JPH0723283B2 - Dissolution aid for pesticides or epidemics granules - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION <Field of Industrial Application> The present invention relates to an elution aid for pesticides or epidemic prevention drug granules.

Pesticides such as insecticides, fungicides, herbicides or epidemic prevention agents are often used in the form of granules when they are applied to the surface of the water for convenience of spraying, but in these granules, It is important to dissolve the active ingredient contained in water and utilize it effectively.

The present invention relates to an auxiliary agent that enhances the elution of the active ingredient contained in the granules into water when the granules as described above are applied to the surface of water to effectively utilize the active ingredients.

<Prior art and its problems> Conventionally, as a means for increasing the elution of the active ingredient contained in granules into water, an example of blending water-swelling bentonite or the like into a granule carrier, or a carboxylic acid or a chelating agent is used. There are examples of blending, and further examples of blending a surfactant.

However, in the conventional means as described above for granules containing a poorly water-soluble active ingredient, the active ingredient is adsorbed to the granule carrier or the soil layer, and their elution into water is insufficient. However, there is a problem that the elution is greatly affected by the water temperature and the water quality. In fact, it is well known that granules require a large amount to be dropped per unit area as compared with emulsions and the like.

<Problems to be Solved by the Invention and Means for Solving the Problems> The present invention provides a new dissolution aid for pesticides or epidemic prevention granules that solves the above-mentioned conventional problems.

However, as a result of earnest research from the above viewpoint, the present inventors have found that
A mixture of a specific sulphate compound and a specific sulphonate compound in a specific ratio enhances the elution of the active ingredient from the granules into water, and found that the change in the elution rate due to water temperature and water quality is small, The present invention has been completed.

That is, the present invention is characterized in that the sulfate compound represented by the following general formula (I) and the sulfonate compound represented by the following general formula (II) are in a weight ratio of the former / the latter = 85 to 30/15 to 70. Concerning the dissolution aid for agricultural chemicals or epidemic prevention drug granules.

General formula (1) [However, (R ¹ ) mA is (poly) styrenated,
A (poly) methylstyrenated, (poly) α-methylstyrenated or (poly) benzylated phenyl group, diphenyl group or naphthyl group. R ² is H or CH ₃ and these are single or mixed. M ¹ is an alkali metal, NH ₄ or mono-trialkanolamine. m is an integer of 1 to 3. n is an integer of 3 to 35] General formula (II) [However, R ³ is a linear or branched alkyl group having 8 to 18 carbon atoms,
M ² is an alkali metal, alkaline earth metal, NH ₄ or mono-
Trialkanolamine] In the present invention, specific examples of the sulfate compound represented by the general formula (I) include Na, K, NH _{4 and} mono-triethanolamine of the following sulfates. 1) POE (8 mol) tristyrenated phenyl ether sulphate (POE is polyoxyethylene, the same below), POE (20 mol) tristyrenated phenyl ether sulphate, POP / POE (2 mol / 8 mol random) POE ( 15 mol / block) Tristyrenated phenyl ether sulphate (POP is polyoxypropylene, the same applies below) and other polyoxyalkylene polystyrene phenyl ether sulphates, 2) POE (20
Polyoxyalkylene poly (methylstyrene) -modified phenyl ether sulphates such as (mol) di (methylstyrene) -modified phenyl ether sulphate, POE (20 mol) tri (methylstyrene) -modified phenyl ether sulphate, 3) POE (15 mol) mono Polyoxyalkylene (poly) α-methyl such as -α-methylstyrenated phenyl ether sulfate, POP / POE (2 mol / 5 mol random) POE (15 mol block) di-α-methylstyrenated phenyl ether sulfate Styrenated phenyl ether sulphates, 4) POE (20 mol) tribenzylated phenyl ether sulphate, POP (5 mol) POE
(15 moles) polyoxyalkylene polybenzylated phenyl ether sulphates such as tribenzylated phenyl ether sulphate, 5) POP / POE (2 moles / 8 moles
Random) POE (15 mol / block) tristyrenated diphenyl ether sulphate, POE (20 mol) tristyrenated diphenyl ether sulphate and other polyoxyalkylene polystyrene diphenyl ether sulphates, 6) POE (15 mol) mono (methyl styrene)
Diphenyl ether sulphate, POP (5 mol) POE
(15 mol) polyoxyalkylene (poly) methyl styrenated diphenyl ether sulfates such as di (methyl styrene) diphenyl ether sulfate, 7) PO
E (20 mol) tri-α-methylstyrenated diphenyl ether sulfate, POP (5 mol) POE (15 mol) di-
polyoxyalkylene poly-α-methylstyrenated diphenyl ether sulfates such as α-methyl styrenated diphenyl ether sulfate, 8) POE (20 mol) tribenzylated diphenyl ether sulfate,
POP / POE (3 mol / 12 mol) tribenzylated diphenyl ether sulfate and other polyoxyalkylene polybenzylated diphenyl ether sulfates, 9) POE (2
0 mol) tristyrenated naphthyl ether sulphate, POP / POE (3 mol / 17 mol) distyrenated naphthyl ether sulphate, etc. polyoxyalkylene polystyrene naphthyl ether sulphates, 10) POE (15
Polyoxyalkylene (poly) methyl styrenated naphthyl ether sulphates such as (mol) mono (methyl styrene) naphthyl ether sulphate, POP (5 mol) POE (15 mol) di (methyl styrene) naphthyl ether sulphate, 11) POE (20 mol) di-α-methylstyrenated naphthyl ether sulfate, POP (5 mol) POE (15 mol) di-α-methylstyrenated naphthyl ether sulfate, and other polyoxyalkylene poly-
Polyoxyalkylene (poly) benzylated naphthyl such as α-methyl styrenated naphthyl ether sulfates, 12) POE (30 mol) tribenzylated naphthyl ether sulfate, POP (5 mol) POE (15 mol) monobenzylated naphthyl ether sulfate Ether sulfates.

