JPH067161B2 - Small animal immobilization device for positron CT device - Google Patents
Small animal immobilization device for positron CT deviceInfo
- Publication number
- JPH067161B2 JPH067161B2 JP1028233A JP2823389A JPH067161B2 JP H067161 B2 JPH067161 B2 JP H067161B2 JP 1028233 A JP1028233 A JP 1028233A JP 2823389 A JP2823389 A JP 2823389A JP H067161 B2 JPH067161 B2 JP H067161B2
- Authority
- JP
- Japan
- Prior art keywords
- positron
- small animal
- support frame
- cage
- small
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004373 animal immobilization Methods 0.000 title claims description 5
- 241001465754 Metazoa Species 0.000 claims description 27
- 230000005251 gamma ray Effects 0.000 claims description 5
- 239000011358 absorbing material Substances 0.000 claims description 2
- 230000003100 immobilizing effect Effects 0.000 claims description 2
- 239000012780 transparent material Substances 0.000 claims description 2
- 230000005855 radiation Effects 0.000 description 7
- 238000005259 measurement Methods 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- High Energy & Nuclear Physics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dentistry (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Nuclear Medicine (AREA)
Description
【発明の詳細な説明】 「産業上の利用分野」 本発明はポジトロンＣＴ装置により小動物を計測する場
合において、複数匹を同時に計測できるようにした小動
物固定装置に関するものである。Description: “Industrial field of application” The present invention relates to a small animal immobilization device capable of simultaneously measuring a plurality of small animals when measuring a small animal with a positron CT device.
「従来の技術」 ポジトロンＣＴ装置は、被検体として人体のみならず、
ラット、マウス、猫、うさぎなどの小動物も計測する。"Prior art" The positron CT device is not only the human body as the subject,
Small animals such as rats, mice, cats and rabbits are also measured.
しかるに、従来はガントリのトンネル内に１匹ずつ固定
して計測し、これを繰返えして多数匹の統計的データを
得ていた。However, conventionally, one animal was fixed in the gantry tunnel and measured, and this was repeated to obtain statistical data for a large number of animals.
「発明が解決しようとする課題」 従来のように、１匹ずつガントリのトンネル内に固定し
て計測する方法では、同じ計測を何回も繰返えさなけれ
ばならないので多くの計測時間がかかること、同じ計測
を繰返えそうとしても環境条件、固定位置、被検体の時
間的な変化などによって計測条件の再現性が困難である
ことなどの問題があった。[Problems to be Solved by the Invention] As in the conventional method, in which the animals are fixed one by one in the gantry tunnel, the same measurement must be repeated many times, which requires a lot of measurement time. However, even if the same measurement is tried to be repeated, there is a problem that the measurement condition is difficult to be reproducible due to environmental conditions, fixed positions, temporal changes of the subject, and the like.
本発明は複数の小動物を同一条件で同時に計測できる固
定装置を得ることを目的とするものである。An object of the present invention is to obtain a fixing device capable of simultaneously measuring a plurality of small animals under the same conditions.
「課題を解決するための手段」 本発明はガントリのトンネル内に小動物を固定してその
断層像を得るためのポジトロンＣＴ装置において、前記
小動物を１または数匹ずつ収納するケージと、このケー
ジを複数個セットする支持枠とを具備し、これらケージ
と支持枠をγ線低吸収材で構成してなるものである。[Means for Solving the Problems] The present invention relates to a positron CT apparatus for fixing a small animal in a tunnel of a gantry and obtaining a tomographic image thereof, and a cage for accommodating one or several small animals, and a cage A plurality of supporting frames are set, and these cages and supporting frames are made of a low gamma ray absorbing material.
