JPH066525B2 - Hair nourishment - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a hair nourishing agent which has an excellent hair nourishing effect and is effective in preventing dandruff and itchiness.

[Conventional technology and problems] Conventionally, as a hair-growth agent and hair-growth agent for preventing and treating male pattern baldness, peripheral vasodilators, cell activating agents, sebum secretion inhibitors, anti-inflammatory agents, amino acids, vitamins, etc. Although various hair nutritional ingredients and medicinal ingredients have been added, none of them has sufficiently satisfactory effects.

In recent years, it has been clarified that 5α-dehydrotestosterone, which is a metabolite of the male hormone testosterone, has a great influence on the cause of alopecia. Accordingly, as preventive and therapeutic agents for male pattern baldness, 5α-reductase inhibitors that suppress the production of 5α-dehydrotestosterone, and binding inhibitors that inhibit the binding of 5α-dehydrotestosterone and its receptor Attention has been paid. As such a 5α-reductase inhibitor, for example, oleic acid is known (JP-A-59-152308).
However, the effect is still unsatisfactory.
Further, any drug that inhibits the binding between 5α-dehydrotestosterone and the receptor has a structure similar to a steroid hormone, and there is concern that it may exert a hormonal action by itself, and it has not been put to practical use.

[Means for Solving the Problems] In view of such circumstances, the present inventors have made earnest studies on a medicinal agent having an excellent effect on the prevention and treatment of alopecia and having no side effect. As a result,
The present invention has been completed by discovering that an excellent hair-growth effect can be obtained by combining the extract of sardines, chamomile and burdock and cepharanthin together, and that it is also effective in preventing dandruff and kayumi.

That is, the present invention provides a hair nourishing agent characterized by containing an extract of at least one plant selected from Scutellaria barbata, Scutellaria baicalensis, Chamomile and Burdock, and cepharanthin as an active ingredient.

The active ingredient of the first group of the hair nourishing agent of the present invention is the flower part of Calendula officinalis L. (Asteraceae),
The root of Scutellaria baicalensis Georgi (Lamiaceae), the flower part of chamomile [Matricaria chamomilla (Asteraceae)] or the root of burdock [Arctium lappa (Asteraceae)] is a suitable solvent, preferably a low monovalent or polyvalent Obtained by extraction with alcohol or a water-containing solvent thereof.

The lower monohydric alcohol used for extraction has 1 to 1 carbon atoms.
3 alcohols such as methanol, ethanol, propanol, isopropanol and the like. Of these, ethanol is preferable, and water-containing ethanol (water content 10
-80%, preferably 30-70%) is the best.

Examples of the lower polyhydric alcohol include alcohols having 2 to 4 carbon atoms, such as ethylene glycol, propylene glycol, 1,3-butylene glycol and glycerin. Of these, 1,3-butylene glycol is most preferred, but hydrous alcohol (water content 10-80
%, Preferably 30 to 70%).

The extraction operation may be carried out by a known method such as a batch method or a reflux method, and 1 part of a dried plant material (finely disintegrated in the case of flower parts, finely chopped in the case of root parts) of extraction solvent 3 Add ~ 30 parts. Extraction temperature is room temperature, under heating,
Either may be used, but approximately 1 in the temperature range of room temperature to 80 ° C.
It is preferable to carry out the stirring for 10 hours under mild conditions. The extraction operation is repeated several times, and the extracts are combined and then concentrated to dryness under reduced pressure at a temperature of 40 ° C. or less as much as possible to obtain an extract.

The extract of Scutellaria baicalensis, Scutellaria baicalensis, Chamomile and Burdock, which are the active ingredients of the hair restorer of the present invention, is not particularly toxic to the human body, and therefore the amount thereof to be added to the hair restorer is not particularly limited, but is usually 0.01 to 20. %, Preferably 0.1-10%.

The second active ingredient, cepharanthin, which is incorporated into the hair nourishing agent of the present invention, is a viscoclaurin-type alkaloid contained in plants of the family Astragalus.

To obtain cepharanthin, a tertiary alkaloid fraction is extracted from an alcoholic extract of a plant belonging to the family Amaranthaceae such as Tamasaki Tsuduraji by the usual plant base extraction method, and then purified and separated by a combination of column chromatography and the like (for example, Yamaguchi. Kazutaka, "Methods for analyzing plant components" (Nankodo, vol. 1, p. 433, 1958).

In the hair nourishing agent of the present invention, the compounding amount of cepharanthin is 0.00
It is 01 to 2%, preferably 0.0005 to 0.1%.

Next, the results of testing the effects of various alcohol extracts of the above-mentioned plants to be incorporated into the hair nourishing agent of the present invention are shown.

[Hair growth promotion test using C3H mouse] Each extract was dissolved in ethanol to adjust the weight to 0.5%. Cepharanthin was added to a concentration of 0.1%. After cutting the back of an 8-week-old C3H male mouse,
From the next day, the extracted extract was applied once a day to the shaved part for 15 days, and the effect on the hair regeneration of the part was examined.

The effect of the extract was expressed as a relative ratio when the hair weight of the control group (ethanol application group) was 100%. The results are shown in Table 1 below.

As is clear from Table 1, all the active ingredients contained in the hair nourishing agent of the present invention have an excellent hair growth promoting effect.

Extracts of Scutellaria barbatifolia, Scutellaria baicalensis, Chamomile, and Burdock Burdock, which are the active ingredients of Group 1 of the hair nourishing agent of the present invention, can be used alone or in combination. The hair nourishing agent of the present invention is a known hair nourishing agent conventionally used (peripheral vasodilator, cell activating agent, sebum secretion inhibitor, in addition to the active ingredient of the first group and the second active ingredient cepharanthin,
Anti-inflammatory agents or amino acids, vitamins, etc.) may be used together.

The dosage form of the hair nourishing agent of the present invention is not particularly limited, and conventionally known hair tonics, hair lotions, hair creams, aerosols, foam types and the like are adjusted. Furthermore, the hair nourishing agent of the present invention may be appropriately mixed with known components depending on the type.

EXAMPLES Next, the present invention will be described more specifically by way of examples.

Examples 1 to 7 According to the formulation shown in Table 2 below, a hair nick was manufactured by a conventional method. The obtained hair tonic showed an excellent hair nourishing effect.

Examples 8 to 13 Hair creams were produced by a conventional method according to the formulation shown in the third item below. The obtained hair cream exhibited an excellent hair-feeding effect.

Examples 14 to 20 Hair lotions were produced by a conventional method according to the formulations shown in Table 4 below. The obtained hair lotion showed an excellent hair nourishing effect.

(Test Example) Using the hair nicks obtained in Examples 1, 5 and 7, a person with a lot of hair loss, a person with a lot of dandruff and itch, 10 each
As a result of administration to a known male (26 to 48 years old) for 3 months, the effects shown in the following Table 5 were obtained.

[Effect of the Invention] The hair nourishing agent of the present invention exhibits an excellent hair nourishing effect, and is also extremely effective in preventing dandruff and itchiness.

Claims (2)

[Claims] 1. A hair nourishing agent, which comprises as an active ingredient an extract of at least one plant selected from quince mosquito, Scutellaria baicalensis, chamomile and burdock, and cepharanthin. 2. The hair nourishment according to claim 1, wherein the plant extract is extracted with a lower monohydric or polyhydric alcohol or a water-containing solvent thereof.