JPH0672106B2 - Laxative composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to a laxative composition, and more particularly to a laxative composition which has good water dispersibility and can be administered in a dosage form easy to take.

[Conventional technology and its problems]

Plantago ovata seed coat, carboxymethyl cellulose,
Swelling laxatives such as sodium alginate increase the bulk of stool and increase the water content of stool to facilitate defecation and relieve constipation.

However, these swelling laxatives form a gel-like hydrate on the surface when they come into contact with water, so that they become so-called lumps and have poor dispersibility in water, resulting in uniform swelling in the digestive tract. There is a drawback that you cannot do it. Nevertheless, it has usually been used by the method of administration in water or a drink before administration.

However, this method also has drawbacks that it is not easy to disperse in water and the like, and the swelling increases the bulk, which makes it difficult to take.

Various studies have been made to overcome such drawbacks, for example, a method of mixing swelling laxatives with a large amount of sugar,
It has been reported that a method of coating the particles with polyethylene glycol or polyvinylpyrrolidone (JP-A-59-500417) improves water dispersibility. However, the effect is not sufficient even by these methods, and it is still unavoidable to disperse and administer in water before taking.

[Means for solving problems]

In such an actual situation, the present inventor has conducted diligent research to solve the above problems, and as a result of dispersing swelling laxatives in fats and oils, it is less likely to become lumps when brought into contact with water, and therefore water. Dispersibility in the digestive tract is improved and an excellent laxative effect is exerted, so there is no need to take it after swelling with water beforehand, and as a result, tablets, pills, capsules, granules, etc. The present invention has been completed by finding that it can be administered as a dosage form which is easy to take.

That is, the present invention provides a laxative composition containing a swelling laxative and an oil or fat.

The swelling laxatives used in the present invention is not particularly limited, for example, plantago ovata seed coat (ispagra seed coat), glucomannan, sodium alginate, agar, carrageenan, guar gum, locust bean gum, tamarind gum, gum arabic, karaya gum, Various dietary fibers such as tragacanth gum and pectin and natural water-soluble polymers; carboxymethyl cellulose, sodium carboxymethyl cellulose, carboxymethyl cellulose calcium, carboxyethyl cellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose Synthetic water-soluble polymer substances such as Of these, plantago ovata seed coat, sodium alginate, sodium carboxymethyl cellulose and carboxymethyl cellulose are preferred, and plant tag ovata seed coat is particularly preferred. These may be used alone or in combination of two or more. Also,
These swelling laxatives are preferably used as a powder (preferably having a particle size of 0.1 mm or less).

Further, as the fat and oil used in the present invention, any edible fat and oil having a melting point of 37 ° C. or lower can be used, and for example, hemp seed oil, linseed oil, isano oil, sumac kernel oil, and sesame seeds. Oil, ouch deer oil, kaya oil, walnut oil, poppy oil, cherry seed coat oil, pomegranate seed oil, safflower oil,
Cinnamon oil, soybean oil, tobacco seed oil, tallow gopher kernel oil, Japanese millet oil, rubber seed oil, sunflower seed oil, grape kernel oil,
Lozenge seed oil, honeysuckle seed oil, rumba nut oil, apricot kernel oil, orange seed oil, cabbage seed oil, mustard seed oil, cucumber seed oil, black mustard oil, sesame oil, wheat germ oil, western plum kernel oil, radish seed oil, corn Oil, tomato seed oil, rapeseed oil, carrot seed oil, bran oil, pecan oil, enthusiast oil, spinach seed oil, cottonseed oil, peach kernel oil, lemon seed oil, morning glory seed oil, quiche oil, olive oil, olive kernel oil, Cashew seed oil, cabbage oil, cabbage seed oil, coffee seed oil, southern oil,
Shiromoji seed oil, tea seed oil, camellia oil, camellia oil, apricot oil, jackpot oil, castor oil, sucrose seed oil, peanut oil, iribe oil, urshiro, cocoa butter, garcinia butter,
Kusu nut fat, Kusumu oil, radix ginseng oil, Kofun kernel oil, Gorri oil, Shea butter, Taiko oil, Tsukan oil, Tsukan kernel oil, Deika butter, Tobaze butter, Tonka bean butter, nutmeg fat,
Citrus butter oil, bakery oil, babassu kernel oil, palm oil, palm kernel oil, hydrocarpus oil, borneo butter, malabar butter,
Vegetable fats and oils such as succulent fat, mokuro and coconut oil; beef tallow,
Animal fats and oils such as lard, milk fat and fish oil; suppository bases represented by hard fat (for example, Isacao manufactured by Kao Corporation); hydrocarbons such as squalane and squalene, various synthetic or purified fatty acid esters, monoglycerides, Diglyceride, triglyceride and the like can be mentioned. Of these, suppository bases, fatty acid esters and soybean oil, oils and fats listed in the Japanese Pharmacopoeia such as rapeseed oil are particularly preferable, and particularly have a melting point of 30 to 37.
Suppository bases (oils and fats) at ℃ are suitable. These may be used alone or in combination of two or more.

In the laxative composition of the present invention, swelling laxatives are mixed with 1/10 to 10 times by weight, preferably 1/4 to 5 times by weight of fats and oils to prepare tablets, pills, granules, capsules and the like. It is obtained by formulating. Mixing is a method of dispersing swelling laxatives in a liquid by melting liquid oil or solid fat, or by making liquid oil adsorbed on powder or solid fat into powder, and swelling It is carried out by a method of mixing purgatives.

In the laxative composition of the present invention, in addition to the above components, various known ingredients generally used in laxative compositions, for example, stimulant laxatives such as bisacodyl and danslon, salt laxatives such as magnesium oxide, dioctylsodium sulfosuccinate. Infiltrative laxatives such as the following, a cathartic auxiliary relaxation ingredient, a stomachic ingredient, a viscosity modifier, a preservative, a stabilizer, a flavoring agent, a flavoring agent, a coating agent and the like can be blended as necessary.

〔The invention's effect〕

Since the laxative composition of the present invention has excellent dispersibility in water, it can be formulated into a dosage form that swells uniformly in the digestive tract and is easy to take.

〔Example〕

Next, examples will be described, but the present invention is not limited thereto.

Example 1 A laxative composition was prepared by using the ingredients shown in Table 1, and each was filled in a pharmacopoeia capsule No. O.

Each of the above capsules in a 50 ml Erlenmeyer flask at 35 ° C,
The mixture was poured into 50 ml of distilled water, and immediately after that, stirring was started at about 700 rpm with a stirrer having a diameter of 5 mm and a length of 15 mm, and the dispersibility in water was examined. After 30 minutes, the product of the present invention was uniformly dispersed,
The comparative product did not disperse as a large lump.

Example 2 Isocacao MO-5 (manufactured by Kao Corporation), which is a suppository base, was melted, and plantago octopus seed coat powder was dispersed at the ratio shown in Table 2, and tablets were prepared using a template with a volume of 0.5 cc. To solidify.

Regarding Nos. 1 to 4, the number of tablets corresponding to 1 g of plantago ovata seed coat was placed in 50 ml of distilled water at 36 ° C., stirred, and observed after 5 minutes. All were uniformly dispersed in water. On the other hand, the control (No. 5) plantago ovata seed coat powder (1 g), which did not contain fats and oils, did not disperse uniformly in water, and remained powdery.

Claims (1)

[Claims] 1. A laxative composition comprising a swelling laxative and an oil and fat.