JPH07103012B2 - Cosmetics - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention contains a new cosmetic composition containing an extract obtained by extracting color components from molasses, having a high whitening effect, and having excellent safety and stability (pharmaceutical department). Including medicated cosmetics that are external products. The same shall apply hereinafter).

[0002]

2. Description of the Related Art Crude sugar, so-called brown sugar, has been said to whiten the skin since ancient times and has been blended with cosmetics, such as brown sugar soap, but because brown sugar was used in an unpurified state, its effect and quality were improved. However, it was not enough. For example, in the case of the above-mentioned brown sugar soap, the sucrose component in the brown sugar is deposited over time and the surface of the soap becomes rough, so that the blending amount is limited and the effectiveness thereof cannot be achieved.

Further, in JP-B-59-48809, the coloring component (sugar color) contained in brown sugar is extracted and separated substantially purely, and the compounding amount can be arbitrarily set without being influenced by the sucrose component. It is disclosed that a cosmetic is obtained. However, cosmetics prepared by blending a coloring component of brown sugar are markedly colored and are difficult to use as general cosmetics. Furthermore, the safety and stability of this coloring component were still insufficient.

[0004]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a new cosmetic composition which has a high whitening effect and is excellent in safety and stability.

[0005]

Means for Solving the Problems As a result of intensive studies for many years in view of such circumstances, the present inventors have found that an extract obtained from molasses and obtained by removing coloring components has a high whitening effect. Based on this, the present invention has been completed. That is,
The present invention relates to a cosmetic characterized by containing an extract obtained by removing a coloring component from molasses.

The present invention will be described in detail below. Crude sugar is usually obtained from sugar cane or sugar beet, but when it is used as a cosmetic composition, it is necessary to remove it because of the precipitation of a large amount of sucrose component. on the other hand,
Molasses used in the present invention, so-called molasses, has a low sucrose content generated as a by-product in the sucrose refining process, but its use is currently only partly used for feed or medium components for fermentation, etc. Have been discarded.

As a result of researching the use of molasses in a cosmetic composition, the present inventors have found that the extract obtained from molasses by removing coloring components has a high whitening effect. Conventionally, no research has been conducted on the blending of an extract using molasses as a raw material into cosmetics and its usefulness, and the whitening effect component in the extract obtained by removing the coloring components extracted from the molasses of the present invention is It is obvious that it is completely different from the coloring component (sugar dye) obtained from the crude sugar described in JP-B-59-48809.

The molasses used in the cosmetic of the present invention is a sucrose obtained by squeezing out the sugar juice contained in sugar cane and sugar beet and purifying the sucrose through steps such as cleaning, concentration and crystallization to evaporate and concentrate the sugar solution. It is obtained as a residual liquid after separating the crystals of.

The method for preparing the extract obtained by removing the coloring component from the molasses of the present invention is not particularly limited as long as the coloring component is removed and the whitening effect component is effectively extracted. As specific examples, water, methanol, ethanol, n-butanol, isopropyl alcohol, 1,3-butylene glycol, propylene glycol, glycerin, ethyl acetate, hexane, acetone, benzene, toluene, chloroform, diethyl ether, methyl cellosolve. Examples of the method for removing the coloring component using the above or a mixture thereof as an extraction solvent include activated carbon, activated clay treatment, or silica gel, activated alumina, a synthetic resin adsorbent, a reverse osmosis membrane, and the like. If necessary, it is also possible to dry by spray drying, freeze drying or the like.

The extract obtained from the molasses of the present invention by removing the coloring components was tested for safety using the extract of Example 1 described later, and it was found that acute toxicity, skin irritation and skin sensitization It was confirmed that there was no particular problem in terms of mutagenicity in practical use, and the safety was high.

Further, with respect to the stability of the cosmetics of the present invention, the properties of the cosmetics of Examples 5 to 11 to be described later after storage at 40 ° C. for 6 months were tested. It was confirmed.