「作用」 被検体である小動物に麻酔処理した後、１匹ずつケージ
に入れる。このケージを支持枠に順次セットする。支持
枠に複数個のケージをセットした後、ガントリのトンネ
ル内に固定して断層像のデータを計測する。なお、心臓
のように、放射線放出強度の著しく高い部位は、支持枠
の外側からγ線吸収体を巻きつけて隣接器官への影響を
低減する。"Action" A small animal, which is a subject, is anesthetized and then placed in a cage one by one. The cage is sequentially set on the support frame. After setting a plurality of cages on the support frame, the cage is fixed in the tunnel of the gantry and the tomographic image data is measured. In addition, in a region where the radiation emission intensity is extremely high, such as the heart, the gamma ray absorber is wound from the outside of the support frame to reduce the influence on the adjacent organs.
「実施例」 以下、本発明の一実施例を図面に基づき説明する。[Example] Hereinafter, an example of the present invention will be described with reference to the drawings.
(1)はガントリで、このガントリ(1)の中央のトンネル(1
0)内には、被検体(2)を固定するための保持装置(3)が進
退自在に設けられ、この保持装置(3)に本発明の小動物
固定装置(11)がセットされる。(1) is a gantry, and the tunnel (1
In (0), a holding device (3) for fixing the subject (2) is provided so as to be movable back and forth, and the small animal fixing device (11) of the present invention is set in this holding device (3).
前記ガントリ(1)はγ線を検出するための多数の放射線
検出器(4)…をリング状に並べてなるもので、１個の放
射線検出器(4)はシンチレータ(5)と光電子増倍管(6)を
対としてなり、これをさらに５重にし、また、放射線検
出器(4)…の内側と外側にはシールドコリメータ(7)(8)
が設けられてなるものである。このシールドコリメータ
(7)(8)は第１図に示すように、内側と外側にそれぞれ配
置して測定部位以外からの背景雑音（散乱線、単一γ
線）の入射を低減するようになっているが、さらに必要
に応じて各シンチレータ(5)毎のスライスコリメータ(9)
が設けられる。The gantry (1) is formed by arranging a large number of radiation detectors (4) for detecting γ rays in a ring shape, and one radiation detector (4) is a scintillator (5) and a photomultiplier tube. (6) becomes a pair, and it is further quintupled, and shield collimators (7) (8) are inside and outside the radiation detectors (4).
Is provided. This shield collimator
As shown in Fig. 1, (7) and (8) are arranged inside and outside respectively, and background noise (scattered ray, single γ
Line), but if necessary, a slice collimator (9) for each scintillator (5).
Is provided.
前記小動物保持装置(11)は第２図に示すように、抽斗状
のケージ(12)と、このケージ(12)を複数個固定するため
の収納孔(13)を有する支持枠(14)とからなる。これらケ
ージ(12)と支持枠(14)はγ線の低吸収性を有し、かつモ
ニターできるように透明な物質、例えばアクリル樹脂か
らなる。また、前記ケージ(12)は蓋(15)は有っても無く
てもよい。もし蓋付きの場合には呼吸用の孔が穿設され
る。前記支持枠(14)とケージ(12)は角形に限られるもの
ではなく、第３図に示すように、円筒形であってもよ
い。このような円筒形の場合には、ケージ(13)…の収納
孔(13)の位置を、支持枠(14)の中心点(O)からすべて等
距離(R)にすることにより、各ケージ(12)…内のすべて
の被検体(2)…に対してガントリ(1)のトンネル軸(16)か
ら物理的に等価な定量性が得られる。As shown in FIG. 2, the small animal holding device (11) includes a drawer-shaped cage (12) and a support frame (14) having storage holes (13) for fixing a plurality of cages (12). Consists of. The cage 12 and the support frame 14 are made of a transparent material, such as acrylic resin, which has a low absorptivity of γ-rays and can be monitored. Further, the cage (12) may or may not have the lid (15). If equipped with a lid, a breathing hole is provided. The support frame (14) and the cage (12) are not limited to the rectangular shape, but may be a cylindrical shape as shown in FIG. In the case of such a cylindrical shape, by setting the positions of the storage holes (13) of the cages (13) ... to the same distance (R) from the center point (O) of the support frame (14), Physically equivalent quantitativeness can be obtained from the tunnel axis (16) of the gantry (1) for all the objects (2) within (12).
