JPH066173B2 - Blitz Chemotherapy Device - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to electric shock chemotherapy which can improve the effect of chemotherapy by arranging electrodes on both sides of the malignant tumor and applying a high voltage pulse to the electrodes when performing chemotherapy for malignant tumor. The present invention relates to a device for safely and reliably executing.

[0002]

2. Description of the Related Art Chemotherapy for malignant tumors generally has a large number of side effects, but even if they effectively act on cancer cells, they also adversely affect normal cells, resulting in wasting of the body, and a sufficient therapeutic effect cannot be expected. On the other hand, a drug with few side effects could hardly be expected to have an effect on cancer cells. However, in experiments using rats and mice, when giving chemotherapy,
When electrodes are placed on both sides of a tumor and a high-voltage pulse is applied to the electrodes, a marked reduction in tumor is observed even in the case of administration of various anticancer agents, which had little effect with the drug alone.

For this reason, the applicant of the present invention has previously proposed JP-A-3
The one described in Japanese Patent No. 236861 is well known.

In this conventional example, an electrocardiographic signal detection unit 1 for picking up an electrocardiographic signal C generated with the contraction of the heart.
And a trigger signal generator 2 for generating a trigger signal F synchronized with the electrocardiographic signal C detected by the electrocardiographic signal detector 1.
And the trigger signal F obtained from this trigger signal generator 2
And a high-voltage pulse generator 3 for outputting a high-voltage pulse H between electrodes P1 and P2 that are paired with each other with the affected cell tissue sandwiched therebetween.

[0005]

In order to prevent careless operation or malfunction of the electrodes P1 and P2 from inadvertently outputting a high-voltage pulse, the high-voltage line is normally grounded to the ground by a manual relay switch. Even if the high-voltage pulse mixes into the high-voltage line side, it flows to the ground and is not applied to the living body. To output a high-voltage impulse, the safety relay circuit is manually opened to ground, and then a high-voltage impulse is generated in synchronization with the R wave of the electrocardiogram.

After the occurrence, safety can be secured by manually grounding the high voltage line. That is, FIG.
First, the safety switch is manually opened to enable output, as shown in FIG. 3, and then the start button is pressed to generate the start signal D.

After the start signal D is generated, the trigger signal F is generated in synchronism with the first electrocardiographic signal R wave, whereby the high voltage trigger circuit is switched and the high voltage impulse H is output.

[0008] In this conventional example, there are the following problems when trying to achieve electrocardiographic synchronization. That is, the electrocardiographic signal is extremely weak at about 1 mv and is easily affected by external noise. When the safety switch is closed, the output lines of the device are all grounded, so the electrocardiographic signal can be safely picked up.

However, when the safety switch is opened and the high-voltage output line floats above the ground, noise is mixed, and the noise is mixed into the living body to be treated (also the target of electrocardiographic detection) through the treatment electrode.

These external noises sometimes reach a level several times higher than that of the electrocardiographic signal, and the electrocardiographic signal cannot be detected. As a result, accurate electric shock chemotherapy cannot often be performed. In addition to the big problem, there was a problem that it was troublesome in terms of operability.

In order to eliminate the above-mentioned problems, the present invention arranges electrodes on both sides of a malignant tumor and applies a high voltage pulse synchronized with an electrocardiographic signal to the malignant tumor when performing electrochemotherapy of the malignant tumor. To provide an execution device capable of safely and surely improving the effect of electrochemotherapy by preventing the external noise from being mixed in and without adversely affecting the heart by releasing the grounding of the high-voltage output line for a predetermined time from immediately before. With the goal.

[0012]

The above-mentioned object of the present invention is to detect an electrocardiographic signal for picking up an electrocardiographic signal generated by the contraction of the heart, and a heart detected by the electrocardiographic signal detecting section. A high-voltage pulse is output between a trigger signal generator that generates a trigger signal synchronized with the electric signal and electrodes that form a pair of electrodes that sandwich the affected tissue based on the trigger signal obtained from the trigger signal generator. A high-voltage pulse generator, a safety circuit for grounding the high-voltage output line of the high-voltage pulse generator, and a grounding contact of the circuit being releasable for a predetermined time in synchronization with the trigger signal. Can be achieved with.