The blending amount of the extract obtained by removing the coloring component extracted from molasses used in the cosmetic of the present invention can be appropriately changed depending on the degree of symptoms, product form, frequency of use, etc. 0.01-10% by weight in the charge,
It is preferably 0.1 to 1% by weight. If the amount is less than 0.01% by weight, the effective amount of the whitening effect of the cosmetic composition of the present invention is not exhibited,
If it is more than 10% by weight, the whitening effect cannot be expected to increase and it is not economically appropriate.

In the cosmetic of the present invention, in addition to the extract obtained by extracting molasses from the molasses and removing the coloring component, other whitening components can be used in combination, and a surfactant commonly used in cosmetics, Oils and fats, polyhydric alcohols, lower alcohols, thickeners, ultraviolet absorbers / scattering agents, preservatives, antioxidants, chelating agents, pH adjusters, fragrances, dyes, water, etc. can be appropriately added. Also, its dosage form is arbitrary,
Further, any of solubilizing system, emulsifying system, powder dispersing system and the like may be used, and the application can be widely applied to basic cosmetics such as lotion, emulsion, cream, pack, body shampoo, and makeup cosmetics such as foundation.

[0014]

EXAMPLES Next, the present invention will be explained based on test examples and examples, but the present invention is not limited by these.

Example 1. Method for preparing extract obtained by extracting colored components from molasses 4 ml of methanol is added to 1 kg of molasses, and the mixture is extracted with stirring, and then insoluble matter is removed by filtration. The filtrate is concentrated under reduced pressure to remove methanol. 4 liters of water, 12 activated carbons
Add 0 g and stir for 1 hour. Then, this is filtered to obtain 4 liters of extract.

Example 2. Method for preparing an extract obtained by extracting color components from molasses After adding 10 liters of ethyl acetate to 1 kg of molasses, stirring and extracting, insoluble matter is removed by filtration. The filtrate is silica gel 1.
Apply to a φ10 × 50 cm column packed with 5 kg and let it flow down. The passing solution is concentrated under reduced pressure to remove ethyl acetate. To this, 1 liter of water and 50 g of dextrin are added and spray-dried to obtain an extract powder of 60 g.

Embodiment 3. Method for preparing extract obtained by extracting color components from molasses Add 5 liters of 70% aqueous ethanol solution to 1 kg of molasses,
After extraction with stirring, insoluble materials are removed by filtration. The filtrate is concentrated under reduced pressure and dried. 5 liters of water, 25 of activated clay
Add 0 g and stir for 1 hour. Then, this is filtered to obtain 5 liters of extract.

Example 4. Method for preparing extract obtained by extracting color component from molasses 5 ml of water is added to 1 kg of molasses to dissolve, and insoluble matter is removed by filtration. The filtrate is passed through a φ3 × 30 cm column packed with 100 g of a synthetic resin adsorbent (Amberlite XAD-2) to obtain 5 liters of extract.

Test Example 1. Melanin production inhibitory effect test in cultured cells 2 × 10 ⁵ B16 melanoma cells were cultured in a culture dish with a diameter of 6 cm using 10% fetal bovine serum-added Eagle's MEM medium containing test substance under air containing 5% carbon dioxide gas. 37
Culture was performed at 7 ° C for 7 days. Thereafter, the cells were detached with a Dulbecco's phosphate buffer containing 0.025% trypsin, the number of cells was measured, and centrifugation was performed to visually compare the degree of whitening of the cells. (Degree of whitening) ++: Large whitening degree +: Somewhat whitening −: No whitening

[0020]

[Table 1]

The results are shown in Table 1. The extracts obtained from molasses of the present invention by removing the coloring components are all B16 melanoma cells, which are more known than kojic acid, which has been known to have a melanin production inhibitory effect. The whitening effect was strong. In addition, cells whitened by the extract obtained by removing the coloring component extracted from molasses in this test, as a result of culturing again without adding the test substance, blackened,
It was confirmed that the effect of suppressing the melanin production of the extract obtained by removing the coloring component extracted from molasses is reversible and does not adversely affect the growth of cells.