以上のような構成において、被検体である小動物(2)…
に麻酔処理をした後、１匹ずつケージ(12)に入れる。こ
の小動物(2)を入れたケージ(12)を順次支持枠(11)の収
納孔(13)に収納固定する。そして保持装置(3)にセット
してガントリ(1)のトンネル(10)内の所定位置へ送り込
む。そして小動物(2)…から放射されたγ線がケージ(1
2)…、支持枠(14)を貫通して放射線検出器(4)…のシン
チレータ(5)…で検出し、光電子増倍管(6)…で増幅され
出力する。In the above configuration, the small animal (2) that is the subject ...
After anesthetizing, the animals are placed in cages (12) one by one. The cage (12) containing the small animal (2) is successively housed and fixed in the housing hole (13) of the support frame (11). Then, it is set on the holding device (3) and sent to a predetermined position in the tunnel (10) of the gantry (1). And the γ rays emitted from the small animals (2) ...
2) penetrating the support frame 14 and detected by the scintillators 5 of the radiation detectors 4 and amplified by the photomultiplier tubes 6 and output.
前記実施例では、１個のケージ(12)に１匹の小動物(2)
を収納したが、より小さな小動物の場合にはケージ(12)
内に仕切り等をして２匹以上を収納することもできる。In the above example, one small animal (2) per cage (12)
But cages (12) for smaller smaller animals
It is possible to store two or more animals by partitioning inside.
つぎに、第４図に示すように、支持枠(14)の外周に、
鉛、タングステンまたはこれらの合金などからなるγ線
吸収リング(17)を移動自在に嵌合し、小動物(2)の心臓
のような放射線放出強度の著しく強い部位をマスクし、
隣接器官等の断層像への影響を低減することもできる。Next, as shown in FIG. 4, on the outer periphery of the support frame (14),
A γ-ray absorption ring (17) made of lead, tungsten or an alloy of these is movably fitted to mask a region with a significantly high radiation emission intensity such as the heart of a small animal (2),
It is also possible to reduce the influence on the tomographic image of the adjacent organ or the like.
「発明の効果」 本発明は上述のように構成したので、つぎのような効果
を有する。"Effects of the Invention" Since the present invention is configured as described above, it has the following effects.
(1)多数の小動物を同一条件で計測でき、定量性の向上
した多数体の統計的データを得ることができる。(1) A large number of small animals can be measured under the same conditions, and statistical data of a large number of animals with improved quantitativeness can be obtained.
(2)薬理効果の判定などでは、精度をあげるため、多数
体について計測しデータをとる必要があるが、このよう
な場合の計測が極めて効率的である。(2) In determining the pharmacological effect, in order to improve the accuracy, it is necessary to measure and collect data for a large number of bodies, but the measurement in such a case is extremely efficient.
図は本発明によるポジトロンＣＴ装置の小動物固定装置
の実施例を示すもので、第１図は計測状態の断面図、第
２図は斜視図、第３図および第４図はそれぞれ本発明の
他の例を示す斜視図である。 (1)…ガントリ、(2)…被検体、(3)…被検体保持装置、
(4)…放射線検出器、(5)…シンチレータ、(6)…光電子
増倍管、(7),(8)…シールドコリメータ、(9)…スライス
コリメータ、(10)…トンネル、(12)…ケージ、(13)…収
納孔、(14)…支持枠、(15)…蓋、(16)…トンネル軸、(1
7)…γ線吸収リング。FIG. 1 shows an embodiment of a small animal immobilizing device of a positron CT device according to the present invention. FIG. 1 is a sectional view of a measuring state, FIG. 2 is a perspective view, and FIGS. It is a perspective view showing an example of. (1) ... Gantry, (2) ... Subject, (3) ... Subject holding device,
(4) ... Radiation detector, (5) ... Scintillator, (6) ... Photomultiplier tube, (7), (8) ... Shield collimator, (9) ... Slice collimator, (10) ... Tunnel, (12) … Cage, (13)… Storage hole, (14)… Support frame, (15)… Lid, (16)… Tunnel shaft, (1
7)… γ-ray absorption ring.
