JPH0649065B2 - Skin damage protection material - Google Patents

Description

TECHNICAL FIELD The present invention relates to a skin-damaged surface protective material for protecting a damaged surface of the skin such as wounds, burns, eczema, frostbite, and sunburns. The present invention relates to a skin-damaged surface protective material which is excellent in safety, moisture permeability and flexibility, and can protect a skin-damaged surface satisfactorily without causing a rash or the like.

(Conventional technology) Conventionally, when protecting a skin-damaged surface such as a wound surface or a burn surface, (1) apply gauze or absorbent cotton to the damaged surface and stop it with adhesive tape (2) use an absorbent pad on the damaged surface. A so-called emergency medical adhesive pad that is combined with an adhesive bond is applied. (3) A method of applying a cloth containing water to the damaged surface is adopted. However, in the method (1), when the gauze or absorbent cotton is exchanged with the repair of the wound, these may get entangled in the wound and break the wound again, or the gauze or absorbent cotton is pressed with an adhesive tape. There is a problem such as rash due to the adhesive of (1), the method of (2), the adhesive tape for emergency medical care has a wider adhesive tape than the pad, so the part stuck is peeled, rash due to adhesive tape etc. The method (3) has a problem that clothes cannot be worn from above, and therefore it is desired to improve these problems from the past. .

[Problems to be Solved by the Invention]

An object of the present invention is to solve the above-mentioned problems of the conventionally used skin-damaged surface protecting material, and to obtain a safe material having a high therapeutic effect and less pain.

[Means for Solving the Problems]

To achieve the above object, according to the present invention, a gel composition containing a hydrophilic polymer forming a colloidal suspension in a polyhydric alcohol and the polyhydric alcohol is applied to a support, The body is provided with a notch that does not reach its entire thickness, which notch can be torn to open the outside of the support.

Hydrophilic polymers that form colloidal suspensions in polyhydric alcohols include, for example, alginic acid, taracant gum,
Gum arabic, karaya gum, gelatin, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid or a salt thereof, polyethylene oxide, carboxymethyl cellulose and the like can be preferably used.

As the polyhydric alcohol, it is possible to use all those usually used, for example, glycerin, sorbitol, propylene glycol, polyethylene glycol,
One or more of di- or triethylene glycol, 1,3-propanediol, 1,4-butanediol and the like can be used.

The amount of the hydrophilic polymer that forms a colloidal suspension in the polyhydric alcohol is preferably 0.5 to 50% (weight%, the same applies below), particularly 10 to 40% of the total gel composition. The blending amount is preferably 0.5 to 80% of the whole gel composition, and if it is out of these ranges, any one of the moisture retaining property, the adhesive property and the flexibility of the gel composition deteriorates.

Any material can be used as the support, but it is particularly preferable to use a non-woven fabric or gauze.

In the practice of the present invention, a hydrophilic polymer that forms a colloidal suspension in the above polyhydric alcohol, the polyhydric alcohol are mixed as they are, or they are mixed with water to prepare a gel composition. A damaged surface protective material is obtained by applying it to a support having a notch that does not reach the entire thickness. In this case, the amount of water is 20 to 8 of the total gel composition.
The gel composition has a good shape-retaining property even when a large amount of water is added, by using the above-mentioned components. In addition, a gel composition containing such water, which has been dried by heating to remove water, or a water-reduced gel composition, can be suitably used as the protective agent of the present invention.

Further, the gel composition further comprises benzethonium chloride,
Benzalkonium chloride, chlorhexidine gluconate,
Fungicides such as cetiripyridinium chloride and biozole, antihistamines such as chlorpheniramine maleate and diphenhydramine hydrochloride, local anesthetics such as dibucaine hydrochloride, lidocaine, benzocaine and pirocaine hydrochloride, hemostats such as ebilemin hydrochloride, phenyleline hydrochloride and nafazoline hydrochloride. , Shikonin, ictamol, aloe, hinokitiol, glycyrrhizic acid, active ingredients such as ingredients having a wound healing effect such as urea, zinc oxide, bentonite,
A shaping agent such as an inorganic powder such as montmorillonite or titanium oxide may be added.

When the gel composition according to the present invention is spread and applied on a support, it is preferable to spread and apply it to a thickness of 0.1 to 5 mm.

Depending on the wound, a large amount of exudate may come out, but if this exudate is trapped by the protective agent and accumulated there,
May decompose and purify. Since the support used in the present invention is preliminarily provided with a notch that does not reach the entire thickness, a large amount of exudate emerging from the wound surface can be used by appropriately opening the notch. It is possible to prevent the exudate from being stored in the wound surface and the protective material after being discharged to the outside of the protective material after passing through.

〔Example〕

 Next, examples of the present invention will be described.

Example 1 A gel composition having the above composition is uniformly spread on a non-woven fabric so as to have a thickness of 1.0 mm, applied, and naturally dried and then steam sterilized, and a skin-damaged surface protective material of the present invention, particularly dermatome skin We were able to obtain the optimal one for wound pain relief. The effectiveness test of the pain reduction was conducted and the following results were obtained.

