JPH0653156B2 - Autotransfusion set - Google Patents

Description

TECHNICAL FIELD The present invention relates to an autologous blood transfusion set capable of performing transfusion of preserved blood and simultaneous collection of fresh blood.

[Prior Art and Problems] Currently, blood collected in a plastic bag is used for transfusion within 21 days, but actually collected blood is used up to about 7 days. If the storage period becomes long, hemolysis in blood and formation of microaggregates will proceed, and it is not preferable to use these bloods for blood transfusion, and it is desirable to use the collected blood for blood transfusions as soon as possible.

Furthermore, at present, the amount of blood that can be collected from a donor at one time is 400
The limit is ~ 500 ml. This is because collecting a large amount of blood from a donor at one time has a large effect on the living body (anemia, decrease in blood components, etc.) in consideration of the balance of body fluid balance. In addition, there is a risk of infection of syphilis and hepatitis with the fresh blood of others, and it is being promoted to secure autologous blood transfusion.

[Means for Solving Problems] Therefore, in order to solve the above problems and safely and efficiently carry out blood transfusion and blood collection, the present invention is basically (1) a liquid introducing needle 7a connecting pipe 8, 9. Infusion member 2 composed of 9 and drip tube 11 (2) Connection pipe 13a and filters 14a, 15 inside
blood transfusion member 3a including drip tube 12a loaded with a and 16a and equipped with blood introduction needle 17a (3) Blood transfusion needle 20a, connecting pipes 21 and 22, and mixed injection unit 2
Blood transfusion member 4 composed of 3a and 24a (4) Cleaning liquid storage member 6 composed of connecting pipes 27 and 28 and waste bag 26 (5) Connector member 52a composed of connector member 52a and connecting pipe 55a 54a, and each of these constituent members 2, 3a, 4, 6, 51a.
The present invention provides an autotransfusion set that is integrally connected via 2, 43.

[Operation] With the above configuration, the transfusion member 2 is filled with physiological saline into the blood transfusion member 3a. Fresh blood is collected from the donor via the blood transfusion member 4 and is prepared in advance via the connection member 51a. 5a Infusion of physiological saline from the transfusion member 2 into the blood transfusion member 4 Transfusion of the blood preserved by the donor to the blood donor via the blood transfusion member 3a and the blood transfusion member 4 The following operations are repeated, Blood sampling and transfusion are performed alternately in good balance without excess or deficiency so as not to burden the blood donor, and finally the blood donor is replenished with an electrolyte solution from the mixed injection part provided in the middle of the blood transfusion member 4 to the blood donor. It is a blood transfusion that does not reduce the body's physical strength.

[Example] FIG. 1 is a schematic view showing an example of an autologous blood transfusion set 1 of the present invention. The autologous blood transfusion set 1 basically includes a transfusion member 2, blood transfusion members 3a and 3b, a blood transfusion member 4, and a connection member 51.
a, 51b, 51c, and the cleaning liquid storage member 6.

The infusion member 2 is loaded with a liquid introducing needle 7a in which a needle 7c made of stainless steel or the like is implanted in a needle base 7b, connecting pipes 8 and 9 made of flexible polyvinyl chloride, etc., and a filter 10 made of polyamide such as nylon. The drip tube 11 is made of polyvinyl chloride or the like.

The blood transfusion member 3a comprises a drip tube 12a made of polyvinyl chloride or the like and a connecting pipe 13a made of flexible polyvinyl chloride or the like, and the drip tube 12a has therein a filter 14a made of polyethylene terephthalate or the like having different pore sizes,
15a and 16a are loaded, and a blood introduction needle 17a made of polycarbonate or the like and a connection pipe 18a made of polyvinyl chloride or the like with the connection pipe 13a are attached to the ends.

The blood transfusion member 4 includes a needle base 20 that is made of stainless steel or the like.
The blood collection needle 20a, which is implanted in c and has the rotary blade 20d attached to the needle base 20c, and the connecting pipes 21 and 22 made of flexible polyvinyl chloride or the like are provided between the two connecting pipes 21 and 22. Mixed injection parts 23a, 24a made of polycarbonate and having puncturing buttons 23b, 24b made of silicone rubber embedded therein are installed.

The cleaning liquid storage member 6 comprises a waste liquid bag 26 made of flexible polyvinyl chloride or the like and connecting pipes 27, 28 made of flexible polyvinyl chloride or the like, and male lures at the ends of the connecting pipes 27, 28. 29 and 30 are mounted and connected via a connecting pipe 31 made of silicone rubber or the like.
A check valve 33 made of flexible polyvinyl chloride or silicone rubber is attached to the waste liquid inlet 32 of the waste liquid bag 26.