[0013]

The electric shock chemotherapeutic device according to the present invention is one of the treatment methods for malignant tumors.
Treatment is performed by applying an impulse of ˜7000V. At this time, in order to avoid adverse effects on the heart, the high-voltage impulse can be applied in synchronization with the electrocardiographic R wave.

That is, the basic operation (action) of the present invention
Detects the electrocardiographic signal due to the R wave in the electrocardiographic signal generated by the contraction of the heart muscle with the electrocardiographic signal detection unit, and AND gates the electrocardiographic signal and the start signal generated by the operation of the operation panel. The affected part while the safety circuit for grounding the high-voltage output line based on the output pulse, that is, the trigger signal obtained in synchronization with the electrocardiographic signal generated during the start signal duration from the operation panel is released for a predetermined time. By outputting a high-voltage pulse of about 3 to 7 KV from the high-voltage pulse generator between the pair of electrodes sandwiching the cell tissue in between during the electrical dead time of the heart, the occurrence of cardiac arrest and fibrillation can be prevented. Can perform blitz chemotherapy while strictly preventing it.

The external inductive noise that is constantly generated in the living body or the high-voltage output line can be grounded and removed by the safety circuit during most of the time except when the high-voltage pulse is applied to the living body, and the electrocardiographic signal is surely picked up. Therefore, it is possible to eliminate the dangerous and useless application of the high-voltage impulse to the living body that occurs when unnecessary.

[0016]

EXAMPLES Examples will be described with reference to the drawings. First, as shown in FIGS. 1 and 2, the basic configuration of the present invention is an electrocardiographic signal detection unit 1 having an electrode A for picking up an electrocardiographic signal C generated with the contraction of the heart, and the electrocardiographic signal. A trigger signal generator 2 with an AND gate circuit, which is synchronized with the electrocardiographic signal C detected by the detector 1 and generates a trigger signal F by a start signal D from the operation panel B.
With.

Then, based on the trigger signal F synchronized with the electrocardiographic signal C obtained from the trigger signal generator 2, a high voltage pulse H is applied between a pair of electrodes P1 and P2 oppositely sandwiching the affected tissue. And a high-voltage pulse generator 3 for outputting.

Further, a safety circuit 4 for grounding the high-voltage output line of the high-voltage pulse generator 3 is provided so that the normally-closed grounding contact piece 4e in the circuit 4 can be released for a predetermined time in synchronization with the trigger signal F. Constitute.

That is, the safety circuit 4 has the trigger signal F generated in the trigger signal generator 2 and the start signal D from the operation panel B as shown in the dotted frame in FIG.
Can be supplied and applied to the input side of the AND circuit 4a, and the time width of the AND output can be applied to the signal time width extension circuit 4b such as the one-shot multivibrator in the next stage.
With the desired time width, the relay coil 4d is excited through the drive circuit 4c, and the normally-closed grounding contact 4e.
Is configured to be released when a high-pressure pulse is applied to the living body.

The electrocardiographic signal detector 1 selectively detects only the R wave from the electrocardiographic signals picked up by the well-known electrode A, and outputs an electrocardiographic signal C as shown in FIG. The trigger signal generator 2 outputs a trigger signal F as shown in FIG. 2 synchronized with the electrocardiographic signal C immediately after the start signal D from the operation panel B is applied. The high voltage pulse generator 3 generates a high voltage pulse H synchronized with the trigger signal F as shown in FIG.

P1 and P2 are therapeutic electrodes, which are arranged on opposite sides of the cancer tissue so as to face each other.

As a means for selectively detecting only the R wave from the three electrocardiographic signals, the fact that the voltage amplitude of the R wave is larger than that of the Q wave and the S wave is used, for example, a well-known slicer circuit or the like. Thus, it is possible to detect only the electrocardiographic signal C due to the R wave that is larger than the set voltage level.

Further, in order to obtain the high voltage pulse H synchronized with the trigger signal F, the current flowing through the primary winding of the step-up transformer whose winding ratio is set to about 1:25 is switched by the switching element such as a power transistor. By intermittently synchronizing with the trigger signal F, a high voltage pulse H of about 5 to 10 KV can be obtained from the secondary high voltage winding in synchronization with the electrocardiographic signal C as shown in FIG.

In FIG. 2, the electrocardiographic signal C is detected as one pulse for each heartbeat. The trigger signal F is output in synchronization with the electrocardiographic signal C immediately after the start signal D is applied.