In addition, specific examples of the sulfonate compound represented by the general formula (II) include octylbenzesulfonic acid, nonylbenzenesulfonic acid, dodecylbenzenesulfonic acid, and the like, Na, K, NH ₄ , Ca, Mg, and mono-to- Examples include triethanolamine.

In the dissolution aid according to the present invention, as illustrated above, the sulfate compound and the sulfonate compound are the former / the latter = 85.
It is composed of a weight ratio of ~ 30 / 15-70, and if it deviates from this weight ratio, it is difficult to obtain the desired dissolution effect, but to the extent that this weight ratio is maintained and the effect of the present invention is not impaired. In addition, various glycols, glycol ethers, nonionic activators, anionic activators and the like can be used in combination.

On the other hand, specific examples of the sparingly water-soluble active ingredients for agricultural chemicals or epidemic prevention drugs include the following. O, O−
Diethyl-O- (2-isopropyl-4-methyl-6-
Pyrimidyl) thiophosphate (diazinone), O, O
-Dimethyl-O- (4-methylthio-m-tolyl) thiophosphate (MPP), O, O-dimethyl-O- (4-nitro-m-tolyl) thiophosphate (MEP), O, O-dipropyl-O -(4-methylthiophenyl) phosphate (propaphos), O, O-diisopropyl-S-benzylthiophosphate (IBP), diethylthiocarbamate-Sp-chlorobenzyl (thiobencarb), or methylcarbamate-o-sec- Butylphenyl (BPM
C).

The dissolution aid according to the present invention is applied to granules containing the above active ingredients, but the present invention does not particularly limit the method for producing granules including the application. .
For example, diatomaceous earth with an average particle size of 0.3 to 1.5 mm, vermiculite, silica, clay or fine powder talc, clay, bentonite as the main raw material, PVA, CMC as a binder are added to this, and the mixture is granulated with water. Dry granule base (average particle size
0.3 to 1.5 mm), the dissolution aid of the present invention and the active ingredient are mixed and dissolved at room temperature or under heating, and then added by a method such as mixed adsorption or spray adsorption. In this case, the content of the dissolution aid according to the present invention in the granule is not particularly limited, but is usually 0.5 to 5%, preferably 1.0 to 3.0%.

Hereinafter, in order to make the configuration and effects of the present invention more specific,
Examples will be given. In the following display,% means weight%
Moreover, a part shows a weight part.