The connecting member 51a is composed of a connector member, that is, a male connector 52a and a connecting pipe 55a, and the lock nut 53a of the male connector 52a is loosely fitted in the middle of the connecting pipe 55a, so that the male connector 52a and the lock nut 53a.
Is covered with the protector 54a and formed so as not to come into contact with the outside air. The connecting member 51a is made of a material such as polyvinyl chloride, polypropylene, or polycarbonate.

These constituent members 2, 3a, 3a, 4, 6, 51a, 5
1b and 51c are connected via connecting pipes 9, 13a and 13b and 21, 22, 27, 28 and 40, respectively, by connecting pipes 41, 42 and 43 made of hard polyvinyl chloride or the like.

Roll clamps A, B, C made of polypropylene or the like are attached to the connecting pipes 9, 13a, 13b, and Jura clamps D, E, F made of polypropylene or the like are attached to the connecting pipes 22, 27, 40.

The liquid introduction needle 7a, the blood introduction needle 17a, and the blood collection needle 20a are capped with needle caps 101, 102, 103 made of polypropylene or the like so as not to come into contact with the outside air.

FIG. 2 shows a blood storage member 5a in which a flexible polyvinyl chloride-based parent bag 56a and a child bag 57a are connected to each other via a connecting pipe 58a.
At the upper end of the, polyvinyl chloride at the tip as a connecting member,
A connecting pipe 59 in which a female connector 81a made of a material such as polypropylene or polycarbonate is attached and a communicating piece 70a made of polycarbonate or the like is arranged in the middle thereof.
a and a connecting pipe 60a to which a slide clamp G made of polypropylene or the like is attached is connected.

The female connector 81a is capped with a protector 82a so as not to contact the outside air.

Next, a method of using the present invention will be described with reference to FIG.

(1) Priming operation The roll clamps A, B, C and the burrs D, E, F are closed and the liquid introducing needle 7a is connected to a container (not shown) in which physiological saline is enclosed. Open roll clamp A and drip tube 11
While pumping, physiological saline is introduced up to a predetermined liquid level in the drip tube 11.

When the liquid level reaches a predetermined level, the roll clamp B is opened, and physiological saline is further introduced into the drip tube 12a through the connecting pipe 13a. When the liquid level reaches a predetermined level, the roll clamp C is further opened to similarly introduce the physiological saline into the drip tube 12b up to the predetermined liquid level.

Then, open the Jura clamps D, E, and F, adjust the opening degree of the roll clamp A, add physiological saline solution, and draw the air in the connecting pipes 40, 27, 28 together with the physiological saline solution in the waste bag 26. Then, the clamps D, E and F are closed and the priming is completed.

(2) The protectors 54a and 82a capped with the male connector 52a of the first blood collection connecting member 51a and the female connector 81a of the blood storage member 5a are broken to fit the male connector 52a and the female connector 81a ( In order to more securely fit and fix the fitting portions, these fitting portions are further fixed with the lock nut 53a.), And the communication piece 70a arranged in the middle of the connecting pipe 59a is cut to disconnect the blood passages of the connecting pipes 55a and 59a. The open blood transfusion needle 20a is punctured in the blood donor to open the clamps E and G.

Blood is collected from the blood transfusion needle 20a, the connecting pipes 21, 22, 55a,
It enters into the parent bag 56a through 60a and 59a.

After the blood collection of a predetermined amount of blood is completed, the slide clamp G arranged in the middle of the connecting pipe 60a is closed, and the roll clamp A. The Jura clamp D is opened and physiological saline is dripped from the infusion member 2 into the blood transfusion member 4 through the connecting pipe 40.
This can prevent blood from stagnating and coagulating in the blood transfusion member 4 before the next operation is performed. At this time, the blood collection needle 20a is left punctured by the blood donor. This is to maintain the closed system until blood transfusion and blood collection are completed.

(3) Blood transfusion operation A blood bag (not shown) in which blood was previously stored and stored by the previous blood collection is attached to the blood introduction needle 17a of the blood transfusion member 13a.
Connect to.

Close roll clamp A, open roll clamp B,
Blood is transfused to the donor via the connecting tubes 13a, 40, 22, 21 and the blood transfusion needle 20a. The blood transfusion rate at this time is about 60 ml /
min (to the extent that a continuous thread does not fall down along the drip core) is preferable.

When the blood transfusion in the blood bag (not shown) is completed, the roll clamp B is closed.