Depending on the operation timing of the operation panel B, if the start signal D is applied in the area of the electrocardiographic signal C, an AND output pulse between the start signal and the electrocardiographic signal does not occur, and the next electrocardiographic signal C is generated. The trigger signal F is output in synchronism with.

The normally-closed contact piece 4e in the safety circuit 4 is opened in synchronization with the trigger signal F as shown in FIG. In this way, the living body is grounded to the ground until the trigger signal F is generated, external noise is not mixed, and the electrocardiographic signal C can be stably picked up. Although the external noise is mixed after the trigger signal is generated, the purpose of picking up the electrocardiographic signal C is to obtain the trigger signal F synchronized with the electrocardiographic signal C. Therefore, mixing the external noise after the trigger signal is generated impairs the operation. Don't come

Since a grounding relay, for example, in the safety circuit 4 is a mechanical component, it takes 10 to 20 msec to operate. The output of the high voltage impulse shall be when the safety circuit 4 is fully open. If it is output before that, it means that a high voltage is applied to the short-circuited circuit, which causes a trouble such as burnout of the output circuit.

Actually, the generation of the high-voltage impulse is made 30 to 30 times from the trigger signal F by a well-known delay circuit or the like as shown in FIG.
It is set after 40 ms.

As a result, the high-voltage impulse H is delayed from the R wave of the electrocardiographic signal by 30 to 40 ms, but such a delay does not adversely affect the living body.

In summary, according to the present invention, the electrocardiographic signal detected by the R wave in the electrocardiographic signal generated by the contraction of the heart muscle is detected by the electrocardiographic signal detecting section, and the electrocardiographic signal and the operation panel are operated. An AND gate output pulse with the generated start signal, that is, a pair of electrodes opposed to each other across the affected tissue based on the trigger signal obtained in synchronization with the electrocardiographic signal during the start signal duration from the operation panel During this period, a high-voltage pulse from the high-voltage pulse generator is output during the electrical dead time of the heart, and the high-voltage output line is released for a predetermined time including this output to apply a high-voltage impulse to the affected part of the living body. It is possible to safely carry out electrochemotherapy while blocking the outbreak of inductive noise that is harmful to the ECG signal pickup while strictly preventing the occurrence of cardiac arrest and fibrillation.

[0031]

Since the present invention is constructed as described above, it has the following effects. By outputting a high-voltage pulse from the high-voltage pulse generator between the paired electrodes that sandwich the affected tissue based on the trigger signal synchronized with the electrocardiographic signal generated with the contraction of the heart, the heart It is possible to safely carry out shock chemotherapeutic therapy while sufficiently preventing the occurrence of stoppage and fibrillation of the patient, and in particular, in the present invention, the external inductive noise that is always generated in the living body or the high voltage output line is applied except when the high pressure pulse is applied to the living body. Since the safety circuit can remove the ground during most of the time, and the ECG signal can be picked up without fail, it is possible to eliminate the dangerous and useless application of high-voltage impulse that is accidentally generated by external noise when unnecessary. There is a great effect that you can.

[Brief description of drawings]

FIG. 1 is an electrical system circuit diagram of an embodiment of the present invention.

FIG. 2 is an explanatory diagram of the operation of FIG.

FIG. 3 is an operation explanatory diagram of a conventional one.

[Explanation of symbols]

 1 ECG signal detector 2 Trigger signal generator 3 High voltage pulse generator 4 Safety circuit 4a Grounding contact A Electrode B Operation panel C ECG signal D Start signal F Trigger signal H High voltage pulse

Claims (1)

[Claims] 1. An electrocardiographic signal C generated with the contraction of the heart.
From the electrocardiographic signal detection unit 1 for picking up the electrocardiogram, the trigger signal generation unit 2 that generates the trigger signal F synchronized with the electrocardiographic signal C detected by the electrocardiographic signal detection unit 1, and the trigger signal generation unit 2 A high-voltage pulse generator 3 for outputting a high-voltage pulse H between electrodes P1 and P2 forming a pair on opposite sides of the affected cell tissue based on the obtained trigger signal F. Provide a safety circuit 4 that grounds the high-voltage output line of the
An apparatus for executing electric shock chemotherapy, which is configured so that 4e can be released for a predetermined time in synchronization with the trigger signal F.