Test Example 2. Membrane spot treatment effect test 40 subjects suffering from liver spots were used as a panel, and half of the 20 subjects were the cream of Example 5 described below, and the remaining 20 subjects were formulations in which the extract of Example 1 from Example 5 was removed. Cream (comparative example)
Was applied to the face every day for 3 months, and the lightening effect after use was evaluated. (Judgment Criteria) Effective: Pigmentation was considerably thinned Fairly: Pigmentation was slightly thinned Invalid: Pigmentation did not change

[0023]

[Table 2]

The results are shown in Table 2. The cosmetic of the present invention of Example 5 showed a significant therapeutic effect on liver spots.

Example 5. Cream Stearic acid 2.0 (%) Stearyl alcohol 7.0 Reduced lanolin 2.0 Squalane 5.0 Octyldodecanol 6.0 Polyoxyethylene (25) cetyl alcohol 3.0 Lipophilic glyceryl monostearate 2.0 Propylene glycol 5.0 Extract of Example 1 5.0 Fragrance, preservative Appropriate amount Purified water Total amount 100

Example 6. Cream Beeswax 6.0 (%) Cetanol 5.0 Reduced lanolin 8.0 Squalane 37.5 Fatty acid glycerin 4.0 Lipophilic glyceryl monostearate 2.0 Polyoxyethylene (20) sorbitan monolaurate 2.0 Propylene Glycol 5.0 Extract of Example 2 1.0 Fragrance, preservative Appropriate amount Antioxidant Appropriate amount Purified water Total amount 100

Example 7. Lotion glycerin 5.0 (%) propylene glycol 4.0 oleyl alcohol 0.1 polyoxyethylene (20) sorbitan monolaurate 1.5 polyoxyethylene (20) lauryl ether 0.5 ethanol 10.0 Example 3 Extract 10.0 Fragrance, antiseptic Adequate amount UV absorber Adequate amount Purified water Total amount 100

Example 8. Emulsion Stearic acid 0.2 (%) Cetanol 1.5 Vaseline 3.0 Lanolin alcohol 2.0 Liquid paraffin 10.0 Polyoxyethylene (10) monooleate 2.0 Glycerin 3.0 Propylene glycol 5.0 Tri Ethanolamine 1.0 Extract of Example 4 0.2 Fragrance, preservative Appropriate amount Purified water Total amount 100

Example 9. Pack Polyvinyl alcohol 15.0 (%) Carboxymethylcellulose sodium 5.0 Propylene glycol 3.0 Ethanol 10.0 Extract of Example 1 20.0 Fragrance, preservative Appropriate amount Purified water Total amount 100

Example 10. Body shampoo Sodium lauryl sulfate 10.0 (%) Sodium lauryl sulfosuccinate 20.0 Lauryl diethanolamide 4.0 Hydrolyzed collagen 1.0 Ethylene glycol distearate 1.0 Tetrasodium edetate tetrahydrate 0.1 Propylene glycol 5 0.0 Extract of Example 2 0.5 Citric acid Appropriate amount Perfume, preservative Appropriate amount Purified water Total amount 100

Example 11. Foundation Stearic acid 2.4 (%) Propylene glycol monostearate 2.0 Cetostearyl alcohol 0.2 Liquid lanolin 2.0 Liquid paraffin 3.0 Isopropyl myristate 8.5 Sodium carboxymethylcellulose 0.2 Bentonite 0.5 Propylene Glycol 4.0 Triethanolamine 1.1 Titanium oxide 8.0 Talc 4.0 Extract of Example 3 0.1 Fragrance, preservative Appropriate amount Purified water Total amount 100

[0032]

As described in detail above, according to the present invention, there is provided a cosmetic having a higher whitening effect than the conventionally known whitening cosmetics and having excellent safety and stability.

Front Page Continuation (72) Inventor Masatsugu Yamashita 9-5 Akahori Shinmachi, Yokkaichi-shi, Mie Solar Chemicals Co., Ltd. Examiner Seiko Tamura (56) Reference JP-A-60-78911 (JP, A) JP Hei 2-229103 (JP, A) Japanese Patent Publication Sho 59-48809 (JP, B2) Patent 108521 (JP, C2) European Patent Application Publication 383467 (EP, A)

Claims (1)

[Claims] 1. A cosmetic comprising an extract obtained by extracting color components from molasses.