The roll clamp A is opened again, and physiological saline is introduced into the blood collection member 4 in order to prevent the blood remaining in the blood collection member 4 from coagulating.

(4) Second blood collection A new blood storage member 5b (not shown, the configuration of each part is
The same as the above-mentioned 5a, a in FIG. 2 will be referred to as b in the following description. ) Is prepared.

Similar to the first blood collection, the male connector 52b and the female connector 81b are fitted to each other, the communication piece 70b is cut, and the Jura clamp E and the slide clamp 60b are opened. For blood, the blood collection needle 20a is connected to the connecting pipes 21, 22, 5
After entering 5b, 60b, and 59b, the parent bag 56b is entered.

After collecting a predetermined amount of blood, the clamp E is closed and the clamp A is opened, and physiological saline is dropped from the transfusion member 2 to the transfusion member 4.

(5) Termination The clamp E is closed and the electrolyte solution prepared in advance is replenished to the blood donor through the mixed injection part 23a, the connecting pipe 21, and the blood transfusion needle 20a.

Finally, the connecting pipes 60a and 60b are hermetically welded with a welder, the blood storage members 5a and 5b are separated, and stored at 4 ° C. for use in the next blood transfusion.

In the autologous blood transfusion set of the present invention, the blood transfusion member 3 is provided by newly connecting the connecting pipes 44 and 45 as shown in FIG.
c, connection members 51d and 51e (in addition to the shape and structure shown in FIG. 1, a blood bag inlet and a protector of a blood bag that are normally used can be used) can be added.

In this way, a dozen or more aspects can be implemented by combining with a blood storage member having various blood volumes,
As shown in Table 1, blood collection patterns are combined according to the donor's health condition and physical strength to determine the amount of blood to be prepared before blood collection.

Next, specific examples of each part of the autotransfusion set of the present invention will be described.

As another embodiment of the connecting member 51a, for example, as shown in FIG. 4, a female connector 91 having a thin film 94 formed therein (for example, a blood transfusion port used in a normal blood bag) is connected to the other end. The thin film 94 is attached to the blood storage member 5a of
A breakable needle member 93 (for example, a Roketon needle used for a normal blood transfusion or infusion set) may be attached. The needle member 93 may be crowned with a needle cap other than the protector.

When there are two or more pairs of blood transfusion members, a plurality of connecting pipes 63a and 63b having blood introducing needles 62a and 62b attached thereto may be attached to one drip tube 61 as shown in Fig. 5 (a). good. Alternatively, as shown in FIG. 5 (b), the connecting tube 64 of the infusion member may be attached to the drip tube 61 together with the connecting tubes 63a and 63b.

As a result, the number of parts can be reduced by the amount of the reduced drip tube.

A specific mode of the check valve 33 formed in the cleaning liquid storage member 6 is shown in FIGS. 6 and 7. (A) is a top view, (b) is an AA sectional view and a BB sectional view of (a).

The check valve 64 shown in FIG. 6 is formed by stacking two sheets of flexible polyvinyl chloride 65 on each other and forming the end portion 66 as a heat seal. The check valve 67 shown in FIG. 7 is generally called a "duck's beak valve", and is integrally formed of flexible polyvinyl chloride or silicone rubber. 68 is a beak portion formed thinly. After introducing the cleaning liquid into the waste liquid bag 26 by mounting these check valves 64, 67 on the waste liquid introduction port 32 of the waste liquid bag 26,
When pressure is applied from the outside of the waste liquid bag 26, the external pressure acts in the direction of crushing the seats 65, 65 of the check valve 64 and the beaks 68, 68 of the check valve 67. Hygiene is maintained without invading the inside of the set.

The male lures 29, 30 attached to the ends of the connecting pipes 27, 28 of the cleaning liquid storage member 6 are used as follows.

When blood is drawn by puncturing a blood donor with the blood transfusion needle 20a, if a problem such as blood cell clogging occurs inside the needle 20b of the blood transfusion needle 20a, remove the connecting tube 31 to expose the male luer 30. Then, for example, as shown in FIG. 9, the blood collecting needle 71 is connected to the female luer 72 of the blood collecting needle 71 prepared for a spare, and the blood collecting needle 71 is punctured by the donor.

Blood is introduced into the main bag 35a of the blood storage member 5a via the connecting pipes 27 and 37a. On the contrary, the blood collection needle 20a is connected to the other male luer 29 and used for waste liquid treatment.

Various filters 14a, 15 loaded inside the drip tube 12a
The pore sizes of a and 16a are 210 μ, 160 μ, and
The size is 35μ, which is small from the blood inlet to the outlet. As a result, it is possible to completely prevent microaggregates in blood from entering the autotransfusion set.