<Examples, etc.> Adjustment of elution aids • Sulfate compound or sulfonate compound used (component of the present invention) A-1; POE (15 mol) tribenzylated phenyl ether sulfate Na A-2; POE (18 mol) Tribenzylated Phenyl Ether Sulfate NH ₄ A-3; POE (18 mol) Tristyrenated Phenyl Ether Sulfate NH ₄ A-4; POP (2 mol) POE (20 mol) Tribenzylated Phenyl Ether Sulfate NH ₄ A-5; POE (20 mol) tri (methylstyrene) -modified phenyl ether sulfate NH ₄ A-6; POP / POE (2 mol / 10 mol random) POE (13 mol block) tristyrenated phenyl ether sulfate NH ₄ A-7; POE (20 mol) tristyrenated ether sulfates _{NH 4 A-8; POE (} 20 mol) tri -α- methyl styrenated diphenyl monkeys phosphate Diethanolamine A-9; POE (20 mol) tribenzyl diphenyl ether sulfates _{NH 4 A-10; POE (} 20 mol) tristyrenated naphthyl ethers sulfate _{NH 4 A-11; POE (} 15 mol) mono (methyl styrene) of naphthyl ethers Sulfate NH ₄ A-12; POP (5 mol) POE (15 mol) Monobenzylated naphthyl ether sulfate NH ₄ B-1; Dodecylbenzenesulfonic acid Na B-2; Dodecylbenzenesulfonic acid monoethanolamine B-3; Dodecyl Benzene sulfonic acid Ca Other compounds used R-1; POE (10 mol) nonylphenyl ether sulphate NH ₄ R-2; POE (8 mol) oleyl ether sulphate NH ₄ R-3; POE (18 mol) tribenzyl Phenyl ether R-4; POE (18 mol) tristyrene phenyl ether R-5; POP / POE (2 mol / 10 mol run POE (15 mol / block) tristyrenated phenyl ether R-6; POE (15 mol) tristyrenated phenyl ether phosphate monoethanolamine R-7; α-olefin sulfone having an alkyl group with 10 to 16 carbon atoms Acid Na R-8; POE (13 mol) / POP (30 mol) / POE (13 mol) block polyether disulfate NH ₄ R-9; Alkyl sulfate Na having 12 to 16 carbon atoms in the alkyl group The compounds were used to prepare the dissolution aids listed in Table 1.

-Evaluation 1 Prepare a mixture of 2 parts of dissolution aid and 5 parts of MPP drug substance and dissolve it in 93 parts of granular diatomaceous earth having an average particle size of 0.8 to 1.5 mm,
It was uniformly adsorbed under stirring to obtain MPP 5% granules. Then, take 100 ml of 3 degree hard water at 20 ℃ into a 100 ml graduated cylinder, add exactly the above granules to about 0.8 g, add it to the same temperature for 24 hours, shake it gently, and then add water. The layer was sampled, the MPP concentration in the aqueous layer was measured by a high performance liquid chromatography method (internal standard diphenyl, detection group UV · 254 nm), and the elution rate was calculated. The results are shown in Table 2.

-Evaluation 2 2 parts of dissolution aid, 4 parts of MPP drug substance and 3 parts of BPMC were prepared by heating and dissolved. Granules were obtained in the same manner as in evaluation 1 and the dissolution rate was measured or calculated. . The results are shown in Table 3.

-Evaluation 3 The dissolution rate of MPP was similarly measured or calculated for the granules of Evaluation 2 by changing the water temperature and the water quality. The results are shown in Table 4.

Evaluation 4 A mixture of 2 parts of dissolution aid and 5 parts of diazinon was prepared and dissolved, and the dissolution rate of diazinon was measured or calculated in the same manner as in Evaluation 1. The results are shown in Table 5.

<Effects of the Invention> As is clear from the results of Tables 2 to 5, in the present invention described above, the elution of the active ingredient from the granules into water is not affected by the water temperature and the water quality. There is an effect that it can be raised and its effective use can be achieved.

Claims (1)

[Claims] 1. A sulfate compound represented by the following general formula (I) and a sulfonate compound represented by the following general formula (II) in a weight ratio of former / latter = 85-30 / 15-70. Dissolution aid for agricultural chemicals or epidemic prevention drug granules. General formula (I) [However, (R ¹ ) mA is (poly) styrenated,
A (poly) methylstyrenated, (poly) α-methylstyrenated or (poly) benzylated phenyl group, diphenyl group or naphthyl group. R ² is H or CH ₃ and these are single or mixed. M ¹ is an alkali metal, NH ₄ or mono-trialkanolamine. m is an integer of 1 to 3. n is an integer of 3 to 35] General formula (II) [However, R ³ is a linear or branched alkyl group having 8 to 18 carbon atoms,
M ² is an alkali metal, alkaline earth metal, NH ₄ or mono-
Trialkanolamine]