JPH066524B2 - Hair nourishing cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION <Industrial field of application> The present invention relates to a hair nourishing cosmetic having excellent hair nourishing and hair-growth effects.

<Prior Art> When the wound part due to burns or the like is covered with the egg yolk film of avian egg, the egg yolk film adheres to the wound part and the epithelial formation of the skin is promoted. As is clear from this, the eggshell membrane has a good wound healing effect.

Although this mechanism is not yet clear, it is not only by a passive action such as suppression of exudate from wounds by the egg membrane and prevention of bacterial infection, but unknown active ingredient is leached from the egg membrane, It is speculated that it may be directly or indirectly due to an active action such as promoting proliferation of fibroblasts.

From these facts, there is known a hair nourishing agent prepared by blending an egg grain film with a usual hair nourishing cosmetic raw material (JP-A-48-48).
No. 40944).

<Problems to be Solved by the Invention> Needless to say, hair is formed by keratinization as hair mother cells move upward, but its growth,
Differentiation requires various nutrients and oxygen supplied from capillaries in the papilla, and interaction with fibroblasts is also an important factor, and there are various other factors. That is, since hair growth and hair growth are the result of complicated entanglement of these factors, it is sufficient to add only a component having a hair mother cell activating action or a component having a blood circulation promoting action to the hair nourishing agent. No effective hair-growth effect can be expected.

Therefore, since the hair restorer proposed above simply contains the egg grain film, it does not exhibit the expected hair restorer effect.

From the above, if an effective hair-growth agent or hair-growth agent is to be obtained, how to combine a plurality of effective hair-growth components having different physiological activities, and how to produce a synergistic effect Seems to be important.

Therefore, as shown in, for example, Japanese Patent Laid-Open No. 63-146806, a combination of a plurality of hair nourishing components is being studied, but due to the weak activity of the hair nourishing components, no one can expect a sufficient effect. Not obtained.

In view of such circumstances, an object of the present invention is to provide a hair nourishing cosmetic excellent in hair nourishing and hair-growth effects.

<Means for Solving the Problems> As a result of earnest research to achieve the above object, the present inventor has found that a hair nourishing cosmetic using a soluble egg grain membrane and vitamin E or a derivative thereof The inventors have found that the effect is excellent and completed the present invention.

The cosmetic of the present invention comprises a soluble egg grain film and vitamin E.
And at least one selected from derivatives thereof.

In the present invention, the soluble egg grain film refers to a film obtained by solubilizing a film (egg layer) attached to the inside of the egg grain of an avian egg such as a chicken egg and a quail egg (egg layer), specifically Means an egg grain film solubilized with an acid agent, an alkali agent, an organic solvent, an oxidizing / reducing agent, an enzyme, or the like. Since such a soluble egg grain membrane is not generally commercially available, an example of a method for obtaining a soluble egg grain membrane by treating the egg grain membrane with an acid, an alkali or the like by a conventional method will be shown here.

First, the egg grain film is decomposed in an alkaline water-containing organic solvent. Here, the alkaline hydrous organic solvent is caustic soda,
Add an alkaline agent such as caustic potash to reduce the alkali concentration to 0.
A mixture of 70 to 40% (weight%; the same applies hereinafter) of 2 to 3.0 N and 30 to 60% of a water-soluble organic solvent such as methanol, ethanol, or acetone. Appropriate conditions for the decomposition treatment are 30 to 60 ° C. and 1 to 8 hours.

Next, the obtained separated liquid is neutralized and passed to obtain a solution of a soluble egg grain film. In addition, if this solution is dried by a conventional method, a powdery soluble egg grain film is obtained.

On the other hand, as vitamin E, α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocoriere, β-tocoriere, γ-tocoliere, which are classified according to the number and position of the methyl group of the chroman nucleus, are used. , Δ-tocolier and eight optical isomers thereof, and these optical isomers exist, and any of them can be used in the present invention.

Further, as the vitamin E derivative, tocopherol succinate, tocopherol acetate, tocopherol calcium succinate, tocopherol nicotinate, etc. are well known, but in the present invention, other similar derivatives and derivatives that can be produced by known techniques Any of these can be used.

In the present invention, one kind or two or more kinds may be selected from these vitamin E and derivatives thereof (both are referred to as vitamin Es hereinafter) and used.

Further, the hair nourishing cosmetics in the present invention include all those similar to hair cosmetics such as hair nourishing agents, scalp agents, hair styling agents, and hair washes.

To obtain the hair nourishing cosmetic of the present invention, the soluble egg grain film,
At least one selected from vitamin Es may be added to a usual cosmetic raw material to prepare a hair nourishing cosmetic by a conventional method.