Claims (4)
その断層像を得るためのポジトロンＣＴ装置において、
前記小動物を１または数匹ずつ収納するケージと、この
ケージを複数個セットする支持枠とを具備し、これらケ
ージと支持枠をγ線低吸収材で構成してなることを特徴
とするポジトロンＣＴ装置の小動物固定装置。1. A positron CT apparatus for fixing a small animal in a gantry tunnel and obtaining a tomographic image thereof,
A positron CT comprising a cage for accommodating one or several small animals, and a support frame for setting a plurality of the cages, the cage and the support frame being made of a low-γ-ray absorbing material. Device small animal immobilization device.
の小動物をモニタできるようにした請求項(1)記載のポ
ジトロンＣＴ装置の小動物固定装置。2. The small animal immobilization device for a positron CT apparatus according to claim 1, wherein the cage and the support frame are made of a transparent material so that the small animals inside can be monitored.
となるように支持枠にケージの収納孔を形成した請求項
(1)または(2)記載のポジトロンＣＴ装置の小動物固定装
置。3. A cage housing hole is formed in a support frame so that a plurality of cages are equidistant from a tunnel axis.
The small animal immobilization device of the positron CT device according to (1) or (2).
てなる(1),(2)または(3)記載のポジトロンＣＴ装置の小
動物固定装置。4. The small animal immobilizing device for a positron CT device according to (1), (2) or (3), wherein a gamma ray absorbing ring is fitted around the outer periphery of the support frame.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1028233A JPH067161B2 (en) | 1989-02-07 | 1989-02-07 | Small animal immobilization device for positron CT device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1028233A JPH067161B2 (en) | 1989-02-07 | 1989-02-07 | Small animal immobilization device for positron CT device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02206789A JPH02206789A (en) | 1990-08-16 |
| JPH067161B2 true JPH067161B2 (en) | 1994-01-26 |
Family
ID=12242878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1028233A Expired - Fee Related JPH067161B2 (en) | 1989-02-07 | 1989-02-07 | Small animal immobilization device for positron CT device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH067161B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006084467A (en) * | 2004-09-14 | 2006-03-30 | Hitachi Ltd | Method and apparatus for performing computed tomography |
| WO2012098604A1 (en) * | 2011-01-19 | 2012-07-26 | 株式会社島津製作所 | Radiation tomography device |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9316752B2 (en) | 2007-09-24 | 2016-04-19 | Koninklijke Philips N.V. | Preclinical time of flight imaging |
| JP5794305B2 (en) * | 2011-09-01 | 2015-10-14 | 株式会社島津製作所 | Data display apparatus and tomography apparatus including the same |
| CN110974283A (en) * | 2019-12-20 | 2020-04-10 | 中南大学湘雅二医院 | A kind of dual-energy X-ray absorptiometry absorptiometry for measuring rat immobilizer and manufacturing method |
-
1989
- 1989-02-07 JP JP1028233A patent/JPH067161B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006084467A (en) * | 2004-09-14 | 2006-03-30 | Hitachi Ltd | Method and apparatus for performing computed tomography |
| WO2012098604A1 (en) * | 2011-01-19 | 2012-07-26 | 株式会社島津製作所 | Radiation tomography device |
| JP5644867B2 (en) * | 2011-01-19 | 2014-12-24 | 株式会社島津製作所 | Radiation tomography equipment |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02206789A (en) | 1990-08-16 |
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