentioned acaricide becomes ultrafine particles and becomes an atomized mist, which can evenly invade every corner throughout the spraying space, and the spraying state can be made uniform. , Acaricidal effect appears early.

[0020]

EFFECTS OF THE INVENTION Since the acaricides of the first and second inventions contain menthol, alcohol and glutaraldehyde as main components, they are safer than organic phosphorus agents conventionally used. It has high properties and can be manufactured at low cost. Further, by mixing glutaraldehyde, it is possible to improve the acaricidal effect obtained by the combination of menthol and alcohol.

[0021]

EXAMPLES Examples of the present invention will be described below, but the present invention is not limited thereto. Examples 1 to 12 and Comparative Examples 1 to 12 As the component (A), an alcohol solution of menthol containing 30% by weight of 1-menthol (pharmaceutical) (Shiono Koryo Co., Ltd., trade name: BREEZY (W3137), In addition to menthol, it contained 13.8% by weight of d-camphor, 11.8% by weight of eucalyptus oil, 2.7% by weight of eugenol and 18.2% by weight of peppermint oil). Hereinafter, this is referred to as the (A-1) liquid.

[0022] Adjustment of acaricides (A-1) solution 20ml was mixed with concentration 68.64% isopropyl alcohol 980 ml (isopropyl alcohol concentration 67.27%). This was used as a comparative acaricide.

20 ml of solution (A-1) has a concentration of 89.80.
% Isopropyl alcohol 780 ml, and further 20% concentration of glutaraldehyde 150 ml and purified water 98.75 ml 99% diethanolamine 1.2.
The pH was set and maintained at about 8.0 by mixing with 50 ml of a buffer solution containing 5 ml of a diethanolamine aqueous solution having a concentration of 1.25%. This was used as an acaricide.

Using the above-mentioned comparative acaricides and acaricides, the acaricidal effect on Phytolacca cerevisiae and Dermatophagoides farinae was examined. The test method is as follows.

0.5 ml of the acaricide was dropped onto filter paper (Toyo Roshi Paper No. 5A) cut into 5 cm × 10 cm, and 100 ml, 20 ml and 1 were added per 1 m ^{2 of} the filter paper.
Included 0 ml of acaricide.

The filter paper, on which the acaricide was dropped, was folded in two, and 100 mosquito mites or mosquito deer mosquitoes were put in the paper, and the open side was sandwiched by clips to encapsulate the mites. These were stored in a large-sized tapper having a volume of 9,000 cm ³ sealed at a temperature of 25 ° C. and a humidity of 100%, and taken out after 24 hours or 48 hours. Then, the mites inside were observed with a microscope, the life and death of each tick was judged, and the mortality rate was calculated. Those that did not move when the tick was touched with the tip of a patterned needle were designated as lethal solids. The results are shown in Tables 1 to 4. The above test was performed twice, and the average value is shown in the table.

[0027]

[Table 1]

[0028]

[Table 2]

[0029]

[Table 3]

[0030]

[Table 4]

As is clear from the table, that is, it is clear by comparing the mortality of the comparative acaricide containing menthol and alcohol with the mortality of the acaricide containing a small amount of glutaraldehyde. The mortality of ticks can be improved by mixing glutaraldehyde.

Further, in acaricides, mortality 80% 100 ml / ^{m 2} is Tyrophagus in contact for 24 hours, the Yakehiyouhidani to obtain 100% mortality in 20 ml / ^{m 2.} From this, it is understood that the acaricide of the present invention has fast-acting properties.

Not only does the effect last for at least 48 hours, it can be seen that the acaricide of the present invention has a certain degree of sustainability.

For comparison, the same test as above was carried out also in the case of using a low concentration of isopropyl alcohol in which the alcohol concentration in the finally obtained acaricide was less than 60% by volume. As a result, although some miticidal effect was obtained, it was far below the mortality rate obtained in the examples.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Office reference number FI technical display area A01N 35:02)

Claims (2)

[Claims] 1. A method comprising (A) menthol, (B) alcohol, (C) glutaraldehyde, and (D) a buffer capable of holding pH 7.5 to 8.5 , and having an alcohol concentration of 60 to 80. An acaricide characterized in that the content is% by volume. 2. A solution containing (A) menthol, (B) alcohol, (C) glutaraldehyde, and (D) a buffer capable of holding pH 7.5 to 8.5, and having an alcohol concentration of 60 to 80. capacity%,
A miticide having a glutaraldehyde concentration of 2 to 4% by volume.