Here, the usual cosmetic raw materials are different depending on the type of hair nourishing cosmetic, but for example, oil, water, surfactants, moisturizers, alcohols, chelating agents, coloring agents, preservatives, coloring agents, perfumes, etc. is there.

The content of the soluble egg grain film is 0.01 to 10% of the total amount of the cosmetic raw material in terms of dry matter, and the content of vitamin Es is 0.
01-5% is desirable.

In any case, if the blending amount is too small, there is a tendency that the hair-restoring and hair-growing effect of the obtained hair-restoring cosmetic cannot be expected.
On the other hand, if the amount is too large, the obtained hair nourishing cosmetic tends to be sticky, which is not desirable.

The hair nourishing cosmetic composition of the present invention is excellent in hair nourishing / hair-growth effect because it simultaneously improves blood flow in the scalp and simultaneously supplies and stimulates various components by using the egg grain film and vitamin E in combination. Conceivable.

<Example> (1) Preparation of soluble egg grain film After breaking the egg with a grain to remove the egg liquid, the resulting egg grain with an egg grain film is put into fresh water, and the egg grain is manually removed. Then, an egg grain film was obtained. Then, the obtained egg grain film was immersed in a 1% hydrochloric acid aqueous solution for 1 hour to dissolve the minute egg grains attached to the egg grain film, followed by washing with water and drying in the sun to obtain a dried egg grain film.

To 100 g of the dried eggshell membrane thus obtained, 1200 ml of 2N sodium hydroxide aqueous solution and 800 ml of absolute ethanol
Was added, and the mixture was treated at 40 ° C. for 5 hours with stirring to solubilize the egg grain film.

Next, the obtained liquid is separated with a cloth filter, neutralized,
After desalting, it was freeze-dried to obtain 53 g of a powdery soluble egg grain film.

(2) Manufacture of hair tonic The following raw materials were prepared.

A hair tonic was produced by a conventional method using these raw materials.

(3) Production of hair cream The following raw materials were prepared.

A hair cream was produced by a conventional method using these raw materials.

<Test Example> Test Example 1 (Hair Growth and Hair Growth Test) The following four types of samples were prepared.

Test group: Hair tonic obtained in Example (2) Control group 1: In the formulation of hair tonic of Example (2),
A hair tonic control group 2: Example (2) obtained by using the same amount of purified water as in Example 2 but substituting the soluble egg yolk membrane with the same amount of purified water In the formulation of hair tonic,
Hair-tonic control group 3: Example (2) ) In the formulation of hair tonic,
A hair tonic obtained by using the same amount as in Example (2) in the same blending ratio as in Example 2 except that the soluble egg yolk membrane and DL-α-tocopherol were replaced with the same amount of purified water. The backs of 40 C3H mice (male, 50 days old) were shaved and divided into 4 groups of 10 mice, and the hair tonics of the above test groups and control groups 1 to 3 were applied to each group twice a day in the morning and evening, 0.1 times. m
l was applied for 20 days. Then, the weight of hair regenerated in the test area was measured, and the average hair weight of each group was calculated. The results shown in Table 1 were obtained.

According to the results shown in Table-1, when the soluble egg grain membrane and vitamin Es were used in combination (test group), they were used alone (control groups 1 and 2) and not used at all (control group). It was confirmed that the hair-growth / hair-growth effect was higher than that of 3).

Test Example 2 (Practical Test) Three types of hair tonics, the test section and the control section 1 and 2 used in Test Example 1, were prepared.

30 test subjects with male baldness were divided into 3 groups of 10 groups, and the hair tonics of the test section and the control sections 1 and 2 were applied to the head continuously for 2 months in the morning and 2 times for each group. After that, when the number of persons who answered that "there is a hair nourishing effect", a "hair loss preventing effect", and a "dandruff and itch preventing effect" was calculated, the results shown in Table 2 were obtained.

From the results shown in Table-2, when the soluble egg grain film and vitamin Es were used in combination (test group), compared to the case where they were used alone (control groups 1 and 2), they were obviously nourished. It was recognized that the hair effect, the hair loss prevention effect, and the dandruff / itch itch prevention effect were high.

<Effects of the Invention> As described above, the hair nourishing cosmetic of the present invention contains a soluble egg grain film and vitamin Es, and therefore has excellent hair nourishing / hair-growth effects, hair loss prevention effects, and dandruff. It has an anti-itch effect.

Claims (1)

[Claims] 1. A hair nourishing cosmetic composition comprising a soluble egg grain film and at least one selected from vitamin E and its derivatives.