The filters 14a, 15a and 16a are laminated and welded in the drip tube, and 16a is attached to the lower end of the drip tube by welding.

14a, 15a and 16a are collectively laminated and attached to the inner surface of the drip tube by welding.

As described above, the drip tube 12a can be loaded.

In the blood storage member 5a (the parent bag 56 via the connecting pipe 58a
The child bag 57a (attached to a) is used when the blood collected in the parent bag 56a is sampled for a blood test or the like. It is especially useful for blood tests that require large sample volumes.

As described above, while repeating blood transfusion and blood collection, it is performed so that the blood collection amount is relatively large, and the blood donor is provided with a replacement fluid corresponding to the amount of blood collected from the blood donor.
The burden on the donor is small.

Further, the liquid introduction needle 7 attached to the autotransfusion set of the present invention
a, the number of blood introducing needles 17a, the number of blood transfusion needles 20a and the connecting tube 4
The shapes of 1, 42, 43 and the respective constituent members 2, 3a, 4,
Materials such as 6, 51a can be arbitrarily set according to the purpose of use.

[Effects of the Invention] As described above, the autotransfusion set of the present invention transfuse blood collected from a donor without loss of freshness, and at the same time, equilibrium the blood in an amount equal to or greater than the amount transfused from the donor. Since it is possible to collect blood without disturbing the balance of the above, and these can be used in a recycling system, it is particularly suitable for the preservation and self-transfusion of the donor's own blood.

The components (1) to (5) are integrally connected, and by appropriately selecting the number of connecting members and the capacity of the parent bag in the blood storage member connected to the connecting members, an autologous house corresponding to various donors Blood transfusion can be carried out.

It is an excellent invention having the effects of the above.

[Brief description of drawings]

FIG. 1 is a schematic diagram showing the basic configuration of the autotransfusion set of the present invention. FIG. 2 is a schematic view of a blood storage member used by connecting to the autotransfusion set of the present invention. FIG. 3 is a schematic view showing another embodiment of the autotransfusion set of the present invention. FIG. 4 is a schematic view showing another embodiment of the connecting member of the autotransfusion set and the connecting member of the blood storing member of the present invention. FIG. 5 (a) is a schematic view showing another embodiment of the infusion member constituting the autotransfusion set. FIG. 5B is a schematic view showing another embodiment of the liquid transfusing member and the blood transfusing member. 6 and 7 show an embodiment of the check valve mounted on the cleaning liquid storage member, (a) is a plan view,
(B) is sectional drawing of (a). FIG. 8 is an enlarged view of the vicinity of the connection pipe of the cleaning liquid storage member. FIG. 9 is a schematic view showing an example of how to use the male luer of the cleaning liquid storage member. In the figure, 1 is an autotransfusion set, 2 is a transfusion member, 3 is a transfusion member, 4 is a transfusion member, 5a and 5b are blood storage members, 6 is a cleaning liquid storage member,
11, 12a and 12b are drip cylinders, 7a is a liquid introduction needle, 1
7a is a blood introduction needle, 20a is a blood transfusion needle, and 23a and 24a.
Is a mixed injection part, 26 is a waste liquid bag, 29 and 30 are male lures, 31 is a connecting pipe, 33 is a check valve, 35a and 35b are parent bags, 36a and 36b are child bags, 41, 42 and 4
3, 44, 45 are connecting pipes, 8, 9, 13a, 13b, 2
1, 22, 27, 28, 55a, 55b, 55c, 59
a, 60a are connecting pipes, 51a, 51b, 51c, 51
d, 51e are connecting members, 52a is a male connector, 53
a is a lock nut, 54a and 82a are protectors, 7
0a is a communication piece, 81a and 91 are female connectors, 9
3 is a needle member, 94 is a thin film, A, B and C are roll clamps, D, E and F are Jura clamps, and G and H are slide clamps.

Claims (1)

[Claims] 1. An autologous blood transfusion set used for collecting a predetermined amount of blood from a blood donor and storing it in advance, and collecting a new predetermined amount of blood from the blood donor. (1) A transfusion member composed of a liquid introduction needle, a connecting pipe and an infusion tube (2) A blood transfusion member composed of an infusion tube having a connecting tube and a filter loaded therein and a blood introduction needle attached (3) Blood collection A blood transfusion member including a needle, a connecting pipe, and a mixed injection unit (4) A cleaning liquid storage member including a connecting pipe and a waste bag (5) A connector member and a connecting pipe, which are covered by a protector A connecting member consisting of the above (1) to (5) are integrally connected via a connecting tube.