(I) Method Select a dermatome wound as a target for use, and regarding the depth, width, site, patient age, etc. of the wound, use the same conditions for both the 15 layers of gauze for comparison of efficacy and this protective material. I chose to be close to.

(ii) Results As a result of comparing the degree of pain every 1, 3, and 7 days after application,
The results shown in FIG. 1 were obtained. a is the case where the protective material according to the present invention is used, b is the case where 15 gauze gauze layers are used, (a) no pain, (b) there is pain,
(C) As a result of dividing into 3 cases of severe pain,
It can be seen that the use of the protective material according to the invention significantly reduces the pain during the day.

Example 2 The gel composition of the above composition is uniformly spread on a non-woven fabric so as to have a thickness of 2.0 mm, applied, dried by heating, and sterilized by steam to protect the skin-damaged surface of the present invention, in particular, red granulation is formed and exudate. We were able to obtain the most suitable material as a therapeutic accelerator for open wounds with reduced number of patients. The efficacy test of the treatment promoting function was conducted and the following results were obtained.

(I) Method The hair of a rat is cut with scissors, the skin surface is washed with soap and water, anesthetized, and a thickness of 25 on both sides of the back with a dermatome.
/ 1000 inch, 7 × 10 mm rectangular scratches were made 10 each. One wound was covered with the protective material of the present invention, and the other wound was overlaid with five pieces of pharmacological gauze, and the area of epithelialization was measured every day to give the epithelialization rate (treatment rate).

(ii) Results The results shown in Fig. 2 were obtained as the rate of epithelialization with respect to the elapsed days. a is the case where the protective material according to the present invention is used, b
In the case of 5 layers of gauze, it can be seen that the present invention achieves a high epithelialization rate in less days.

The same test was carried out on the skin-damaged surface protecting materials of Examples 1 and 2 above, which were dried by heating to remove water, or those which were soaked in physiological saline for 1 to 2 minutes immediately before use. It was confirmed to have an effect.

FIG. 3a is an example of a notch pattern formed on a support, in which discontinuous notches formed on a straight line are arranged in parallel to each other, and the positions of the notches are alternately shifted to row A and row B. It is formed from and. FIG. 4 is a cross-section of the support cut perpendicularly to the longitudinal direction of the cut, and it can be seen that a cut 2 having a depth t smaller than the total thickness d of the support 1 is formed. In Fig. 3a, for example, if a line is cut along the position of a notch in row A and is pulled to both sides in the direction of arrow P at right angles to the longitudinal direction of the notch, the notch at that position tears and the depth t in Fig. 4 becomes Reaches the total thickness d, the third
The holes will be opened as shown in FIG. Therefore,
By selecting the pulling position, it is possible to change the hole position and the number of holes. Therefore, by changing the open state of the cut depending on the amount of exudate on the damaged surface, the exudate can be sufficiently permeated and the accumulation of exudate, which causes suppuration, can be prevented.

The size of the cut is preferably 1 mm≤a (a ') ≤10 mm 0.5 mm≤b (b') ≤5 mm 1 mm≤c (c ') ≤10 mm 0 mm≤x≤a mm in FIG. The cut pattern is not limited to that shown in FIG. 3a, and various combinations of straight lines or curved lines can be used.

〔The invention's effect〕

According to the present invention, a gel composition containing a polyhydric alcohol and a hydrophilic polymer that forms a colloidal suspension in a polyhydric alcohol has adhesiveness when used against a skin-damaged surface. It fits well on the affected area, and it is only necessary to lightly cover it over it with an auxiliary material such as a bandage to prevent it from getting rash due to adhesive tape, etc. Of course, no rashes occur in other parts, and since the moisture permeability is high, the affected area does not get swelled or rashes caused by swelling do not occur, and since it is more flexible, physical irritation of the outside and itself Since there is no notch, and the support is provided with notches that do not reach the entire thickness of the support, an appropriate number of notches are torn and opened depending on the amount of exudate emerging from the damaged surface. Allowed, by discharging the exudate protective material outside, it has various excellent effects such can be prevented danger of suppuration by retention of exudates, which is very effective in the protection of the skin-damaging.

[Brief description of drawings]

1a and 1b are diagrams showing the test results of the pain reducing effect of the protective material according to the present invention and the conventional one, and FIG. 2 shows the test results of the therapeutic effect of the protective material according to the present invention and the conventional one. 3A and 3B are explanatory diagrams of an example of a pattern formed on the support used in the present invention before and after opening, respectively, and FIG. 4 is an example of the support used in the present invention. FIG. 5 is an explanatory view of the size of the pattern formed on the support. 1 ... Support, 2 ... Notch.

Claims (1)

[Claims] 1. A gel composition containing a hydrophilic polymer that forms a colloidal suspension in a polyhydric alcohol and a polyhydric alcohol is applied to a support, and the support reaches the entire thickness thereof. A material for protecting a skin-damaged surface, wherein a notch is provided, and the notch can be torn to open a hole outside the support.